Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Gαs and Gαi/Gαo activation

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1546, Issue 1, 2001, Pages 79-86

  Hällbrink, Mattias ^a   Holmqvist, Tomas ^a   Olsson, Magnus ^a   Östenson, Claes Göran ^b,c   Efendic, Suad ^b   Langel, Ülo ^a,c  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

cAMP; Cholera toxin; G protein; G protein coupled receptor; GLP 1 glucagon like peptide 1; GLP 1 glucagon like peptide 1 receptor; GTP S; GTPase; Pertussis toxin; Receptor domain; Synthetic peptide; Third intracellular loop

Indexed keywords

ADENYLATE CYCLASE; CHOLERA TOXIN; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATASE; PERTUSSIS TOXIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; RAT; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ADENYLATE CYCLASE TOXIN; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL MEMBRANE; CHOLERA TOXIN; CYCLIC AMP; ENZYME ACTIVATION; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HETEROTRIMERIC GTP-BINDING PROTEINS; MOLECULAR SEQUENCE DATA; PEPTIDES; PERTUSSIS TOXIN; PROTEIN BINDING; RECEPTORS, GLUCAGON; SIGNAL TRANSDUCTION; VIRULENCE FACTORS, BORDETELLA;

EID: 0035831283     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(00)00270-3     Document Type: Article

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