Silibinin enhances ultraviolet B-induced apoptosis in MCF-7 human breast cancer cells

Journal of Breast Cancer

Volumn 14, Issue 1, 2011, Pages 8-13

  Noh, Eun Mi ^a   Yi, Mi Suk ^a   Youn, Hyun Jo ^a   Lee, Byoung Kil ^a   Lee, Young Rae ^a   Han, Ji Hey ^a   Yu, Hong Nu ^a   Kim, Jong Suk ^a   Jung, Sung Hoo ^a  

^a Chonbuk National University Medical School   (South Korea)

Author keywords

Apoptosis; MCF 7; p53; Silibinin; Ultraviolet B

Indexed keywords

PROTEIN P53; SILIBININ;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN MCF 7; CELL VIABILITY; CONCENTRATION RESPONSE; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN INDUCTION; ULTRAVIOLET B RADIATION;

EID: 79955378381     PISSN: 17386756     EISSN: None     Source Type: Journal    
DOI: 10.4048/jbc.2011.14.1.8     Document Type: Article

References (29)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Tun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009;59:225-249.
2. Lee SO, Jeong YJ, Im HG, Kim CH, Chang YC, Lee IS. Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells. Biochem Biophys Res Commun 2007;354:165-171.
3. Tyagi AK, Agarwal C, Chan DC, Agarwal R. Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB 468 cells. Oncol Rep 2004;11:493-499.
4. Li L, Gao Y, Zhang L, Zeng J, He D, Sun Y. Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma. Cancer Lett 2008;272:61-69.
5. Kaur M, Agarwal R. Silymarin and epithelial cancer chemoprevention: how close we are to bedside? Toxicol Appl Pharmacol 2007;224:350-359.
6. Singh R P, Agarwal R. Prostate cancer chemoprevention by silibinin: bench to bedside. Mol Carcinog 2006;45:436-442.
7. Wellington K, Jarvis B. Silymarin: a review of its clinical properties in the management of hepatic disorders. BioDrugs 2001;15:465-489.
8. Singh RP, Dhanalakshmi S, Tyagi AK, Chan DC, Agarwal C, Agarwal R. Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels. Cancer Res 2002;62:3063-3069.
9. Katiyar SK, Korman NJ, Mukhtar H, Agarwal R. Protective effects of si-lymarin against photocarcinogenesis in a mouse skin model. J Natl Cancer Inst 1997;89:556-566.
10. Kohno H, Tanaka T, Kawabata K, Hirose Y, Sugie S, Tsuda H, et al. Silymarin, a naturally occurring polyphenolic antioxidant favonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats. Int J Cancer 2002;101:461-468.
11. Flaig T, Agarwal R, Su L, Harrison GS, Gustafson DL, Glode LM. A phase I study of silibinin in hormone refractory prostate cancer. 2005 ASCO Annual Meeting. 2005;23. Abstract #4698.
12. Kim S, Choi JH, Lim HI, Lee SK, Kim W W, Kim JS, et al. Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells. Phytomedicine 2009;16:573-580.
13. Yarosh DB, Boumakis S, Brown AB, Canning MT, Galvin JW, Both DM, et al. Measurement of UVB-induced DNA damage and its consequences in models of immunosuppression. Methods 2002;28:55-62.
14. Kulms D, Schwarz T. Molecular mechanisms of UV-induced apoptosis. Photodermatol Photoimmunol Photomed 2000;16:195-201.
15. John EM, Schwartz GG, Dreon DM, Koo J. Vitamin D and breast cancer risk: the NHANES I Epidemiologic follow-up study, 1971-1975 to 1992. National Health and Nutrition Examination Survey. Cancer Epidemiol Biomarkers Prev 1999;8:399-406.
16. Ferguson HA, Marietta PM, Van Den Berg CL. UV-induced apoptosis is mediated independent of caspase-9 in MCF-7 cells: a model for cyto-chrome c resistance. J Biol Chem 2003;278:45793-45800.
17. Dhanalakshmi S, Mallikarjuna GU, Singh R P, Agarwal R. Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes. Carcinogenesis 2004;25:99-106.
18. Vogel G, Trost W, Braatz R, Odenthal K P, Brüsewitz G, Antweiler H, et al. Pharmacodynamics, site and mechanism of action of silymarin, the antihepatoxic principle from Silybum mar. (L) Gaertn. 1. Acute toxicology or tolerance, general and specific (liver-) pharmacology. Arzneimit-telforschung 1975;25:82-89.
19. Mereish KA, Bunner DL, Ragland DR, Creasia DA. Protection against microcystin-LR-induced hepatotoxicity by Silymarin: biochemistry, histopathology, and lethality. Pharm Res 1991;8:273-277.
20. Katiyar SK, Roy AM, Baliga MS. Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation. Mol Cancer Ter 2005;4:207-216.
21. Bhatia N, Zhao J, Wolf DM, Agarwal R. Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin. Cancer Lett 1999;147:77-84.
22. Ellis RE, Yuan JY, Horvitz HR. Mechanisms and functions of cell death. Annu Rev Cell Biol 1991;7:663-698.
23. Raf MC, Barres BA, Burne JF, Coles HS, Ishizaki Y, Jacobson MD. Programmed cell death and the control of cell survival: lessons from the nervous system. Science 1993;262:695-700.
24. Lowe S W, Lin AW. Apoptosis in cancer. Carcinogenesis 2000;21:485-495.
25. Finlay CA, Hinds P W, Levine AJ. The p53 proto-oncogene can act as a suppressor of transformation. Cell 1989;57:1083-1093.
26. Dhanalakshmi S, Agarwal C, Singh R P, Agarwal R. Silibinin up-regu-lates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells. J Biol Chem 2005;280: 20375-20383.
27. Gu M, Dhanalakshmi S, Mohan S, Singh R P, Agarwal R. Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin. Carcinogen-esis 2005;26:1404-1413.
28. Tonks NK, Myers M P. Structural assets of a tumor suppressor. Science 1999;286:2096-2097.
29. Mohan S, Dhanalakshmi S, Mallikarjuna GU, Singh R P, Agarwal R. Silibinin modulates UVB-induced apoptosis via mitochondrial proteins, caspases activation, and mitogen-activated protein kinase signaling in human epidermoid carcinoma A431 cells. Biochem Biophys Res Commun 2004;320:183-189.