New insights into the role of the GABAA-benzodiazepine receptor in psychiatric disorder

British Journal of Psychiatry

Volumn 179, Issue NOV., 2001, Pages 390-396

  Nutt, D J ^a   Malizia, A L ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; CHLORAL HYDRATE; CLOMETHIAZOLE;

ANIMAL BEHAVIOR; ANXIETY NEUROSIS; CHLORIDE TRANSPORT; DIAGNOSTIC IMAGING; DISEASE COURSE; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; IMAGE ANALYSIS; LEARNING; MEMORY; MENTAL DISEASE; MOLECULAR BIOLOGY; MOLECULAR GENETICS; NONHUMAN; PATHOPHYSIOLOGY; REVIEW;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY DISORDERS; BENZODIAZEPINES; HUMANS; MICE; RECEPTORS, GABA-A; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0035186421     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/bjp.179.5.390     Document Type: Review

References (34)

1. XV. Subtypes of gamma-aminobutyric acid (A) receptors: Classification on the basis of subunit structure and receptor function
2. Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors
3. Benzodiazepine-like substances and hepatic encephalopathy. Implications for treatment
4. A-receptor clustering results in enhanced anxiety and a bias for threat cues
5. Structural requirements for ligand interactions at the benzodiazepine recognition site of the GABA(A) receptor
6. New insights into the mechanism of action of hypnotics
7. Function of endogenous monoamine oxidase inhibitors (tribulin)
8. Reductions in occipital cortex GABA levels in panic disorder detected with IH-magnetic resonance spectroscopy
9. Central action of benzodiazepines: General introduction
10. A receptor subunit mRNAs in the rat cortex
11. Regional and molecular separation of the four bioactivities of 'tribulin'
12. Role of GABA in memory and anxiety
13. Imaging the α5-subunit containing GABA-benzodiazepine receptor subtype in vivo with PET
14. Chronic benzodiazepine treatment increases the effects of the inverse agonist FG7142
15. Molecular and neuronal substrate for the selective attenuation of anxiety
16. Acute effects of low dose flumazenil in panic disorder
17. What do brain imaging studies tell us about anxiety disorders?
18. A-benzodiazepine receptor binding in panic disorder: Preliminary results from a quantitative PET study
19. A receptor determined by electron microscopic image analysis
20. Evidence for a late evolutionary appearance of brain-specific benzodiazepine receptors: An investigation of 18 vertebrate and 5 invertebrate species
21. Flumazenil provocation of panic attacks: Evidence for altered benzodiazepine receptor sensitivity in panic disorders
22. Reduced benzodiazepine sensitivity in panic disorder
23. Benzodiazepine actions mediated by specific gamma-aminobutyric acid (A) receptor subtypes
24. Purification of a benzodiazepine from bovine brain and detection of benzodiazepine-like immunoreactivity in the human brain
25. A receptor shows a ligand-gated receptor super-family
26. Selective genotyping for the role of 5-HT2C and GABA alpha 6 receptors and the serotonin transporter in the level of response to alcohol: A pilot study
27. Behavioural, neuroendocrine and cardiovascular response to flumazenil: No evidence for altered benzodiazepine sensitivity in panic disorder
28. Idiopathic recurring stupor
29. Cerebral benzodiazepine receptor binding and distribution in generalized anxiety disorder: A fractal analysis
30. A receptor subtype
31. Decreased agonist sensitivity of human GABA(A) receptors by an amino acid variant, isoleucine to valine, in the alpha I subunit
32. Behavioural, biochemical, cardiovascular responses to the benzodiazepine receptor antagonist flumazenil
33. Benzodiazepines: Time for reassessment