High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943

British Journal of Pharmacology

Volumn 165, Issue 7, 2012, Pages 2260-2273

  Cheng, Hongwei ^a   Zhang, Yihong ^a   Du, Chunyun ^a   Dempsey, Christopher E ^a   Hancox, Jules C ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

hERG; I hERG; I Kr; KB R7943; NCX; rapid delayed rectifier K + current; sodium calcium exchange

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; ALANINE; F 656; PROTEIN INHIBITOR; SN 6; UNCLASSIFIED DRUG; Y 652;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOPLASM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ELECTRIC POTENTIAL; HUMAN; HUMAN CELL; IC 50; MALE; MEMBRANE DEPOLARIZATION; MOLECULAR DOCKING; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; TIME; VOLTAGE CLAMP;

AMINO ACID SUBSTITUTION; ANIMALS; BENZYL COMPOUNDS; ETHER-A-GO-GO POTASSIUM CHANNELS; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; RABBITS; RECOMBINANT PROTEINS; SODIUM-CALCIUM EXCHANGER; THIAZOLIDINES; THIOUREA;

EID: 84863231966     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01688.x     Document Type: Article

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