Development of new carbon-11 labelled radiotracers for imaging GABA A- and GABA B-benzodiazepine receptors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 14, 2012, Pages 4482-4488

  Moran, Matthew D ^a   Wilson, Alan A ^a   Elmore, Charles S ^b,c   Parkes, Jun ^a   Ng, Alvina ^a   Sadovski, Oleg ^a   Graff, Ariel ^a   Daskalakis, Zafiris J ^a   Houle, Sylvain ^a   Chapdelaine, Marc J ^b   Vasdev, Neil ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b ASTRAZENECA   (United Kingdom)

^c ASTRAZENECA R AND D   (Sweden)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Carbon 11; GABA A receptors; GABA B receptors; Positron emission tomography; Radiopharmaceuticals

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA; 4 AMINOBUTYRIC ACID A RECEPTOR BETA; 9 AMINO 2 CYCLOBUTYL 5 ( 1 METHYL 2 OXO 1,2 DIHYDROPYRIDIN 3 YL) 2,3 DIHYDRO 1H PYRROLO[3,4 B]QUINOLIN 1 ONE; 9 AMINO 2 CYCLOBUTYL 5 ( 2 METHOXYPYRIDIN 3 YL) 2,3 DIHYDRO 1H PYRROLO[3,4 B]QUINOLIN 1 ONE; 9 AMINO 2 CYCLOBUTYL 5 ( 2 METHYL 6 OXO 1,6 DIHYDROPYRIDIN 3 YL) 2,3 DIHYDRO 1H PYRROLO[3,4 B]QUINOLIN 1 ONE; 9 AMINO 2 CYCLOBUTYL 5 (1,2 DIMETHYL 6 OXO 1,6 DIHYDROPYRIDIN 3 YL) 2,3 DIHYDRO 1H PYRROLO[3,4 B]QUINOLIN 1 ONE; 9 AMINO 2 CYCLOBUTYL 5 (2 OXO 1,2 DIHYDROPYRIDIN 3 YL) 2,3 DIHYDRO 1H PYRROLO[3,4 B]QUINOLIN 1 ONE; 9 AMINO 2 CYCLOBUTYL 5 (6 METHOXY 2 METHYLPYRIDIN 3 YL) 2,3 DIHYDRO 1H PYRROLO[3,4 B]QUINOLIN 1 ONE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; CARBON 11; FLUMAZENIL; METHYL IODIDE; N [1 (3 CHLORO 4 HYDROXYPHENYL)ETHYL] 3,3 DIPHENYL PROPAN 1 AMINE; PYRIDINOL; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG ISOLATION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; EX VIVO STUDY; ISOTOPE LABELING; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; RAT;

ANIMALS; BRAIN; CARBON RADIOISOTOPES; POSITRON-EMISSION TOMOGRAPHY; PYRROLES; QUINOLONES; RADIOPHARMACEUTICALS; RATS; RECEPTORS, GABA-A; RECEPTORS, GABA-B; TISSUE DISTRIBUTION;

RATTUS; RODENTIA;

EID: 84863211347     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.046     Document Type: Article

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