Retinoid-suppressed phosphorylation of RARα mediates the differentiation pathway of osteosarcoma cells

Oncogene

Volumn 29, Issue 19, 2010, Pages 2772-2783

  Luo, P ^a   Yang, X ^a   Ying, M ^a   Chaudhry, P ^a   Wang, A ^a   Shimada, H ^a,b   May, W A ^a,b   Adams, G B ^b   Mock, D ^a   Triche, T J ^a,b   He, Q ^c   Wu, L ^a,b  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Cell cycle G1 exit; Decreased CAK phosphorylation of RAR ; RA response pathways; RARAR FGF8f signaling; Transcriptional expression of RA target genes

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CYCLIN DEPENDENT KINASE 7; FIBROBLAST GROWTH FACTOR 8; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN FIBROBLAST GROWTH FACTOR 8F; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSTEOSARCOMA; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASES; FIBROBLAST GROWTH FACTOR 8; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, INBRED BALB C; MUTATION; OSTEOBLASTS; OSTEOSARCOMA; PHOSPHORYLATION; RECEPTORS, RETINOIC ACID; SIGNAL TRANSDUCTION; TRETINOIN;

MUS MUSCULUS;

EID: 77952423434     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.50     Document Type: Article

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