Nuclear magnetic resonance-based metabolomics enable detection of the effects of a whole grain rye and rye bran diet on the metabolic profile of plasma in prostate cancer patients

Journal of Nutrition

Volumn 141, Issue 12, 2011, Pages 2126-2132

  Moazzami, Ali A ^a   Zhang, Jie Xian ^b   Kamal Eldin, Afaf ^a   Åman, Per ^a   Hallmans, Göran ^b   Johansson, Jan Erik ^c   Andersson, Sven Olof ^c  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETONE; ADIPONECTIN; BETAINE; DIMETHYL SULFONE; DIMETHYLGLYCINE; GLUCAGON; HOMOCYSTEINE; INSULIN; LEPTIN; PROSTATE SPECIFIC ANTIGEN;

AGED; ARTICLE; BIOSYNTHESIS; CANCER GROWTH; CANCER PATIENT; CATABOLISM; CLINICAL ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET; ENERGY METABOLISM; HUMAN; MALE; METABOLOMICS; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; RYE; RYE BRAN; WHEAT; WHITE WHEAT; WHOLE GRAIN RYE;

3-HYDROXYBUTYRIC ACID; AGED; AGED, 80 AND OVER; BETAINE; CROSS-OVER STUDIES; DIET; HOMOCYSTEINE; HUMANS; INSULIN; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOME; METABOLOMICS; MULTIVARIATE ANALYSIS; PLANT PREPARATIONS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; SARCOSINE; SECALE CEREALE; TRITICUM; UNITED STATES;

SECALE CEREALE; TRITICUM AESTIVUM;

EID: 84862929916     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.111.148239     Document Type: Article

References (49)

1. Nelson WG, De Marzo AM, Isaacs WB. Prostate cancer. N Engl J Med. 2003;349:366-81.
2. Weissbach L, Altwein J. Active surveillance or active treatment in localized prostate cancer? Dtsch Arztebl Int. 2009;106:371-6.
3. Hayes JH, Ollendorf DA, Pearson SD, Barry MJ, Kantoff PW, Stewart ST, Bhatnagar V, Sweeney CJ, Stahl JE, McMahon PM. Active surveillance compared with initial treatment for men with low-risk prostate cancer: a decision analysis. JAMA. 2010;304:2373-80.
4. Bylund A, Lundin E, Zhang JX, Nordin A, Kaaks R, Stenman UH, Aman P, Adlercreutz H, Nilsson TK, Hallmans G, et al. Randomised controlled short-term intervention pilot study on rye bran bread in prostate cancer. Eur J Cancer Prev. 2003;12:407-15.
5. Landberg R, Andersson SO, Zhang JX, Johansson JE, Stenman UH, Adlercreutz H, Kamal-Eldin A, Aman P, Hallmans G. Rye whole grain and bran intake compared with refined wheat decreases urinary Cpeptide, plasma insulin, and prostate specific antigen in men with prostate cancer. J Nutr. 2010;140:2180-6.
6. Bylund A, Zhang JX, Bergh A, Damber JE, Widmark A, Johansson A, Adlercreutz H, Aman P, Shepherd MJ, Hallmans G. Rye bran and soy protein delay growth and increase apoptosis of human LNCaP prostate adenocarcinoma in nude mice. Prostate. 2000;42:304-14.
7. Landström M, Zhang JX, Hallmans G, Aman P, Bergh A, Damber JE, Mazur W, Wahala K, Adlercreutz H. Inhibitory effects of soy and rye diets on the development of Dunning R3327 prostate adenocarcinoma in rats. Prostate. 1998;36:151-61.
8. Wikstrom P, Bylund A, Zhang JX, Hallmans G, Stattin P, Bergh A. Rye bran diet increases epithelial cell apoptosis and decreases epithelial cell volume in TRAMP (transgenic adenocarcinoma of the mouse prostate) tumors. Nutr Cancer. 2005;53:111-6.
9. Leinonen K, Liukkonen K, Poutanen K, Uusitupa M, Mykkanen H. Rye bread decreases postprandial insulin response but does not alter glucose response in healthy Finnish subjects. Eur J Clin Nutr. 1999;53:2627.
10. Juntunen KS, Laaksonen DE, Autio K, Niskanen LK, Holst JJ, Savolainen KE, Liukkonen KH, Poutanen KS, Mykkanen HM. Structural differences between rye and wheat breads but not total fiber content may explain the lower postprandial insulin response to rye bread. Am J Clin Nutr. 2003;78:957-64.
11. Kallio P, Kolehmainen M, Laaksonen DE, Pulkkinen L, Atalay M, Mykkanen H, Uusitupa M, Poutanen K, Niskanen L. Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome. Am J Clin Nutr. 2008;87:1497-503.
12. Ma J, Li H, Giovannucci E, Mucci L, Qiu W, Nguyen PL, Gaziano JM, Pollak M, Stampfer MJ. Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis. Lancet Oncol. 2008;9: 1039-47.
13. Hammarsten J, Hogstedt B. Hyperinsulinaemia: a prospective risk factor for lethal clinical prostate cancer. Eur J Cancer. 2005;41:2887-95.
14. Cannata D, Fierz Y, Vijayakumar A, LeRoith D. Type 2 diabetes and cancer: what is the connection? Mt Sinai J Med. 2010;77:197-213.
15. Rezzi S, Ramadan Z, Fay LB, Kochhar S. Nutritional metabonomics: applications and perspectives. J Proteome Res. 2007;6:513-25.
16. Rosén LA, Ostman EM, Bjorck IM. Effects of cereal breakfasts on postprandial glucose, appetite regulation and voluntary energy intake at a subsequent standardized lunch; focusing on rye products. Nutr J. 2011;10:7.
17. Rosén LA, Silva LO, Andersson UK, Holm C, Ostman EM, Bjorck IM. Endosperm and whole grain rye breads are characterized by low postprandial insulin response and a beneficial blood glucose profile. Nutr J. 2009;8:42.
18. Landberg R, Kamal-Eldin A, Andersson SO, Johansson JE, Zhang JX, Hallmans G, Aman P. Reproducibility of plasma alkylresorcinols during a 6-week rye intervention study in men with prostate cancer. J Nutr. 2009;139:975-80.
19. Tiziani S, Einwas AH, Lodi A, Ludwig C, Bunce CM, Viant MR, Gunther UL. Optimized metabolite extraction from blood serum for H-1 nuclear magnetic resonance spectroscopy. Anal Biochem. 2008;377:16-23.
20. Hwang TL, Shaka AJ. Water suppression that works: excitation sculpting using arbitrary wave-forms and pulsed-field gradients. J Magn Reson A. 1995;112:275-9.
21. Minniti G, Piana A, Armani U, Cerone R. Determination of plasma and serum homocysteine by high-performance liquid chromatography with fluorescence detection. J Chromatogr A. 1998;828:401-5.
22. Moazzami AA, Andersson R, Kamal-Eldin A. Changes in the metabolic profile of rat liver after alpha-tocopherol deficiency as revealed by metabolomics analysis. NMR Biomed. 2011;24:499-505.
23. van Velzen EJ, Westerhuis JA, van Duynhoven JP, van Dorsten FA, Hoefsloot HC, Jacobs DM, Smit S, Draijer R, Kroner CI, Smilde AK. Multilevel data analysis of a crossover designed human nutritional intervention study. J Proteome Res. 2008;7:4483-91.
24. Westerhuis JA, van Velzen EJ, Hoefsloot HC, Smilde AK. Multivariate paired data analysis: multilevel PLSDA versus OPLSDA. Metabolomics. 2010;6:119-28.
25. Fardet A. New hypotheses for the health-protective mechanisms of wholegrain cereals: what is beyond fibre? Nutr Res Rev. 2010;23:65-134.
26. Mathews CK, van Holde KE, Ahern KG. Biochemistry. 3rd ed. San Francisco, CA: Addison Wesley Longman Inc.; 2000.
27. Heinonen L, Korpela R, Mantere S. The effect of different types of Finnish bread on postprandial glucose response in diabetic patients. Hum Nutr Appl Nutr. 1985;39:108-13.
28. Wachters-Hagedoorn RE, Priebe MG, Heimweg JA, Heiner AM, Englyst KN, Holst JJ, Stellaard F, Vonk RJ. The rate of intestinal glucose absorption is correlated with plasma glucose-dependent insulinotropic polypeptide concentrations in healthy men. J Nutr. 2006;136:1511-6.
29. Juntunen KS, Niskanen LK, Liukkonen KH, Poutanen KS, Holst JJ, Mykkanen HM. Postprandial glucose, insulin, and incretin responses to grain products in healthy subjects. Am J Clin Nutr. 2002;75:254-62.
30. Zhang BB, Zhou G, Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab. 2009;9:407-16.
31. Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol. 2007;8:774-85.
32. Zhou G, Myers R, Li Y, Chen YL, Shen XL, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001;108:1167-74.
33. Huo T, Cai S, Lu X, Sha Y, Yu M, Li F. Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride. J Pharm Biomed Anal. 2009;49:976-82.
34. Andersson U, Rosen L, Ostman E, Strom K, Wierup N, Bjorck I, Holm C. Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse. Nutrition. 2010;26:230-9.
35. Kallio P, Kolehmainen M, Laaksonen DE, Kekalainen J, Salopuro T, Sivenius K, Pulkkinen L, Mykkanen HM, Niskanen L, Uusitupa M, et al. Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: the FUNGENUT Study. Am J Clin Nutr. 2007;85:1417-27.
36. Bruce SJ, Guy PA, Rezzi S, Ross AB. Quantitative measurement of betaine and free choline in plasma, cereals and cereal products by isotope dilution LC-MS/MS. J Agric Food Chem. 2010;58:2055-61.
37. Bertram HC, Malmendal A, Nielsen NC, Straadt IK, Larsen T, Knudsen KE, Laerke HN. NMR-based metabonomics reveals that plasma betaine increases upon intake of high-fiber rye buns in hypercholesterolemic pigs. Mol Nutr Food Res. 2009;53:1055-62.
38. Delgado-Reyes CV, Garrow TA. High sodium chloride intake decreases betaine-homocysteine S-methyltransferase expression in guinea pig liver and kidney. Am J Physiol Regul Integr Comp Physiol. 2005;288:R182-7.
39. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med. 1991;324:1149-55.
40. Kang SS, Wong PW, Malinow MR. Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annu Rev Nutr. 1992;12: 279-98.
41. Vizzardi E, Bonadei I, Zanini G, Frattini S, Fiorina C, Raddino R, Dei Cas L. Homocysteine and heart failure: an overview. Recent Pat Cardiovasc Drug Discov. 2009;4:15-21.
42. Ratnam S, Wijekoon EP, Hall B, Garrow TA, Brosnan ME, Brosnan JT. Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver. Am J Physiol Endocrinol Metab. 2006; 290:E933-9.
43. Engelke UF, Tangerman A, Willemsen MA, Moskau D, Loss S, Mudd SH, Wevers RA. Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one-dimensional (1)H and two-dimensional (1)H-(13)C NMR. NMR Biomed. 2005;18:331-6.
44. Nilsson AC, Ostman EM, Knudsen KE, Holst JJ, Bjorck IM. A cerealbased evening meal rich in indigestible carbohydrates increases plasma butyrate the next morning. J Nutr. 2010;140:1932-6.
45. Mukherjee P, Sotnikov AV, Mangian HJ, Zhou JR, Visek WJ, Clinton SK. Energy intake and prostate tumor growth, angiogenesis, and vascular endothelial growth factor expression. J Natl Cancer Inst. 1999;91:512-23.
46. Flavin R, Zadra G, Loda M. Metabolic alterations and targeted therapies in prostate cancer. J Pathol. 2011;223:283-94.
47. Mistry T, Digby JE, Desai KM, Randeva HS. Leptin and adiponectin interact in the regulation of prostate cancer cell growth via modulation of p53 and bcl-2 expression. BJU Int. 2008;101:1317-22.
48. Lopez Fontana CM, Maselli ME, Perez Elizalde RF, Di Milta Monaco NA, Uvilla Recupero AL, Lopez Laur JD. Leptin increases prostate cancer aggressiveness. J Physiol Biochem. Epub 2011 May 11.
49. Venkateswaran V, Haddad AQ, Fleshner NE, Fan R, Sugar LM, Nam R, Klotz LH, Pollak M. Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts. J Natl Cancer Inst. 2007;99:1793-800.