The consumption of a Jerte Valley cherry product in humans enhances mood, and increases 5-hydroxyindoleacetic acid but reduces cortisol levels in urine

Experimental Gerontology

Volumn 47, Issue 8, 2012, Pages 573-580

  Garrido, María ^a   Espino, Javier ^a   González Gómez, David ^b   Lozano, Mercedes ^b   Barriga, Carmen ^a   Paredes, Sergio D ^c   Rodríguez, Ana B ^a  

^a UNIVERSITY OF EXTREMADURA   (Spain)

^b Technological Institute of Food and Agriculture of Extremadura INTAEX   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Cortisol; Jerte valley cherry; Melatonin; Mood; Serotonin; Tryptophan

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; HYDROCORTISONE;

ADULT; AGE DISTRIBUTION; AGED; AGING; ANXIETY; ARTICLE; CHERRY; COGNITION; FAMILY RELATION; FEMALE; FITNESS; FOOD INTAKE; HUMAN; HUMAN EXPERIMENT; JERTE VALLEY CHERRY PRODUCT; MALE; MOOD; NORMAL HUMAN; PRIORITY JOURNAL; SPAIN; URINE LEVEL;

ADULT; AFFECT; AGED; AGED, 80 AND OVER; AGING; ANXIETY; BEVERAGES; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYDROCORTISONE; HYDROXYINDOLEACETIC ACID; INTERPERSONAL RELATIONS; MALE; MIDDLE AGED; PRUNUS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOMETRICS; YOUNG ADULT;

EID: 84863101654     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2012.05.003     Document Type: Article

References (54)

1. Aguilera G. HPA axis responsiveness to stress: implications for healthy aging. Exp. Gerontol. 2011, 46:90-95.
2. Alonso J., Angermeyer M.C., Bernert S., Bruffaerts R., Brugha T.S., Bryson H., Girolamo G., Graaf R., Demyttenaere K., Gasquet I. Prevalence of mental disorders in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr. Scand. 2004, 109:21-27.
3. Baeken C., Leyman L., De Raedt R., Vanderhasselt M.A., D'Haenen H. Left and right high frequency repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex does not affect mood in female volunteers. Clin. Neurophysiol. 2008, 119:568-575.
4. Blando F., Gerardi C., Nicoletti I. Sour cherry (Prunus cerasus L.) anthocyanins as ingredients for functional foods. J. Biomed. Biotechnol. 2004, 2004:253-258.
5. Ciarleglio C.M., Resuehr H.E., McMahon D.G. Interactions of the serotonin and circadian systems: nature and nurture in rhythms and blues. Neuroscience 2011, 197:8-16.
6. Connolly D.A., McHugh M.P., Padilla-Zakour O.I., Carlson L., Sayers S.P. Efficacy of a tart cherry juice blend in preventing the symptoms of muscle damage. Br. J. Sports Med. 2006, 40:679-683.
7. Cubero J., Toribio F., Garrido M., Hernández M., Maynar J., Barriga C., Rodríguez A. Assays of the amino acid tryptophan in cherries by HPLC-fluorescence. Food Anal. Methods 2010, 3:36-39.
8. Diego M.A., Field T., Hernandez-Reif M., Cullen C., Schanberg S., Kuhn C. Prepartum, postpartum, and chronic depression effects on newborns. Psychiatry 2004, 67:63-80.
9. Duncan M.J., Hensler J.G. Aging alters in a region-specific manner serotonin transporter sites and 5-HT(1A) receptor-G protein interactions in hamster brain. Neuropharmacology 2002, 43:36-44.
10. Duncan M.J., Crafton C.J., Wheeler D.L. Aging regulates 5-HT(1B) receptors and serotonin reuptake sites in the SCN. Brain Res. 2000, 856:213-219.
11. Duval F., Mokrani M.C., Correa H., Bailey P., Valdebenito M., Monreal J., Crocq M.A., Macher J.P. Lack of effect of HPA axis hyperactivity on hormonal responses to d-fenfluramine in major depressed patients: implications for pathogenesis of suicidal behaviour. Psychoneuroendocrinology 2001, 26:521-537.
12. Ferrari E., Magri F. Role of neuroendocrine pathways in cognitive decline during aging. Ageing Res. Rev. 2008, 7:225-233.
13. Fietta P., Fietta P., Delsante G. Central nervous system effects of natural and synthetic glucocorticoids. Psychiatry Clin. Neurosci. 2009, 63:613-622.
14. Firk C., Markus C.R. Mood and cortisol responses following tryptophan-rich hydrolyzed protein and acute stress in healthy subjects with high and low cognitive reactivity to depression. Clin. Nutr. 2009, 28:266-271.
15. Garrido M., Espino J., González-Gómez D., Lozano M., Cubero J., Toribio-Delgado A.F., Maynar-Mariño J.I., Terrón M.P., Muñoz J.L., Pariente J.A., Barriga C., Paredes S.D., Rodriguez A.B. A nutraceutical product based on Jerte Valley cherries improves sleep and augments the antioxidant status in humans. e-SPEN 2009, 4:e321-e323.
16. Garrido M., Paredes S.D., Cubero J., Lozano M., Toribio-Delgado A.F., Munoz J.L., Reiter R.J., Barriga C., Rodriguez A.B. Jerte Valley cherry-enriched diets improve nocturnal rest and increase 6-sulfatoxymelatonin and total antioxidant capacity in the urine of middle-aged and elderly humans. J. Gerontol. A Biol. Sci. Med. Sci. 2010, 65:909-914.
17. González-Gomez D., Lozano M., Fernández-León M.F., Ayuso M.C., Bernalte M.J., Rodríguez A.B. Detection and quantification of melatonin and serotonin in eight sweet cherry cultivars (Prunus avium L.). Eur. Food Res. Technol. 2009, 229:223-229.
18. González-Gómez D., Lozano M., Fernández-León M.F., Bernalte M.J., Ayuso M.C., Rodríguez A.B. Sweet cherry phytochemicals: identification and characterization by HPLC-DAD/ESI-MS in six sweet-cherry cultivars grown in Valle del Jerte (Spain). J. Food Compos. Anal. 2010, 23:533-539.
19. Heber D. Vegetables, fruits and phytoestrogens in the prevention of diseases. J. Postgrad. Med. 2004, 50:145-149.
20. Het S., Wolf O.T. Mood changes in response to psychosocial stress in healthy young women: effects of pretreatment with cortisol. Behav. Neurosci. 2007, 121:11-20.
21. Kindler C.H., Harms C., Amsler F., Ihde-Scholl T., Scheidegger D. The visual analog scale allows effective measurement of preoperative anxiety and detection of patients' anesthetic concerns. Anesth. Analg. 2000, 90:706-712.
22. Klok M.D., Alt S.R., Irurzun Lafitte A.J., Turner J.D., Lakke E.A., Huitinga I., Muller C.P., Zitman F.G., Ronald de Kloet E., Derijk R.H. Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorder. J. Psychiatr. Res. 2011, 45:871-878.
23. Kudielka B.M., Kirschbaum C. Sex differences in HPA axis responses to stress: a review. Biol. Psychol. 2005, 69:113-132.
24. Kuehl K.S., Perrier E.T., Elliot D.L., Chesnutt J.C. Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial. J. Int. Soc. Sports Nutr. 2010, 7:7-17.
25. Lepage O., Tottmar O., Winberg S. Elevated dietary intake of l-tryptophan counteracts the stress-induced elevation of plasma cortisol in rainbow trout (Oncorhynchus mykiss). J. Exp. Biol. 2002, 205:3679-3687.
26. Levine A., Zagoory-Sharon O., Feldman R., Lewis J.G., Weller A. Measuring cortisol in human psychobiological studies. Physiol. Behav. 2007, 90:43-53.
27. Lin C.L., Wu T.J., Machacek D.A., Jiang N.S., Kao P.C. Urinary free cortisol and cortisone determined by high performance liquid chromatography in the diagnosis of Cushing's syndrome. J. Clin. Endocrinol. Metab. 1997, 82:151-155.
28. Maes M., Lin A., Bonaccorso S., van Hunsel F., Van Gastel A., Delmeire L., Biondi M., Bosmans E., Kenis G., Scharpe S. Increased 24-hour urinary cortisol excretion in patients with post-traumatic stress disorder and patients with major depression, but not in patients with fibromyalgia. Acta Psychiatr. Scand. 1998, 98:328-335.
29. Markus C.R., Olivier B., Panhuysen G.E., Van Der Gugten J., Alles M.S., Tuiten A., Westenberg H.G., Fekkes D., Koppeschaar H.F., de Haan E.E. The bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress. Am. J. Clin. Nutr. 2000, 71:1536-1544.
30. Mateos S.S., Sanchez C.L., Paredes S.D., Barriga C., Rodriguez A.B. Circadian levels of serotonin in plasma and brain after oral administration of tryptophan in rats. Basic Clin. Pharmacol. Toxicol. 2009, 104:52-59.
31. Mayorga M., Iborra A., Estany S., Martinez P. Protective effect of vitamin E in an animal model of LPS-induced inflammation. Am. J. Reprod. Immunol. 2004, 52:356-361.
32. McCormack H.M., Horne D.J., Sheather S. Clinical applications of visual analogue scales: a critical review. Psychol. Med. 1988, 18:1007-1019.
33. McCune L.M., Kubota C., Stendell-Hollis N.R., Thomson C.A. Cherries and health: a review. Crit. Rev. Food Sci. Nutr. 2011, 51:1-12.
34. Mello A.F., Mello M.F., Carpenter L.L., Price L.H. Update on stress and depression: the role of the hypothalamic-pituitary-adrenal (HPA) axis. Rev. Bras. Psiquiatr. 2003, 25:231-238.
35. Mosimann U.P., Rihs T.A., Engeler J., Fisch H., Schlaepfer T.E. Mood effects of repetitive transcranial magnetic stimulation of left prefrontal cortex in healthy volunteers. Psychiatry Res. 2000, 94:251-256.
36. Murphy D.L., Fox M.A., Timpano K.R., Moya P.R., Ren-Patterson R., Andrews A.M., Holmes A., Lesch K.P., Wendland J.R. How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology 2008, 55:932-960.
37. Pardridge W.M. Blood-brain barrier carrier-mediated transport and brain metabolism of amino acids. Neurochem. Res. 1998, 23:635-644.
38. Paredes S.D., Marchena A.M., Bejarano I., Espino J., Barriga C., Rial R.V., Reiter R.J., Rodriguez A.B. Melatonin and tryptophan affect the activity-rest rhythm, core and peripheral temperatures, and interleukin levels in the ringdove: changes with age. J. Gerontol. A Biol. Sci. Med. Sci. 2009, 64:340-350.
39. Pariante C.M., Lightman S.L. The HPA axis in major depression: classical theories and new developments. Trends Neurosci. 2008, 31:464-468.
40. Pitts A.F., Samuelson S.D., Meller W.H., Bissette G., Nemeroff C.B., Kathol R.G. Cerebrospinal fluid corticotropin-releasing hormone, vasopressin, and oxytocin concentrations in treated patients with major depression and controls. Biol. Psychiatry 1995, 38:330-335.
41. Porter R.J., Gallagher P., Watson S., Young A.H. Corticosteroid-serotonin interactions in depression: a review of the human evidence. Psychopharmacology (Berl) 2004, 173:1-17.
42. Rajewska J., Rybakowski J.K. Depression in premenopausal women: gonadal hormones and serotonergic system assessed by d-fenfluramine challenge test. Prog. Neuropsychopharmacol. Biol. Psychiatry 2003, 27:705-709.
43. Rios E.R., Venancio E.T., Rocha N.F., Woods D.J., Vasconcelos S., Macedo D., Sousa F.C., Fonteles M.M. Melatonin: pharmacological aspects and clinical trends. Int. J. Neurosci. 2010, 120:583-590.
44. Schaller G., Lenz B., Friedrich K., Dygon D., Richter-Schmidinger T., Jacobi A., Mueller S.E., Maihofner C., Sperling W., Kornhuber J. Repetitive transcranial magnetic stimulation influences mood in healthy male volunteers. J. Psychiatr. Res. 2011, 45:1178-1183.
45. Scholey A., Haskell C., Robertson B., Kennedy D., Milne A., Wetherell M. Chewing gum alleviates negative mood and reduces cortisol during acute laboratory psychological stress. Physiol. Behav. 2009, 97:304-312.
46. Sibille E., Su J., Leman S., Le Guisquet A.M., Ibarguen-Vargas Y., Joeyen-Waldorf J., Glorioso C., Tseng G.C., Pezzone M., Hen R., Belzung C. Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity. Mol. Psychiatry 2007, 12:1042-1056.
47. Silber B.Y., Schmitt J.A. Effects of tryptophan loading on human cognition, mood, and sleep. Neurosci. Biobehav. Rev. 2010, 34:387-407.
48. Slotkin T.A., Cousins M.M., Tate C.A., Seidler F.J. Serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats. Neuropsychopharmacology 2005, 30:52-57.
49. Tafet G.E., Toister-Achituv M., Shinitzky M. Enhancement of serotonin uptake by cortisol: a possible link between stress and depression. Cogn. Affect. Behav. Neurosci. 2001, 1:96-104.
50. Tizabi Y., Aguilera G., Gilad G.M. Age-related reduction in pituitary corticotropin-releasing hormone receptors in two rat strains. Neurobiol. Aging 1992, 13:227-230.
51. Toker L., Amar S., Bersudsky Y., Benjamin J., Klein E. The biology of tryptophan depletion and mood disorders. Isr. J. Psychiatry Relat. Sci. 2010, 47:46-55.
52. Traustadottir T., Davies S.S., Stock A.A., Su Y., Heward C.B., Roberts L.J., Harman S.M. Tart cherry juice decreases oxidative stress in healthy older men and women. J. Nutr. 2009, 139:1896-1900.
53. Vreeburg S.A., Hoogendijk W.J., van Pelt J., Derijk R.H., Verhagen J.C., van Dyck R., Smit J.H., Zitman F.G., Penninx B.W. Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study. Arch. Gen. Psychiatry 2009, 66:617-626.
54. Young S., Leyton M., Benkelfat C. PET studies of serotonin synthesis in the human brain. Tryptophan, Serotonin, and Melatonin: Basic Aspects and Applications 1999, 11. Kluwer Academic Publishers, New York. G. Huether, W. Kochen, T.J. Simat, H. Steinhart (Eds.).