Embryonic stem cell-derived factors inhibit T effector activation and induce T regulatory cells by suppressing PKC-θ activation

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Mohib, Kanishka ^a   AlKhamees, Bodour ^a   Zein, Haggag S ^a   Allan, David ^a,b   Wang, Lisheng ^a,b,c  

^a UNIVERSITY OF OTTAWA   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; I KAPPA B ALPHA; INTERLEUKIN 10; INTERLEUKIN 2; PROTEIN KINASE C THETA; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; CYCLOSPORIN; CYTOKINE; IMMUNOSUPPRESSIVE AGENT; ISOENZYME; PRKCQ PROTEIN, MOUSE; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; DOWN REGULATION; EFFECTOR CELL; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; CELL PROLIFERATION; CULTURE MEDIUM; DRUG EFFECT; ENZYMOLOGY; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PHOSPHORYLATION; T LYMPHOCYTE;

ANIMALS; CELL LINE; CELL PROLIFERATION; CULTURE MEDIA, CONDITIONED; CYCLOSPORINE; CYTOKINES; EMBRYONIC STEM CELLS; ENZYME ACTIVATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ISOENZYMES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PHOSPHORYLATION; PROTEIN KINASE C; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 84863233865     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032420     Document Type: Article

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