Survivin deficiency induces apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells

Oncology Reports

Volumn 27, Issue 3, 2012, Pages 621-627

  Dai, Dejian ^a   Liang, Yunjia ^a   Xie, Zhihua ^a   Fu, Jun ^a   Zhang, Yuhao ^a   Zhang, Zhijin ^a  

^a JIANGSU UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle; Hepatocellular carcinoma; Survivin

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; APOPTOSIS INHIBITOR; CASPASE 3; MESSENGER RNA; SURVIVIN;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL DIVISION; CELL STRAIN HEPG2; CELL STRUCTURE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC FIDELITY; GENETIC PARAMETERS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOSIS; MULTINUCLEAR CELL; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; S PHASE CELL CYCLE CHECKPOINT; TIME LAPSE IMAGING;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL SURVIVAL; DOWN-REGULATION; HEP G2 CELLS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; LIVER NEOPLASMS; MITOSIS; OLIGONUCLEOTIDES, ANTISENSE; PEPTIDE HYDROLASES; POLYPLOIDY; RNA, MESSENGER; TIME-LAPSE IMAGING;

EID: 84863014312     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1544     Document Type: Article

References (34)

1. Salvesen GS and Duckett CS: IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol 3: 401-410, 2002. (Pubitemid 34685698)
2. Zhu ZB, Chen Y, Makhija SK, et al: Survivin promoter-based conditionally replicative adenoviruses target cholangiocarcinoma. Int J Oncol 29: 1319-1329, 2006.
3. Altieri DC: Validating survivin as a cancer therapeutic target. Nat Rev Cancer 3: 46-54, 2003.
4. Chau GY, Lee AF, Tsay SH, Ke YR, Kao HL, Wong FH, Tsou AP and Chau XP: Clinicopathological significance of survivin expression in patients with hepatocellular carcinoma. Histopathology 51: 204-218, 2007. (Pubitemid 47083982)
5. Beltrami E, Plescia J, Wilkinson JC, Duckett CS and Altieri DC: Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis. J Biol Chem 279: 2077-2084, 2004. (Pubitemid 38084480)
6. Grossman D, Kim PJ, Blanc-Brude OP, Brash DE, Tognin S, Marchisio PC and Altieri DC: Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53. J Clin Invest 108: 991-999, 2001. (Pubitemid 32946073)
7. Okada H, Bakal C, Shahinian A, Elia A, Wakeham A, Suh WK, Duncan GS, Ciofani M, Rottapel R, Zuniga-Pflucker JC and Mak TW: Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. J Exp Med 199: 399-410, 2004. (Pubitemid 38252051)
8. Bolton MA, Lan W, Powers SE, McCleland ML, Kuang J and Stukenberg PT: Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell 13: 3064-3077, 2002. (Pubitemid 35034246)
9. Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A and Funabiki H: The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell 118: 187-202, 2004. (Pubitemid 38962575)
10. Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL and Earnshaw WC: Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol 166: 179-191, 2004. (Pubitemid 38988771)
11. Vagnarelli P and Earnshaw WC: Chromosomal passengers: the four-dimensional regulation of mitotic events. Chromosoma 113: 211-222, 2004. (Pubitemid 39462364)
12. Beardmore VA, Ahonen LJ, Gorbsky GJ and Kallio MJ: Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity. J Cell Sci 117: 4033-4042, 2004. (Pubitemid 39328292)
13. Skoufias DA, Mollinari C, Lacroix FB and Margolis RL: Human survivin is a kinetochore-associated passenger protein. J Cell Biol 151: 1575-1582, 2000.
14. Li F, Yang J, Ramnath N, Javle MM and Tan D: Nuclear or cytoplasmic expression of survivin: what is the significance? Int J Cancer 114: 509-512, 2005. (Pubitemid 40349608)
15. Rosa J, Canovas P, Islam A, Altieri DC and Doxsey SJ: Survivin modulates microtubule dynamics and nucleation throughout the cell cycle. Mol Biol Cell 17: 1483-1493, 2006. (Pubitemid 43376565)
16. Platica M, Ionescu A, Ivan E, Holland JF, Mandeli J and Platica O: PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins. Int J Oncol 38: 777-785, 2011.
17. Abou Alaiwi WA, Ratnam S, Booth RL, Shah JV and Nauli SM: Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation. Hum Mol Genet 20: 354-367, 2011.
18. Carvalho A, Carmena M, Sambade C, Earnshaw WC and on in taxol-treated HeLa cells. J Cell Sci 116: 2987-Wheatley SP: Survivin is required for stable checkpoint activati2998, 2003.
19. Zaffaroni N, Pennati M and Daidone MG: Survivin as a target for new anticancer interventions. J Cell Mol Med 9: 360-372, 2005.
20. Jin X, Li Q, Wu Q, Li P, Matsumoto Y, Furusawa Y, Gong L, Hao J and Dai Z: Radiosensitization by inhibiting survivin in human hepatoma HepG2 cells to high-LET radiation. J Radiat Res 52: 335-341, 2011.
21. Altieri DC: The case for survivin as a regulator of microtubule dynamics and cell-death decisions. Curr Opin Cell Biol 18: 609-615, 2006.
22. Olie RA, Simoes-Wust AP, Baumann B, Leech SH, Fabbro D, Stahel RA and Zangemeister-Wittke U: A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy. Cancer Res 60: 2805-2809, 2000. (Pubitemid 30395796)
23. Li F, Ambrosini G, Chu EY, Plescia J, Tognin S, Marchisio PC and Altieri DC: Control of apoptosis and mitotic spindle checkpoint by surviving. Nature 396: 580-584, 1998. (Pubitemid 28563719)
24. Vogel C, Hager C and Bastians H: Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation. Cancer Res 67: 339-345, 2007. (Pubitemid 46142793)
25. Austin KM, Gupta ML, Coats SA, Tulpule A, Mostoslavsky G, Balazs AB, Mulligan RC, Daley G, Pellman D and Shimamura A: Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome. J Clin Invest 118: 1511-1518, 2008. (Pubitemid 351500444)
26. Tao W: The mitotic checkpoint in cancer therapy. Cell Cycle 4: 1495-1499, 2005.
27. Weaver BA and Cleveland DW: Decoding the links between mitosis, cancer, and chemotherapy: the mitotic checkpoint, adaptation and cell death. Cancer Cell 8: 7-12, 2005. (Pubitemid 40991810)
28. Kang BH and Altieri DC: Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein. J Biol Chem 281: 24721-24727, 2006.
29. Bourhis E, Hymowitz SG and Cochran AG: The mitotic regulator survivin binds as a monomer to its functional interactor Borealin. J Biol Chem 282: 35018-35023, 2007. (Pubitemid 350232464)
30. Yagi Y, Fushida S, Harada S, et al: Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line. J Exp Clin Cancer Res 29: 149-160, 2010.
31. Li F, Ackermann EJ, Bennett CF, Rothermel AL, Plescia J, Tognin S, Villa A, Marchisio PC and Altieri DC: Pleiotropic cell-division defects and apoptosis induced by interference with survivin function. Nat Cell Biol 1: 461-466, 1999. (Pubitemid 129503664)
32. Temme A, Rieger M, Reber F, Lindemann D, Weigle B, Diestelkoetter-Bachert P, Ehninger G, Tatsuka M, Terada Y and Rieber EP: Localization, dynamics, and function of survivin revealed by expression of functional survivin DsRed fusion proteins in the living cell. Mol Biol Cell 14: 78-92, 2003. (Pubitemid 36106021)
33. Fortugno P, Wall NR, Giodini A, O'onnor DS, Plescia J, Padgett KM, Tognin S, Marchisio PC and Altieri DC: Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J Cell Sci 115: 575-585, 2002. (Pubitemid 34182984)
34. Asumen MG, Ifeacho TV, Cockerham L, Pfandl C and Wall NR: Dynamic changes to survivin subcellular localization are initiated by DNA damage. Onco Targets Ther 3: 129-137, 2010.