Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through γ-secretase

Journal of Biological Chemistry

Volumn 284, Issue 44, 2009, Pages 30177-30186

  Ablonczy, Zsolt ^a,c   Prakasam, Annamalai ^a   Fant, James ^a   Fauq, Abdul ^b   Crosson, Craig ^a   Sambamurti, Kumar ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE-RELATED MACULAR DEGENERATION; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; BARRIER SYSTEMS; ECTODOMAIN; FUNCTIONAL INTERACTION; GROWTH FACTOR; INHIBITORY EFFECT; INTRACELLULAR DOMAIN; MONOLAYER CULTURE; PROTECTIVE EFFECTS; RETINAL PIGMENT EPITHELIUM; RPE CELL; SECRETASES; VASCULAR ENDOTHELIAL GROWTH FACTOR; VEGFR-2; WESTERN-BLOT ANALYSIS;

AMINES; BIOACTIVITY; CELL CULTURE; GLYCOPROTEINS; LEAD DEPOSITS; MONOLAYERS; OPHTHALMOLOGY; PEPTIDES; SELF ASSEMBLY;

ALDEHYDES;

AMYLOID BETA PROTEIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; N2 [2 (3,5 DIFLUOROPHENYL) 2 HYDROXYACETYL] N1 (6,7 DIHYDRO 5 METHYL 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL)ALANINAMIDE; PIGMENT EPITHELIUM DERIVED FACTOR; PLACENTAL GROWTH FACTOR; VASCULOTROPIN E; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUSEN; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MONOLAYER CULTURE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PROCESSING; PROTEIN SECRETION; RETINA MACULA AGE RELATED DEGENERATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELLS, CULTURED; EYE PROTEINS; HUMANS; MACULAR DEGENERATION; NERVE GROWTH FACTORS; PERMEABILITY; RETINAL PIGMENT EPITHELIUM; SERPINS; SIGNAL TRANSDUCTION; SWINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 71049140394     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.032391     Document Type: Article

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