Screening approach for chiral separation of pharmaceuticals: Part III. Supercritical fluid chromatography for analysis and purification in drug discovery

Journal of Chromatography A

Volumn 1088, Issue 1-2, 2005, Pages 67-81

  Maftouh, Mohamed ^a   Granier Loyaux, Christine ^a   Chavana, Evelyne ^a   Marini, Jerome ^a   Pradines, Antoine ^a   Vander Heyden, Yvan ^b   Picard, Claudine ^a  

^a SANOFI   (France)

^b PHARMACEUTICAL INSTITUTE   (Belgium)

Author keywords

Drug discovery; High throughput chiral separations; Screening strategy; Supercritical fluid chromatography

Indexed keywords

LIQUID CHROMATOGRAPHY; METHANOL; MODIFICATION; MOLECULES; PHASE SEPARATION; PURIFICATION;

CHIRALS; ENANTIOMERS; PERFORMANCE ANALYSIS; PHARMACOLOGICAL TESTING;

DRUG PRODUCTS;

2 PROPANOL; ACEBUTOLOL; ADRENALIN; ALPRENOLOL; AMFEBUTAMONE; AMISULPRIDE; ATROPINE; CLENBUTEROL; CLOPIDOGREL; DILTIAZEM; EPHEDRINE; FLUOXETINE; KETAMINE; METHADONE; METHANOL; METOPROLOL; MIANSERIN; NADOLOL; OXAZEPAM; OXPRENOLOL; PINDOLOL; PRAZIQUANTEL; PROMETHAZINE; PROPIOMAZINE; PROPRANOLOL; SOTALOL; SULPIRIDE; THIOPENTAL; UNINDEXED DRUG; VERAPAMIL;

AUTOMATION; CHIRAL CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; CONFERENCE PAPER; DRUG MARKETING; DRUG PROGRAM; DRUG PURIFICATION; DRUG SCREENING; ENANTIOMER; INSTRUMENTATION; METHODOLOGY; MOLECULE; PERFORMANCE; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; SUPERCRITICAL FLUID CHROMATOGRAPHY; TECHNIQUE; TIME;

CHROMATOGRAPHY, SUPERCRITICAL FLUID; DRUG DESIGN; PHARMACEUTICAL PREPARATIONS; PRESSURE; STEREOISOMERISM; TEMPERATURE;

EID: 23044486916     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2004.12.038     Document Type: Conference Paper

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