A high throughput approach to purifying chiral molecules using 3μm analytical chiral stationary phases via supercritical fluid chromatography

Journal of Chromatography A

Volumn 1218, Issue 22, 2011, Pages 3529-3536

  Hamman, Chris ^a   Wong, Mengling ^a   Hayes, Michael ^a   Gibbons, Paul ^a  

^a GENENTECH INC   (United States)

Author keywords

Chiral; Purification; SFC

Indexed keywords

CHIRAL; CHIRAL MOLECULE; CHIRAL SCREENING; CHIRAL STATIONARY PHASIS; CHIRAL TECHNOLOGIES; CHIRALCEL OJ COLUMN; CHIRALPAK AD; EMPIRICAL APPROACH; HIGH-THROUGHPUT APPROACHES; INDUSTRY STANDARDS; ISOCRATIC; SCALE-UP; SFC; STATIONARY PHASE; SUPER CRITICAL FLUID CHROMATOGRAPHY;

CELLULOSE; EFFLUENT TREATMENT; GAS CHROMATOGRAPHY; GRADIENT METHODS; SUPERCRITICAL FLUIDS;

PURIFICATION;

1,1' BINAPHTHYL 2,2' DIAMINE; 2,2' DIHYDROXY 1,1' BINAPHTHYL; 2,2,2 TRIFLUORO 1 9 ANTHRYLETHANOL; ATENOLOL; BENDROFLUMETHIAZIDE; BENZOIN; CHLORPHENIRAMINE MALEATE; CLENBUTEROL; DRUG; FLAVANONE; FLURBIPROFEN; HOMATROPINE; IBUPROFEN; INDAPAMIDE; KETOPROFEN; MANDELAMIDE; MIANSERIN; NORFENEFRINE; PROPRANOLOL; STILBENE OXIDE; STYRENE GLYCOL; SULINDAC; THALIDOMIDE; UNCLASSIFIED DRUG; WARFARIN;

ARTICLE; CHIRAL STATIONARY PHASE; CHIRALITY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SCREENING; HIGH THROUGHPUT SCREENING; INTERMETHOD COMPARISON; PARTICLE SIZE; PHYSICAL PHASE; PRIORITY JOURNAL; PURIFICATION; SEPARATION TECHNIQUE; SUPERCRITICAL FLUID CHROMATOGRAPHY;

AMYLOSE; CELLULOSE; CHROMATOGRAPHY, SUPERCRITICAL FLUID; HIGH-THROUGHPUT SCREENING ASSAYS; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; PHENYLCARBAMATES; STEREOISOMERISM;

EID: 79955730754     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.03.066     Document Type: Article

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