Overview of paediatric obesity for the paediatric mental health provider

International Review of Psychiatry

Volumn 24, Issue 3, 2012, Pages 231-240

  Scheimann, Ann O ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANOREXIGENIC AGENT; ARIPIPRAZOLE; CLOZAPINE; METFORMIN; OLANZAPINE; QUETIAPINE; RIMONABANT; RISPERIDONE; SIBUTRAMINE; TETRAHYDROLIPSTATIN; THIORIDAZINE; ZIPRASIDONE;

BARIATRIC SURGERY; BIPOLAR DISORDER; BODY COMPOSITION; BODY MASS; CHILDHOOD OBESITY; CLINICAL FEATURE; COMORBIDITY; DRUG MECHANISM; ENDOCRINE DISEASE; FAT MASS AND OBESITY ASSOCIATED GENE; GASTROINTESTINAL DISEASE; GENE; GENE MUTATION; HEALTH CARE PERSONNEL; HEART DISEASE; HUMAN; LIFESTYLE MODIFICATION; LUNG DISEASE; MUSCULOSKELETAL DISEASE; PATHOPHYSIOLOGY; PHYSICAL ACTIVITY; PREVALENCE; PRIORITY JOURNAL; PSEUDOTUMOR; PSEUDOTUMUR CEREBRI; PSYCHOSIS; REVIEW; SIDE EFFECT; SOCIAL PSYCHOLOGY; WEIGHT GAIN;

ADOLESCENT; CHILD; CHILD HEALTH SERVICES; CHILD, PRESCHOOL; HUMANS; OBESITY;

EID: 84862862141     PISSN: 09540261     EISSN: 13691627     Source Type: Journal    
DOI: 10.3109/09540261.2012.678816     Document Type: Review

References (105)

1. Abrams, P. & Levitt Katz, L.E. (2011). Metabolic effects of obesity causing disease in childhood. Current Opinion in Endocrinology, Diabetes, and Obesity, 18, 23-27. doi:10.1097/MED.0b013e 3283424b37
2. Allison, D.B., Mentore, J.L., Heo, M., Chandler, L.P., Cappelleri, J.C., Infante, M.C. & Weiden, P.J. (1999). Antipsychotic-induced weight gain: A comprehensive research synthesis. American Journal of Psychiatry, 156, 1686-1696.
3. American Academy of Pediatrics Committee on Public Education (2001). American Academy of Pediatrics: Children, adolescents, and television. Pediatrics, 107, 423-426.
4. Avenell, A., Brown, T.J., McGee, M.A., Campbell, M.K., Grant, A.M., Broom, J., Smith, W.C. (2004). What are the long-term benefits of weight reducing diets in adults? A systematic review of randomized controlled trials. Journal of Human Nutrition and Dietetics, 17, 317-335. doi:10.1111/j. 1365 - 277X.2004.00531.x
5. Baker, S., Barlow, S., Cochran, W., Fuchs, G., Klish, W., Krebs, N., Udall, J. (2005). Overweight children and adolescents: A clinical report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Journal of Pediatric Gastroenterology and Nutrition, 40, 533-543.
6. Barton M. (2010). Screening for Obesity in Children and Adolescents: US Preventive Services Task Force Recommendation Statement. Pediatrics, 125, 361-7.
7. Baskin, D.G., Wilcox, B.J., Figlewicz, D.P. & Dorsa, D.M. (1988). Insulin and insulin-like growth factors in the CNS. Trends in Neurosciences, 11, 107-111.
8. Batterham, R.L., Cowley, M.A., Small, C.J., Herzog, H., Cohen, M.A., Dakin, C.L., Bloom, S.R. (2002). Gut hormone PYY(3 - 36) physiologically inhibits food intake. Nature, 418, 650-654. doi:10.1038/nature02666
9. Bitar, A., Vermorel, M., Fellmann, N. & Coudert, J. (1995). Twenty-four-hour energy expenditure and its components in prepubertal children as determined by whole-body indirect calorimetry and compared with young adults. American Journal of Clinical Nutrition, 62, 308-315.
10. Bitar, A., Vernet, J., Coudert, J. & Vermorel, M. (2000). Longitudinal changes in body composition, physical capacities and energy expenditure in boys and girls during the onset of puberty. European Journal of Nutrition, 39, 157-163.
11. Blaak, E.E., Saris, W.H. & van Baak, M.A. (1993). Adrenoceptor subtypes mediating catecholamine-induced thermogenesis in man. International Journal of Obesity and Related Metabolic Disorders, 17, S78-81; discussion S82.
12. Black, A.E., Coward, W.A., Cole, T.J. & Prentice, A.M. (1996). Human energy expenditure in affluent societies: An analysis of 574 doubly-labelled water measurements. European Journal of Clinical Nutrition, 50, 72-92.
13. Braet, C., Mervielde, I. & Vandereycken, W. (1997). Psychological aspects of childhood obesity: A controlled study in a clinical and nonclinical sample. Journal of Pediatric Psychology, 22, 59-71.
14. Brooks, L.J. & Topol, H.I. (2003). Enuresis in children with sleep apnea. Journal of Pediatrics, 142, 515-518. doi:10.1067/mpd.2003.158
15. Caterson, I.D., Finer, N., Coutinho, W., Van Gaal, L.F., Maggioni, A.P., Torp-Pedersen, C., &#x;on behalf of the SCOUT Investigators. (2011). Maintained intentional weight loss reduces cardiovascular outcomes: Results from the sibutramine cardiovascular OUTcomes (SCOUT) trial. Diabetes, Obesity & Metabolism, doi:10.1111/j.1463 - 1326.2011.01554.x; 10.1111/j.1463 - 1326.2011.01554.x
16. Chanoine, J.P., Hampl, S., Jensen, C., Boldrin, M. & Hauptman, J. (2005). Effect of orlistat on weight and body composition in obese adolescents: A randomized controlled trial. Journal of the American Medical Association, 29, 2873-2883. doi:10.1001/jama.293.23.2873
17. Colman, E. (2005). Anorectics on trial: A half century of federal regulation of prescription appetite suppressants. Annals of Internal Medicine, 143, 380-385.
18. Cook, S. & Kavey, R.E. (2011). Dyslipidemia and pediatric obesity. Pediatric Clinics of North America, 58, 1363-1373, ix. doi:10.1016/j.pcl.2011. 09.003
19. Cummings, D.E., Purnell, J.Q., Frayo, R.S., Schmidova, K., Wisse, B.E. & Weigle, D.S. (2001). A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes, 50, 1714-1719.
20. Curtin, C., Anderson, S.E., Must, A. & Bandini, L. (2010). The prevalence of obesity in children with autism: A secondary data analysis using nationally representative data from the national survey of children's health. BMC Pediatrics, 10, 11. doi:10.1186/ 1471 - 2431-10-11
21. Davies, P.S. & Lucas, A. (1989). Quetelet's index as a measure of body fatness in young infants. Early Human Development, 20, 135-141.
22. Diabetes Prevention Program Research Group, Knowler, W.C., Fowler, S.E., Hamman, R.F., Christophi, C.A., Hoffman, H.J., Nathan, D.M. (2009). 10-year follow-up of diabetes incidence and weight loss in the diabetes prevention program outcomes study. Lancet, 374, 1677-1686. doi:10.1016/S0140 - 6736 (09)61457-4
23. Donahoo, W.T., Levine, J.A. & Melanson, E.L. (2004). Variability in energy expenditure and its components. Current Opinion in Clinical Nutrition and Metabolic Care, 7, 599-605.
24. Douketis, J.D., Macie, C., Thabane, L. & Williamson, D.F. (2005). Systematic review of long-term weight loss studies in obese adults: Clinical significance and applicability to clinical practice. International Journal of Obesity, 29, 1153-1167. doi:10.1038/sj.ijo.0802982
25. Druce, M.R., Small, C.J. & Bloom, S.R. (2004). Minireview: Gut peptides regulating satiety. Endocrinology, 145, 2660-2665. doi:10.1210/en.2004 - 0089
26. Drucker, D.J. (2005). Biologic actions and therapeutic potential of the proglucagon-derived peptides. Nature: Clinical Practice, Endocrinology & Metabolism, 1, 22-31. doi:10.1038/ncpendmet0017
27. Elmquist, J.K., Ahima, R.S., Elias, C.F., Flier, J.S. & Saper, C.B. (1998). Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proceedings of the National Academy of Sciences of the United States of America, 95, 741-746.
28. Epstein, L.H., Paluch, R.A., Gordy, C.C. & Dorn, J. (2000). Decreasing sedentary behaviors in treating pediatric obesity. Archives of Pediatrics & Adolescent Medicine, 154, 220-226.
29. Farooqi, I.S. & O'Rahilly, S. (2005). New advances in the genetics of early onset obesity. International Journal of Obesity, 29, 1149-1152. doi:10.1038/sj.ijo.0803056
30. Faz, G., Butler, I.J. & Koenig, M.K. (2010). Incidence of papilledema and obesity in children diagnosed with idiopathic 'benign' intracranial hypertension: Case series and review. Journal of Child Neurology, 25, 1389-1392. doi:10.1177/ 0883073810 364853
31. Fennoy, I. (2010). Metabolic and respiratory comorbidities of childhood obesity. Pediatric Annals, 39, 140-146. doi:10.3928/00904481 - 20100223-08; 10.3928/00904481 - 20100223-08
32. Flegal, K.M., Wei, R., Ogden, C.L., Freedman, D.S., Johnson, C.L. & Curtin, L.R. (2009). Characterizing extreme values of body mass index-for-age by using the 2000 centers for disease control and prevention growth charts. The American Journal of Clinical Nutrition, 90, 1314-1320. doi:10.3945/ajcn.2009. 28335
33. Freemark, M. (2010). Childhood obesity and the regulation of growth, thyroid function, sexual development, and calcium homeostasis. In M. Freemark (Ed.), Contemporary Endocrinology: Pediatric Obesity Etiology, Pathogenesis, and Treatment (pp. 155-162), Humana Press.
34. Garland, C.F., Garland, F.C., Gorham, E.D., Lipkin, M., Newmark, H., Mohr, S.B. & Holick, M.F. (2006). The role of vitamin D in cancer prevention. American Journal of Public Health, 96, 252-261. doi:10.2105/AJPH. 2004.045260
35. Gordon, K. (1997). Pediatric pseudotumor cerebri: Descriptive epidemiology. Canadian Journal of Neurological Sciences, 24, 219-221.
36. Gotfredsen, A., Westergren Hendel, H. & Andersen, T. (2001). Influence of orlistat on bone turnover and body composition. International Journal of Obesity and Related Metabolic Disorders, 25, 1154-60.
37. Grimm, E.R. & Steinle, N.I. (2011). Genetics of eating behavior: Established and emerging concepts. Nutrition Reviews, 69, 52-60. doi:10.1111/j.1753 - 4887.2010.00361.x; 10.1111/j. 1753-4887. 2010.00361.x
38. Han, J.C., Lawlor, D.A. & Kimm, S.Y. (2010). Childhood obesity. Lancet, 375, 1737-1748. doi:10.1016/S0140-6736(10) 60171-7
39. Haqq, A.M. (2010). Syndromic obesity. In M. Freemark (Ed.), Contemporary Endocrinology: Pediatric Obesity Etiology, Pathogenesis and Treatment (pp. 47-64), Humana Press.
40. Hellstrom, P.M., Geliebter, A., Naslund, E., Schmidt, P.T., Yahav, E.K., Hashim, S.A. & Yeomans, M.R. (2004). Peripheral and central signals in the control of eating in normal, obese and binge-eating human subjects. British Journal of Nutrition, 92, S47-57.
41. Henry, C.J., Lightowler, H.J. & Strik, C.M. (2007). Effects of long-term intervention with low- and high-glycaemic-index breakfasts on food intake in children aged 8-11 years. British Journal of Nutrition, 98, 636-640. doi:10.1017/S0007114507 727459
42. Herbert, A., Gerry, N.P., McQueen, M.B., Heid, I.M., Pfeufer, A., Illig, T.,Christman, M.F. (2006). A common genetic variant is associated with adult and childhood obesity. Science, 312, 279-283. doi:10.1126/science.1124779
43. Hession, M., Rolland, C., Kulkarni, U., Wise, A. & Broom, J. (2009). Systematic review of randomized controlled trials of low-carbohydrate vs. low-fat/low-calorie diets in the management of obesity and its comorbidities. Obesity Reviews, 10, 36-50. doi:10.1111/j.1467-789X.2008.00518.x
44. Hinney, A. & Hebebrand, J. (2008). Polygenic obesity in humans. Obesity Facts, 1, 35-42. doi:10.1159/000113935
45. Hinney, A. & Hebebrand, J. (2010). Polygenic obesity. In M. Freemark (Ed.), Contemporary Endocrinology: Pediatric Obesity Etio-logy, Pathogenesis and Treatment (pp. 54-73).
46. Holmes, K. W. & Kwiterovich, P. O., Jr. (2005). Treatment of dyslipidemia in children and adolescents. Current Cardiology Reports, 7, 445-456.
47. Huang, Y.S., Guilleminault, C., Li, H.Y., Yang, C.M., Wu, Y.Y. & Chen, N.H. (2007). Attention-deficit/hyperactivity disorder with obstructive sleep apnea: A treatment outcome study. Sleep Medicine, 8, 18-30. doi:10.1016/j.sleep.2006.05.016
48. Ingelfinger, J.R. (2011). Bariatric surgery in adolescents. New England Journal of Medicine, 365, 1365-1367. doi:10.1056/NEJMp1109981
49. Janssen, I., Craig, W.M., Boyce, W.F. & Pickett, W. (2004). Associations between overweight and obesity with bullying behaviors in school-aged children. Pediatrics, 113, 1187-1194.
50. Jin, H., Meyer, J.M. & Jeste, D.V. (2002). Phenomenology of and risk factors for new-onset diabetes mellitus and diabetic ketoacidosis associated with atypical antipsychotics: An analysis of 45 published cases. Annals of Clinical Psychiatry, 14, 59-64.
51. Jorde, R., Sneve, M., Emaus, N., Figenschau, Y. & Grimnes, G. (2010). Cross-sectional and longitudinal relation between serum 25-hydroxyvitamin D and body mass index: The Tromso study. European Journal of Nutrition, 49, 401-407. doi:10.1007/s00394 - 010-0098-7
52. Jorde, R., Sneve, M., Figenschau, Y., Svartberg, J. & Waterloo, K. (2008). Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: Randomized double blind trial. Journal of Internal Medicine, 264, 599-609. doi:10.1111/j.1365 - 2796.2008.02008.x
53. Kim, G. & Caprio, S. (2011). Diabetes and insulin resistance in pediatric obesity. Pediatric Clinics of North America, 58, 1355-1361, ix. doi:10.1016/j.pcl.2011.09.002
54. Kohli, R., Stefater, M.A. & Inge, T.H. (2011). Molecular insights from bariatric surgery. Reviews in Endocrine & Metabolic Disorders, 12, 211-217. doi:10.1007/s11154 - 011-9172 - 6; 10.1007/s11154 - 011-9172-6
55. Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H. & Kangawa, K. (1999). Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402, 656-660. doi:10.1038/45230
56. Lambourne, K. & Donnelly, J.E. (2011). The role of physical acti-vity in pediatric obesity. Pediatric Clinics of North America, 58, 1481-1491, xi-xii. doi:10.1016/j.pcl.2011.09.004
57. Lanningham-Foster, L. & Levine, J.A. (2010). Energy expenditure of children: The role of NEAT. In M. Freemark (Ed.), Contemporary Endocrinology: Pediatric Obesity Etiology, Pathogenesis and Treatment (pp. 137-151)
58. Lee, Y.S. (2009). Consequences of childhood obesity. Annals of the Academy of Medicine, Singapore, 38, 75-77.
59. Levine, J.A. (2007). Nonexercise activity thermogenesis-Liberating the life-force. Journal of Internal Medicine, 262, 273-287. doi:10.1111/j.1365 - 2796.2007.01842.x
60. Lim, J.S., Mietus-Snyder, M., Valente, A., Schwarz, J.M. & Lustig, R.H. (2010). The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome. Nature Reviews. Gastroenterology & Hepatology, 7, 251-264. doi:10.1038/nrgastro.2010.41
61. Ludwig, D.S. (2007). Clinical update: The low-glycaemic-index diet. Lancet, 369, 890-892. doi:10.1016/S0140 - 6736(07) 60427-9
62. Lumeng, J.C., Forrest, P., Appugliese, D.P., Kaciroti, N., Corwyn, R.F. & Bradley, R.H. (2010). Weight status as a predictor of being bullied in third through sixth grades. Pediatrics, 125, e1301-7. doi:10.1542/peds.2009 - 0774
63. Lustig, R.H. (2003). Autonomic dysfunction of the beta-cell and the pathogenesis of obesity. Reviews in Endocrine & Metabolic Disorders, 4, 23-32.
64. Lustig, R.H. (2006). Childhood obesity: Behavioral aberration or biochemical drive? reinterpreting the first law of thermodynamics. Nature Clinical Practice.Endocrinology & Metabolism, 2, 447-458. doi:10.1038/ncpendmet0220
65. Lustig, R.H. (2010). The neuroendocrine control of energy balance. In M. Freemark (Ed.), Contemporary endocrinology: Pediatric obesity etiology, pathogenesis and treatment (pp. 15-32)
66. Maayan, L. & Correll, C.U. (2011). Weight gain and metabolic risks associated with antipsychotic medications in children and adolescents. Journal of Child and Adolescent Psychopharmacology, 21, 517-535. doi:10.1089/cap.2011. 0015
67. Maffeis, C. & Tato, L. (2001). Long-term effects of childhood obesity on morbidity and mortality. Hormone Research, 55, S42-45.
68. Maloney, A.E. (2011). Pediatric obesity: A review for the child psychiatrist. Pediatric Clinics of North America, 58, 955-972, doi:10.1016/j.pcl.2011.06.005
69. Mark, A.L., Rahmouni, K., Correia, M. & Haynes, W.G. (2003). A leptin-sympathetic-leptin feedback loop: Potential implications for regulation of arterial pressure and body fat. Acta Physiologica Scandinavica, 177, 345-349.
70. McIlvenny, S., DeGlume, A., Elewa, M., Fernandez, O. & Dormer, P. (2000). Factors associated with fatigue in a family medicine clinic in the United Arab Emirates. Family Practice, 17, 408-413.
71. Mencin, A.A. & Lavine, J.E. (2011). Advances in pediatric nonalcoholic fatty liver disease. Pediatric Clinics of North America, 58, 1375-1392, x. doi:10.1016/j.pcl.2011.09.005
72. Michalsky, M., Reichard, K., Inge, T., Pratt, J., Lenders, C. & American Society for Metabolic and Bariatric Surgery (2012). ASMBS pediatric committee best practice guidelines. Surgery for Obesity and Related Diseases, 8, 1-7. doi:10.1016/j.soard.2011. 09.009
73. Michelson, P.H., Williams, L.W., Benjamin, D.K. & Barnato, A.E. (2009). Obesity, inflammation, and asthma severity in childhood: Data from the national health and nutrition examination survey 2001-2004. Annals of Allergy, Asthma & Immunology, 103, 381-385. doi:10.1016/S1081 - 1206(10)60356-0
74. Mirza, N.M., Klein, C.J., Palmer, M.G., McCarter, R., He, J., Ebbeling, C.B., Yanovski, J.A. (2011). Effects of high and low glycemic load meals on energy intake, satiety and hunger in obese Hispanic-American youth. International Journal of Pediatric Obesity, 6, e523-531. doi:10.3109/17477166. 2010.544740
75. Molnar, D. & Schutz, Y. (1997). The effect of obesity, age, puberty and gender on resting metabolic rate in children and adolescents. European Journal of Pediatrics, 156, 376-381.
76. Montague, C.T., Farooqi, I.S., Whitehead, J.P., Soos, M.A., Rau, H., Wareham, N.J., O'Rahilly, S. (1997). Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature, 387, 903-908. doi:10.1038/43185
77. Montgomery, C.O., Young, K.L., Austen, M., Jo, C.H., Blasier, R D. & Ilyas, M. (2010). Increased risk of blount disease in obese children and adolescents with vitamin D deficiency. Journal of Pediatric Orthopedics, 30, 879-882. doi:10.1097/BPO.0b013e 3181f5a0b3
78. Morton, G.J., Cummings, D.E., Baskin, D.G., Barsh, G.S. & Schwartz, M.W. (2006). Central nervous system control of food intake and body weight. Nature, 443, 289-295. doi:10.1038/nature05026
79. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004). The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics, 114, 555-576.
80. Niswender, K.D. & Schwartz, M.W. (2003). Insulin and leptin revisited: Adiposity signals with overlapping physiological and intracellular signaling capabilities. Frontiers in Neuroendocrino-logy, 24, 1-10.
81. Ogden, C.L., Carroll, M.D., Curtin, L.R., McDowell, M.A., Tabak, C.J. & Flegal, K.M. (2006). Prevalence of overweight and obesity in the United States, 1999-2004. Journal of the American Medical Association, 295, 1549-1555. doi:10.1001/jama.295.13.1549
82. Pardee, P.E., Norman, G.J., Lustig, R.H., Preud'homme, D. & Schwimmer, J.B. (2007). Television viewing and hypertension in obese children. American Journal of Preventive Medicine, 33, 439-443. doi:10.1016/j.amepre.2007. 07.036
83. Powley, T.L. & Laughton, W. (1981). Neural pathways involved in the hypothalamic integration of autonomic responses. Diabetologia, 20, S378-387.
84. Pratt, J.S., Lenders, C.M., Dionne, E.A., Hoppin, A.G., Hsu, G.L., Inge, T.H., Sanchez, V.M. (2009). Best practice updates for pediatric/adolescent weight loss surgery. Obesity, 17, 901-910. doi:10.1038/oby.2008.577
85. Robinson, S. (2006). Victimization of obese adolescents. Journal of School Nursing, 22, 201-206.
86. Rohner-Jeanrenaud, F. & Jeanrenaud, B. (1985). Involvement of the cholinergic system in insulin and glucagon oversecretion of genetic preobesity. Endocrinology, 116, 830-834.
87. Saunders, C.L., Chiodini, B.D., Sham, P., Lewis, C.M., Abkevich, V., Adeyemo, A.A., Collier, D.A. (2007). Meta-analysis of genome-wide linkage studies in BMIand obesity. Obesity, 15, 2263-2275. doi:10.1038/oby.2007.269
88. Schechter, M.S. & Section on Pediatric Pulmonology, Subcommittee on Obstructive Sleep Apnea Syndrome (2002). Technical report: Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics, 109, e69.
89. Schwimmer, J.B., Burwinkle, T.M. & Varni, J.W. (2003). Health-related quality of life of severely obese children and adolescents. Journal of the American Medical Association, 289, 1813-1819. doi:10.1001/jama.289.14.1813
90. Schwimmer, J.B., Deutsch, R., Kahen, T., Lavine, J.E., Stanley, C. & Behling, C. (2006). Prevalence of fatty liver in children and adolescents. Pediatrics, 118, 1388-1393. doi:10.1542/peds. 2006 - 1212
91. Skelton, J.A., Cook, S.R., Auinger, P., Klein, J.D. & Barlow, S.E. (2009). Prevalence and trends of severe obesity among US children and adolescents. Academic Pediatrics, 9, 322-329. doi:10.1016/j.acap.2009.04.005
92. Sondike, S.B., Kay, G.A. & Emmett, M.K. (2008). Weight loss regimens that control for carbohydrate quality or quantity: A review. Pediatric Diabetes, 9, 33-45. doi:10.1111/j.1399 - 5448. 2007.00312.x
93. Spear, B.A., Barlow, S.E., Ervin, C., Ludwig, D.S., Saelens, B.E., Schetzina, K.E. & Taveras, E.M. (2007). Recommendations for treatment of child and adolescent overweight and obesity. Pediatrics, 120, S254-88. doi:10.1542/peds. 2007 - 2329F
94. Starrenburg, F.C. & Bogers, J.P. (2009). How can antipsychotics cause diabetes mellitus? Insights based on receptor-binding profiles, humoral factors and transporter proteins. European Psychiatry, 24, 164-170. doi:10.1016/j.eurpsy.2009.01.001
95. Stunkard, A.J., Foch, T.T. & Hrubec, Z. (1986). A twin study of human obesity. Journal of the American Medical Association, 256, 51-54.
96. Torgerson, J.S., Hauptman, J., Boldrin, M.N. & Sjostrom, L. (2004). XENical in the prevention of diabetes in obese subjects (XENDOS) study: A randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care, 27, 155-161.
97. Tschritter, O., Preissl, H., Yokoyama, Y., Machicao, F., Haring, H.U. & Fritsche, A. (2007). Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans. Diabetologia, 50, 2602-2603. doi:10.1007/s00125 - 007-0839-1
98. Valoski, A. & Epstein, L.H. (1990). Nutrient intake of obese children in a family-based behavioral weight control program. International Journal of Obesity, 14, 667-677.
99. Varner, A.E. (2000). An immunologic mechanism for the association between obesity and asthma. Archives of Internal Medicine, 160, 2395-2396; author reply 2396-2397.
100. Viguerie, N., Clement, K., Barbe, P., Courtine, M., Benis, A., Larrouy, D., . . . Langin, D. (2004). In vivo epinephrine-mediated regulation of gene expression in human skeletal muscle. Journal of Clinical Endocrinology and Metabolism, 89, 2000-2014.
101. Walley, A.J., Asher, J.E. & Froguel, P. (2009). The genetic contribution to non-syndromic human obesity. Nature Reviews.Genetics, 10, 431-442. doi:10.1038/nrg2594
102. Westerterp, K.R. (2000). Daily physical activity and ageing. Current Opinion in Clinical Nutrition and Metabolic Care, 3, 485-488.
103. Whitaker, R.C. & Orzol, S.M. (2006). Obesity among US urban preschool children: Relationships to race, ethnicity, and socioeconomic status. Archives of Pediatrics & Adolescent Medicine, 160, 578-584. doi:10.1001/archpedi.160. 6.578
104. Xanthakos, S.A. (2009). Nutritional deficiencies in obesity and after bariatric surgery. Pediatric Clinics of North America, 56, 1105-1121. doi:10.1016/j.pcl.2009.07.002
105. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. & Friedman, J.M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature, 372(6505), 425-432. doi:10.1038/372425a0