Aging alters in a region-specific manner serotonin transporter sites and 5-HT1A receptor-G protein interactions in hamster brain

Neuropharmacology

Volumn 43, Issue 1, 2002, Pages 36-44

  Duncan, Marilyn J ^a   Hensler, Julie G ^b  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

35S GTP S binding; 3H MPPF binding; 3H paroxetine binding; Autoradiography; CA1; Dentate gyrus; Dorsal raphe nucleus; Hippocampus; Median raphe nucleus

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 (2' METHOXY)PHENYL 1 [2' (N 2'' PYRIDINYL) 4 FLUOROBENZAMIDO]ETHYLPIPERAZINE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); PAROXETINE; RADIOLIGAND; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN TRANSPORTER; SULFUR 35; TRITIUM; UNCLASSIFIED DRUG;

AGE; AGING; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING SITE; BRAIN; CONTROLLED STUDY; DENTATE GYRUS; DORSAL RAPHE NUCLEUS; HAMSTER; HIPPOCAMPUS; MALE; MEDIAN RAPHE NUCLEUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAPHE NUCLEUS; RECEPTOR DENSITY; TISSUE SPECIFICITY;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; AGING; ANIMALS; AUTORADIOGRAPHY; BINDING, COMPETITIVE; BRAIN; CARRIER PROTEINS; CRICETINAE; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HIPPOCAMPUS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MESOCRICETUS; NERVE TISSUE PROTEINS; PAROXETINE; PIPERAZINES; PYRIDINES; RAPHE NUCLEI; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS;

EID: 0036629779     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00072-2     Document Type: Article

References (48)

1. Adell A., Artigas F. Differential effect of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex. Naunyn Schmiedeberg's Archives of Pharmacology. 343:1991;237-244.
2. Barefoot J.C., Helms M.J., Mortensen E.L., Aylund K., Schroll M. A longitudinal study of gender differences in depressive symptoms from age 50 to 80. Psychology and Aging. 16:2001;342-345.
3. Barnes C.A. Normal aging: regionally specific changes in hippocampal synaptic transmission. Trends in Neuroscience. 17:1994;13-18.
4. Blier P., De Montigny C. Current advances and trends in the treatment of depression. Trends in Pharmacological Sciences. 15:1994;220-226.
5. Carli M., Lazarova M., Tatarczynska E., Samanin R. Stimulation of 5-HT1A receptors in the dorsal hippocampus impairs acquisition and performance of a spatial task in a water maze. Brain Research. 595:1992;50-56.
6. 1A receptors in the hippocampus. Behavioural Brain Research. 67:1995;67-74.
7. Carskadon M.A., Brown E.D., Dement W.C. Sleep fragmentation in the elderly: relationship to daytime sleep tendency. Neurobiology of Aging. 3:1982;321-327.
8. Copinschi G., Van Cauter E. Pituitary hormone secretion in aging: roles of circadian rhythmicity and sleep. Acta Endocrinology (Copenhagen). 131:1994;441-442.
9. Czeisler C.A., Dumont M., Dufy J.F., Steinberg J.D., Richardson G.S., Brown E.N., Sanchez R., Rios C.D., Ronda J.M. Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet. 340:1992;933-936.
10. Dudley T.E., DiNardo L.A., Glass J.D. In vivo assessment of the midbrain raphe nuclear regulation of serotonin release in the hamster suprachiasmatic nucleus. Journal of Neurophysiology. 81:1999;1469-1477.
11. 1B receptors and serotonin reuptake sites in the suprachiasmatic nucleus and other brain regions. Brain Research. 856:2000;213-219.
12. 125I]-iodomelatonin binding sites in Siberian hamsters by endogenous and exogenous melatonin. Brain Research. 631:1993;107-113.
13. 1A receptors in discrete regions of the circadian timing system in hamsters. Brain Research. 829:1999;39-45.
14. Ehlen J.C., Grossman G.H., Glass J.D. In vivo resetting of the hamster circadian clock by 5-HT7 receptors in the suprachiasmatic nucleus. Journal of Neuroscience. 21:2001;5351-5357.
15. 1B receptors in knock-out mice lacking the 5-HT transporter. European Journal of Neuroscience. 12:2000;2299-2310.
16. Fabre V., Boutrel B., Hanoun N., Lanfumey L., Fataccini C.M., Demeneix B., Adrien J., Hamon M., Martres M.P. Homeostatic regulation of serotonergic function by the serotonin transporter as revealed by nonviral gene transfer. Journal of Neuroscience. 20:2000;5065-5075.
17. 3H-serotonin: correlations with serotonergic impulse flow. Journal of Pharmacology and Experimental Therapeutics. 193:1975;785-795.
18. Geary W.A., Toga A.W., Wooten G.F. Quantitative film autoradiography for tritium: methodological considerations. Brain Research. 337:1985;99-108.
19. Geary W.W., Wooten G.F. Quantitative film autoradiography of opiate agonist and antagonist binding in rat brain. Journal of Pharmacology and Experimental Therapeutics. 225:1983;234-240.
20. Glass J.D., DiNardo L.A., Ehlen J.C. Dorsal raphe nuclear stimulation of SCN serotonin release and circadian phase-resetting. Brain Research. 859:2000;224-232.
21. 1A receptor-G protein interactions in brain following chronic antidepressant administration. Neuropsychopharmacology. 26:2002;565-573.
22. 35S]-GTPγS binding as measured by quantitative autoradiography following chronic agonist administration. British Journal of Pharmacology. 132:2001;605-611.
23. Hensler J.G., Kovachich G.B., Frazer A. A quantitative autoradiographic study of serotonin 1A receptor regulation. Effect of 5,7-dihydroxytryptamine and antidepressant treatments. Neuropsychopharmacology. 4:1991;131-144.
24. 3H]imipramine localization and relationship to serotonin transporter. Journal of Pharmacology and Experimental Therapeutics. 252:1990;410-418.
25. Invernizzi R., Belli S., Samamin R. Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex. Brain Research. 584:1992;322-324.
26. Kirkman H., Yau P.K.S. Longevity of male and female, intact and gonadectomized, untreated and hormone-treated, neoplastic and non-neoplastic Syrian hamsters. American Journal of Anatomy. 135:1972;205-220.
27. Kreiss D.S., Lucki I. Effects of acute and repeated administration of antidepresant drugs on extracellular levels of 5-hydroxytryptamine. Journal of Pharmacology Experimental Therapeutics. 274:1995;866-867.
28. 1B receptors and 5-HT transporter in rats treated chronically with fluoxetine. Neuropharmacology. 39:2000;110-122.
29. 1A receptor mRNA expression in the rat dentate gyrus. European Journal of Pharmacology. 266:1994;355-361.
30. 1A receptors in rat forebrain. Neuroendocrinology. 56:1992;881-888.
31. Mintz E.M., Gillespie C.F., Marvel C.L., Huhman K.L., Albers H.E. Serotonergic regulation of circadian rhythms in Syrian hamsters. Neuroscience. 79:1997;563-569.
32. Moffat S.D., Zonderman A.B., Resnick S.M. Age differences in spatial memory in a virtual environment navigation task. Neurobiology of Aging. 22:2001;787-796.
33. Molliver M.E. Serotonergic neuronal systems: what their anatomic organization tells us about function. Journal of Clinical Psychopharmacology. 7:1987;3S-23S.
34. Moore R.Y., Halaris A.E., Jones B.E. Serotonin neurons of the midbrain raphe: ascending projections. Journal of Comparative Neurology. 180:1978;417-438.
35. Morin L.P., Meyer-Bernstein E.L. The ascending serotonergic system in the hamster: comparison with projections of the dorsal and median raphe nuclei. Neuroscience. 91:1999;81-105.
36. Morin L.P., Wood R.I. A Stereotaxic Atlas of the Golden Hamster Brain. 2001;Academic Press, San Diego.
37. 7 receptor regulation in the rat hypothalamus. Neuropsychopharmacology. 21:1999;352-367.
38. 1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging. Journal of Chemical Neuroanatomy. 13:1997;53-61.
39. Penev P.D., Zee P.C., Wallen E.P., Turek F.W. Aging alters the phase-resetting properties of a serotonin agonist on hamster circadian rhythmicity. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 268:1995;R293-R298.
40. Scarbrough K., Losee-Olson S., Wallen E.P., Turek F.W. Aging and photoperiod effects on entrainment and quantitative aspects of locomotor behavior in Syrian hamsters. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 272:1997;R1219-R1225.
41. 1A autoreceptors on serotoninergic neurons in the midbrain raphe nuclei. European Journal of Neuroscience. 2:1990;1144-1154.
42. 1A selective agonists. European Journal of Pharmacology. 128:1986;295-298.
43. 1B agonists. Synapse. 1:1987;3-9.
44. 7 Receptors in Rat Hypothalamus Following Chronic Paroxetine Administration. Society for Neuroscience Abstracts 27, #380.15.
45. Van Reeth O., Zhang Y., Zee P.C., Turek F.W. Aging alters feedback effects of the activity-rest cycle on the circadian clock. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 263:1992;R981-R986.
46. 1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. Journal of Neuroscience. 6:1986;3474-3482.
47. Zee P.C., Rosenberg R.S., Turek F.W. Effects of aging on entrainment and rate of resynchronization of circadian locomotor activity. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 263:1992;R1099-R1103.
48. 1 of the hippocampus. Journal of Neuroscience. 6:1986;2950-2967.