Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferase

Molecular Biology Reports

Volumn 39, Issue 4, 2012, Pages 4375-4381

  Deželak, Matjaž ^a   Bavec, Aljoša ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

ADP ribosylation; Diabetes; Glucagon like peptide 1 receptor; Posttranslational modification; Synthetic receptor loop peptides

Indexed keywords

ARGININE; ARGININE 348; CYSTEINE; CYSTEINE 341; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG; GLUCAGON LIKE PEPTIDE RECEPTOR; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; PEPTIDE;

ADENOSINE DIPHOSPHATE RIBOSYLATION; AMINO ACID SEQUENCE; ARTICLE; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME LOCALIZATION; IMMUNOBLOTTING; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; PEPTIDE SYNTHESIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; RESIDUE ANALYSIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CELL MEMBRANE; CHEMISTRY; CRICETULUS; DRUG EFFECT; ENZYMOLOGY; HAMSTER; METABOLISM; MOLECULAR GENETICS;

ADP RIBOSE TRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; GTP-BINDING PROTEIN BETA SUBUNITS; MOLECULAR SEQUENCE DATA; PEPTIDES; RECEPTORS, GLUCAGON;

EID: 84863001686     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-1225-0     Document Type: Article

References (44)

1. Dillon JS, Tanizawa Y, Wheeler MB, Leng XH, Ligon BB, Rabin DU, Yoo WH, Permutt MA, Boyd AD (1993) Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor. Endocrinology 133:1907-1910
2. Thorens B (1992) Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide-1. Proc Natl Acad Sci 89:8641-8645
3. Thorens B, Porret A, Bühler L, Deng SP, Morel P, Widmann C (1993) Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 42:1678-1682
4. Göke R, Conlon JM (1988) Receptors for glucagon-like peptide-1(7-36)amide on rat insulinoma-derived cells. J Endocrinol 116:357-362
5. Kreymann B, Williams G, Ghatei MA, Bloom SR (1987) Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 2(8571):1300-1304
6. Barragan JM, Rodriguez RE, Blazquez E (1994) Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats. Am J Physiol 266:459-466
7. Navarro M, Rodriquez de Fonseca F, Alvarez E, Chowen JA, Zueco JA, Gomez R, Eng J, Blázquez E (1996) Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake. J Neurochem 67:1982-1991
8. During MJ, Cao L, Zuzga DS, Francis JS, Fitzsimons HL, Jiao X, Bland RJ, Klugmann M, Banks WA, Drucker DJ, Haile CN (2003) Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med 9:1173-1179
9. Gutniak M, Orskov C, Holst JJ, Ahrén BB, Efendic S (1992) Antidiabetogenic effect of glucagon-like peptide-1(7-36)amide in normal subjects and patients with mellitus. N Engl J Med 326:1316-1322
10. Montrose-Rafizadeh C, Avdonin P, Garant MJ, Rodgers BD, Kole S, Yang H, Levine MA, Schwindinger W, Bernier M (1999) Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activate mitogen-activated protein kinase pathways in Chinese hamster ovary cells. Endocrinology 140:1132-1140
11. Bavec A, Hällbrink M, Langel Ü , Zorko M (2003) Different role of intracellular loops of glucagon-like peptide-1 receptor in G-protein coupling. Regul Peptides 111:137-144
12. Takhar S, Gyomorey S, Su RC, Mathi SK, Li XF, Wheeler MB (1996) The third cytoplasmic domain of the GLP-1[7-36]amide receptor is required for coupling to the adenylyl cyclase system. Endocrinology 137:2175-2178
13. Heller RS, Kieffer J, Habaner JF (1996) Point mutation in the first and third intracellular loops of the glucagon-like peptide-1 receptor alter intracellular signaling. Biochem Biophys Res Commun 223:624-632
14. Bavec A, Jiang Y, Langel Ü , Zorko M (2007) Role of cysteine 341 and arginine 348 of GLP-1 receptor in G-protein coupling. Mol Biol Rep 34:53-60
15. Widmann C, Dolci W, Thorens B (1996) Heterologous desensitization of the glucagon-like peptide-1 receptor by phorbol esters requires phosphorylation of the cytoplasmic tail at four different sites. J Biol Chem 271:19957-19963
16. Corda D, Di Girolamo M (2003) Functional aspects of protein mono-ADP-ribosylation. EMBO J 22(9):1953-1958
17. Lupi R, Corda D, Di Girolamo M (2000) Endogenous ADPribosylation of the G protein beta subunit prevents the inhibition of type 1 adenylyl cyclase. J Biol Chem 275:9418-9424
18. Lupi R, Dani N, Dietrich A, Marchegiani A, Turacchio S, Berrie CP, Moss J, Gierschik P, Corda D, Di Girolamo M (2002) Endogenous mono-ADP-ribosylation of the free Gbc prevents stimulation of phosphoinositide 3-kinase-c and phospholipase C-b2 and is activated by G-protein-coupled receptors. Biochem J 367:825-832
19. Deželak M, Bavec A (2011) Third intracellular loop of glucagon like-peptide-1 receptor is coupled with endogenous mono-ADPribosyltransferase- novel type of receptor regulation? Eur J Phar 666:35-42
20. Grahnert A, Friedrich M, Pfister M, Haag F, Koch-Nolte F, Hauschildt S (2002) Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide. Biochem J 362: 717-723
21. Choi MM, Huh JW, Yang SJ, Cho EH, Choi SY, Cho SW (2005) Identification of ADP-ribosylation site in human glutamate dehydrogenase isozymes. FEBS Lett 579:4125-4130
22. Cohen-Armon M, Hammel I, Anis Y, Homburg S, Dekel N (1996) Evidence for endogenous ADP-ribosylation of GTPbinding proteins in neuronal cell nucleus. Possible induction by membrane depolarization. J Biol Chem 271:26200-26208
23. Bavec A (2004) Novel features of amphiphilic peptide Mas7 in signalling via heterotrimeric G-proteins. J Pept Sci 10:691-699
24. Bavec A (2004) Immunoassay for visualization of protein-protein interactions on Ni-nitrilotriacetate support-example of a laboratory exercise with recombinant heterotrimeric G alpha(i2)beta(1 gamma 2) tagged by hexahistidine from SF9 cells. Biochem Mol Bio Edu 32:258-262
25. Widmann C, Dolci W, Thorens B (1997) Internalization and homologous desensitization of the GLP-1 receptor depend on phosphorylation of the receptor carboxyl tail at the same three sites. Mol Endocrinol 11:1094-1102
26. Daaka Y, Luttrell L, Lefkowitz RJ (1997) Switching of the coupling of the b2-adrenergic receptor to different G proteins by protein kinase A. Nature 390:88-91
27. Malek D, Münch G, Palm D (1993) Two sites in the third intracellular loop of the D2 receptor are involved in functional G protein-mediated coupling to adenylylate cyclase. FEBS Lett 325:215-219
28. Grasso P, Deziel MR, Reichert LE (1995) Synthetic peptides corresponding to residues 551 to 555 and 650 to 653 of the rat testicular follicle-stimulating hormone (FSH) receptor are sufficient for post-receptor modulation of Sortoli cell responsiveness to FSH stimulation. Regul Pept 60:177-183
29. Hällbrink M, Holmqvis T, Olsson M, Ö estenson CG, Efendic S, Langel Ü (2001) Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Gas and Gai/Ga0 activation. Biochim Biophys Acta 1546:79-86
30. Okamoto T, Nishimoto I (1992) Detection of G-protein-activator regions in M4 subtype muscarinic, cholinergic, and alpha 2-adrenergic receptors based upon characteristics in primary structure. J Biol Chem 267:8342-8346
31. Okazaki IJ, Moss J (1999) Characterization of glycosylphosphatidylinositol-anchored, secreted and intracellular vertebrate mono-ADP-ribosyltransferases. Annu Rev Nutr 19:485-509
32. Hassa PO et al (2006) Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going? Microbiol Mol Biol Rev 70:789-829
33. Hottiger MO, Hassa PO, Lüscher B, Schüler H, Koch-Nolte F (2010) Toward a unified nomenclature for mammalian ADP-ribosyltransferases. Trends Biochem Sci 35(4):208-219
34. Han S, Arvai AS, Clancy SB, Tainer JA (2001) Crystal structure and novel recognition motif of rho ADP-ribosylating C3 exoenzyme from Clostridium botulinum: structural insights for recognition specificity and catalysis. J Mol Biol 305:95-107
35. Koch-Nolte F, Reche P, Haag F, Bazan F (2001) ADP-ribosyltransferases: plastic tools for inactivating protein and small molecular weight targets. J Biotechnol 92:81-87
36. Maehama T, Hoshino S, Katada T (1996) Increase in ADP-ribosyltransferase activity of rat T lymphocyte alloantigen RT6.1 by a single amino acid mutation. FEBS Lett 388:189-191
37. Hara N, Tsuchiya M, Shimoyama M (1996) Glutamic acid 207 in rodent T-cell RT6 antigens is essential for arginine-specific ADPribosylation. J Biol Chem 271:29552-29555
38. Vogelsgesang M, Aktories K (2006) Exchange of glutamine-217 to glutamate of Clostridium limosum exoenzyme C3 turns the asparagine-specific ADP-ribosyltransferase into an arginine modifying enzyme. Biochemistry 45:1017-1025
39. Jørgensen R, Wang Y, Visschedyk D, Merrill AR (2008) The nature and character of the transition state for the ADP-ribosyltransferase reaction. EMBO Rep 9:802-809
40. Tsuge H, Nagahama M, Oda M, Iwamoto S, Utsunomiya H, Marquez VE, Katunuma N, Nishizawa M, Sakurai J (2008) Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens iota-toxin. Proc Natl Acad Sci USA 105:7399-7404
41. Bourgeois C, Okazaki I, Cavanaugh E, Nightingale M, Moss J (2003) Identification of regulatory domains in ADP-ribosyltransferase-1 that determine transferase and NAD glycohydrolase activities. J Biol Chem 278:26351-26355
42. Golicnik M, Fournier D, Stojan J (2001) Interaction of Drosophila acetylcholinesterases with D-tubocurarine: an explanation of the activation by an inhibitor. Biochemistry 40:1214-1219
43. Debeljak N, Sytkowski AJ (2008) Erythropoietin: new approaches to improved molecular designs and therapeutic alternatives. Curr Pharm Des 14:1302-1310
44. Mars T, King MP, Miranda AF, Walker WF, Mis K, Grubic Z (2003) Functional innervation of cultured human skeletal muscle proceeds by two modes with regard to agrin effects. Neuroscience 118:87-97