Characterization of recombinant hERG K+ channel inhibition by the active metabolite of amiodarone desethyl-amiodarone

Journal of Electrocardiology

Volumn 43, Issue 5, 2010, Pages 440-448

  Zhang, Yi H ^a   Cheng, Hongwei ^a   Alexeenko, Vadim A ^a   Dempsey, Christopher E ^a   Hancox, Jules C ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Amiodarone; Antiarrhythmic; Class III; Desethyl amiodarone; HERG; Human ether go go related gene; IKr; Potassium channel; QT interval

Indexed keywords

AMIODARONE; DEETHYLAMIODARONE; POTASSIUM CHANNEL HERG; ANTIARRHYTHMIC AGENT; DRUG DERIVATIVE; KCNH6 PROTEIN, HUMAN;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; ION CURRENT; MEMBRANE POTENTIAL; PATCH CLAMP; PRIORITY JOURNAL; REPOLARIZATION; ANALYSIS OF VARIANCE; DRUG EFFECT;

AMIODARONE; ANALYSIS OF VARIANCE; ANTI-ARRHYTHMIA AGENTS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; PATCH-CLAMP TECHNIQUES;

EID: 79952116131     PISSN: 00220736     EISSN: 15328430     Source Type: Journal    
DOI: 10.1016/j.jelectrocard.2010.04.007     Document Type: Article

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