Prevalidation of a human cornea construct as an alternative to animal corneas for in vitro drug absorption studies

Journal of Pharmaceutical Sciences

Volumn 101, Issue 8, 2012, Pages 2976-2988

  Hahne, Matthias ^a   Zorn Kruppa, Michaela ^b   Guzman, Gustavo ^c   Brandner, Johanna M ^b   Haltner Ukomado, Eleonore ^c   Wätzig, Hermann ^a   Reichl, Stephan ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c ACROSS BARRIERS GMBH   (Germany)

Author keywords

Cell culture; Cornea; Drug absorption; In vitro model; Prevalidation; Serum free cultivation

Indexed keywords

ACICLOVIR; AGENTS ACTING ON THE EYE; BIMATOPROST; DEXAMETHASONE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; FLUORESCEIN SODIUM; RHODAMINE B; TIMOLOL MALEATE;

ADULT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; COMPARATIVE STUDY; CORNEA; CORNEA CELL; CORNEA PERMEABILITY; DRUG ABSORPTION; EX VIVO STUDY; EYE IRRITATION; FEMALE; HEMICORNEA; HUMAN; HUMAN CELL; IN VITRO STUDY; MATHEMATICAL ANALYSIS; NONHUMAN; PERMEABILITY BARRIER; RABBIT; REPRODUCIBILITY; SWINE; VALIDATION STUDY; VALIDITY;

EID: 84862896138     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23190     Document Type: Article

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