Toward eradicating HIV reservoirs in the brain: Inhibiting P-glycoprotein at the blood-brain barrier with prodrug abacavir dimers

Journal of the American Chemical Society

Volumn 134, Issue 6, 2012, Pages 2976-2980

  Namanja, Hilda A ^a   Emmert, Dana ^a   Davis, David A ^b   Campos, Christopher ^c   Miller, David S ^c   Hrycyna, Christine A ^a   Chmielewski, Jean ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; ANTI-HIV ACTIVITY; ANTIVIRAL AGENTS; BLOOD-BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELLS; CAPILLARY MODEL; CHEMICAL STRATEGY; P-GLYCOPROTEIN; PLATFORM TECHNOLOGY; PRODRUGS; REDUCING ENVIRONMENT;

BLOOD; CELL CULTURE; GLYCOPROTEINS;

DIMERS;

ABACAVIR; ANTIVIRUS AGENT; DIMER; GLYCOPROTEIN P; PRODRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN CAPILLARY; CARBON NUCLEAR MAGNETIC RESONANCE; CELL DEATH; DIMERIZATION; DRUG PENETRATION; DRUG STRUCTURE; ENDOTHELIUM CELL; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; T LYMPHOCYTE;

ADENOSINE TRIPHOSPHATE; ANTI-HIV AGENTS; BLOOD-BRAIN BARRIER; BRAIN; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; DIDEOXYNUCLEOSIDES; DIMERIZATION; HIV INFECTIONS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; P-GLYCOPROTEIN; PRODRUGS;

EID: 84863116499     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja206867t     Document Type: Article

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