Rapid method development for chiral separation in drug discovery using sample pooling and supercritical fluid chromatography-mass spectrometry

Journal of Chromatography A

Volumn 1003, Issue 1-2, 2003, Pages 157-166

  Zhao, Yining ^a   Woo, Gregory ^a   Thomas, Samuel ^a   Semin, David ^a   Sandra, Pat ^b  

^a AMGEN INC   (United States)

^b Research Institute for Chromatography   (Belgium)

Author keywords

Drug discovery; Enantiomer separation; Sample pooling; Supercritical fluid chromatography

Indexed keywords

DATA PROCESSING; DRUG PRODUCTS; MASS SPECTROMETRY; SEPARATION; SUPERCRITICAL FLUIDS; ULTRAVIOLET RADIATION;

DRUG DISCOVERY;

LIQUID CHROMATOGRAPHY;

ISOPROPYLAMINE; METHANOL; PROPYLAMINE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; CONCENTRATION RESPONSE; INFORMATION PROCESSING; MASS SPECTROMETRY; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SAMPLING; SCREENING TEST; SIGNAL DETECTION; SUPERCRITICAL FLUID CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY;

EID: 0037630936     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(03)00725-8     Document Type: Article

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