-
1
-
-
77952363301
-
Glutamate receptor ion channels: Structure, regulation, and function
-
Traynelis, S. F. et al. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol. Rev. 62, 405-496 (2010).
-
(2010)
Pharmacol. Rev.
, vol.62
, pp. 405-496
-
-
Traynelis, S.F.1
-
2
-
-
48849113877
-
Ionotropic glutamate receptors and CNS disorders
-
Bowie, D. Ionotropic glutamate receptors and CNS disorders. CNS Neurol. Disord. Drug Targets 7, 129-143 (2008).
-
(2008)
CNS Neurol. Disord. Drug Targets
, vol.7
, pp. 129-143
-
-
Bowie, D.1
-
3
-
-
7444240214
-
The three-dimensional structure of an ionotropic glutamate receptor reveals a dimer-of-dimers assembly
-
DOI 10.1016/j.jmb.2004.09.048, PII S0022283604012045
-
Tichelaar, W., Safferling, M., Keinanen, K., Stark, H. & Madden, D. R. The three-dimensional structure of an ionotropic glutamate receptor reveals a dimer-of-dimers assembly. J. Mol. Biol. 344, 435-442 (2004). (Pubitemid 39441215)
-
(2004)
Journal of Molecular Biology
, vol.344
, Issue.2
, pp. 435-442
-
-
Tichelaar, W.1
Safferling, M.2
Keinanen, K.3
Stark, H.4
Madden, D.R.5
-
4
-
-
0041921002
-
+ channels
-
Sobolevsky, A. I., Yelshansky, M. V. & Wollmuth, L. P. Different gating mechanisms in glutamate receptor and K+ channels. J. Neurosci. 23, 7559-7568 (2003). (Pubitemid 37034072)
-
(2003)
Journal of Neuroscience
, vol.23
, Issue.20
, pp. 7559-7568
-
-
Sobolevsky, A.I.1
Yelshansky, M.V.2
Wollmuth, L.P.3
-
5
-
-
2442675355
-
Block of AMPA receptor desensitization by a point mutation outside the ligand-binding domain
-
DOI 10.1523/JNEUROSCI.0757-04.2004
-
Yelshansky, M. V., Sobolevsky, A. I., Jatzke, C. & Wollmuth, L. P. Block of AMPA receptor desensitization by a point mutation outside the ligand-binding domain. J. Neurosci. 24, 4728-4736 (2004). (Pubitemid 38668197)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.20
, pp. 4728-4736
-
-
Yelshansky, M.V.1
Sobolevsky, A.I.2
Jatzke, C.3
Wollmuth, L.P.4
-
7
-
-
0032578635
-
Structural of a glutamate-receptor ligand-binding core in complex with kainate
-
DOI 10.1038/27692
-
Armstrong, N., Sun, Y., Chen, G. Q. & Gouaux, E. Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature 395, 913-917 (1998). (Pubitemid 28503434)
-
(1998)
Nature
, vol.395
, Issue.6705
, pp. 913-917
-
-
Armstrong, N.1
Sun, Y.2
Chen, G.-Q.3
Gouaux, E.4
-
8
-
-
0036968894
-
Structural basis for AMPA receptor activation and ligand selectivity: Crystal structures of five agonist complexes with the GluR2 ligand-binding core
-
DOI 10.1016/S0022-2836(02)00650-2
-
2 ligand-binding core. J. Mol. Biol. 322, 93-109 (2002). (Pubitemid 36138726)
-
(2002)
Journal of Molecular Biology
, vol.322
, Issue.1
, pp. 93-109
-
-
Hogner, A.1
Kastrup, J.S.2
Jin, R.3
Liljefors, T.4
Mayer, M.L.5
Egebjerg, J.6
Larsen, I.K.7
Gouaux, E.8
-
10
-
-
0043033172
-
Structural basis for partial agonist action at ionotropic glutamate receptors
-
DOI 10.1038/nn1091
-
Jin, R., Banke, T. G., Mayer, M. L., Traynelis, S. F. & Gouaux, E. Structural basis for partial agonist action at ionotropic glutamate receptors. Nat. Neurosci. 6, 803-810 (2003). (Pubitemid 36929700)
-
(2003)
Nature Neuroscience
, vol.6
, Issue.8
, pp. 803-810
-
-
Jin, R.1
Banke, T.G.2
Mayer, M.L.3
Traynelis, S.F.4
Gouaux, E.5
-
11
-
-
38549125923
-
Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating
-
DOI 10.1523/JNEUROSCI.3309-07.2008
-
Zhang, W., Cho, Y., Lolis, E. & Howe, J. R. Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. J. Neurosci. 28, 932-943 (2008). (Pubitemid 351158996)
-
(2008)
Journal of Neuroscience
, vol.28
, Issue.4
, pp. 932-943
-
-
Zhang, W.1
Cho, Y.2
Lolis, E.3
Howe, J.R.4
-
12
-
-
24744467813
-
Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2
-
DOI 10.1073/pnas.0505522102
-
Holm, M. M., Lunn, M. L., Traynelis, S. F., Kastrup, J. S. & Egebjerg, J. Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2. Proc. Natl Acad. Sci. USA 102, 12053-12058 (2005). (Pubitemid 41291127)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.34
, pp. 12053-12058
-
-
Holm, M.M.1
Lunn, M.-L.2
Traynelis, S.F.3
Kastrup, J.S.4
Egebjerg, J.5
-
13
-
-
44949109192
-
Rigid body essential X-ray crystallography: Distinguishing the bend and twist of glutamate receptor ligand binding domains
-
DOI 10.1002/prot.21941
-
Bjerrum, E. J. & Biggin, P. C. Rigid body essential X-ray crystallography: distinguishing the bend and twist of glutamate receptor ligand binding domains. Proteins 72, 434-446 (2008). (Pubitemid 351809178)
-
(2008)
Proteins: Structure, Function and Genetics
, vol.72
, Issue.1
, pp. 434-446
-
-
Bjerrum, E.J.1
Biggin, P.C.2
-
14
-
-
75349094219
-
Enhanced efficacy without further cleft closure: Reevaluating twist as a source of agonist efficacy in AMPA receptors
-
Birdsey-Benson, A., Gill, A., Henderson, L. P. & Madden, D. R. Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors. J. Neurosci. 30, 1463-1470 (2010).
-
(2010)
J. Neurosci.
, vol.30
, pp. 1463-1470
-
-
Birdsey-Benson, A.1
Gill, A.2
Henderson, L.P.3
Madden, D.R.4
-
15
-
-
1242293631
-
Regulation of AMPA receptor gating by ligand binding core dimers
-
DOI 10.1016/S0896-6273(04)00018-2
-
Horning, M. S. & Mayer, M. L. Regulation of AMPA receptor gating by ligand binding core dimers. Neuron 41, 379-388 (2004). (Pubitemid 38221042)
-
(2004)
Neuron
, vol.41
, Issue.3
, pp. 379-388
-
-
Horning, M.S.1
Mayer, M.L.2
-
16
-
-
17644377289
-
AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization
-
DOI 10.1523/JNEUROSCI.0188-05.2005
-
Robert, A., Armstrong, N., Gouaux, J. E. & Howe, J. R. AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization. J. Neurosci. 25, 3752-3762 (2005). (Pubitemid 40570408)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.15
, pp. 3752-3762
-
-
Robert, A.1
Armstrong, N.2
Gouaux, J.E.3
Howe, J.R.4
-
17
-
-
33749059766
-
Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor
-
DOI 10.1016/j.cell.2006.08.037, PII S0092867406011597
-
Armstrong, N., Jasti, J., Beich-Frandsen, M. & Gouaux, E. Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor. Cell 127, 85-97 (2006). (Pubitemid 44466635)
-
(2006)
Cell
, vol.127
, Issue.1
, pp. 85-97
-
-
Armstrong, N.1
Jasti, J.2
Beich-Frandsen, M.3
Gouaux, E.4
-
18
-
-
77953103088
-
Role of dimer interface in activation and desensitization in AMPA receptors
-
Gonzalez, J., Du, M., Parameshwaran, K., Suppiramaniam, V. & Jayaraman, V. Role of dimer interface in activation and desensitization in AMPA receptors. Proc. Natl Acad. Sci. USA 107, 9891-9896 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 9891-9896
-
-
Gonzalez, J.1
Du, M.2
Parameshwaran, K.3
Suppiramaniam, V.4
Jayaraman, V.5
-
19
-
-
25644454403
-
Mechanism of positive allosteric modulators acting on AMPA receptors
-
DOI 10.1523/JNEUROSCI.2567-05.2005
-
Jin, R. et al. Mechanism of positive allosteric modulators acting on AMPA receptors. J. Neurosci. 25, 9027-9036 (2005). (Pubitemid 41384472)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.39
, pp. 9027-9036
-
-
Jin, R.1
Clark, S.2
Weeks, A.M.3
Dudman, J.T.4
Gouaux, E.5
Partin, K.M.6
-
20
-
-
0032191104
-
A point mutation in the glutamate binding site blocks desensitization of AMPA receptors
-
DOI 10.1016/S0896-6273(00)80605-4
-
Stern-Bach, Y., Russo, S., Neuman, M. & Rosenmund, C. A point mutation in the glutamate binding site blocks desensitization of AMPA receptors. Neuron 21, 907-918 (1998). (Pubitemid 28498797)
-
(1998)
Neuron
, vol.21
, Issue.4
, pp. 907-918
-
-
Stern-Bach, Y.1
Russo, S.2
Neuman, M.3
Rosenmund, C.4
-
21
-
-
72049124287
-
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
-
Sobolevsky, A. I., Rosconi, M. P. & Gouaux, E. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature 462, 745-756 (2009).
-
(2009)
Nature
, vol.462
, pp. 745-756
-
-
Sobolevsky, A.I.1
Rosconi, M.P.2
Gouaux, E.3
-
22
-
-
26944451291
-
Molecular mechanism of AMPA receptor noncompetitive antagonism
-
DOI 10.1016/j.neuron.2005.09.024, PII S0896627305007919
-
Balannik, V., Menniti, F. S., Paternain, A. V., Lerma, J. & Stern-Bach, Y. Molecular mechanism of AMPA receptor noncompetitive antagonism. Neuron 48, 279-288 (2005). (Pubitemid 41476361)
-
(2005)
Neuron
, vol.48
, Issue.2
, pp. 279-288
-
-
Balannik, V.1
Menniti, F.S.2
Paternain, A.V.3
Lerma, J.4
Stern-Bach, Y.5
-
23
-
-
36048978613
-
A domain linking the AMPA receptor agonist binding site to the ion pore controls gating and causes lurcher properties when mutated
-
DOI 10.1523/JNEUROSCI.3175-07.2007
-
Schmid, S. M., Korber, C., Herrmann, S., Werner, M. & Hollmann, M. A domain linking the AMPA receptor agonist binding site to the ion pore controls gating and causes lurcher properties when mutated. J. Neurosci. 27, 12230-12241 (2007). (Pubitemid 350085461)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.45
, pp. 12230-12241
-
-
Schmid, S.M.1
Korber, C.2
Herrmann, S.3
Werner, M.4
Hollmann, M.5
-
24
-
-
0036154304
-
Molecular dynamics simulations of the ligand-binding domain of the ionotropic glutamate receptor GluR2
-
Arinaminpathy, Y., Sansom, M. S. & Biggin, P. C. Molecular dynamics simulations of the ligand-binding domain of the ionotropic glutamate receptor GluR2. Biophys. J. 82, 676-683 (2002). (Pubitemid 34111209)
-
(2002)
Biophysical Journal
, vol.82
, Issue.2
, pp. 676-683
-
-
Arinaminpathy, Y.1
Sansom, M.S.P.2
Biggin, P.C.3
-
25
-
-
79952354508
-
The hidden energetics of ligand binding and activation in a glutamate receptor
-
Lau, A. Y. & Roux, B. The hidden energetics of ligand binding and activation in a glutamate receptor. Nat. Struct. Mol. Biol. 18, 283-287 (2010).
-
(2010)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 283-287
-
-
Lau, A.Y.1
Roux, B.2
-
26
-
-
78751681223
-
2 ligand binding domain core-dimer
-
Yonkunas, M. & Kurnikova, M. Characterizing the energetic states of the GluR2 ligand binding domain core-dimer. Biophys. J. 100, L5-L7 (2011).
-
(2011)
Biophys. J.
, vol.100
-
-
Yonkunas, M.1
Kurnikova, M.2
-
27
-
-
67650252005
-
2 glutamate receptor
-
Speranskiy, K. & Kurnikova, M. G. Modeling of peptides connecting the ligand-binding and transmembrane domains in the GluR2 glutamate receptor. Proteins 76, 271-280 (2009).
-
(2009)
Proteins
, vol.76
, pp. 271-280
-
-
Speranskiy, K.1
Kurnikova, M.G.2
-
28
-
-
1242293628
-
The Outer Pore of the Glutamate Receptor Channel Has 2-Fold Rotational Symmetry
-
DOI 10.1016/S0896-6273(04)00008-X
-
Sobolevsky, A. I., Yelshansky, M. V. & Wollmuth, L. P. The outer pore of the glutamate receptor channel has 2-fold rotational symmetry. Neuron 41, 367-378 (2004). (Pubitemid 38221041)
-
(2004)
Neuron
, vol.41
, Issue.3
, pp. 367-378
-
-
Sobolevsky, A.I.1
Yelshansky, M.V.2
Wollmuth, L.P.3
-
29
-
-
0032486422
-
The tetrameric structure of a glutamate receptor channel
-
DOI 10.1126/science.280.5369.1596
-
Rosenmund, C., Stern-Bach, Y. & Stevens, C. F. The tetrameric structure of a glutamate receptor channel. Science 280, 1596-1599 (1998). (Pubitemid 28277703)
-
(1998)
Science
, vol.280
, Issue.5369
, pp. 1596-1599
-
-
Rosenmund, C.1
Stern-Bach, Y.2
Stevens, C.F.3
-
30
-
-
0033623299
-
Concentration-dependent substate behavior of native AMPA receptors
-
Smith, T. C. & Howe, J. R. Concentration-dependent substate behavior of native AMPA receptors. Nat. Neurosci. 3, 992-997 (2000).
-
(2000)
Nat. Neurosci.
, vol.3
, pp. 992-997
-
-
Smith, T.C.1
Howe, J.R.2
-
31
-
-
77949816724
-
Gating modes in AMPA receptors
-
Prieto, M. L. & Wollmuth, L. P. Gating modes in AMPA receptors. J. Neurosci. 30, 4449-4459 (2010).
-
(2010)
J. Neurosci.
, vol.30
, pp. 4449-4459
-
-
Prieto, M.L.1
Wollmuth, L.P.2
-
32
-
-
46149085900
-
Spontaneous conformational change and toxin binding in α7 acetylcholine receptor: Insight into channel activation and inhibition
-
DOI 10.1073/pnas.0710530105
-
Yi, M., Tjong, H. & Zhou, H. X. Spontaneous conformational change and toxin binding in alpha7 acetylcholine receptor: insight into channel activation and inhibition. Proc. Natl Acad. Sci. USA 105, 8280-8285 (2008). (Pubitemid 351904747)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.24
, pp. 8280-8285
-
-
Yi, M.1
Tjong, H.2
Zhou, H.-X.3
-
33
-
-
0037442813
-
Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits
-
Schorge, S. & Colquhoun, D. Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits. J. Neurosci. 23, 1151-1158 (2003). (Pubitemid 36258894)
-
(2003)
Journal of Neuroscience
, vol.23
, Issue.4
, pp. 1151-1158
-
-
Schorge, S.1
Colquhoun, D.2
-
34
-
-
0037414788
-
A site in the fourth membrane-associated domain of the N-methyl-D-aspartate receptor regulates desensitization and ion channel gating
-
DOI 10.1074/jbc.M209486200
-
Ren, H., Honse, Y., Karp, B. J., Lipsky, R. H. & Peoples, R. W. A site in the fourth membrane-associated domain of the N-methyl-D-aspartate receptor regulates desensitization and ion channel gating. J. Biol. Chem. 278, 276-283 (2003). (Pubitemid 36043573)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.1
, pp. 276-283
-
-
Ren, H.1
Honse, Y.2
Karp, B.J.3
Lipsky, R.H.4
Peoples, R.W.5
-
35
-
-
0031961764
-
Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors
-
Anson, L. C., Chen, P. E., Wyllie, D. J., Colquhoun, D. & Schoepfer, R. Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors. J. Neurosci. 18, 581-589 (1998). (Pubitemid 28041894)
-
(1998)
Journal of Neuroscience
, vol.18
, Issue.2
, pp. 581-589
-
-
Anson, L.C.1
Chen, P.E.2
Wyllie, D.J.A.3
Colquhoun, D.4
Schoepfer, R.5
-
36
-
-
55749104248
-
Embedded cholesterol in the nicotinic acetylcholine receptor
-
Brannigan, G., Henin, J., Law, R., Eckenhoff, R. & Klein, M. L. Embedded cholesterol in the nicotinic acetylcholine receptor. Proc. Natl Acad. Sci. USA 105, 14418-14423 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 14418-14423
-
-
Brannigan, G.1
Henin, J.2
Law, R.3
Eckenhoff, R.4
Klein, M.L.5
-
37
-
-
77950868175
-
One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue
-
Nury, H. et al. One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue. Proc. Natl Acad. Sci. USA 107, 6275-6280 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 6275-6280
-
-
Nury, H.1
-
38
-
-
33749331062
-
Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors
-
Cheng, X., Wang, H., Grant, B., Sine, S. M. & McCammon, J. A. Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors. PLoS Comput. Biol. 2, e134 (2006).
-
(2006)
PLoS Comput. Biol.
, vol.2
-
-
Cheng, X.1
Wang, H.2
Grant, B.3
Sine, S.M.4
McCammon, J.A.5
-
39
-
-
0028455053
-
Targeted molecular dynamics: A new approach for searching pathways of conformational transitions
-
DOI 10.1016/0263-7855(94)80072-3
-
Schlitter, J., Engels, M. & Kruger, P. Targeted molecular dynamics: a new approach for searching pathways of conformational transitions. J. Mol. Graph. 12, 84-89 (1994). (Pubitemid 24219247)
-
(1994)
Journal of Molecular Graphics
, vol.12
, Issue.2
, pp. 84-89
-
-
Schlitter, J.1
Engels, M.2
Kruger, P.3
-
40
-
-
47149096704
-
CHARMM-GUI: A web-based graphical user interface for CHARMM
-
Jo, S., Kim, T., Iyer, V. G. & Im, W. CHARMM-GUI: a web-based graphical user interface for CHARMM. J. Comput. Chem. 29, 1859-1865 (2008).
-
(2008)
J. Comput. Chem.
, vol.29
, pp. 1859-1865
-
-
Jo, S.1
Kim, T.2
Iyer, V.G.3
Im, W.4
-
41
-
-
27344436659
-
Scalable molecular dynamics with NAMD
-
DOI 10.1002/jcc.20289
-
Phillips, J. C. et al. Scalable molecular dynamics with NAMD. J. Comput. Chem. 26, 1781-1802 (2005). (Pubitemid 43078511)
-
(2005)
Journal of Computational Chemistry
, vol.26
, Issue.16
, pp. 1781-1802
-
-
Phillips, J.C.1
Braun, R.2
Wang, W.3
Gumbart, J.4
Tajkhorshid, E.5
Villa, E.6
Chipot, C.7
Skeel, R.D.8
Kale, L.9
Schulten, K.10
-
42
-
-
2942675244
-
Lipid Bilayer pressure profiles and mechanosensitive channel gating
-
DOI 10.1529/biophysj.103.034322
-
Gullingsrud, J. & Schulten, K. Lipid bilayer pressure profiles and mechanosensitive channel gating. Biophys. J. 86, 3496-3509 (2004). (Pubitemid 38780232)
-
(2004)
Biophysical Journal
, vol.86
, Issue.6
, pp. 3496-3509
-
-
Gullingsrud, J.1
Schulten, K.2
-
43
-
-
3142714765
-
Extending the treatment of backbone energetics in protein force fields: Limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations
-
Mackerell, A. D., Feig, M. & Brooks, C. L. Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations. J. Comput. Chem. 25, 1400-1415 (2004).
-
(2004)
J. Comput. Chem.
, vol.25
, pp. 1400-1415
-
-
MacKerell, A.D.1
Feig, M.2
Brooks, C.L.3
-
44
-
-
0034250744
-
An improved empirical potential energy function for molecular simulations of phospholipids
-
Feller, S. E. & MacKerell, A. D. An improved empirical potential energy function for molecular simulations of phospholipids. J. Phys. Chem. B 104, 7510-7515 (2000).
-
(2000)
J. Phys. Chem.
, vol.104
, pp. 7510-7515
-
-
Feller, S.E.1
MacKerell, A.D.2
-
45
-
-
0030404988
-
HOLE: A program for the analysis of the pore dimensions of ion channel structural models
-
DOI 10.1016/S0263-7855(97)00009-X, PII S026378559700009X
-
Smart, O. S., Neduvelil, J. G., Wang, X., Wallace, B. A. & Sansom, M. S. HOLE: a program for the analysis of the pore dimensions of ion channel structural models. J. Mol. Graph 14, 354-360 (1996). (Pubitemid 27302826)
-
(1996)
Journal of Molecular Graphics
, vol.14
, Issue.6
, pp. 354-360
-
-
Smart, O.S.1
Neduvelil, J.G.2
Wang, X.3
Wallace, B.A.4
Sansom, M.S.P.5
|