Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Sharif, Tanveer ^a   Alhosin, Mahmoud ^a   Auger, Cyril ^a   Minker, Carole ^a   Kim, Jong Hun ^a   Etienne Selloum, Nelly ^a   Bories, Pierre ^a   Gronemeyer, Hinrich ^a   Lobstein, Annelise ^a   Bronner, Christian ^a   Fuhrmann, Guy ^a   Schini Kerth, Valérie B ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CHLOROGENIC ACID; CYCLIN B1; CYTOCHROME C; NATURAL PRODUCT; ONCOPROTEIN; POLYPHENOL; PROTEIN P73; QUERCETIN; REACTIVE OXYGEN METABOLITE; UBIQUITIN LIKE CONTAINING PHD AND RING FINGER DOMAIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CCAAT ENHANCER BINDING PROTEIN; DNA BINDING PROTEIN; NUCLEAR PROTEIN; PLANT EXTRACT; TUMOR SUPPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN P73; UHRF1 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARONIA MELANOCARPA; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL FRACTIONATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; FRUIT JUICE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MEDICINAL PLANT; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; T LYMPHOCYTE; UPREGULATION; CELL CYCLE CHECKPOINT; CHEMISTRY; DRUG EFFECT; GENETICS; IMMUNOLOGY; LEUKEMIA; LEUKEMIA CELL LINE; LYMPHOCYTE; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION; PHOTINIA; TUMOR CELL LINE;

PHOTINIA MELANOCARPA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CCAAT-ENHANCER-BINDING PROTEINS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; DNA-BINDING PROTEINS; HUMANS; JURKAT CELLS; LEUKEMIA; LYMPHOCYTES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NUCLEAR PROTEINS; OXIDATION-REDUCTION; PHOTINIA; PLANT EXTRACTS; POLYPHENOLS; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEINS;

EID: 84863292702     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032526     Document Type: Article

References (48)

1. Surh YJ, (2003) Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3: 768-780.
2. Chung FL, Schwartz J, Herzog CR, Yang YM, (2003) Tea and cancer prevention: studies in animals and humans. J Nutr 133: 3268S-3274S.
3. Sharif T, Auger C, Alhosin M, Ebel C, Achour M, et al. (2010) Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1. Eur J Cancer 46: 983-994.
4. Walter A, Etienne-Selloum N, Brasse D, Khallouf H, Bronner C, et al. (2010) Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis. FASEB J 24: 3360-3369.
5. Hakimuddin F, Paliyath G, Meckling K, (2006) Treatment of mcf-7 breast cancer cells with a red grape wine polyphenol fraction results in disruption of calcium homeostasis and cell cycle arrest causing selective cytotoxicity. J Agric Food Chem 54: 7912-7923.
6. Sharif T, Auger C, Bronner C, Alhosin M, Klein T, et al. (2011) Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell. Invest New Drugs 29: 239-247.
7. Kulling SE, Rawel HM, (2008) Chokeberry (Aronia melanocarpa)- A review on the characteristic components and potential health effects. Planta Med 74: 1625-1634.
8. Bermudez-Soto MJ, Tomas-Barberan FA, (2004) Evaluation of commercial red fruit juice concentrates as ingredients for antioxidant functional juices. Eur Food Res Technol 219: 133-141.
9. Malik M, Zhao C, Schoene N, Guisti MM, Moyer MP, et al. (2003) Anthocyanin-rich extract from Aronia meloncarpa E induces a cell cycle block in colon cancer but not normal colonic cells. Nutr Cancer 46: 186-196.
10. Lala G, Malik M, Zhao C, He J, Kwon Y, et al. (2006) Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in rats. Nutr Cancer 54: 84-93.
11. Bermundez-Soto MJ, Larrosa M, Garcia-Cantalejo JM, Espin JC, Tomas-Barberan FA, et al. (2007) Up-regulation of tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 in human colon cancer Caco-2 cells following repetitive exposure to dietary levels of a polyphenol-rich chokeberry juice. J Nutr Biochem 18: 259-271.
12. Li GX, Chen YK, Hou Z, Xiao H, Jin H, et al. (2010) Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro. Carcinogenesis 31: 902-910.
13. Juan ME, Wenzel U, Daniel H, Planas JM, (2008) Resveratrol induces apoptosis through ROS-dependent mitochondria pathway in HT-29 human colorectal carcinoma cells. J Agric Food Chem 56: 4813-4818.
14. Chen W, Zhao Z, Li L, Wu B, Chen SF, et al. (2008) Hispolon induces apoptosis in human gastric cancer cells through a ROS-mediated mitochondrial pathway. Free Radic Biol Med 45: 60-72.
15. Das A, Banik NL, Ray SK, (2010) Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes. Cancer 116: 164-176.
16. Kwan ML, Block G, Selvin S, Month S, Buffler PA, (2004) Food consumption by children and the risk of childhood acute leukemia. Am J Epidemiol 160: 1098-1107.
17. Liu CY, Hsu YH, Wu MT, Pan PC, Ho CK, et al. (2009) Cured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: a population based case-control study. BMC Cancer 9: 15.
18. Alhosin M, Abusnina A, Achour M, Sharif T, Muller C, et al. (2010) Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1. Biochem Pharmacol 79: 1251-1260.
19. Jost CA, Marin MC, Kaelin WG Jr, (1997) p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Nature 389: 191-194.
20. Porter LA, Donoghue DJ, (2003) Cyclin B1 and CDK1: nuclear localization and upstream regulators. Prog Cell Cycle Res 5: 335-347.
21. Mousli M, Hopfner R, Abbady AQ, Monte D, Jeanblanc M, et al. (2003) ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells. Br J Cancer 89: 120-127.
22. Jenkins Y, Markovtsov V, Lang W, Sharma P, Pearsall D, et al. (2005) Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth. Mol Biol Cell 16: 5621-5629.
23. Bronner C, Achour M, Arima Y, Chataigneau T, Saya H, et al. (2007) The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future? Pharmacol Ther 115: 419-434.
24. Feng R, Ni HM, Wang SY, Tourkova IL, Shurin MR, et al. (2007) Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress. J Biol Chem 282: 13468-13476.
25. Rigas B, Sun Y, (2008) Induction of oxidative stress as a mechanism of action of chemopreventive agents against cancer. Br J Cancer 98: 1157-1160.
26. Sanchez-Duffhues G, Calzado MA, de Vinuesa AG, Appendino G, Fiebich BL, et al. (2009) Denbinobin inhibits nuclear factor-kappaB and induces apoptosis via reactive oxygen species generation in human leukemic cells. Biochem Pharmacol 77: 1401-1409.
27. Gusman J, Malonne H, Atassi G, (2001) A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol. Carcinogenesis 22: 1111-1117.
28. Duvoix A, Blasius R, Delhalle S, Schnekenburger M, Morceau F, et al. (2005) Chemopreventive and therapeutic effects of curcumin. Cancer Lett 223: 181-190.
29. Miller PE, Lesko SM, Muscat JE, Lazarus P, Hartman TJ, (2010) Dietary patterns and colorectal adenoma and cancer risk: a review of the epidemiological evidence. Nutr Cancer 62: 413-424.
30. Skupien K, Kostrzewa-Nowak D, Oszmianski J, Tarasiuk J, (2008) In vitro antileukaemic activity of extracts from chokeberry (Aronia melanocarpa [Michx] Elliott) and mulberry (Morus alba L.) leaves against sensitive and multidrug resistant HL60 cells. Phytother Res 22: 689-694.
31. Jeong JC, Jang SW, Kim TH, Kwon CH, Kim YK, (2010) Mulberry fruit (Moris fructus) extracts induce human glioma cell death in vitro through ROS-dependent mitochondrial pathway and inhibits glioma tumor growth in vivo. Nutr Cancer 62: 402-412.
32. Aiyer HS, Gupta RC, (2010) Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. Cancer Prev Res (Phila) 3: 727-737.
33. Misikangas M, Pajari AM, Paivarinta E, Oikarinen SI, Rajakangas J, et al. (2007) Three Nordic berries inhibit intestinal tumorigenesis in multiple intestinal neoplasia/+ mice by modulating beta-catenin signaling in the tumor and transcription in the mucosa. J Nutr 137: 2285-2290.
34. Cheng J, Haas M, (1990) Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines. Mol Cell Biol 10: 5502-5509.
35. Boominathan L, (2007) Some facts and thoughts: p73 as a tumor suppressor gene in the network of tumor suppressors. Mol Cancer 6: 27.
36. Tien AL, Senbanerjee S, Kulkarni A, Mudbhary R, Goudreau B, et al. (2011) UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis. Biochem J 435: 175-185.
37. Avvakumov GV, Walker JR, Xue S, Li Y, Duan S, et al. (2008) Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1. Nature 455: 822-825.
38. Bostick M, Kim JK, Esteve PO, Clark A, Pradhan S, et al. (2007) UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317: 1760-1764.
39. Jeanblanc M, Mousli M, Hopfner R, Bathami K, Martinet N, et al. (2005) The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle. Oncogene 24: 7337-7345.
40. Achour M, Jacq X, Ronde P, Alhosin M, Charlot C, et al. (2008) The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression. Oncogene 27: 2187-2197.
41. Hsiao MH, Yu AL, Yeargin J, Ku D, Haas M, (1994) Nonhereditary p53 mutations in T-cell acute lymphoblastic leukemia are associated with the relapse phase. Blood 83: 2922-2930.
42. Warburg O, (1925) Über den Stoffwechsel der Carcinomzelle. Klin Wochenschr Berl 4: 534-536.
43. DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, et al. (2007) Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA 104: 19345-19350.
44. Azam S, Hadi N, Khan NU, Hadi SM, (2004) Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties. Toxicol In Vitro 18: 555-561.
45. Poyton RO, Ball KA, Castello PR, (2009) Mitochondrial generation of free radicals and hypoxic signaling. Trends Endocrinol Metab 20: 332-340.
46. Murias M, Luczak MW, Niepsuj A, Krajka-Kuzniak V, Zielinska-Przyjemska M, et al. (2008) Cytotoxic activity of 3,3′,4,4′,5,5′-hexahydroxystilbene against breast cancer cells is mediated by induction of p53 and downregulation of mitochondrial superoxide dismutase. Toxicol In Vitro 22: 1361-1370.
47. Singleton VL, Rossi JA, (1965) Colorimetry of total phenols with phosphomolybdic-phosphotungstic reagents. Amer J Enol Viticult 16: 144-158.
48. Fuhrmann G, Sylvester I, Scholer HR, (1999) Repression of Oct-4 during embryonic cell differentiation correlates with the appearance of TRIF, a transiently induced DNA-binding factor. Cell Mol Biol 45: 717-724.