A new model of Pde4d deficiency: Genetic knock-down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects

Genes, Brain and Behavior

Volumn 11, Issue 5, 2012, Pages 614-622

  Schaefer, T L ^a   Braun, A A ^a   Amos Kroohs, R M ^a   Williams, M T ^a   Ostertag, E ^b   Vorhees, C V ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b Transposagen Biopharmaceuticals Inc   (United States)

Author keywords

Acoustic startle; Cincinnati water maze; F344 rats; Fear conditioning; Locomotor activity; Morris water maze; Pde4; Pde4d; Phosphodiesterase

Indexed keywords

PHOSPHODIESTERASE 4D; PHOSPHODIESTERASE IV; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITION; CONDITIONING; CONTROLLED STUDY; DEPRESSION; ENZYME ACTIVITY; ENZYME DEFICIENCY; GENE; NONHUMAN; PDE 4D GENE; PHENOTYPE; PHOSPHODIESTERASE 4D DEFICIENCY; PRIORITY JOURNAL; RAT; REINFORCEMENT; STIMULUS RESPONSE;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CONDITIONING, CLASSICAL; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; DEPRESSION; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; EXTINCTION, PSYCHOLOGICAL; FEAR; MAZE LEARNING; MOTOR ACTIVITY; RATS; STARTLE REACTION;

MUS; RATTUS;

EID: 84863207728     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2012.00796.x     Document Type: Article

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