Rituximab plus HyperCVAD alternating with high dose cytarabine and methotrexate for the initial treatment of patients with mantle cell lymphoma, a multicentre trial from Gruppo Italiano Studio Linfomi

British Journal of Haematology

Volumn 156, Issue 3, 2012, Pages 346-353

  Merli, Francesco ^a   Luminari, Stefano ^b   Ilariucci, Fiorella ^a   Petrini, Mario ^c   Visco, Carlo ^d   Ambrosetti, Achille ^e   Stelitano, Caterina ^f   Caracciolo, Francesco ^c   di Renzo, Nicola ^g   Angrilli, Francesco ^h   Carella, Angelo M ⁱ   Capodanno, Isabella ^a   Barbolini, Elisa ^a   Galimberti, Sara ^c   Federico, Massimo ^b  

^a S MARIA NUOVA HOSPITAL   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY OF PISA   (Italy)

^d SAN BORTOLO HOSPITAL   (Italy)

^e UNIVERSITY OF VERONA   (Italy)

^f Ematologia Ospedale M Morelli   (Italy)

^g VITO FAZZI HOSPITAL   (Italy)

^h SPIRITO SANTO HOSPITAL   (Italy)

ⁱ UNIVERSITY OF GENOA   (Italy)

Author keywords

Chemotherapy; Clinical trials; Monoclonal antibodies; Non Hodgkin lymphoma; Prognostic factors

Indexed keywords

CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; DOXORUBICIN; METHOTREXATE; RITUXIMAB; VINCRISTINE;

ACUTE PANCREATITIS; ADULT; AGED; ANEMIA; ARTICLE; ASPERGILLOSIS; CANCER MORTALITY; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG FEVER; DRUG MEGADOSE; DRUG SAFETY; DRUG WITHDRAWAL; EPIDERMOLYSIS; FEMALE; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HUMAN; INJECTION SITE REACTION; ITALY; MAJOR CLINICAL STUDY; MALE; MANTLE CELL LYMPHOMA; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; NEUTROPENIA; OVERALL SURVIVAL; PARALYTIC ILEUS; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; SEPSIS; SINUS BRADYCARDIA; SURVIVAL RATE; SURVIVAL TIME; THROMBOCYTOPENIA; THROMBOEMBOLISM; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; AGED; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; DISEASE-FREE SURVIVAL; DOXORUBICIN; DRUG ADMINISTRATION SCHEDULE; FOLLOW-UP STUDIES; GENETIC MARKERS; HEMATOLOGIC DISEASES; HUMANS; INFECTION; KAPLAN-MEIER ESTIMATE; LYMPHOMA, MANTLE-CELL; METHOTREXATE; MIDDLE AGED; PROSPECTIVE STUDIES; TREATMENT OUTCOME; VINCRISTINE; YOUNG ADULT;

EID: 84855796484     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2011.08958.x     Document Type: Article

References (22)

1. Argatoff, L.H., Connors, J.M., Klasa, R.J., Horsman, D.E. & Gascoyne, R.D. (1997) Mantle cell lymphoma: a clinicopathologic study of 80 cases. Blood, 89, 2067-2078.
2. Cheson, B.D., Horning, S.J., Coiffier, B., Shipp, M.A., Fisher, R.I., Connors, J.M., Lister, T.A., Vose, J., Grillo-Lopez, A., Hagenbeek, A., Cabanillas, F., Klippensten, D., Hiddemann, W., Castellino, R., Harris, N.L., Armitage, J.O., Carter, W., Hoppe, R. & Canellos, G.P. (1999) Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group. Journal of Clinical Oncology, 17, 1244.
3. Cuzick, J. (1985) A Wilcoxon-type test for trend. Statistics in Medicine, 4, 87-90.
4. van Dongen, J.J., Langerak, A.W., Bruggemann, M., Evans, P.A., Hummel, M., Lavender, F.L., Delabesse, E., Davi, F., Schuuring, E., Garcia-Sanz, R., van Krieken, J.H., Droese, J., Gonzalez, D., Bastard, C., White, H.E., Spaargaren, M., Gonzalez, M., Parreira, A., Smith, J.L., Morgan, G.J., Kneba, M. & Macintyre, E.A. (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 concerted action BMH4-CT98-3936. Leukemia, 17, 2257-2317.
5. Dreyling, M., Lenz, G., Hoster, E., Van Hoof, A., Gisselbrecht, C., Schmits, R., Metzner, B., Truemper, L., Reiser, M., Steinhauer, H., Boiron, J.M., Boogaerts, M.A., Aldaoud, A., Silingardi, V., Kluin-Nelemans, H.C., Hasford, J., Parwaresch, R., Unterhalt, M. & Hiddemann, W. (2005) Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the European MCL Network. Blood, 105, 2677-2684.
6. Forstpointner, R., Dreyling, M., Repp, R., Hermann, S., Hanel, A., Metzner, B., Pott, C., Hartmann, F., Rothmann, F., Rohrberg, R., Bock, H.P., Wandt, H., Unterhalt, M. & Hiddemann, W. (2004) The addition of rituximab to a combination of fludarabine, cyclophosphamide, mitoxantrone (FCM) significantly increases the response rate and prolongs survival as compared with FCM alone in patients with relapsed and refractory follicular and mantle cell lymphomas: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group. Blood, 104, 3064-3071.
7. Galimberti, S., Brizzi, F., Mameli, M. & Petrini, M. (1999) An advantageous method to evaluate IgH rearrangement and its role in minimal residual disease detection. Leukemia Research, 23, 921-929.
8. Geisler, C.H., Kolstad, A., Laurell, A., Andersen, N.S., Pedersen, L.B., Jerkeman, M., Eriksson, M., Nordstrom, M., Kimby, E., Boesen, A.M., Kuittinen, O., Lauritzsen, G.F., Nilsson-Ehle, H., Ralfkiaer, E., Akerman, M., Ehinger, M., Sundstrom, C., Langholm, R., Delabie, J., Karjalainen-Lindsberg, M.L., Brown, P. & Elonen, E. (2008) Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue: a nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group. Blood, 112, 2687-2693.
9. Herrmann, A., Hoster, E., Zwingers, T., Brittinger, G., Engelhard, M., Meusers, P., Reiser, M., Forstpointner, R., Metzner, B., Peter, N., Wormann, B., Trumper, L., Pfreundschuh, M., Einsele, H., Hiddemann, W., Unterhalt, M. & Dreyling, M. (2009) Improvement of overall survival in advanced stage mantle cell lymphoma. Journal of Clinical Oncology, 27, 511-518.
10. Hoster, E., Dreyling, M., Klapper, W., Gisselbrecht, C., van Hoof, A., Kluin-Nelemans, H.C., Pfreundschuh, M., Reiser, M., Metzner, B., Einsele, H., Peter, N., Jung, W., Wormann, B., Ludwig, W.D., Duhrsen, U., Eimermacher, H., Wandt, H., Hasford, J., Hiddemann, W. & Unterhalt, M. (2008) A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma. Blood, 111, 558-565.
11. Khouri, I.F., Romaguera, J., Kantarjian, H., Palmer, J.L., Pugh, W.C., Korbling, M., Hagemeister, F., Samuels, B., Rodriguez, A., Giralt, S., Younes, A., Przepiorka, D., Claxton, D., Cabanillas, F. & Champlin, R. (1998) Hyper-CVAD and high-dose methotrexate/cytarabine followed by stem-cell transplantation: an active regimen for aggressive mantle-cell lymphoma. Journal of Clinical Oncology, 16, 3803-3809.
12. Lefrere, F., Delmer, A., Levy, V., Delarue, R., Varet, B. & Hermine, O. (2004) Sequential chemotherapy regimens followed by high-dose therapy with stem cell transplantation in mantle cell lymphoma: an update of a prospective study. Haematologica, 89, 1275-1276.
13. Magni, M., Di Nicola, M., Carlo-Stella, C., Matteucci, P., Devizzi, L., Tarella, C., Benedetti, F., Martelli, M., Patti, C., Parvis, G., Rambaldi, A., Barbui, T. & Gianni, A.M. (2009) High-dose sequential chemotherapy and in vivo rituximab-purged stem cell autografting in mantle cell lymphoma: a 10-year update of the R-HDS regimen. Bone Marrow Transplantation, 43, 509-511.
14. Norton, A.J., Matthews, J., Pappa, V., Shamash, J., Love, S., Rohatiner, A.Z. & Lister, T.A. (1995) Mantle cell lymphoma: natural history defined in a serially biopsied population over a256.
15. Romaguera, J.E., Fayad, L., Rodriguez, M.A., Broglio, K.R., Hagemeister, F.B., Pro, B., McLaughlin, P., Younes, A., Samaniego, F., Goy, A., Sarris, A.H., Dang, N.H., Wang, M., Beasley, V., Medeiros, L.J., Katz, R.L., Gagneja, H., Samuels, B.I., Smith, T.L. & Cabanillas, F.F. (2005) High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine. Journal of Clinical Oncology, 23, 7013-7023.
16. Schulz, H., Bohlius, J.F., Trelle, S., Skoetz, N., Reiser, M., Kober, T., Schwarzer, G., Herold, M., Dreyling, M., Hallek, M. & Engert, A. (2007) Immunochemotherapy with rituximab and overall survival in patients with indolent or mantle cell lymphoma: a systematic review and meta-analysis. Journal of the National Cancer Institute, 99, 706-714.
17. Swerdlow, S.H. & Williams, M.E. (2002) From centrocytic to mantle cell lymphoma: a clinicopathologic and molecular review of 3 decades. Human Pathology, 33, 7-20.
18. Teodorovic, I., Pittaluga, S., Kluin-Nelemans, J.C., Meerwaldt, J.H., Hagenbeek, A., van Glabbeke, M., Somers, R., Bijnens, L., Noordijk, E.M. & Peeters, C.D. (1995) Efficacy of four different regimens in 64 mantle-cell lymphoma cases: clinicopathologic comparison with 498 other non-Hodgkin's lymphoma subtypes. European Organization for the Research and Treatment of Cancer Lymphoma Cooperative Group. Journal of Clinical Oncology, 13, 2819-2826.
19. Thieblemont, C., Antal, D., Lacotte-Thierry, L., Delwail, V., Espinouse, D., Michallet, A.S., Traulle, C., Bouafia-Sauvy, F., Giraud, C., Salles, G., Guilhot, F. & Coiffier, B. (2005) Chemotherapy with rituximab followed by high-dose therapy and autologous stem cell transplantation in patients with mantle cell lymphoma. Cancer, 104, 1434-1441.
20. Vandenberghe, E., Ruiz de Elvira, C., Loberiza, F.R., Conde, E., Lopez-Guillermo, A., Gisselbrecht, C., Guilhot, F., Vose, J.M., van Biesen, K., Rizzo, J.D., Weisenburger, D.D., Isaacson, P., Horowitz, M.M., Goldstone, A.H., Lazarus, H.M. & Schmitz, N. (2003) Outcome of autologous transplantation for mantle cell lymphoma: a study by the European blood and bone marrow transplant and autologous blood and marrow transplant registries. British Journal Haematology, 120, 793-800.
21. van 't Veer, M.B., de Jong, D., MacKenzie, M., Kluin-Nelemans, H.C., van Oers, M.H., Zijlstra, J., Hagenbeek, A. & van Putten, W.L. (2009) High-dose Ara-C and beam with autograft rescue in R-CHOP responsive mantle cell lymphoma patients. British Journal Haematology, 144, 524-530.
22. Zucca, E., Roggero, E., Pinotti, G., Pedrinis, E., Cappella, C., Venco, A. & Cavalli, F. (1995) Patterns of survival in mantle cell lymphoma. Annals of Oncology, 6, 257-262.