-
1
-
-
34249028688
-
Personalized medicine: Elusive dream or imminent reality?
-
Lesko LJ: Personalized medicine: elusive dream or imminent reality? Clin. Pharmacol. Ther. 81(6), 807-816 (2007).
-
(2007)
Clin. Pharmacol. Ther
, vol.81
, Issue.6
, pp. 807-816
-
-
Lesko, L.J.1
-
2
-
-
33846646004
-
The prospects for 'personalized medicine' in drug development and drug therapy
-
Woodcock J: The prospects for 'personalized medicine' in drug development and drug therapy. Clin. Pharmacol. Ther. 81(2), 164-169 (2007).
-
(2007)
Clin. Pharmacol. Ther
, vol.81
, Issue.2
, pp. 164-169
-
-
Woodcock, J.1
-
3
-
-
67649480496
-
The twin questions of personalized medicine: Who are you and whom do you most resemble?
-
Kohane IS: The twin questions of personalized medicine: who are you and whom do you most resemble? Genome Med. 1(1), 4 (2009).
-
(2009)
Genome Med
, vol.1
, Issue.1
, pp. 4
-
-
Kohane, I.S.1
-
4
-
-
2442728636
-
Construction of biologically functional bacterial plasmids in vitro
-
Cohen SN, Chang AC, Boyer HW et al.: Construction of biologically functional bacterial plasmids in vitro. Proc. Natl Acad. Sci. USA 70(11) (1973).
-
(1973)
Proc. Natl Acad. Sci. USA
, vol.70
, Issue.11
-
-
Cohen, S.N.1
Chang, A.C.2
Boyer, H.W.3
-
6
-
-
0037458916
-
A part of the human genome sequence
-
Venter D: A part of the human genome sequence. Science 299, 1183-1184 (2003).
-
(2003)
Science
, vol.299
, pp. 1183-1184
-
-
Venter, D.1
-
7
-
-
2342562447
-
Timeline: Thomas Willis (1621-1675), the founder of clinical neuroscience
-
Molnár Z: Timeline: Thomas Willis (1621-1675), the founder of clinical neuroscience. Nat. Rev. Neurosci. 5, 329-335 (2004).
-
(2004)
Nat. Rev. Neurosci
, vol.5
, pp. 329-335
-
-
Molnár, Z.1
-
8
-
-
0029622428
-
The pharmacogenetics of codeine hypoalgesia
-
Sindrup SH, Brøsen K: The pharmacogenetics of codeine hypoalgesia. Pharmacogenetics 5(6), 335-346 (1995).
-
(1995)
Pharmacogenetics
, vol.5
, Issue.6
, pp. 335-346
-
-
Sindrup, S.H.1
Brøsen, K.2
-
9
-
-
0025868355
-
Impact of environmental and genetic factors on codeine analgesia
-
Desmeules J, Gascon MP, Dayer P et al.: Impact of environmental and genetic factors on codeine analgesia. Eur. J. Clin. Pharmacol. 41, 23-26 (1991).
-
(1991)
Eur. J. Clin. Pharmacol
, vol.41
, pp. 23-26
-
-
Desmeules, J.1
Gascon, M.P.2
Dayer, P.3
-
10
-
-
11144221180
-
Codeine intoxication associated with ultrarapid CYP2D6 metabolism
-
Gasche Y, Daali Y, Fathi M et al.: Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N. Engl. J. Med. 351(27), 2827-2831 (2004).
-
(2004)
N. Engl. J. Med
, vol.351
, Issue.27
, pp. 2827-2831
-
-
Gasche, Y.1
Daali, Y.2
Fathi, M.3
-
11
-
-
33747134323
-
Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother
-
Koren G, Cairns J, Chitayat D et al.: Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet 368(9536), 704 (2006).
-
(2006)
Lancet
, vol.368
, Issue.9536
, pp. 704
-
-
Koren, G.1
Cairns, J.2
Chitayat, D.3
-
12
-
-
57749180179
-
Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: A case-control study
-
Madadi P, Ross CJ, Hayden MR et al.: Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study. Clin. Pharmacol. Ther. 85(1), 31-35(2009).
-
(2009)
Clin. Pharmacol. Ther
, vol.85
, Issue.1
, pp. 31-35
-
-
Madadi, P.1
Ross, C.J.2
Hayden, M.R.3
-
13
-
-
67649979950
-
Personalized medicine - a paradigm for a sustainable pharmaceutical industry?
-
Chackalamannil S, Desai MC: Personalized medicine - a paradigm for a sustainable pharmaceutical industry? Curr. Opin. Drug Discov. Devel. 12, 443-445 (2009).
-
(2009)
Curr. Opin. Drug Discov. Devel
, vol.12
, pp. 443-445
-
-
Chackalamannil, S.1
Desai, M.C.2
-
14
-
-
2442665410
-
Personalized medicine
-
Thrall JH. Personalized medicine. Radiology 231, 613-616 (2004).
-
(2004)
Radiology
, vol.231
, pp. 613-616
-
-
Thrall, J.H.1
-
15
-
-
0035100888
-
Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework Biomarkers Definitions Working Group
-
Atkinson AJ, Colburn WA, DeGruttola VG et al.: Biomarkers and surrogate endpoints: preferred definitions and conceptual framework Biomarkers Definitions Working Group. Clin. Pharmacol. Ther. 69, 89-95 (2001).
-
(2001)
Clin. Pharmacol. Ther
, vol.69
, pp. 89-95
-
-
Atkinson, A.J.1
Colburn, W.A.2
DeGruttola, V.G.3
-
16
-
-
33646198860
-
Pharmaco-metabonomic phenotyping and personalized drug treatment
-
Describes the potential of metabonomic profiling for understanding response to medications, ■■
-
Clayton TA, Lindon JC, Cloarec O et al.: Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 440(7087), 1073-1077 (2006). ■■ Describes the potential of metabonomic profiling for understanding response to medications.
-
(2006)
Nature
, vol.440
, Issue.7087
, pp. 1073-1077
-
-
Clayton, T.A.1
Lindon, J.C.2
Cloarec, O.3
-
17
-
-
60349116928
-
Translational toxicology and the work of the predictive safety testing consortium
-
Mattes WB, Walker EG: Translational toxicology and the work of the predictive safety testing consortium Clin. Pharmacol. Ther. 85(3), 327-330 (2009).
-
(2009)
Clin. Pharmacol. Ther
, vol.85
, Issue.3
, pp. 327-330
-
-
Mattes, W.B.1
Walker, E.G.2
-
18
-
-
57149114936
-
-
Gieger C, Geistlinger L, Altmaier E et al.: Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet. 4(11), e1000282 (2008).
-
Gieger C, Geistlinger L, Altmaier E et al.: Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet. 4(11), e1000282 (2008).
-
-
-
-
19
-
-
33750475205
-
Metabolomics-based systems biology and personalized medicine: Moving towards n = 1 clinical trials?
-
van der Greef J, Hankemeier T, McBurney RN: Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials? Pharmacogenomics 7(7), 1087-1094 (2006).
-
(2006)
Pharmacogenomics
, vol.7
, Issue.7
, pp. 1087-1094
-
-
van der Greef, J.1
Hankemeier, T.2
McBurney, R.N.3
-
20
-
-
6344231838
-
Pharmacogenetics of irinotecan toxicity
-
Marsh S, McLeod HL. Pharmacogenetics of irinotecan toxicity. Pharmacogenomics 5, 835-843 (2004).
-
(2004)
Pharmacogenomics
, vol.5
, pp. 835-843
-
-
Marsh, S.1
McLeod, H.L.2
-
21
-
-
34548598459
-
UGT1A1*28 genotype and irinotecaninduced neutropenia: Dose matters
-
Hoskins JM, Goldberg RM, Qu P et al.: UGT1A1*28 genotype and irinotecaninduced neutropenia: dose matters. J. Natl Cancer Inst. 99(17), 1290-1295 (2007).
-
(2007)
J. Natl Cancer Inst
, vol.99
, Issue.17
, pp. 1290-1295
-
-
Hoskins, J.M.1
Goldberg, R.M.2
Qu, P.3
-
22
-
-
34347395733
-
A mechanism of action and use in clinical practice trastuzumab
-
Hudis C. A mechanism of action and use in clinical practice trastuzumab. N. Engl. J. Med. 357, 39-51 (2007).
-
(2007)
N. Engl. J. Med
, vol.357
, pp. 39-51
-
-
Hudis, C.1
-
23
-
-
1542647611
-
Targeted therapy for cancer: The HER-2/neu and herceptin story
-
Ross JS, Gray GS: Targeted therapy for cancer: the HER-2/neu and herceptin story. Clin. Leadersh. Manag. Rev. 17(6), 333-340 (2003).
-
(2003)
Clin. Leadersh. Manag. Rev
, vol.17
, Issue.6
, pp. 333-340
-
-
Ross, J.S.1
Gray, G.S.2
-
24
-
-
68049124818
-
-
Jimeno A, Messersmith WA, Hirsch FR et al.: KRAS mutations and susceptibility to cetuximab and panitumumab in colorectal cancer. Cancer J. 15(2), 110-113 (2009).
-
Jimeno A, Messersmith WA, Hirsch FR et al.: KRAS mutations and susceptibility to cetuximab and panitumumab in colorectal cancer. Cancer J. 15(2), 110-113 (2009).
-
-
-
-
25
-
-
64949091729
-
KRAS mutation in metastatic colorectal cancer and its impact on the use of EGFR inhibitors
-
Lenz HJ, Chu E, Grothey A: KRAS mutation in metastatic colorectal cancer and its impact on the use of EGFR inhibitors. Clin. Adv. Hematol. Oncol. 6(12), 1-13 (2008).
-
(2008)
Clin. Adv. Hematol. Oncol
, vol.6
, Issue.12
, pp. 1-13
-
-
Lenz, H.J.1
Chu, E.2
Grothey, A.3
-
26
-
-
74549176572
-
KRAS mutational status as a predictor of epidermal growth factor receptor inhibitor efficacy in colorectal cancer
-
Epub ahead of print
-
Baynes RD, Gansert J: KRAS mutational status as a predictor of epidermal growth factor receptor inhibitor efficacy in colorectal cancer. Am. J. Ther. (2009) (Epub ahead of print).
-
(2009)
Am. J. Ther
-
-
Baynes, R.D.1
Gansert, J.2
-
27
-
-
55549101623
-
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
-
Describes the whole-genome sequencing of a patient's acute myeloid leukemia genome. This represents a major advance in the development of personalized healthcare, ■■
-
Ley TJ, Mardis ER, Ding L et al.: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 456(7218), 66-72 (2008). ■■ Describes the whole-genome sequencing of a patient's acute myeloid leukemia genome. This represents a major advance in the development of personalized healthcare.
-
(2008)
Nature
, vol.456
, Issue.7218
, pp. 66-72
-
-
Ley, T.J.1
Mardis, E.R.2
Ding, L.3
-
28
-
-
0345874500
-
Enfuvirtide (Fuzeon): The first fusion inhibitor
-
Williams IG: Enfuvirtide (Fuzeon): the first fusion inhibitor. Int. J. Clin. Pract. 57(10), 890-897 (2003).
-
(2003)
Int. J. Clin. Pract
, vol.57
, Issue.10
, pp. 890-897
-
-
Williams, I.G.1
-
29
-
-
28544434492
-
CCR5 antagonists: Host-targeted antivirals for the treatment of HIV infection
-
Westby M, van der Ryst E: CCR5 antagonists: host-targeted antivirals for the treatment of HIV infection. Antivir. Chem. Chemother. 16(6), 339-354 (2005).
-
(2005)
Antivir. Chem. Chemother
, vol.16
, Issue.6
, pp. 339-354
-
-
Westby, M.1
van der Ryst, E.2
-
30
-
-
30744447460
-
Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1
-
Fätkenheuer G, Pozniak AL, Johnson MA et al.: Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1. Nat. Med. 11(11), 1170-1172 (2005).
-
(2005)
Nat. Med
, vol.11
, Issue.11
, pp. 1170-1172
-
-
Fätkenheuer, G.1
Pozniak, A.L.2
Johnson, M.A.3
-
31
-
-
62549162552
-
Maraviroc, a CCR5 coreceptor antagonist that blocks entry of human immunodeficiency virus type 1
-
Hunt JS, Romanelli F: Maraviroc, a CCR5 coreceptor antagonist that blocks entry of human immunodeficiency virus type 1. Pharmacotherapy 29(3), 295-304 (2009).
-
(2009)
Pharmacotherapy
, vol.29
, Issue.3
, pp. 295-304
-
-
Hunt, J.S.1
Romanelli, F.2
-
32
-
-
54749100057
-
CCR5 as target for HIV-1 gene therapy
-
Nazari R, Joshi S: CCR5 as target for HIV-1 gene therapy. Curr. Gene Ther. 8(4), 264-272 (2008).
-
(2008)
Curr. Gene Ther
, vol.8
, Issue.4
, pp. 264-272
-
-
Nazari, R.1
Joshi, S.2
-
33
-
-
55049107630
-
HIV coreceptor phenotyping in the clinical setting
-
Low AJ, Swenson LC, Harrigan PR: HIV coreceptor phenotyping in the clinical setting. AIDS Rev. 10(3), 143-151 (2008).
-
(2008)
AIDS Rev
, vol.10
, Issue.3
, pp. 143-151
-
-
Low, A.J.1
Swenson, L.C.2
Harrigan, P.R.3
-
34
-
-
34447322271
-
-
Bruno Dubois, Howard H Feldman, Claudia Jacova et al.: Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 6(8), 734-746 (2007). ■■ This position paper describes a proposal for the incorporation of revised criteria to update the diagnosis of Alzheimer's disease (AD) to include imaging and fluid biomarkers. The adoption of these criteria has the potential to identify patients much earlier in the disease progression.
-
Bruno Dubois, Howard H Feldman, Claudia Jacova et al.: Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 6(8), 734-746 (2007). ■■ This position paper describes a proposal for the incorporation of revised criteria to update the diagnosis of Alzheimer's disease (AD) to include imaging and fluid biomarkers. The adoption of these criteria has the potential to identify patients much earlier in the disease progression.
-
-
-
-
35
-
-
0021271971
-
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
-
McKhann G, Drachman D, Folstein M et al.: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34(7), 939-944 (1984).
-
(1984)
Neurology
, vol.34
, Issue.7
, pp. 939-944
-
-
McKhann, G.1
Drachman, D.2
Folstein, M.3
-
36
-
-
34248579291
-
Imaging b-amyloid burden in aging and dementia
-
Rowe CC, Ng S, Ackermann U et al.: Imaging b-amyloid burden in aging and dementia. Neurology 68(20), 1718-1725 (2007).
-
(2007)
Neurology
, vol.68
, Issue.20
, pp. 1718-1725
-
-
Rowe, C.C.1
Ng, S.2
Ackermann, U.3
-
37
-
-
10744232413
-
-
Klunk WE, Engler H, Nordberg A et al.: Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann. Neurol. 55(3), 306-319 (2004). ■■ First study that described the potential for the amyloid-imaging positron emission tomography tracer, termed Pittsburgh compound-B. This compound has provided valuable information on the progression of AD.
-
Klunk WE, Engler H, Nordberg A et al.: Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann. Neurol. 55(3), 306-319 (2004). ■■ First study that described the potential for the amyloid-imaging positron emission tomography tracer, termed Pittsburgh compound-B. This compound has provided valuable information on the progression of AD.
-
-
-
-
38
-
-
33947223454
-
Cerebrospinal fluid tau/b-amyloid42 ratio as a prediction of cognitive decline in nondemented older adults
-
42 could be used as predictive biomarkers of future dementia in cognitively normal individuals, ■
-
42 could be used as predictive biomarkers of future dementia in cognitively normal individuals.
-
(2007)
Arch. Neurol
, vol.64
, Issue.3
, pp. 343-349
-
-
Fagan, A.M.1
Roe, C.M.2
Xiong, C.3
-
39
-
-
32544435900
-
Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: A follow-up study
-
Together with the Fagan et al. study, this was one of the first to provide longitudinal data on the potential for CSF fluid biomarkers to be useful in predicting the conversion from mild cognitive impairment to AD, ■
-
Hansson O, Zetterberg H, Buchhave P et al.: Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol. 5(3), 228-234 (2006). ■ Together with the Fagan et al. study, this was one of the first to provide longitudinal data on the potential for CSF fluid biomarkers to be useful in predicting the conversion from mild cognitive impairment to AD.
-
(2006)
Lancet Neurol
, vol.5
, Issue.3
, pp. 228-234
-
-
Hansson, O.1
Zetterberg, H.2
Buchhave, P.3
-
40
-
-
33749041047
-
Neurobiology of schizophrenia
-
Ross CA, Margolis RL, Reading SA et al.: Neurobiology of schizophrenia. Neuron 52(1), 139-153 (2006).
-
(2006)
Neuron
, vol.52
, Issue.1
, pp. 139-153
-
-
Ross, C.A.1
Margolis, R.L.2
Reading, S.A.3
-
41
-
-
67651204382
-
CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment
-
Mattsson N, Zetterberg H, Hansson O et al.: CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment JAMA 302(4), 385-393 (2009).
-
(2009)
JAMA
, vol.302
, Issue.4
, pp. 385-393
-
-
Mattsson, N.1
Zetterberg, H.2
Hansson, O.3
-
42
-
-
67651204380
-
Use of Alzheimer disease biomarkers: Potentially yes for clinical trials but not yet for clinical practice
-
Petersen RC, Trojanowski JQ: Use of Alzheimer disease biomarkers: potentially yes for clinical trials but not yet for clinical practice. JAMA 302(4), 436-437 (2009).
-
(2009)
JAMA
, vol.302
, Issue.4
, pp. 436-437
-
-
Petersen, R.C.1
Trojanowski, J.Q.2
-
43
-
-
69149098714
-
Should we be applying warfarin pharmacogenetics to clinical practice? No, not now
-
Rosove MH, Grody WW: Should we be applying warfarin pharmacogenetics to clinical practice? No, not now. Ann. Intern. Med. 151(4), 270-273 (2009).
-
(2009)
Ann. Intern. Med
, vol.151
, Issue.4
, pp. 270-273
-
-
Rosove, M.H.1
Grody, W.W.2
-
44
-
-
67650074908
-
Novel consortium to address shortfall in innovative medicines for psychiatric disorders
-
Hughes B. Novel consortium to address shortfall in innovative medicines for psychiatric disorders. Nat. Rev. Drug Discov. 8(7), 523-524 (2009).
-
(2009)
Nat. Rev. Drug Discov
, vol.8
, Issue.7
, pp. 523-524
-
-
Hughes, B.1
-
46
-
-
75149152366
-
-
FDA Public Health Advisory, may lead to life-threatening side effects in nursing babies
-
FDA Public Health Advisory. Use of codeine by some breastfeeding mothers may lead to life-threatening side effects in nursing babies. www.fda.gov/Drugs/DrugSafety/PublicHealthAdvisories/ucm054717.htm
-
Use of codeine by some breastfeeding mothers
-
-
-
48
-
-
75149139472
-
-
CAMPTOSAR Label FDA. www.accessdata.fda.gov/drugsatfda-docs/label/2002/ 20571s16lbl.pdf
-
CAMPTOSAR Label FDA
-
-
-
49
-
-
75149181399
-
-
Selzentry Label FDA. www.accessdata.fda.gov/drugsatfda-docs/label/2007/ 022128lbl.pdf
-
Selzentry Label FDA
-
-
-
50
-
-
75149119774
-
-
Biomarker validation From FDA Guidance for Industry:, March
-
Biomarker validation From FDA Guidance for Industry: Pharmacogenomic data submissions, March 2005. www.fda.gov/cber/gdlns/pharmdtasub.pdf
-
(2005)
Pharmacogenomic data submissions
-
-
|