γ-secretase inhibition of murine choroidal neovascularization is associated with reduction of superoxide and proinflammatory cytokines

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 2, 2012, Pages 574-585

  Qi, Xiaoping ^a   Cai, Jun ^a   Ruan, Qing ^a   Liu, Li ^a   Boye, Sanford L ^a   Chen, Zhijuan ^a   Hauswirth, William W ^a   Ryals, Renee C ^a   Shaw, Lynn ^a   Caballero, Sergio ^a   Grant, Maria B ^a   Boulton, Michael E ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIN; ANGIOGENIN 1; CYTOKINE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MANGANESE SUPEROXIDE DISMUTASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NICASTRIN; PARVOVIRUS VECTOR; PIGMENT EPITHELIUM DERIVED FACTOR; PRESENILIN 1; SMALL INTERFERING RNA; SUPEROXIDE; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENZYME INHIBITION; FEMALE; GENE; GENE OVEREXPRESSION; GENE SILENCING; IN VITRO STUDY; LASER; MICROGLIA; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRESENILIN 1 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RETINAL ENDOTHELIAL CELL; SUBRETINAL NEOVASCULARIZATION; UPREGULATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CHOROIDAL NEOVASCULARIZATION; CYTOKINES; DISEASE MODELS, ANIMAL; EYE PROTEINS; FEMALE; FLUORESCEIN ANGIOGRAPHY; FUNDUS OCULI; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; INTRAVITREAL INJECTIONS; MICE; MICE, INBRED C57BL; NERVE GROWTH FACTORS; OXIDATIVE STRESS; PROTEASE INHIBITORS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERPINS; SUPEROXIDES;

EID: 84863073446     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8728     Document Type: Article

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