Recent advances in pharmaceutical separations with supercritical fluid chromatography using chiral stationary phases

TrAC - Trends in Analytical Chemistry

Volumn 37, Issue , 2012, Pages 83-100

  Ren Qi, Wang ^a   Teng Teng, Ong ^a   Siu Choon, Ng ^a   Weihua, Tang ^b  

^a Nanyang Technological University   (Singapore)

^b NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Achiral separation; Chiral separation; Chiral stationary phase (CSP); Drug discovery; Enantioseparation; Packed column; Preparative chromatography; Screening strategy; Supercritical fluid chromatography (SFC); Tandem column

Indexed keywords

CHIRAL SEPARATIONS; CHIRAL STATIONARY PHASE; DRUG DISCOVERY; ENANTIOSEPARATIONS; PACKED COLUMN; PREPARATIVE CHROMATOGRAPHY; SCREENING STRATEGY; SUPER CRITICAL FLUID CHROMATOGRAPHY;

CHIRALITY; COLUMN CHROMATOGRAPHY; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PURIFICATION;

SEPARATION;

ACEBUTOLOL; ADRENALIN; ALPRENOLOL; ALTIZIDE; BENDROFLUMETHIAZIDE; CLENBUTEROL; ECONAZOLE; EPHEDRINE; FENOPROFEN; FLURBIPROFEN; IBUPROFEN; ITRACONAZOLE; KETOCONAZOLE; KETOPROFEN; LANSOPRAZOLE; METOPROLOL; MICONAZOLE; NAPROXEN; NOREPHEDRINE; OMEPRAZOLE; OXFENDAZOLE; OXPRENOLOL; PANTOPRAZOLE; PINDOLOL; PROPRANOLOL; RABEPRAZOLE; SULCONAZOLE; SUPROFEN; TRICHLORMETHIAZIDE; UNINDEXED DRUG;

ACCURACY; CHIRAL CHROMATOGRAPHY; CHIRALITY; COLUMN CHROMATOGRAPHY; DRUG DETERMINATION; DRUG PURIFICATION; DRUG STRUCTURE; ENANTIOMER; ENANTIOSELECTIVITY; HYDROGEN BOND; HYDROPHOBICITY; PHASE SEPARATION; PREDICTION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; PRODUCT RECOVERY; REPRODUCIBILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REVIEW; SENSITIVITY AND SPECIFICITY; SUPERCRITICAL FLUID CHROMATOGRAPHY; TEMPERATURE SENSITIVITY;

EID: 84863222291     PISSN: 01659936     EISSN: 18793142     Source Type: Journal    
DOI: 10.1016/j.trac.2012.02.012     Document Type: Review

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