Internalization and homologous desensitization of the GLP-1 receptor depend on phosphorylation of the receptor carboxyl tail at the same three sites

Molecular Endocrinology

Volumn 11, Issue 8, 1997, Pages 1094-1102

  Widmann, Christian ^a,b   Dolci, Wanda ^a   Thorens, Bernard ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE RECEPTOR;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DESENSITIZATION; INTERNALIZATION; LUNG FIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

EID: 0031001096     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.11.8.9959     Document Type: Article

References (36)

1. Johnson JA, Clark RB, Friedman J, Dixon RAF, Strader CD 1990 Identification of a specific domain in the β-adrenergic receptor required for phorbol ester-induced inhibition of catecholamine-stimulated adenylyl cyclase. Mol Pharmacol 38:289-293
2. Yuan N, Friedman J, Whaley BS, Clark RB 1994 cAMP-dependent protein kinase and protein kinase C consensus site mutation of the β-adrenergic receptor. Effect on desensitization and stimulation of adenylyl cyclase. J Biol Chem 269:23032-23038
3. 2-adrenergic receptor desensitization. Delineation with specific inhibitors. J Biol Chem 265:3202-3209
4. Bouvier M, Hausdorff WP, De Blasi A, O'Dowd BF, Kobilka BK, Caron MG, Lefkowitz RJ 1988 Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization. Nature 333:370-373
5. Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ 1986 β-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci USA 83:2797-2801
6. Inglese J, Freedman NJ, Koch WJ, Lefkowitz RJ 1993 Structure and mechanism of the G protein-coupled receptor kinases. J Biol Chem 268:23735-23738
7. Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ 1990 β-arrestin: a protein that regulates β-adrenergic receptor function. Science 248:1547-1550
8. Attramadal H, Arriza JL, Aoki C, Dawson TM, Codina J, Kwatra MM, Snyder SH, Caron MG, Lefkowitz RJ 1992 β-arrestin2, a novel member of the arrestin/β-arrestin gene family. J Biol Chem 267:17882-17890
9. Lohse MJ, Andexinger S, Pitcher J, Trukawinski S, Codina J, Faure J-P, Caron MG, Lefkowitz RJ 1992 Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta2-adrenergic receptor and rhodopsin systems. J Biol Chem 267:8558-8564
10. Pippig S, Andexinger S, Daniel K, Puzicha M, Caron MG, Lefkowitz RJ, Lohse MJ 1993 Overexpression of ß-arrestin and β-adrenergic receptor kinase augment desensitization of β2-adrenergic receptors. J Biol Chem 268:3201-3208
11. Harden TK 1983 Agonist-induced desensitization of the β-adrenergic receptor-linked adenylate cyclase. Pharmacol Rev 35:5-32
12. Lefkowitz RJ, Stadel JM, Caron MG 1983 Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization. Annu Rev Biochem 52:159-186
13. Strader CD, Sigal IS, Blake AD, Cheung AH, Register RB, Rands E, Zemcik BA, Candelore MR, Dixon RAF 1987 The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration. Cell 49:855-863
14. Barak LS, Tiberi M, Freedman NJ, Kwatra MM, Lefkowitz RJ, Caron MG 1994 A highly conserved tyrosine residue in G protein-coupled receptor is required for agonist-mediated β2-adrenergic receptor sequestration. J Biol Chem 269:2790-2795
15. Yu SS, Lefkowitz RJ, Hausdorff WP 1993 β-adrenergic receptor sequestration. A potential mechanism of receptor resensitization. J Biol Chem 268:337-341
16. Tsuga H, Kameyama K, Haga T, Kurose H, Nagao T 1995 Sequestration of muscarinic acetylcholine receptor m2 subtypes. Facilitation by G protein-coupled receptor kinase (GRK2) and attenuation by a dominant-negative mutant of GRK2. J Biol Chem 269:32522-32527
17. Ferguson SSG, Ménard L, Barak LS, Koch WJ, Colapietro A-M, Caron MG 1995 Role of phosphorylation in agonist-promoted β2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by bARK1. J Biol Chem 270:24782-24789
18. Ferguson SSG, Downey III WE, Colapietro A-M, Barak LS, Ménard L, Caron MG 1996 Role of β-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science 271:363-366
19. Goodman OB, Krupnick JG, Santini F, Gurevich W, Penn RB, Gagnon AW, Keen JH, Benovic JL 1996 β-arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor. Nature 383:447-450
20. Chen WJ, Goldstein JL, Brown MS 1990 NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. J Biol Chem 265:3116-3123
21. Trowbridge IS, Collawn JF, Hopkins CR 1993 Signal-dependent membrane protein trafficking in the endocytic pathway. Annu Rev Cell Biol 9:129-161
22. Letourneur F, Klausner RD 1992 A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell 69:1143-1157
23. Hunziker W, Fumey C 1994 A di-leucine motif mediates endocytosis and basolateral sorting of macrophage IgG Fc receptors in MDCK cells. EMBO J 13:2963-2969
24. Verhey KJ, Birnbaum MJ 1994 A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblasts. J Biol Chem 269:2353-2356
25. Yang J, Williams JA, Yule DI, Logsdon CD 1995 Mutation of the carboxy-terminal threonine residues in human m3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization. Mol Pharmacol 48:477-485
26. Rohrer J, Bénédetti H, Zanolari B, Riezman H 1993 Identification of a novel sequence mediating regulated endocytosis of the G protein coupled α-pheromone receptor in yeast. Mol Biol Cell 4:511-521
27. Thorens B 1992 Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide I. Proc Natl Acad Sci USA 89: 8641-8645
28. Thorens B, Waeber G 1993 Glucagon-like peptide-1 and the control of insulin secretion in the normal state and in NIDDM. Diabetes 42:1219-1225
29. Thorens B 1994 The gluco-incretin hormone glucagon-like peptide-1 and its βcell receptor. In: Draznin B, LeRoith D (eds) Molecular Biology of Diabetes, Part I. Humana Press, Totowa, NJ, pp 357-379
30. Widmann C, Dolci W, Thorens B 1996 Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate. Mol Endocrinol 10:62-75
31. Widmann C, Dolci W, Thorens B 1996 Heterologous desensitization of the GLP-1 receptor by phorbol esters requires phosphorylation of the cytoplasmic tail at four different sites. J Biol Chem 271:19957-19963
32. Widmann C, Dolci W, Thorens B 1995 Agonist-induced internalization and recycling of the glucagon-like peptide-1 receptor in transfected fibroblast and in insulinomas. Biochem J 310:203-214
33. Pippig S, Andexinger S, Lohse MJ 1995 Sequestration and recycling of β2-adrenergic receptors permit receptor resensitization. Mol Pharmacol 47:666-676
34. Widmann C, Bürki E, Dolci W, Thorens B 1994 Signal transduction by the cloned glucagon-like peptide-1 receptor. Comparison with signalling by the endogenous receptors of βcell lines. Mol Pharmacol 45:1029-1035
35. Nelson RM, Long GL 1989 A general method of site-specific mutagenesis using a modification of the Thermus aquaticus polymerase chain reaction. Anal Biochem 180:147-151
36. Cooper JA, Sefton BM, Hunter T 1983 Detection and quantitation of phosphotyrosine in proteins. Methods Enzymol 99:387-402