Retinoid-regulated FGF8f secretion by osteoblasts bypasses retinoid stimuli to mediate granulocytic differentiation of myeloid leukemia cells

Molecular Cancer Therapeutics

Volumn 11, Issue 2, 2012, Pages 267-276

  Chaudhry, Parvesh ^a   Yang, Xiaochun ^a   Wagner, Michael ^c   Jong, Ambrose ^a,b   Wu, Lingtao ^a,b  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE ACTIVATING KINASE; FIBROBLAST GROWTH FACTOR 8; MITOGEN ACTIVATED PROTEIN KINASE; RECOMBINANT FIBROBLAST GROWTH FACTOR; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; SERINE;

ARTICLE; AUTOCRINE EFFECT; CD34 SELECTION; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME PHOSPHORYLATION; GRANULOCYTE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL; MOUSE; MUTANT; MYELOBLAST; MYELOID LEUKEMIA; NONHUMAN; OSTEOBLAST; OSTEOSARCOMA CELL; PARACRINE SIGNALING; PRIORITY JOURNAL; STEM CELL NICHE;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYCLIN-DEPENDENT KINASES; FIBROBLAST GROWTH FACTOR 8; GRANULOCYTES; HEMATOPOIETIC STEM CELLS; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID; MICE; MICE, INBRED NOD; MICE, NUDE; MICE, SCID; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; OSTEOBLASTS; PHOSPHORYLATION; PROTEIN ISOFORMS; RECEPTORS, RETINOIC ACID; RETINOIDS; STEM CELL NICHE;

EID: 84863138104     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-11-0584     Document Type: Article

References (50)

1. Evans T. Regulation of hematopoiesis by retinoid signaling. Exp Hematol 2005;33:1055-61. (Pubitemid 41225428)
2. Fenaux P, Chomienne C, Degos L. Acute promyelocytic leukemia: biology and treatment. Semin Oncol 1997;24:92-102. (Pubitemid 27104907)
3. Melnick A, Licht JD. Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 1999;93:3167-215. (Pubitemid 29220886)
4. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J 1996;10:940-54. (Pubitemid 26285969)
5. Rochette-Egly C, Plassat JL, Taneja R, Chambon P. The AF-1 and AF-2 activating domains of retinoic acid receptor-alpha (RARalpha) and their phosphorylation are differentially involved in parietal endodermal differentiation of F9 cells and retinoid-induced expression of target genes. Mol Endocrinol 2000;14:1398-410.
6. Wang A, Alimova IN, Luo P, Jong A, Triche TJ, Wu L. Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation. FASEB J 2010;24:833-43.
7. Soprano DR, Qin P, Soprano KJ. Retinoic acid receptors and cancers. Annu Rev Nutr 2004;24:201-21. (Pubitemid 38938791)
8. Losel RM, Falkenstein E, Feuring M, Schultz A, Tillmann HC, Rossol-Haseroth K, et al. Nongenomic steroid action: controversies, questions, and answers. Physiol Rev 2003;83:965-1016. (Pubitemid 36828929)
9. Liao YP, Ho SY, Liou JC. Non-genomic regulation of transmitter release by retinoic acid at developing motoneurons in Xenopus cell culture. J Cell Sci 2004;15:2917-24.
10. Zanotto-Filho A, Cammarota M, Gelain DP, Oliveira RB, Delgado-Canedo A, Dalmolin RJ, et al. Retinoic acid induces apoptosis by a non-classical mechanism of ERK1/2 activation. Toxicol In Vitro 2008;22:1205-12.
11. Masia S, Alvarez S, de Lera AR, Barettino D. Rapid, nongenomic actions of retinoic acid on phosphatidylinositol-3-kinase signaling pathway mediated by the retinoic acid receptor. Mol Endocrinol 2007;21:2391-402. (Pubitemid 47529353)
12. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003;425:841-6. (Pubitemid 37351468)
13. Li Z, Li L. Understanding hematopoietic stem-cell microenvironments. Trends Biochem Sci 2006;31:589-95. (Pubitemid 44436938)
14. Weaver VM, Gilbert P. Watch thy neighbor: cancer is acommunal affair. J Cell Sci 2004;117:1287-90. (Pubitemid 38559806)
15. Rochette-Egly C, Adam S, Rossignol M, Egly JM, Chambon P. Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7. Cell 1997;90:97-107. (Pubitemid 28009422)
16. Wu L, Yee A, Liu L, Carbonaro-Hall D, Venkatesan N, Tolo VT, et al. Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase. Oncogene 1994;9:2089-96. (Pubitemid 24194179)
17. Fisher RP, Morgan DO. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 1994;78:713-24. (Pubitemid 24268593)
18. Tassan JP, Jaquenoud M, Fry AM, Frutiger S, Hughes GJ, Nigg EA. In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein. EMBO J 1995;14:5608-17.
19. Wu L, Chen P, Shum CH, Chen C, Barsky LW, Weinberg KI, et al. MAT1-modulated CAK activity regulates cell cycle G(1) exit. Mol Cell Biol 2001;21:260-70.
20. Wang J, Barsky LW, Shum CH, Jong A, Weinberg KI, Collins SJ, et al. Retinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of retinoic acid receptor alpha. J Biol Chem 2002;277:43369-76. (Pubitemid 35285725)
21. Wang JG, Barsky LW, Davicioni E, Weinberg KI, Triche TJ, Zhang XK, et al. Retinoic acid induces leukemia cell G1 arrest and transition into differentiation by inhibiting cyclin-dependent kinase-activating kinase binding and phosphorylation of PML/RARalpha. FASEB J 2006;20:2142-4.
22. Luo P, Wang A, Payne KJ, Peng H, Wang JG, Parrish YK, et al. Intrinsic retinoic acid receptor alpha-cyclin-dependent kinase-activating kinase signaling involves coordination of the restricted proliferation and granulocytic differentiation of human hematopoietic stem cells. Stem Cells 2007;25:2628-37. (Pubitemid 47582756)
23. Luo P, Yang X, Ying M, Chaudhry P, Wang A, Shimada H, et al. Retinoid-suppressed phosphorylation of RARalpha mediates the differentiation pathway of osteosarcoma cells. Oncogene 2010;29:2772-83.
24. Mayack SR, Wagers AJ. Osteolineage niche cells initiate hematopoietic stem cell mobilization. Blood 2008;112:519-31.
25. Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, et al. Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood 2007;109:3706-12. (Pubitemid 46641719)
26. Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, et al. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature 2006;441:518-22. (Pubitemid 44050154)
27. Orimo H, Shimada T. Regulation of the human tissue-nonspecific alkaline phosphatase gene expression by all-trans-retinoic acid in SaOS-2 osteosarcoma cell line. Bone 2005;36:866-76. (Pubitemid 40616021)
28. Kenny PA, Bissell MJ. Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer 2003;107:688-95. (Pubitemid 37339720)
29. Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003;425:836-41. (Pubitemid 37351467)
30. Zhang W, Deng ZL, Chen L, Zuo GW, Luo Q, Shi Q, et al. Retinoic acids potentiate BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. PLoS One 2010;5:e11917.
31. Wu L, Chen P, Hwang JJ, Barsky LW, Weinberg KI, Jong A, et al. RNA antisense abrogation of MAT1 induces G1 phase arrest and triggers apoptosis in aortic smooth muscle cells. J Biol Chem 1999;274:5564-72. (Pubitemid 29109206)
32. Wagner MA. Use of reporter cells to study endogenous retinoid sources in embryonic tissues. Methods Enzymol 1997;282:98-107. (Pubitemid 27412767)
33. Gnanapragasam VJ, Robson CN, Neal DE, Leung HY. Regulation of FGF8 expression by the androgen receptor in human prostate cancer. Oncogene 2002;21:5069-80.
34. Taichman RS, Emerson SG. Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor. J Exp Med 1994;179:1677-82. (Pubitemid 24129586)
35. Gemel J, Gorry M, Ehrlich GD, MacArthur CA. Structure and sequence of human FGF8. Genomics 1996;35:253-7. (Pubitemid 26236178)
36. Collins SJ, Robertson KA, Mueller L. Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha). Mol Cell Biol 1990;10:2154-63.
37. Robertson KA, Emami B, Collins SJ. Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activity. Blood 1992;80:1885-9.
38. Xiao M, Dooley DC. Cellular and molecular aspects of human CD34+ CD38- precursors: analysis of a primitive hematopoietic population. Leuk Lymphoma 2000;38:489-97. (Pubitemid 30614533)
39. Hoang T. The origin of hematopoietic cell type diversity. Oncogene 2004;23:7188-98. (Pubitemid 39382153)
40. Collins SJ. The role of retinoids and retinoic acid receptors in normal hematopoiesis. Leukemia 2002;16:1896-905. (Pubitemid 35203432)
41. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-11. (Pubitemid 33041634)
42. Jackson RA, Nurcombe V, Cool SM. Coordinated fibroblast growth factor and heparan sulfate regulation of osteogenesis. Gene 2006;379:79-91. (Pubitemid 44262446)
43. Brondani V, Klimkait T, Egly JM, Hamy F. Promoter of FGF8 reveals a unique regulation by unliganded RARalpha. J Mol Biol 2002;319:715-28. (Pubitemid 34729445)
44. Allouche M. Basic fibroblast growth factor and hematopoiesis. Leukemia 1995;9:937-42.
45. Bikfalvi A, Han ZC. Angiogenic factors are hematopoietic growth factors and vice versa. Leukemia 1994;8:523-9. (Pubitemid 24096713)
46. Stavridis MP, Collins BJ, Storey KG. Retinoic acid orchestrates fibroblast growth factor signaling to drive embryonic stem cell differentiation. Development 2010;137:881-90.
47. Wang J, Yen A. A MAPK-positive feedback mechanism for BLR1 signaling propels retinoic acid-triggered differentiation and cell cycle arrest. J Biol Chem 2008;283:4375-86.
48. Glasow A, Prodromou N, Xu K, von Lindern M, Zelent A. Retinoids and myelomonocytic growth factors cooperatively activate RARA and induce human myeloid leukemia cell differentiation via MAP kinase pathways. Blood 2005;105:341-9. (Pubitemid 40053102)
49. Katoh M. Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades. Cancer Biol Ther 2006;5:1059-64. (Pubitemid 44772212)
50. Scholl S, Bondeva T, Liu Y, Clement JH, Hoffken K, Wetzker R. Additive effects of PI3-kinase and MAPK activities on NB4 cell granulocyte differentiation: potential role of phosphatidylinositol 3-kinase gamma. J Cancer Res Clin Oncol 2008;134:861-72.