-
1
-
-
79960470913
-
MTOR complex 2 signaling and functions
-
PMID:21670596
-
Oh WJ, Jacinto E. mTOR complex 2 signaling and functions. Cell Cycle 2011; 10:2305-16; PMID:21670596; http://dx.doi.org/10.4161/cc.10.14.16586.
-
(2011)
Cell Cycle
, vol.10
, pp. 2305-2316
-
-
Oh, W.J.1
Jacinto, E.2
-
2
-
-
78650510609
-
mTOR: From growth signal integration to cancer, diabetes and ageing
-
PMID:21157483
-
Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12:21-35; PMID:21157483; http://dx.doi.org/10.1038/nrm3025.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
3
-
-
82555166000
-
mTOR signaling in disease
-
PMID:21963299
-
Dazert E, Hall MN. mTOR signaling in disease. Curr Opin Cell Biol 2011; 23:744-55; PMID:21963299; http://dx.doi.org/10.1016/j.ceb.2011.09.003.
-
(2011)
Curr Opin Cell Biol
, vol.23
, pp. 744-755
-
-
Dazert, E.1
Hall, M.N.2
-
4
-
-
79959191028
-
mTOR signaling in protein homeostasis: Less is more?
-
PMID:21555915
-
Conn CS, Qian SB. mTOR signaling in protein homeostasis: less is more? Cell Cycle 2011; 10:1940- 7; PMID:21555915; http://dx.doi.org/10.4161/cc.10.12. 15858.
-
(2011)
Cell Cycle
, vol.10
, pp. 1940-1947
-
-
Conn, C.S.1
Qian, S.B.2
-
5
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
PMID:19587680
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460:392-5; PMID:19587680.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
-
7
-
-
0032512636
-
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
-
PMID:9461583
-
Noda T, Ohsumi Y. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem 1998; 273:3963-6; PMID:9461583; http://dx.doi.org/10.1074/jbc.273.7.3963.
-
(1998)
J Biol Chem
, vol.273
, pp. 3963-3966
-
-
Noda, T.1
Ohsumi, Y.2
-
8
-
-
34249054108
-
Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast
-
PMID:17179073
-
Weisman R, Roitburg I, Schonbrun M, Harari R, Kupiec M. Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast. Genetics 2007; 175:1153-62; PMID:17179073; http://dx.doi.org/10.1534/genetics.106.064170.
-
(2007)
Genetics
, vol.175
, pp. 1153-1162
-
-
Weisman, R.1
Roitburg, I.2
Schonbrun, M.3
Harari, R.4
Kupiec, M.5
-
9
-
-
34147207884
-
Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast
-
PMID:17261596
-
Matsuo T, Otsubo Y, Urano J, Tamanoi F, Yamamoto M. Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. Mol Cell Biol 2007; 27:3154- 64; PMID:17261596; http://dx.doi.org/10.1128/MCB.01039-06.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 3154-3164
-
-
Matsuo, T.1
Otsubo, Y.2
Urano, J.3
Tamanoi, F.4
Yamamoto, M.5
-
10
-
-
0042322370
-
TOR action in mammalian cells and in Caenorhabditis elegans
-
PMID:14560955
-
Long X, Müller F, Avruch J. TOR action in mammalian cells and in Caenorhabditis elegans. Curr Top Microbiol Immunol 2004; 279:115-38; PMID:14560955; http://dx.doi.org/10.1007/978-3-642-18930-2-8.
-
(2004)
Curr Top Microbiol Immunol
, vol.279
, pp. 115-138
-
-
Long, X.1
Müller, F.2
Avruch, J.3
-
11
-
-
4344632329
-
Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans
-
PMID:15155758
-
Meissner B, Boll M, Daniel H, Baumeister R. Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans. J Biol Chem 2004; 279:36739-45; PMID:15155758; http://dx.doi.org/10.1074/jbc. M403415200.
-
(2004)
J Biol Chem
, vol.279
, pp. 36739-36745
-
-
Meissner, B.1
Boll, M.2
Daniel, H.3
Baumeister, R.4
-
12
-
-
0034312315
-
Regulation of cellular growth by the Drosophila target of rapamycin dTOR
-
PMID:11069888
-
Zhang H, Stallock JP, Ng JC, Reinhard C, Neufeld TP. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev 2000; 14:2712- 24; PMID:11069888; http://dx.doi.org/10.1101/ gad.835000.
-
(2000)
Genes Dev
, vol.14
, pp. 2712-2724
-
-
Zhang, H.1
Stallock, J.P.2
Ng, J.C.3
Reinhard, C.4
Neufeld, T.P.5
-
13
-
-
15544376264
-
+in Schizosaccharomyces pombe is sensitive to rapamycin
-
PMID:15466417
-
+ in Schizosaccharomyces pombe is sensitive to rapamycin. Genetics 2005; 169:539-50; PMID:15466417; http://dx.doi.org/10.1534/genetics. 104.034983.
-
(2005)
Genetics
, vol.169
, pp. 539-550
-
-
Weisman, R.1
Roitburg, I.2
Nahari, T.3
Kupiec, M.4
-
14
-
-
35748973557
-
TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases
-
PMID:17952063
-
Petersen J, Nurse P. TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases. Nat Cell Biol 2007; 9:1263-72; PMID:17952063; http://dx.doi.org/10.1038/ncb1646.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1263-1272
-
-
Petersen, J.1
Nurse, P.2
-
15
-
-
84155163063
-
Tor complex 1 controls telomere length by affecting the level of Ku
-
PMID:22169538
-
Ungar L, Harari Y, Toren A, Kupiec M. Tor complex 1 controls telomere length by affecting the level of Ku. Curr Biol 2011; 21:2115-20; PMID:22169538; http://dx.doi.org/10.1016/j.cub.2011.11.024.
-
(2011)
Curr Biol
, vol.21
, pp. 2115-2120
-
-
Ungar, L.1
Harari, Y.2
Toren, A.3
Kupiec, M.4
-
16
-
-
80052325960
-
Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast
-
PMID:21901113
-
Kwan EX, Foss E, Kruglyak L, Bedalov A. Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. PLoS Genet 2011; 7:1002250; PMID:21901113; http://dx.doi.org/10.1371/journal.pgen.1002250.
-
(2011)
PLoS Genet
, vol.7
, pp. 1002250
-
-
Kwan, E.X.1
Foss, E.2
Kruglyak, L.3
Bedalov, A.4
-
17
-
-
47549086947
-
How telomerase reaches its end: Mechanism of telomerase regulation by the telomeric complex
-
PMID:18657499
-
Bianchi A, Shore D. How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex. Mol Cell 2008; 31:153-65; PMID:18657499; http://dx.doi.org/10.1016/j.molcel.2008.06.013.
-
(2008)
Mol Cell
, vol.31
, pp. 153-165
-
-
Bianchi, A.1
Shore, D.2
-
18
-
-
2942532256
-
A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length
-
PMID:15161972
-
Askree SH, Yehuda T, Smolikov S, Gurevich R, Hawk J, Coker C, et al. A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci USA 2004; 101:8658-63; PMID:15161972; http://dx.doi.org/10.1073/pnas.0401263101.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 8658-8663
-
-
Askree, S.H.1
Yehuda, T.2
Smolikov, S.3
Gurevich, R.4
Hawk, J.5
Coker, C.6
-
19
-
-
33645793749
-
Telomere length as a quantitative trait: Genome-wide survey and genetic mapping of telomere length-control genes in yeast
-
PMID:16552446
-
Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, et al. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet 2006; 2:35; PMID:16552446; http://dx.doi.org/10.1371/journal.pgen.0020035.
-
(2006)
PLoS Genet
, vol.2
, pp. 35
-
-
Gatbonton, T.1
Imbesi, M.2
Nelson, M.3
Akey, J.M.4
Ruderfer, D.M.5
Kruglyak, L.6
-
20
-
-
42949168427
-
A systems-level approach to mapping the telomere length maintenance gene circuitry
-
PMID:18319724
-
Shachar R, Ungar L, Kupiec M, Ruppin E, Sharan R. A systems-level approach to mapping the telomere length maintenance gene circuitry. Mol Syst Biol 2008; 4:172; PMID:18319724; http://dx.doi.org/10.1038/msb.2008.13.
-
(2008)
Mol Syst Biol
, vol.4
, pp. 172
-
-
Shachar, R.1
Ungar, L.2
Kupiec, M.3
Ruppin, E.4
Sharan, R.5
-
21
-
-
62549145762
-
Toward accurate reconstruction of functional protein networks
-
PMID:19293828
-
Yosef N, Ungar L, Zalckvar E, Kimchi A, Kupiec M, Ruppin E, et al. Toward accurate reconstruction of functional protein networks. Mol Syst Biol 2009; 5:248; PMID:19293828; http://dx.doi.org/10.1038/msb.2009.3.
-
(2009)
Mol Syst Biol
, vol.5
, pp. 248
-
-
Yosef, N.1
Ungar, L.2
Zalckvar, E.3
Kimchi, A.4
Kupiec, M.5
Ruppin, E.6
-
22
-
-
0033540030
-
The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
-
PMID:10604478
-
Beck T, Hall MN. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 1999; 402:689-92; PMID:10604478; http://dx.doi.org/10.1038/45287.
-
(1999)
Nature
, vol.402
, pp. 689-692
-
-
Beck, T.1
Hall, M.N.2
-
23
-
-
0034640545
-
Nitrogen catabolite repression of DAL80 expression depends on the relative levels of Gat1p and Ure2p production in Saccharomyces cerevisiae
-
PMID:10799523
-
Cunningham TS, Andhare R, Cooper TG. Nitrogen catabolite repression of DAL80 expression depends on the relative levels of Gat1p and Ure2p production in Saccharomyces cerevisiae. J Biol Chem 2000; 275:14408-14; PMID:10799523; http://dx.doi.org/10.1074/jbc.275.19.14408.
-
(2000)
J Biol Chem
, vol.275
, pp. 14408-14414
-
-
Cunningham, T.S.1
Andhare, R.2
Cooper, T.G.3
-
24
-
-
84455192426
-
Nitrogenresponsive regulation of GATA protein family activators Gln3 and Gat1 occurs by two distinct pathways, one inhibited by rapamycin and the other by methionine sulfoximine
-
PMID:22039046
-
Georis I, Tate JJ, Cooper TG, Dubois E. Nitrogenresponsive regulation of GATA protein family activators Gln3 and Gat1 occurs by two distinct pathways, one inhibited by rapamycin and the other by methionine sulfoximine. J Biol Chem 2011; 286:44897- 912; PMID:22039046; http://dx.doi.org/10.1074/jbc.M111.290577.
-
(2011)
J Biol Chem
, vol.286
, pp. 44897-44912
-
-
Georis, I.1
Tate, J.J.2
Cooper, T.G.3
Dubois, E.4
-
25
-
-
0037312507
-
Tor signalling in bugs, brain and brawn
-
PMID:12563289
-
Jacinto E, Hall MN. Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol 2003; 4:117- 26; PMID:12563289; http://dx.doi.org/10.1038/ nrm1018.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 117-126
-
-
Jacinto, E.1
Hall, M.N.2
-
26
-
-
33645092389
-
Differing responses of Gat1 and Gln3 phosphorylation and localization to rapamycin and methionine sulfoximine treatment in Saccharomyces cerevisiae
-
PMID:16487345
-
Kulkarni A, Buford TD, Rai R, Cooper TG. Differing responses of Gat1 and Gln3 phosphorylation and localization to rapamycin and methionine sulfoximine treatment in Saccharomyces cerevisiae. FEMS Yeast Res 2006; 6:218-29; PMID:16487345; http://dx.doi.org/10.1111/j.1567-364.2006.00031.x.
-
(2006)
FEMS Yeast Res
, vol.6
, pp. 218-229
-
-
Kulkarni, A.1
Buford, T.D.2
Rai, R.3
Cooper, T.G.4
-
27
-
-
44049095588
-
Tor pathway control of the nitrogen-responsive DAL5 gene bifurcates at the level of Gln3 and Gat1 regulation in Saccharomyces cerevisiae
-
PMID:18245087
-
Georis I, Tate JJ, Cooper TG, Dubois E. Tor pathway control of the nitrogen-responsive DAL5 gene bifurcates at the level of Gln3 and Gat1 regulation in Saccharomyces cerevisiae. J Biol Chem 2008; 283:8919- 29; PMID:18245087; http://dx.doi.org/10.1074/jbc.M708811200.
-
(2008)
J Biol Chem
, vol.283
, pp. 8919-8929
-
-
Georis, I.1
Tate, J.J.2
Cooper, T.G.3
Dubois, E.4
-
28
-
-
68949145880
-
TOR complex 2 controls gene silencing, telomere length maintenance and survival under DNA-damaging conditions
-
PMID:19546237
-
Schonbrun M, Laor D, López-Maury L, Bähler J, Kupiec M, Weisman R. TOR complex 2 controls gene silencing, telomere length maintenance and survival under DNA-damaging conditions. Mol Cell Biol 2009; 29:4584-94; PMID:19546237; http://dx.doi.org/10.1128/MCB.01879-08.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 4584-4594
-
-
Schonbrun, M.1
Laor, D.2
López-Maury, L.3
Bähler, J.4
Kupiec, M.5
Weisman, R.6
-
29
-
-
0035831446
-
+, is required for the response to starvation and other stresses via a conserved serine
-
PMID:11096119
-
+, is required for the response to starvation and other stresses via a conserved serine. J Biol Chem 2001; 276:7027-32; PMID:11096119; http://dx.doi.org/10.1074/ jbc.M010446200.
-
(2001)
J Biol Chem
, vol.276
, pp. 7027-7032
-
-
Weisman, R.1
Choder, M.2
-
30
-
-
0035006616
-
Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity and high temperature
-
PMID:11409178
-
Kawai M, Nakashima A, Ueno M, Ushimaru T, Aiba K, Doi H, et al. Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity and high temperature. Curr Genet 2001; 39:166-74; PMID:11409178; http://dx.doi.org/10.1007/s002940100198.
-
(2001)
Curr Genet
, vol.39
, pp. 166-174
-
-
Kawai, M.1
Nakashima, A.2
Ueno, M.3
Ushimaru, T.4
Aiba, K.5
Doi, H.6
-
31
-
-
32044445067
-
TORgeting oncogene addiction for cancer therapy
-
PMID:16473275
-
Choo AY, Blenis J. TORgeting oncogene addiction for cancer therapy. Cancer Cell 2006; 9:77- 9; PMID:16473275; http://dx.doi.org/10.1016/j.ccr.2006. 01.021.
-
(2006)
Cancer Cell
, vol.9
, pp. 77-79
-
-
Choo, A.Y.1
Blenis, J.2
-
32
-
-
27744511769
-
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
-
PMID:16293764
-
Kaeberlein M, Powers RW, 3rd, Steffen KK, Westman EA, Hu D, Dang N, et al. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 2005; 310:1193-6; PMID:16293764; http://dx.doi.org/10.1126/ science.1115535.
-
(2005)
Science
, vol.310
, pp. 1193-1196
-
-
Kaeberlein, M.1
Powers III, R.W.2
Steffen, K.K.3
Westman, E.A.4
Hu, D.5
Dang, N.6
-
33
-
-
0642367846
-
Genetics: Influence of TOR kinase on lifespan in C. elegans
-
PMID:14668850
-
Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Müller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 2003; 426:620; PMID:14668850; http://dx.doi.org/10.1038/426620a.
-
(2003)
Nature
, vol.426
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
Müller, F.6
-
34
-
-
70349669095
-
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
-
PMID:19797661
-
Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009; 326:140-4; PMID:19797661; http://dx.doi.org/10.1126/science.1177221.
-
(2009)
Science
, vol.326
, pp. 140-144
-
-
Selman, C.1
Tullet, J.M.2
Wieser, D.3
Irvine, E.4
Lingard, S.J.5
Choudhury, A.I.6
-
35
-
-
0028077099
-
Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age
-
PMID:7937905
-
Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci USA 1994; 91:9857-60; PMID:7937905; http://dx.doi.org/10.1073/pnas.91.21.9857.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 9857-9860
-
-
Vaziri, H.1
Dragowska, W.2
Allsopp, R.C.3
Thomas, T.E.4
Harley, C.B.5
Lansdorp, P.M.6
-
36
-
-
77149141403
-
Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin
-
PMID:20144990
-
Nakashima A, Sato T, Tamanoi F. Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin. J Cell Sci 2010; 123:777- 86; PMID:20144990; http://dx.doi.org/10.1242/jcs.060319.
-
(2010)
J Cell Sci
, vol.123
, pp. 777-786
-
-
Nakashima, A.1
Sato, T.2
Tamanoi, F.3
|