Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis

Bone

Volumn 50, Issue 1, 2012, Pages 409-419

  Wang, Yuying ^a   Liu, Wenguang ^a,b   Masuyama, Ritsuko ^a   Fukuyama, Ryo ^c   Ito, Masako ^a   Zhang, Quan ^a,f   Komori, Hisato ^a   Murakami, Tomohiko ^d   Moriishi, Takeshi ^a   Miyazaki, Toshihiro ^a   Kitazawa, Riko ^e   Yoshida, Carolina A ^a   Kawai, Yosuke ^a   Izumi, Shinichi ^a   Komori, Toshihisa ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b NORTHEAST NORMAL UNIVERSITY   (China)

^c HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

^d UNIVERSITY OF MIYAZAKI   (Japan)

^e KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f WUHAN UNIVERSITY   (China)

Author keywords

Disuse osteoporosis; Osteoclast; Pdk4; Rankl; Unloading

Indexed keywords

COLONY STIMULATING FACTOR 1; OSTEOCLAST DIFFERENTIATION FACTOR; PYRUVATE DEHYDROGENASE KINASE 4;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BED REST; BONE MASS; CONTROLLED STUDY; FEMUR; IMMOBILIZATION; MACROPHAGE; MALE; MECHANOTRANSDUCTION; MOLECULAR MECHANICS; MONOCYTE; MOUSE; NONHUMAN; OSTEOCLASTOGENESIS; OSTEOCYTE; OSTEOLYSIS; PROTEIN EXPRESSION; TIBIA; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; BONE RESORPTION; CELL DIFFERENTIATION; GENE EXPRESSION; HINDLIMB SUSPENSION; HUMANS; MACROPHAGES; MALE; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROARRAY ANALYSIS; OSTEOBLASTS; OSTEOCLASTS; OSTEOPOROSIS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RANK LIGAND;

EID: 84455191881     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2011.07.012     Document Type: Article

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