Vitamin C inhibits p53-induced replicative senescence through suppression of ROS production and p38 MAPK activity

International Journal of Molecular Medicine

Volumn 22, Issue 5, 2008, Pages 651-655

  Kim, Jee Eun ^a   Jin, Dong Hoon ^a   Lee, Soon Duck ^b   Hong, Seung Woo ^a   Shin, Jae Sik ^a   Lee, Seung Koo ^a   Jung, Da Jung ^a   Kang, Jae Seung ^a   Lee, Wang Jae ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Sookmyung Women's University   (South Korea)

Author keywords

p38 mitogen activated protein kinase; p53; Reactive oxygen species; Vitamin C

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ASCORBIC ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; ANTIOXIDANT; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; PROTEIN P53; PYRIDINE DERIVATIVE; TP53 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PRIORITY JOURNAL; SENESCENCE; CELL AGING; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; TUMOR CELL LINE;

ANTIOXIDANTS; ASCORBIC ACID; CELL AGING; CELL LINE, TUMOR; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 59149093827     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000068     Document Type: Article

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