메뉴 건너뛰기




Volumn 18, Issue 13, 2012, Pages 3499-3508

New strategies in the treatment of mantle cell lymphoma

Author keywords

[No Author keywords available]

Indexed keywords

5 FLUORO 3 PHENYL 2 [1 (9H PURIN 6 YLAMINO)PROPYL] 3H QUINAZOLIN 4 ONE; 6 ACETYL 8 CYCLOPENTYL 5 METHYL 2 [5 (1 PIPERAZINYL) 2 PYRIDINYLAMINO] 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; BENDAMUSTINE; BORTEZOMIB; CARFILZOMIB; CHLORAMBUCIL; CLADRIBINE; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; DINACICLIB; DOXORUBICIN; FLAVOPIRIDOL; FLUDARABINE; FOSTAMATINIB; GEMCITABINE; IBRUTINIB; LENALIDOMIDE; METHOTREXATE; PICETANNOL; PLERIXAFOR; PREDNISONE; PROTEIN KINASE SYK INHIBITOR; RITUXIMAB; TEMSIROLIMUS; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE; VORINOSTAT;

EID: 84863303079     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-11-3152     Document Type: Review
Times cited : (9)

References (122)
  • 1
    • 45249090747 scopus 로고    scopus 로고
    • Mantle cell lymphoma: Identifying novel molecular targets in growth and survival pathways
    • O'Connor OA. Mantle cell lymphoma: identifying novel molecular targets in growth and survival pathways. Hematology (Am Soc Hematol Educ Program) 2007;270-6.
    • (2007) Hematology (Am Soc Hematol Educ Program) , pp. 270-276
    • O'Connor, O.A.1
  • 2
    • 0025787039 scopus 로고
    • Rearrangement of the chromosome 11 bcl-1 locus in centrocytic lymphoma: Analysis with multiple breakpoint probes
    • Williams ME, Meeker TC, Swerdlow SH. Rearrangement of the chromosome 11 bcl-1 locus in centrocytic lymphoma: analysis with multiple breakpoint probes. Blood 1991;78:493-8.
    • (1991) Blood , vol.78 , pp. 493-498
    • Williams, M.E.1    Meeker, T.C.2    Swerdlow, S.H.3
  • 3
    • 0025836326 scopus 로고
    • Bcl-1, t(11;14), and mantle cell-derived lymphomas
    • Raffeld M, Jaffe ES. bcl-1, t(11;14), and mantle cell-derived lymphomas. Blood 1991;78:259-63.
    • (1991) Blood , vol.78 , pp. 259-263
    • Raffeld, M.1    Jaffe, E.S.2
  • 4
    • 0028360822 scopus 로고
    • Cyclin D1 (Bcl-1, PRAD1) protein expression in low-grade B-cell lymphomas and reactive hyperplasia
    • Yang WI, Zukerberg LR, Motokura T, Arnold A, Harris NL. Cyclin D1 (Bcl-1, PRAD1) protein expression in low-grade B-cell lymphomas and reactive hyperplasia. Am J Pathol 1994;145:86-96. (Pubitemid 24217487)
    • (1994) American Journal of Pathology , vol.145 , Issue.1 , pp. 86-96
    • Yang, W.-I.1    Zukerberg, L.R.2    Motokura, T.3    Arnold, A.4    Harris, N.L.5
  • 6
    • 78650985963 scopus 로고    scopus 로고
    • Mantle cell lymphoma: Biology, pathogenesis, and the molecular basis of treatment in the genomic era
    • Pérez-Galán P, Dreyling M, Wiestner A. Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era. Blood 2011;117:26-38.
    • (2011) Blood , vol.117 , pp. 26-38
    • Pérez-Galán, P.1    Dreyling, M.2    Wiestner, A.3
  • 11
    • 50949125416 scopus 로고    scopus 로고
    • Truncation in CCND1 mRNA alters miR-16-1 regulation in mantle cell lymphoma
    • Chen RW, Bemis LT, Amato CM, Myint H, Tran H, Birks DK, et al. Truncation in CCND1 mRNA alters miR-16-1 regulation in mantle cell lymphoma. Blood 2008;112:822-9.
    • (2008) Blood , vol.112 , pp. 822-829
    • Chen, R.W.1    Bemis, L.T.2    Amato, C.M.3    Myint, H.4    Tran, H.5    Birks, D.K.6
  • 12
    • 0034671768 scopus 로고    scopus 로고
    • Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation
    • DOI 10.1101/gad.854900
    • Alt JR, Cleveland JL, Hannink M, Diehl JA. Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev 2000;14:3102-14. (Pubitemid 32015129)
    • (2000) Genes and Development , vol.14 , Issue.24 , pp. 3102-3114
    • Alt, J.R.1    Cleveland, J.L.2    Hannink, M.3    Diehl, J.A.4
  • 14
    • 0032533225 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
    • Diehl JA, Cheng M, Roussel MF, Sherr CJ. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 1998;12:3499-511. (Pubitemid 28553242)
    • (1998) Genes and Development , vol.12 , Issue.22 , pp. 3499-3511
    • Diehl, J.A.1    Cheng, M.2    Roussel, M.F.3    Sherr, C.J.4
  • 15
    • 46749155539 scopus 로고    scopus 로고
    • Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma
    • Dal Col J, Zancai P, Terrin L, Guidoboni M, Ponzoni M, Pavan A, et al. Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma. Blood 2008;111:5142-51.
    • (2008) Blood , vol.111 , pp. 5142-5151
    • Dal Col, J.1    Zancai, P.2    Terrin, L.3    Guidoboni, M.4    Ponzoni, M.5    Pavan, A.6
  • 16
    • 45849131324 scopus 로고    scopus 로고
    • Fbx4 Ligase and Contribute to Cyclin D1 Overexpression in Human Cancer
    • DOI 10.1016/j.ccr.2008.05.017, PII S1535610808001906
    • Barbash O, Zamfirova P, Lin DI, Chen X, Yang K, Nakagawa H, et al. Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. Cancer Cell 2008;14:68-78. (Pubitemid 351885497)
    • (2008) Cancer Cell , vol.14 , Issue.1 , pp. 68-78
    • Barbash, O.1    Zamfirova, P.2    Lin, D.I.3    Chen, X.4    Yang, K.5    Nakagawa, H.6    Lu, F.7    Rustgi, A.K.8    Diehl, J.A.9
  • 17
    • 0027494864 scopus 로고
    • Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression
    • Jiang W, Kahn SM, Zhou P, Zhang YJ, Cacace AM, Infante AS, et al. Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene 1993;8:3447-57. (Pubitemid 23342646)
    • (1993) Oncogene , vol.8 , Issue.12 , pp. 3447-3457
    • Jiang, W.1    Kahn, S.M.2    Zhou, P.3    Zhang, Y.-J.4    Cacace, A.M.5    Infante, A.S.6    Doi, S.7    Santella, R.M.8    Weinstein, I.B.9
  • 19
    • 0026778547 scopus 로고
    • Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins
    • Matsushime H, Ewen ME, Strom DK, Kato JY, Hanks SK, Roussel MF, et al. Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell 1992; 71:323-34.
    • (1992) Cell , vol.71 , pp. 323-334
    • Matsushime, H.1    Ewen, M.E.2    Strom, D.K.3    Kato, J.Y.4    Hanks, S.K.5    Roussel, M.F.6
  • 20
    • 0026459047 scopus 로고
    • D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
    • Xiong Y, Zhang H, Beach D. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 1992;71:505-14.
    • (1992) Cell , vol.71 , pp. 505-514
    • Xiong, Y.1    Zhang, H.2    Beach, D.3
  • 21
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ. Cancer cell cycles. Science 1996;274:1672-7.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 23
    • 0035437143 scopus 로고    scopus 로고
    • Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray
    • Hofmann WK, de Vos S, Tsukasaki K, Wachsman W, Pinkus GS, Said JW, et al. Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray. Blood 2001;98:787-94.
    • (2001) Blood , vol.98 , pp. 787-794
    • Hofmann, W.K.1    De Vos, S.2    Tsukasaki, K.3    Wachsman, W.4    Pinkus, G.S.5    Said, J.W.6
  • 27
    • 0032523043 scopus 로고    scopus 로고
    • p16(INK4a) gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin's lymphomas
    • Pinyol M, Cobo F, Bea S, Jares P, Nayach I, Fernandez PL, et al. p16 (INK4a) gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin's lymphomas. Blood 1998;91:2977-84. (Pubitemid 28227549)
    • (1998) Blood , vol.91 , Issue.8 , pp. 2977-2984
    • Pinyol, M.1    Cobo, F.2    Bea, S.3    Jares, P.4    Nayach, I.5    Fernandez, P.L.6    Montserrat, E.7    Cardesa, A.8    Campo, E.9
  • 28
    • 0037108299 scopus 로고    scopus 로고
    • Expression of Skp2, a p27(Kip1) ubiquitin ligase, in malignant lymphoma: Correlation with p27(Kip1) and proliferation index
    • Lim MS, Adamson A, Lin Z, Perez-Ordonez B, Jordan RC, Tripp S, et al. Expression of Skp2, a p27(Kip1) ubiquitin ligase, in malignant lymphoma: correlation with p27(Kip1) and proliferation index. Blood 2002;100:2950-6.
    • (2002) Blood , vol.100 , pp. 2950-2956
    • Lim, M.S.1    Adamson, A.2    Lin, Z.3    Perez-Ordonez, B.4    Jordan, R.C.5    Tripp, S.6
  • 30
    • 34547137412 scopus 로고    scopus 로고
    • Skp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas
    • DOI 10.1182/blood-2006-11-060350
    • Lwin T, Hazlehurst LA, Dessureault S, Lai R, Bai W, Sotomayor E, et al. Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas. Blood 2007;110: 1631-8. (Pubitemid 47443981)
    • (2007) Blood , vol.110 , Issue.5 , pp. 1631-1638
    • Lwin, T.1    Hazlehurst, L.A.2    Dessureault, S.3    Lai, R.4    Bai, W.5    Sotomayor, E.6    Moscinski, L.C.7    Dalton, W.S.8    Tao, J.9
  • 31
    • 49149120031 scopus 로고    scopus 로고
    • Correlation of cyclin D1 transcript levels, transcript type and protein expressionwith proliferation and histology among mantle cell lymphoma
    • Shakir R, Ngo N, Naresh KN. Correlation of cyclin D1 transcript levels, transcript type and protein expressionwith proliferation and histology among mantle cell lymphoma. J Clin Pathol 2008;61:920-7.
    • (2008) J Clin Pathol , vol.61 , pp. 920-927
    • Shakir, R.1    Ngo, N.2    Naresh, K.N.3
  • 33
    • 56249117299 scopus 로고    scopus 로고
    • Specific lentiviral shRNA-mediated knockdown of cyclin D1 in mantle cell lymphoma has minimal effects on cell survival and reveals a regulatory circuit with cyclin D2
    • Klier M, Anastasov N, Hermann A, Meindl T, Angermeier D, Raffeld M, et al. Specific lentiviral shRNA-mediated knockdown of cyclin D1 in mantle cell lymphoma has minimal effects on cell survival and reveals a regulatory circuit with cyclin D2. Leukemia 2008;22:2097-105.
    • (2008) Leukemia , vol.22 , pp. 2097-2105
    • Klier, M.1    Anastasov, N.2    Hermann, A.3    Meindl, T.4    Angermeier, D.5    Raffeld, M.6
  • 34
    • 77955720554 scopus 로고    scopus 로고
    • Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line
    • Chen R, Chubb S, Cheng T, Hawtin RE, Gandhi V, Plunkett W. Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line. Cancer Res 2010;70:6587-97.
    • (2010) Cancer Res , vol.70 , pp. 6587-6597
    • Chen, R.1    Chubb, S.2    Cheng, T.3    Hawtin, R.E.4    Gandhi, V.5    Plunkett, W.6
  • 35
    • 0028961423 scopus 로고
    • A clinical analysis of two indolent lymphoma entities: Mantle celllymphoma and marginal zone lymphoma (including the mucosa-associated lymphoid tissue and monocytoid B-cell subcategories): A Southwest Oncology Group study
    • Fisher RI, Dahlberg S, Nathwani BN, Banks PM, Miller TP, Grogan TM. A clinical analysis of two indolent lymphoma entities: mantle celllymphoma and marginal zone lymphoma (including the mucosa-associated lymphoid tissue and monocytoid B-cell subcategories): a Southwest Oncology Group study. Blood 1995;85:1075-82.
    • (1995) Blood , vol.85 , pp. 1075-1082
    • Fisher, R.I.1    Dahlberg, S.2    Nathwani, B.N.3    Banks, P.M.4    Miller, T.P.5    Grogan, T.M.6
  • 36
    • 0028881792 scopus 로고
    • European Organization for the Research and Treatment of Cancer Lymphoma Cooperative Group. Efficacy of four different regimens in 64 mantle-cell lymphoma cases: Clinicopathologic comparison with 498 other non-Hodgkin's lymphoma subtypes
    • Teodorovic I, Pittaluga S, Kluin-Nelemans JC, Meerwaldt JH, Hagenbeek A, van Glabbeke M, et al.European Organization for the Research and Treatment of Cancer Lymphoma Cooperative Group. Efficacy of four different regimens in 64 mantle-cell lymphoma cases: clinicopathologic comparison with 498 other non-Hodgkin's lymphoma subtypes. J Clin Oncol 1995;13:2819-26.
    • (1995) J Clin Oncol , vol.13 , pp. 2819-2826
    • Teodorovic, I.1    Pittaluga, S.2    Kluin-Nelemans, J.C.3    Meerwaldt, J.H.4    Hagenbeek, A.5    Van Glabbeke, M.6
  • 38
    • 72949104417 scopus 로고    scopus 로고
    • The addition of rituximab to first-line chemotherapy (R-CHOP) results in superior response rates, time to treatment failure and response duration in patients with advanced stage mantle cell lymphoma: Long term results of a randomized GLSG trial
    • Hoster E, Unterhalt M, Wormann B, Duhrsen U, Metzner B, Eimermacher H, et al. The addition of rituximab to first-line chemotherapy (R-CHOP) results in superior response rates, time to treatment failure and response duration in patients with advanced stage mantle cell lymphoma: long term results of a randomized GLSG trial. Blood 2008;112:3049.
    • (2008) Blood , vol.112 , pp. 3049
    • Hoster, E.1    Unterhalt, M.2    Wormann, B.3    Duhrsen, U.4    Metzner, B.5    Eimermacher, H.6
  • 39
    • 80855144802 scopus 로고    scopus 로고
    • Addition of rituximab to chemotherapy alone as first-line therapy improves overall survival in elderly patients with mantle cell lymphoma
    • Griffiths R, Mikhael J, Gleeson M, Danese M, Dreyling M. Addition of rituximab to chemotherapy alone as first-line therapy improves overall survival in elderly patients with mantle cell lymphoma. Blood 2011;118:4808-16.
    • (2011) Blood , vol.118 , pp. 4808-4816
    • Griffiths, R.1    Mikhael, J.2    Gleeson, M.3    Danese, M.4    Dreyling, M.5
  • 41
    • 27244452464 scopus 로고    scopus 로고
    • High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine
    • Romaguera JE, Fayad L, Rodriguez MA, Broglio KR, Hagemeister FB, Pro B, et al. High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine. J Clin Oncol 2005;23:7013-23.
    • (2005) J Clin Oncol , vol.23 , pp. 7013-7023
    • Romaguera, J.E.1    Fayad, L.2    Rodriguez, M.A.3    Broglio, K.R.4    Hagemeister, F.B.5    Pro, B.6
  • 42
    • 77954334194 scopus 로고    scopus 로고
    • Ten-year follow-up after intense chemoimmunotherapy with rituximab-HyperCVAD alternating with rituximab-high dose methotrexate/ cytarabine (R-MA) and without stem cell transplantation in patients with untreated aggressive mantle cell lymphoma
    • Romaguera JE, Fayad LE, Feng L, Hartig K, Weaver P, RodriguezMA, et al. Ten-year follow-up after intense chemoimmunotherapy with rituximab-HyperCVAD alternating with rituximab-high dose methotrexate/ cytarabine (R-MA) and without stem cell transplantation in patients with untreated aggressive mantle cell lymphoma. Br J Haematol 2010;150:200-8.
    • (2010) Br J Haematol , vol.150 , pp. 200-208
    • Romaguera, J.E.1    Fayad, L.E.2    Feng, L.3    Hartig, K.4    Weaver, P.5    Rodriguez, M.A.6
  • 43
    • 84855796484 scopus 로고    scopus 로고
    • Rituximab plus HyperCVADalternating with high dose cytarabine and methotrexate for the initial treatment of patients with mantle cell lymphoma, a multicentre trial from Gruppo Italiano Studio Linfomi
    • Merli F, Luminari S, Ilariucci F, Petrini M, Visco C, Ambrosetti A, et al. Rituximab plus HyperCVADalternating with high dose cytarabine and methotrexate for the initial treatment of patients with mantle cell lymphoma, a multicentre trial from Gruppo Italiano Studio Linfomi. Br J Haematol 2012;156:346-53.
    • (2012) Br J Haematol , vol.156 , pp. 346-353
    • Merli, F.1    Luminari, S.2    Ilariucci, F.3    Petrini, M.4    Visco, C.5    Ambrosetti, A.6
  • 44
    • 0028950965 scopus 로고
    • The role of high-dose therapy and autologous hematopoietic stem cell transplantation for mantle cell lymphoma
    • Stewart DA, Vose JM, Weisenburger DD, Anderson JR, Ruby EI, Bast MA, et al. The role of high-dose therapy and autologous hematopoietic stem cell transplantation for mantle cell lymphoma. Ann Oncol 1995;6:263-6.
    • (1995) Ann Oncol , vol.6 , pp. 263-266
    • Stewart, D.A.1    Vose, J.M.2    Weisenburger, D.D.3    Anderson, J.R.4    Ruby, E.I.5    Bast, M.A.6
  • 49
    • 0344667602 scopus 로고    scopus 로고
    • 2-Microglobulin and the Tumor Score
    • DOI 10.1002/cncr.11838
    • Khouri IF, Saliba RM, Okoroji GJ, Acholonu SA, Champlin RE. Long-term follow-up of autologous stem cell transplantation in patients with diffuse mantle cell lymphoma in first disease remission: the prognostic value of beta2-microglobulin and the tumor score. Cancer 2003;98:2630-5. (Pubitemid 37509526)
    • (2003) Cancer , vol.98 , Issue.12 , pp. 2630-2635
    • Khouri, I.F.1    Saliba, R.M.2    Okoroji, G.-J.3    Acholonu, S.A.4    Champlin, R.E.5
  • 50
    • 74949115388 scopus 로고    scopus 로고
    • Immunochemotherapy and autologous stem-cell transplantation for untreated patients with mantle-cell lymphoma: CALGB 59909
    • Damon LE, Johnson JL, Niedzwiecki D, Cheson BD, Hurd DD, Bartlett NL, et al. Immunochemotherapy and autologous stem-cell transplantation for untreated patients with mantle-cell lymphoma: CALGB 59909. J Clin Oncol 2009;27:6101-8.
    • (2009) J Clin Oncol , vol.27 , pp. 6101-6108
    • Damon, L.E.1    Johnson, J.L.2    Niedzwiecki, D.3    Cheson, B.D.4    Hurd, D.D.5    Bartlett, N.L.6
  • 51
    • 53449089095 scopus 로고    scopus 로고
    • Nordic Lymphoma Group. Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue: A nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group
    • Geisler CH, Kolstad A, Laurell A, Andersen NS, Pedersen LB, Jerkeman M, et al.Nordic Lymphoma Group. Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue: a nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group. Blood 2008;112:2687-93.
    • (2008) Blood , vol.112 , pp. 2687-2693
    • Geisler, C.H.1    Kolstad, A.2    Laurell, A.3    Andersen, N.S.4    Pedersen, L.B.5    Jerkeman, M.6
  • 53
    • 0029665778 scopus 로고    scopus 로고
    • 1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells
    • Carlson BA, Dubay MM, Sausville EA, Brizuela L, Worland PJ. Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Cancer Res 1996;56:2973-8. (Pubitemid 26200251)
    • (1996) Cancer Research , vol.56 , Issue.13 , pp. 2973-2978
    • Carlson, B.A.1    Dubay, M.M.2    Sausville, E.A.3    Brizuela, L.4    Worland, P.J.5
  • 56
    • 0036240601 scopus 로고    scopus 로고
    • Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma
    • DOI 10.1080/10428190290016908
    • Lin TS, Howard OM, Neuberg DS, Kim HH, Shipp MA. Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma. Leuk Lymphoma 2002;43:793-7. (Pubitemid 34428666)
    • (2002) Leukemia and Lymphoma , vol.43 , Issue.4 , pp. 793-797
    • Lin, T.S.1    Howard, O.M.2    Neuberg, D.S.3    Kim, H.H.4    Shipp, M.A.5
  • 57
    • 84863320909 scopus 로고    scopus 로고
    • Mutation burden in CDKN2C, CDK1 and E2F2 is associated with differential response to targeting CDK4/CDK6 in combination with bortezomib in mantle cell lymphoma
    • Mason CE, Di Liberto M, Huang X, Chiron D, Bretz J, Abdallah R, et al. Mutation burden in CDKN2C, CDK1 and E2F2 is associated with differential response to targeting CDK4/CDK6 in combination with bortezomib in mantle cell lymphoma. Blood 2011;118: 3738.
    • (2011) Blood , vol.118 , pp. 3738
    • Mason, C.E.1    Di Liberto, M.2    Huang, X.3    Chiron, D.4    Bretz, J.5    Abdallah, R.6
  • 58
    • 84863322436 scopus 로고    scopus 로고
    • Preliminary results of a phase 2 study of PD 0332991 in combination with bortezomib and dexamethasone in patients with relapsed and refractory multiple myeloma
    • Niesvizky R, Costa LJ, Haideri NA, Hess G, Singhal S, Spicka I, et al. Preliminary results of a phase 2 study of PD 0332991 in combination with bortezomib and dexamethasone in patients with relapsed and refractory multiple myeloma. Blood 2011;118:2940.
    • (2011) Blood , vol.118 , pp. 2940
    • Niesvizky, R.1    Costa, L.J.2    Haideri, N.A.3    Hess, G.4    Singhal, S.5    Spicka, I.6
  • 60
    • 69949154222 scopus 로고    scopus 로고
    • Cdk4/6 inhibitor PD 0332991 demonstrates cell cycle inhibition via FLT-PET imaging and tissue analysis in patients with recurrent mantle cell lymphoma
    • Leonard JP, LaCasce A, Smith MR, Noy A, Yap JT, Van den Abbeele AD, et al. Cdk4/6 inhibitor PD 0332991 demonstrates cell cycle inhibition via FLT-PET imaging and tissue analysis in patients with recurrent mantle cell lymphoma. Blood 2008;112:264.
    • (2008) Blood , vol.112 , pp. 264
    • Leonard, J.P.1    LaCasce, A.2    Smith, M.R.3    Noy, A.4    Yap, J.T.5    Van Den Abbeele, A.D.6
  • 62
    • 84863299833 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the pediatric preclinical testing program
    • Feb 7. [Epub ahead of print]
    • Gorlick R, Kolb EA, Houghton PJ, Morton CL, Neale G, Keir ST, et al. Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the pediatric preclinical testing program. Pediatr Blood Cancer. 2012 Feb 7. [Epub ahead of print].
    • (2012) Pediatr Blood Cancer
    • Gorlick, R.1    Kolb, E.A.2    Houghton, P.J.3    Morton, C.L.4    Neale, G.5    Keir, S.T.6
  • 63
    • 84859749541 scopus 로고    scopus 로고
    • Early evidence of anti-lymphoma activity of the cyclin dependent kinase inhibitor dinaciclib (SCH 727965) in heavily pre-treated low grade lymphoma and diffuse large cell lymphoma patients
    • Baiocchi RA, Flynn JM, Jones JA, Blum KA, Hofmeister CC, Poon J, et al. Early evidence of anti-lymphoma activity of the cyclin dependent kinase inhibitor dinaciclib (SCH 727965) in heavily pre-treated low grade lymphoma and diffuse large cell lymphoma patients. Blood 2010;116:3966.
    • (2010) Blood , vol.116 , pp. 3966
    • Baiocchi, R.A.1    Flynn, J.M.2    Jones, J.A.3    Blum, K.A.4    Hofmeister, C.C.5    Poon, J.6
  • 64
    • 79955757849 scopus 로고    scopus 로고
    • Update on the phase I study of the cyclin dependent kinase inhibitor dinaciclib (SCH 727965) in patients with relapsed or refractory chronic lymphocytic leukemia (CLL): Confirmation of clinical activity and feasibility of long-term administration
    • Flynn JM, Jones JA, Andritsos L, Blum KA, Johnson AJ, Hessler J, et al. Update on the phase I study of the cyclin dependent kinase inhibitor dinaciclib (SCH 727965) in patients with relapsed or refractory chronic lymphocytic leukemia (CLL): confirmation of clinical activity and feasibility of long-term administration. Blood 2010;116: 1396.
    • (2010) Blood , vol.116 , pp. 1396
    • Flynn, J.M.1    Jones, J.A.2    Andritsos, L.3    Blum, K.A.4    Johnson, A.J.5    Hessler, J.6
  • 65
    • 79955771812 scopus 로고    scopus 로고
    • Phase II study of the cyclin-dependent kinase (CDK) inhibitor dinaciclib (SCH 727965) in patients with advanced acute leukemias
    • Gojo I, Walker A, Cooper M, Feldman EJ, Padmanabhan S, Baer MR, et al. Phase II study of the cyclin-dependent kinase (CDK) inhibitor dinaciclib (SCH 727965) in patients with advanced acute leukemias. Blood 2010;116:3287.
    • (2010) Blood , vol.116 , pp. 3287
    • Gojo, I.1    Walker, A.2    Cooper, M.3    Feldman, E.J.4    Padmanabhan, S.5    Baer, M.R.6
  • 66
    • 79960917689 scopus 로고    scopus 로고
    • Phosphoproteomic analysis of mantle cell lymphoma cells suggests a prosurvival role of B-cell receptor signaling
    • Dordr
    • Pighi C, GuTL, Dalai I, Barbi S, Parolini C, Bertolaso A, et al. Phosphoproteomic analysis of mantle cell lymphoma cells suggests a prosurvival role of B-cell receptor signaling. Cell Oncol (Dordr) 2011;34:141-53.
    • (2011) Cell Oncol , vol.34 , pp. 141-153
    • Pighi, C.1    Gu, T.L.2    Dalai, I.3    Barbi, S.4    Parolini, C.5    Bertolaso, A.6
  • 67
    • 0034987582 scopus 로고    scopus 로고
    • Regulation of B lymphocyte development and activation by Bruton's tyrosine kinase
    • DOI 10.1385/IR:23:2-3:147
    • Khan WN. Regulation of B lymphocyte development and activation by Bruton's tyrosine kinase. Immunol Res 2001;23:147-56. (Pubitemid 32575356)
    • (2001) Immunologic Research , vol.23 , Issue.2-3 , pp. 147-156
    • Khan, W.N.1
  • 70
    • 84863324720 scopus 로고    scopus 로고
    • Activity of Bruton's tyrosine kinase (Btk) inhibitor PCI-32765 in mantle cell lymphoma (MCL) identifies Btk as a novel therapeutic target
    • Ponader S, Balasubramanian S, Pham LV, Chen J, Tamayo AT, Wang M, et al. Activity of Bruton's tyrosine kinase (Btk) inhibitor PCI-32765 in mantle cell lymphoma (MCL) identifies Btk as a novel therapeutic target. Blood 2011;118:3688.
    • (2011) Blood , vol.118 , pp. 3688
    • Ponader, S.1    Balasubramanian, S.2    Pham, L.V.3    Chen, J.4    Tamayo, A.T.5    Wang, M.6
  • 71
    • 77955625479 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
    • Honigberg LA, Smith AM, Sirisawad M, Verner E, Loury D, Chang B, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A 2010;107:13075-80.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 13075-13080
    • Honigberg, L.A.1    Smith, A.M.2    Sirisawad, M.3    Verner, E.4    Loury, D.5    Chang, B.6
  • 72
    • 79959404661 scopus 로고    scopus 로고
    • Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
    • Herman SEM, Gordon AL, Hertlein E, Ramanunni A, Zhang X, Jaglowski S, et al. Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood 2011;117:6287-96.
    • (2011) Blood , vol.117 , pp. 6287-6296
    • Herman, S.E.M.1    Gordon, A.L.2    Hertlein, E.3    Ramanunni, A.4    Zhang, X.5    Jaglowski, S.6
  • 73
    • 84858636448 scopus 로고    scopus 로고
    • The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- And chemokine-controlled adhesion and migration in chronic lymphocytic leukemia
    • de Rooij MF, Kuil A, Geest CR, Eldering E, Chang BY, Buggy JJ, et al. The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia. Blood 2012;119:2590-4.
    • (2012) Blood , vol.119 , pp. 2590-2594
    • De Rooij, M.F.1    Kuil, A.2    Geest, C.R.3    Eldering, E.4    Chang, B.Y.5    Buggy, J.J.6
  • 74
    • 78649797979 scopus 로고    scopus 로고
    • Effect of Btk inhibitor PCI-32765 monotherapy on responses in patients with relapsed aggressive NHL: Evidence of antitumor activity from a phase I study
    • abstr 8012
    • Advani R, Sharman JP, Smith SM, Pollyea DA, Boyd TE, Grant BW, et al. Effect of Btk inhibitor PCI-32765 monotherapy on responses in patients with relapsed aggressive NHL: evidence of antitumor activity from a phase I study. J Clin Oncol 28:15s, 2010 (suppl; abstr 8012).
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Advani, R.1    Sharman, J.P.2    Smith, S.M.3    Pollyea, D.A.4    Boyd, T.E.5    Grant, B.W.6
  • 75
    • 84860430028 scopus 로고    scopus 로고
    • The Bruton's tyrosine kinase inhibitor PCI-32765 is highly active as single-agent therapy in previously-treated mantle cell lymphoma (MCL): Preliminary results of a phase II trial
    • Wang L, Martin P, Blum KA, Kahl BS, Maeda LS, Advani R, et al. The Bruton's tyrosine kinase inhibitor PCI-32765 is highly active as single-agent therapy in previously-treated mantle cell lymphoma (MCL): preliminary results of a phase II trial. Blood 2011;118:442.
    • (2011) Blood , vol.118 , pp. 442
    • Wang, L.1    Martin, P.2    Blum, K.A.3    Kahl, B.S.4    Maeda, L.S.5    Advani, R.6
  • 76
    • 84863329356 scopus 로고    scopus 로고
    • Egress of CD19+CD5+ cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor, PCI-32765, in mantle cell lymphoma patients
    • Chang BY, Francesco M, Magadala P, Huang MM, Spaargaren M, Buggy JJ, et al. Egress of CD19+CD5+ cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor, PCI-32765, in mantle cell lymphoma patients. Blood 2011;118:954.
    • (2011) Blood , vol.118 , pp. 954
    • Chang, B.Y.1    Francesco, M.2    Magadala, P.3    Huang, M.M.4    Spaargaren, M.5    Buggy, J.J.6
  • 78
    • 77951002653 scopus 로고    scopus 로고
    • Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
    • Friedberg JW, Sharman J, Sweetenham J, Johnston PB, Vose JM, Lacasce A, et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood 2010;115:2578-85.
    • (2010) Blood , vol.115 , pp. 2578-2585
    • Friedberg, J.W.1    Sharman, J.2    Sweetenham, J.3    Johnston, P.B.4    Vose, J.M.5    Lacasce, A.6
  • 79
    • 33745909399 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies
    • Witzig TE, Kaufmann SH. Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies. Curr Treat Options Oncol 2006;7:285-94. (Pubitemid 44043658)
    • (2006) Current Treatment Options in Oncology , vol.7 , Issue.4 , pp. 285-294
    • Witzig, T.E.1    Kaufmann, S.H.2
  • 80
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target for cancer therapy
    • Bjornsti M-A, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer 2004;4:335-48. (Pubitemid 38579480)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.5 , pp. 335-348
    • Bjornsti, M.-A.1    Houghton, P.J.2
  • 81
    • 24944592507 scopus 로고    scopus 로고
    • Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3KAKT, WNT and TGFbeta signalling pathways
    • Rizzatti EG, Falcão RP, Panepucci RA, Proto-Siqueira R, Anselmo-Lima WT, Okamoto OK, et al. Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3KAKT, WNT and TGFbeta signalling pathways. Br J Haematol 2005;130:516-26.
    • (2005) Br J Haematol , vol.130 , pp. 516-526
    • Rizzatti, E.G.1    Falcão, R.P.2    Panepucci, R.A.3    Proto-Siqueira, R.4    Anselmo-Lima, W.T.5    Okamoto, O.K.6
  • 82
    • 79958784935 scopus 로고    scopus 로고
    • Clinical safety and activity in a phase 1 study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110δ, in patients with relapsed or refractory non-Hodgkin lymphoma
    • Kahl B, Byrd JC, Flinn IW, Wagner-Johnston N, Spurgeon S, Benson DMJr, et al. Clinical safety and activity in a phase 1 study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110δ, in patients with relapsed or refractory non-Hodgkin lymphoma. Blood 2010;116:1777.
    • (2010) Blood , vol.116 , pp. 1777
    • Kahl, B.1    Byrd, J.C.2    Flinn, I.W.3    Wagner-Johnston, N.4    Spurgeon, S.5    Benson Jr., D.M.6
  • 83
    • 68949102180 scopus 로고    scopus 로고
    • Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
    • Hess G, Herbrecht R, Romaguera J, Verhoef G, Crump M, Gisselbrecht C, et al. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. J Clin Oncol 2009;27:3822-9.
    • (2009) J Clin Oncol , vol.27 , pp. 3822-3829
    • Hess, G.1    Herbrecht, R.2    Romaguera, J.3    Verhoef, G.4    Crump, M.5    Gisselbrecht, C.6
  • 84
    • 40749085662 scopus 로고    scopus 로고
    • Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents
    • DOI 10.1158/1078-0432.CCR-07-1061
    • Leoni LM, Bailey B, Reifert J, Bendall HH, Zeller RW, Corbeil J, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res 2008;14:309-17. (Pubitemid 351378007)
    • (2008) Clinical Cancer Research , vol.14 , Issue.1 , pp. 309-317
    • Leoni, L.M.1    Bailey, B.2    Reifert, J.3    Bendall, H.H.4    Zeller, R.W.5    Corbeil, J.6    Elliott, G.7    Niemeyer, C.C.8
  • 85
    • 63049113411 scopus 로고    scopus 로고
    • Bendamustine: Rebirth of an old drug
    • Cheson BD, Rummel MJ. Bendamustine: rebirth of an old drug. J Clin Oncol 2009;27:1492-501.
    • (2009) J Clin Oncol , vol.27 , pp. 1492-1501
    • Cheson, B.D.1    Rummel, M.J.2
  • 86
    • 77955944557 scopus 로고    scopus 로고
    • Japanese Bendamustine Lymphoma Study Group. Multicenter phase II study of bendamustine for relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma
    • Ohmachi K, Ando K, Ogura M, Uchida T, Itoh K, Kubota N, et al. Japanese Bendamustine Lymphoma Study Group. Multicenter phase II study of bendamustine for relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma. Cancer Sci 2010;101:2059-64.
    • (2010) Cancer Sci , vol.101 , pp. 2059-2064
    • Ohmachi, K.1    Ando, K.2    Ogura, M.3    Uchida, T.4    Itoh, K.5    Kubota, N.6
  • 87
    • 52649177173 scopus 로고    scopus 로고
    • Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma
    • Robinson KS, Williams ME, van der Jagt RH, Cohen P, Herst JA, Tulpule A, et al. Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma. J Clin Oncol 2008;26:4473-9.
    • (2008) J Clin Oncol , vol.26 , pp. 4473-4479
    • Robinson, K.S.1    Williams, M.E.2    Van Der Jagt, R.H.3    Cohen, P.4    Herst, J.A.5    Tulpule, A.6
  • 88
    • 79953077610 scopus 로고    scopus 로고
    • The combination of bendamustine, bortezomib, and rituximab for patients with relapsed/refractory indolent and mantle cell non-Hodgkin lymphoma
    • Friedberg JW, Vose JM, Kelly JL, Young F, Bernstein SH, Peterson D, et al. The combination of bendamustine, bortezomib, and rituximab for patients with relapsed/refractory indolent and mantle cell non-Hodgkin lymphoma. Blood 2011;117:2807-12.
    • (2011) Blood , vol.117 , pp. 2807-2812
    • Friedberg, J.W.1    Vose, J.M.2    Kelly, J.L.3    Young, F.4    Bernstein, S.H.5    Peterson, D.6
  • 89
    • 84862183095 scopus 로고    scopus 로고
    • Rituximab, bendamustine and cytarabine (R-BAC) is a very active regimen in patients with mantle cell lymphoma not eligible for intensive chemotherapy or autologous transplant
    • Visco C, Zambello R, Paolini R, Finotto S, Zanotti R, Zaja F, et al. Rituximab, bendamustine and cytarabine (R-BAC) is a very active regimen in patients with mantle cell lymphoma not eligible for intensive chemotherapy or autologous transplant. Blood 2011;118:2677.
    • (2011) Blood , vol.118 , pp. 2677
    • Visco, C.1    Zambello, R.2    Paolini, R.3    Finotto, S.4    Zanotti, R.5    Zaja, F.6
  • 90
    • 2342613652 scopus 로고    scopus 로고
    • The proteasome: A suitable antineoplastic target
    • Adams J. The proteasome: a suitable antineoplastic target. Nat Rev Cancer 2004;4:349-60.
    • (2004) Nat Rev Cancer , vol.4 , pp. 349-360
    • Adams, J.1
  • 91
    • 30144442233 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status
    • DOI 10.1182/blood-2005-05-2091
    • Pérez-Galán P, Roué G, Villamor N, Montserrat E, Campo E, Colomer D. The proteasome inhibitor bortezomib induces apoptosis in mantlecell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood 2006;107:257-64. (Pubitemid 43053550)
    • (2006) Blood , vol.107 , Issue.1 , pp. 257-264
    • Perez-Galan, P.1    Roue, G.2    Villamor, N.3    Montserrat, E.4    Campo, E.5    Colomer, D.6
  • 92
    • 0038206722 scopus 로고    scopus 로고
    • Inhibition of constitutive NF-kappaB activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis
    • Pham LV, Tamayo AT, Yoshimura LC, Lo P, Ford RJ. Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis. J Immunol 2003;171:88-95. (Pubitemid 36745276)
    • (2003) Journal of Immunology , vol.171 , Issue.1 , pp. 88-95
    • Pham, L.V.1    Tamayo, A.T.2    Yoshimura, L.C.3    Lo, P.4    Ford, R.J.5
  • 97
  • 98
    • 78049528598 scopus 로고    scopus 로고
    • Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: A prospective analysis of data from the HOVON-65/ GMMG-HD4 trial
    • Broyl A, Corthals SL, Jongen JL, van der Holt B, Kuiper R, de Knegt Y, et al. Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/ GMMG-HD4 trial. Lancet Oncol 2010;11:1057-65.
    • (2010) Lancet Oncol , vol.11 , pp. 1057-1065
    • Broyl, A.1    Corthals, S.L.2    Jongen, J.L.3    Van Der Holt, B.4    Kuiper, R.5    De Knegt, Y.6
  • 99
    • 79955461011 scopus 로고    scopus 로고
    • Subcutaneous versus intravenous administration of bortezomib in patients with relapsedmultiplemyeloma: A randomised, phase 3, non-inferiority study
    • Moreau P, Pylypenko H, Grosicki S, Karamanesht I, Leleu X, Grishunina M, et al. Subcutaneous versus intravenous administration of bortezomib in patients with relapsedmultiplemyeloma: a randomised, phase 3, non-inferiority study. Lancet Oncol 2011;12: 431-40.
    • (2011) Lancet Oncol , vol.12 , pp. 431-440
    • Moreau, P.1    Pylypenko, H.2    Grosicki, S.3    Karamanesht, I.4    Leleu, X.5    Grishunina, M.6
  • 101
    • 50249150555 scopus 로고    scopus 로고
    • Phase 1 single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies
    • Alsina M, Trudel S, Vallone M, Molineaux C, Kunkel L, Goy A. Phase 1 single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies. Blood 2007;110:411.
    • (2007) Blood , vol.110 , pp. 411
    • Alsina, M.1    Trudel, S.2    Vallone, M.3    Molineaux, C.4    Kunkel, L.5    Goy, A.6
  • 102
    • 79955731920 scopus 로고    scopus 로고
    • Carfilzomib: High single agent response rate with minimal neuropathy even in high-risk patients
    • Vij R, Kaufman JL, Jakubowiak AJ, Stewart AK, Jagannath S, Kukreti V, et al. Carfilzomib: high single agent response rate with minimal neuropathy even in high-risk patients. Blood 2010;116:1938.
    • (2010) Blood , vol.116 , pp. 1938
    • Vij, R.1    Kaufman, J.L.2    Jakubowiak, A.J.3    Stewart, A.K.4    Jagannath, S.5    Kukreti, V.6
  • 103
    • 84862507585 scopus 로고    scopus 로고
    • An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma
    • Vij R, Wang M, Kaufman JL, Lonial S, Jakubowiak AJ, Stewart AK, et al. An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma. Blood 2012;119:5661-70.
    • (2012) Blood , vol.119 , pp. 5661-5670
    • Vij, R.1    Wang, M.2    Kaufman, J.L.3    Lonial, S.4    Jakubowiak, A.J.5    Stewart, A.K.6
  • 104
    • 72549116835 scopus 로고    scopus 로고
    • Aphase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies
    • O'Connor OA, Stewart AK, Vallone M, Molineaux CJ, Kunkel LA, Gerecitano JF, et al.Aphase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies. Clin Cancer Res 2009;15:7085-91.
    • (2009) Clin Cancer Res , vol.15 , pp. 7085-7091
    • O'Connor, O.A.1    Stewart, A.K.2    Vallone, M.3    Molineaux, C.J.4    Kunkel, L.A.5    Gerecitano, J.F.6
  • 105
    • 80052784486 scopus 로고    scopus 로고
    • Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo
    • Dasmahapatra G, Lembersky D, Son MP, Attkisson E, Dent P, Fisher RI, et al. Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo. Mol Cancer Ther 2011;10:1686-97.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1686-1697
    • Dasmahapatra, G.1    Lembersky, D.2    Son, M.P.3    Attkisson, E.4    Dent, P.5    Fisher, R.I.6
  • 106
    • 79952154013 scopus 로고    scopus 로고
    • Bortezomib plus CHOP-rituximab for previously untreated diffuse large B-cell lymphoma and mantle cell lymphoma
    • Ruan J, Martin P, Furman RR, Lee SM, Cheung K, Vose JM, et al. Bortezomib plus CHOP-rituximab for previously untreated diffuse large B-cell lymphoma and mantle cell lymphoma. J Clin Oncol 2011;29:690-7.
    • (2011) J Clin Oncol , vol.29 , pp. 690-697
    • Ruan, J.1    Martin, P.2    Furman, R.R.3    Lee, S.M.4    Cheung, K.5    Vose, J.M.6
  • 107
    • 80053567237 scopus 로고    scopus 로고
    • VcR-CVAD induction chemotherapy followed by maintenance rituximab in mantle cell lymphoma: A Wisconsin Oncology Network study
    • Chang JE, Peterson C, Choi S, Eickhoff JC, Kim K, Yang DT, et al. VcR-CVAD induction chemotherapy followed by maintenance rituximab in mantle cell lymphoma: a Wisconsin Oncology Network study. Br J Haematol 2011;155:190-7.
    • (2011) Br J Haematol , vol.155 , pp. 190-197
    • Chang, J.E.1    Peterson, C.2    Choi, S.3    Eickhoff, J.C.4    Kim, K.5    Yang, D.T.6
  • 109
    • 70350734809 scopus 로고    scopus 로고
    • The microenvironment in mature B-cell malignancies: A target for new treatment strategies
    • Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood 2009;114:3367-75.
    • (2009) Blood , vol.114 , pp. 3367-3375
    • Burger, J.A.1    Ghia, P.2    Rosenwald, A.3    Caligaris-Cappio, F.4
  • 111
    • 66549113998 scopus 로고    scopus 로고
    • Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): Importance for interactions with the stromal microenvironment and specific targeting
    • Kurtova AV, Tamayo AT, Ford RJ, Burger JA. Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting. Blood 2009;113:4604-13.
    • (2009) Blood , vol.113 , pp. 4604-4613
    • Kurtova, A.V.1    Tamayo, A.T.2    Ford, R.J.3    Burger, J.A.4
  • 112
    • 84863335826 scopus 로고    scopus 로고
    • CXCR4 antagonist BKT140 synergizes with rituximab, targeting non Hodgkin lymphoma (NHL) in vitro and in vivo in a xenograft model with bone marrow involvement
    • Beider K, Ribakovsky E, Abraham M, Wald H, Eizenberg O, Avigdor A, et al. CXCR4 antagonist BKT140 synergizes with rituximab, targeting non Hodgkin lymphoma (NHL) in vitro and in vivo in a xenograft model with bone marrow involvement. Blood 2011;118:952.
    • (2011) Blood , vol.118 , pp. 952
    • Beider, K.1    Ribakovsky, E.2    Abraham, M.3    Wald, H.4    Eizenberg, O.5    Avigdor, A.6
  • 113
    • 77958514558 scopus 로고    scopus 로고
    • Recent advances of IMiDs in cancer therapy
    • Li S, Gill N, Lentzsch S. Recent advances of IMiDs in cancer therapy. Curr Opin Oncol 2010;22:579-85.
    • (2010) Curr Opin Oncol , vol.22 , pp. 579-585
    • Li, S.1    Gill, N.2    Lentzsch, S.3
  • 114
    • 84857740069 scopus 로고    scopus 로고
    • Salvage treatment with lenalidomide and dexamethasone in relapsed/refractory mantle cell lymphoma: Clinical results and effects on microenvironment and neoangiogenic biomarkers
    • Zaja F, De Luca S, Vitolo U, Orsucci L, Levis A, Salvi F, et al. Salvage treatment with lenalidomide and dexamethasone in relapsed/refractory mantle cell lymphoma: clinical results and effects on microenvironment and neoangiogenic biomarkers. Haematologica 2012;97: 416-22.
    • (2012) Haematologica , vol.97 , pp. 416-422
    • Zaja, F.1    De Luca, S.2    Vitolo, U.3    Orsucci, L.4    Levis, A.5    Salvi, F.6
  • 116
  • 117
    • 73949145763 scopus 로고    scopus 로고
    • Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's lymphoma
    • Witzig TE, Wiernik PH, Moore T, Reeder C, Cole C, Justice G, et al. Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's lymphoma. J Clin Oncol 2009;27:5404-9.
    • (2009) J Clin Oncol , vol.27 , pp. 5404-5409
    • Witzig, T.E.1    Wiernik, P.H.2    Moore, T.3    Reeder, C.4    Cole, C.5    Justice, G.6
  • 118
    • 64149112784 scopus 로고    scopus 로고
    • Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma
    • Habermann TM, Lossos IS, Justice G, Vose JM, Wiernik PH, McBride K, et al. Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma. Br J Haematol 2009;145:344-9.
    • (2009) Br J Haematol , vol.145 , pp. 344-349
    • Habermann, T.M.1    Lossos, I.S.2    Justice, G.3    Vose, J.M.4    Wiernik, P.H.5    McBride, K.6
  • 119
    • 79959722615 scopus 로고    scopus 로고
    • An international phase II trial of single-agent lenalidomide for relapsed or refractory aggressive B-cell non-Hodgkin's lymphoma
    • Witzig TE, Vose JM, Zinzani PL, Reeder CB, Buckstein R, Polikoff JA, et al. An international phase II trial of single-agent lenalidomide for relapsed or refractory aggressive B-cell non-Hodgkin's lymphoma. Ann Oncol 2011;22:1622-7.
    • (2011) Ann Oncol , vol.22 , pp. 1622-1627
    • Witzig, T.E.1    Vose, J.M.2    Zinzani, P.L.3    Reeder, C.B.4    Buckstein, R.5    Polikoff, J.A.6
  • 120
    • 80053184266 scopus 로고    scopus 로고
    • Oral lenalidomide plus 4 doses of rituximab induced prolonged remissions in relapsed/refractory mantle cell lymphoma: A completed phase I/II clinical trial
    • Wang M, Fayad L, Wagner-Bartak N, Hagemeister F, Neelapu S, Fanale M, et al. Oral lenalidomide plus 4 doses of rituximab induced prolonged remissions in relapsed/refractory mantle cell lymphoma: a completed phase I/II clinical trial. Ann Oncol 2011;22 (Suppl 4):109.
    • (2011) Ann Oncol , vol.22 , Issue.SUPPL. 4 , pp. 109
    • Wang, M.1    Fayad, L.2    Wagner-Bartak, N.3    Hagemeister, F.4    Neelapu, S.5    Fanale, M.6
  • 121
    • 84862212752 scopus 로고    scopus 로고
    • Lenalidomide, bendamustine, and rituximab as first-line therapy for patients >65 years with mantle cell lymphoma: Results from the phase I portion of the Nordic lymphoma group MCL4 (LENA-BERIT) trial
    • Jerkeman M, Kolstad A, Laurell A, Raty R, Gronbaek K, Pedersen LB, et al. Lenalidomide, bendamustine, and rituximab as first-line therapy for patients >65 years with mantle cell lymphoma: results from the phase I portion of the Nordic lymphoma group MCL4 (LENA-BERIT) trial. Blood 2011;118:2700.
    • (2011) Blood , vol.118 , pp. 2700
    • Jerkeman, M.1    Kolstad, A.2    Laurell, A.3    Raty, R.4    Gronbaek, K.5    Pedersen, L.B.6
  • 122
    • 82255184040 scopus 로고    scopus 로고
    • European Mantle Cell Lymphoma Network. Update on the molecular pathogenesis and clinical treatment of mantle cell lymphoma: Report of the 10th annual conference of the European Mantle Cell Lymphoma Network
    • Dreyling M, Kluin-Nelemans HC, Beà S, Hartmann E, Salaverria I, Hutter G, et al.European Mantle Cell Lymphoma Network. Update on the molecular pathogenesis and clinical treatment of mantle cell lymphoma: report of the 10th annual conference of the European Mantle Cell Lymphoma Network. Leuk Lymphoma 2011;52: 2226-36.
    • (2011) Leuk Lymphoma , vol.52 , pp. 2226-2236
    • Dreyling, M.1    Kluin-Nelemans, H.C.2    Beà, S.3    Hartmann, E.4    Salaverria, I.5    Hutter, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.