ADP-ribosyltransferases: Plastic tools for inactivating protein and small molecular weight targets

Journal of Biotechnology

Volumn 92, Issue 2, 2001, Pages 81-87

  Koch Nolte, Friedrich ^a   Reche, Pedro ^b   Haag, Friedrich ^a   Bazan, Fernando ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

ADP ribosylation; Amino acid sequence alignment; Bacterial toxins; Protein design; Sequence homology; Structure prediction

Indexed keywords

CATALYSIS; CRYSTALLIZATION; ENZYMES; TOXIC MATERIALS;

METABOLIC REGULATORS;

BIOTECHNOLOGY;

BACTERIAL TOXIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

AMINO ACID SEQUENCE; CATALYSIS; CONFERENCE PAPER; CRYSTALLIZATION; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; LIGAND BINDING; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; REDUCTION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BIOTECHNOLOGY; DRUG DESIGN; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 0035909796     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(01)00356-X     Document Type: Review

References (34)

1. Botulinum C2 toxin ADP-ribosylates actin
2. Structure of exotoxin A of Pseudomonas aeruginosa at 3.0 angstrom resolution
3. PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase
4. Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis
5. Sequence and structural links between distant ADP-ribosyltransferase families
6. Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide
7. NAD+ binding site of diphtheria toxin: Identification of a residue within the nicotinamide subsite by photochemical modification with NAD
8. The crystal structure of diphtheria toxin
9. Three conserved consensus sequences identify the NAD-binding site of ADP-ribosylating enzymes, expressed by eukaryotes, bacteria and T-even bacteriophages
10. Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex
11. Crystal structure and novel recognition motif and Rho ADP-ribosylating C3 exoenzyme from Clostridium botulinum: Structural insights for recognition specificity and catalysis
12. Glutamic acid 207 in rodent T-cell RT6 antigens is essential for arginine-specific ADP-ribosylation
13. Cell-surface ADP-ribosylation of fibroblast growth factor-2 by an arginine-specific ADP-ribosyltransferase
14. Expression and comparative analysis of recombinant rat and mouse RT6 T cell mono(ADP-ribosyl)transferases in E. coli
15. The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase
16. Uncovered: The family relationship of a T-cell-membrane protein and bacterial toxins
17. Mouse T cell membrane proteins Rt6-1 and Rt6-2 are arginine/protein mono(ADPribosyl)transferases and share secondary structure motifs with ADP-ribosylating bacterial toxins
18. A cell surface ADP-ribosyltransferase modulates T cell receptor association and signalling
19. Molecular and immunological characterization of ADP-ribosylarginine hydrolases
20. Characterization of the enzymatic component of Clostridium perfringens iota-toxin
21. Poly(ADP-ribose) polymerase in the cellular response to DNA damage, apoptosis, and disease
22. ADP-ribosylation as an intermediate step in inactivation of rifampin by a mycobacterial gene
23. Pseudomonas aeruginosa exoenzyme S is a biglutamic acid ADP-ribosyltransferase
24. The mechanism of the elongation and branching reaction of poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis
25. Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli
26. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
27. Transient ADP-ribosylation of a 2′-phosphate implicated in its removal from ligated tRNA during splicing in yeast
28. The crystal structure of pertussis toxin
29. ADP-ribosylation of tuftsin suppresses its receptor-binding capacity and phagocytosis-stimulating activity to murine peritoneal macrophages
30. The Salmonella enterica virulence protein SPVB mediates ADP-ribosylation of actin
31. Diphtheria toxin and Pseudomonas aeruginosa exotoxin A: Active-site structure and enzymic mechanism
32. The three-dimensional crystal structure of cholera toxin