The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU

Apoptosis

Volumn 16, Issue 12, 2011, Pages 1285-1294

  Kline, Christina Leah B ^a   Irby, Rosalyn B ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

5 FU; Colon cancer; Par 4; Src

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; CELL PROTEIN; FLUOROURACIL; PROSTATE APOPTOSIS RESPONSE PROTEIN 4; PROTEIN 14 3 3; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL NUCLEUS; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT;

14-3-3 PROTEINS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; COLONIC NEOPLASMS; EXONUCLEASES; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SRC-FAMILY KINASES; TUMOR MARKERS, BIOLOGICAL;

EID: 82955214868     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-011-0648-3     Document Type: Article

References (46)

1. A Pohl W Zhang Y Ning PC Manegold G Lurje HJ Lenz 2008 Targeting metastatic colorectal cancer in 2008: a long way from 5-FU Oncology (Williston Park) 22 4 456 462 discussion 62-63, 67-68, 74 passim
2. P Piedbois M Buyse 2008 Endpoints and surrogate endpoints in colorectal cancer: a review of recent developments Curr Opin Oncol 20 4 466 471 18525345 10.1097/CCO.0b013e32830218fe
3. T Shrestha-Bhattarai VM Rangnekar 2010 Cancer-selective apoptotic effects of extracellular and intracellular Par-4 Oncogene 29 27 3873 3880 20440265 10.1038/onc.2010.141 1:CAS:528:DC%2BC3cXlsVyhs7g%3D
4. S Sells D Wood S Joshi-Barve S Muthukamar R Jacob S Crist S Humphreys 1994 Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells Cell Growth Differ 5 457 466 8043520 1:CAS:528:DyaK2cXmslOgsLg%3D (Pubitemid 24251397)
5. Q Guo W Fu J Xie H Luo S Sells J Geddes V Bondada V Rangnekar M Mattson 1998 Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease Nat Med 4 957 962 9701251 10.1038/nm0898-957 1:CAS:528:DyaK1cXltVCju7w%3D (Pubitemid 28364038)
6. A Goswami R Burikhanov A de Thonel N Fujita M Goswami Y Zhao JE Eriksson T Tsuruo VM Rangnekar 2005 Binding and phosphorylation of par-4 by akt is essential for cancer cell survival Mol Cell 20 1 33 44 16209943 10.1016/j.molcel.2005.08.016 1:CAS:528:DC%2BD2MXhtFent7zJ (Pubitemid 41396560)
7. JW Lee KF Lee HY Hsu LP Hsu WL Shih YC Chu WT Hsiao PF Liu 2007 Protein expression and intracellular localization of prostate apoptosis response-4 (Par-4) are associated with apoptosis induction in nasopharyngeal carcinoma cell lines Cancer Lett 257 2 252 262 17881119 10.1016/j.canlet.2007.08.004 1:CAS:528:DC%2BD2sXhtFGkt7bJ (Pubitemid 47538832)
8. S Boehrer K Chow F Beske N Kukoc-Zivojnov E Puccetti M Ruthardt C Baum V Rangnekar D Hoelzer P Mitrou E Weidmann 2002 In lymphatic cells Par-4 sensitizes to apoptosis by down-regulating Bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation Cancer Res 62 1768 1775 11912153 1:CAS:528:DC%2BD38XisVSitro%3D (Pubitemid 34408501)
9. SF Sells SS Han S Muthukkumar N Maddiwar R Johnstone E Boghaert D Gillis G Liu P Nair S Monnig P Collini MP Mattson VP Sukhatme SG Zimmer DP Wood Jr JW McRoberts Y Shi VM Rangnekar 1997 Expression and function of the leucine zipper protein Par-4 in apoptosis Mol Cell Biol 17 7 3823 3832 9199316 1:CAS:528:DyaK2sXktFOnu7k%3D (Pubitemid 27281857)
10. TJ Lee JT Lee SH Kim YH Choi KS Song JW Park TK Kwon 2008 Overexpression of Par-4 enhances thapsigargin-induced apoptosis via down-regulation of XIAP and inactivation of Akt in human renal cancer cells J Cell Biochem 103 2 358 368 18041764 10.1002/jcb.21642 1:CAS:528:DC%2BD1cXhsFOnsr8%3D (Pubitemid 351171908)
11. AS Azmi PA Philip SF Zafar FH Sarkar RM Mohammad 2010 PAR-4 as a possible new target for pancreatic cancer therapy Expert Opin Ther Targets 14 6 611 620 20426700 10.1517/14728222.2010.487066 1:CAS:528:DC%2BC3cXlvVGgsrc%3D
12. AS Azmi Z Wang R Burikhanov VM Rangnekar G Wang J Chen S Wang FH Sarkar RM Mohammad 2008 Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis Mol Cancer Ther 7 9 2884 2893 18790769 10.1158/1535-7163.MCT-08-0438 1:CAS:528:DC%2BD1cXhtFSms7fJ
13. A Franchitto A Torrice R Semeraro C Napoli G Nuzzo F Giuliante G Alpini G Carpino PB Berloco L Izzo A Bolognese P Onori A Renzi A Cantafora E Gaudio D Alvaro 2010 Prostate apoptosis response-4 is expressed in normal cholangiocytes, is down-regulated in human cholangiocarcinoma, and promotes apoptosis of neoplastic cholangiocytes when induced pharmacologically Am J Pathol 177 4 1779 1790 20724592 10.2353/ajpath.2010.091171 1:CAS:528:DC%2BC3cXhsVSqu7nI
14. J Cook S Krishnan S Ananth SF Sells Y Shi MM Walther WM Linehan VP Sukhatme MH Weinstein VM Rangnekar 1999 Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma Oncogene 18 5 1205 1208 10022126 10.1038/sj.onc.1202416 1:CAS:528:DyaK1MXhsVyrsLo%3D (Pubitemid 29085993)
15. PJ Fernandez-Marcos S Abu-Baker J Joshi A Galvez EA Castilla M Canamero M Collado C Saez G Moreno-Bueno J Palacios M Leitges M Serrano J Moscat MT Diaz-Meco 2009 Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma Proc Natl Acad Sci USA 106 31 12962 12967 19470463 10.1073/pnas.0813055106 1:CAS:528: DC%2BD1MXhtVKru77O
16. G Moreno-Bueno PJ Fernandez-Marcos M Collado MJ Tendero SM Rodriguez-Pinilla I Garcia-Cao D Hardisson MT Diaz-Meco J Moscat M Serrano J Palacios 2007 Inactivation of the candidate tumor suppressor par-4 in endometrial cancer Cancer Res 67 5 1927 1934 17332319 10.1158/0008-5472.CAN-06- 2687 1:CAS:528:DC%2BD2sXit12qur8%3D (Pubitemid 46424208)
17. M Saegusa M Hashimura T Kuwata I Okayasu 2010 Transcriptional regulation of pro-apoptotic Par-4 by NF-kappaB/p65 and its function in controlling cell kinetics during early events in endometrial tumourigenesis J Pathol 221 1 26 36 20186924 10.1002/path.2680 1:CAS:528:DC%2BC3cXntFyjs7Y%3D
18. JW Lee PF Liu LP Hsu PR Chen CH Chang WL Shih 2009 EBV LMP-1 negatively regulates expression and pro-apoptotic activity of Par-4 in nasopharyngeal carcinoma cells Cancer Lett 279 2 193 201 19250735 10.1016/j.canlet.2009.01.037 1:CAS:528:DC%2BD1MXls1ylt7Y%3D
19. S Gurumurthy A Goswami KM Vasudevan VM Rangnekar 2005 Phosphorylation of Par-4 by protein kinase A is critical for apoptosis Mol Cell Biol 25 3 1146 1161 15657440 10.1128/MCB.25.3.1146-1161.2005 1:CAS:528:DC%2BD2MXptFyqtQ%3D%3D (Pubitemid 40165820)
20. N El-Guendy Y Zhao S Gurumurthy R Burikhanov V Rangnekar 2003 Identification of a unique core domain of Par-4 sufficient for selective apoptosis induction in cancer cells Mol Cell Biol 23 5516 5525 12897127 10.1128/MCB.23.16.5516-5525.2003 1:CAS:528:DC%2BD3sXmt1Srtr0%3D (Pubitemid 36951320)
21. CL Kline R Jackson R Engelman WJ Pledger TJ Yeatman RB Irby 2008 Src kinase induces tumor formation in the c-SRC C57BL/6 mouse Int J Cancer 122 12 2665 2673 18351644 10.1002/ijc.23445 1:CAS:528:DC%2BD1cXht1eku73J (Pubitemid 351631367)
22. MS Talamonti MS Roh SA Curley GE Gallick 1993 Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer J Clin Invest 91 1 53 60 7678609 10.1172/JCI116200 1:STN:280:DyaK3s7jvFamsQ%3D%3D (Pubitemid 23037252)
23. D Hanahan RA Weinberg 2000 The hallmarks of cancer Cell 100 1 57 70 10647931 10.1016/S0092-8674(00)81683-9 1:CAS:528:DC%2BD3cXks1CktA%3D%3D (Pubitemid 30046295)
24. TC Windham NU Parikh DR Siwak JM Summy DJ McConkey AJ Kraker GE Gallick 2002 Src activation regulates anoikis in human colon tumor cell lines Oncogene 21 51 7797 7807 12420216 10.1038/sj.onc.1205989 1:CAS:528:DC%2BD38XosVektb4%3D (Pubitemid 35398837)
25. VM Golubovskaya S Gross AS Kaur RI Wilson LH Xu XH Yang WG Cance 2003 Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines Mol Cancer Res 1 10 755 764 12939401 1:CAS:528:DC%2BD3sXms1Glu78%3D (Pubitemid 37025594)
26. GJ Griffiths MY Koh VG Brunton C Cawthorne NA Reeves M Greaves MJ Tilby DG Pearson CJ Ottley P Workman MC Frame C Dive 2004 Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis J Biol Chem 279 44 46113 46121 15326164 10.1074/jbc.M408550200 1:CAS:528: DC%2BD2cXovVCntb4%3D (Pubitemid 39491605)
27. T Jiang Y Qiu 2003 Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation J Biol Chem 278 18 15789 15793 12600984 10.1074/jbc.M212525200 1:CAS:528:DC%2BD3sXjt1ehsrk%3D (Pubitemid 36799692)
28. R Chen O Kim J Yang K Sato KM Eisenmann J McCarthy H Chen Y Qiu 2001 Regulation of Akt/PKB activation by tyrosine phosphorylation J Biol Chem 276 34 31858 31862 11445557 10.1074/jbc.C100271200 1:CAS:528:DC%2BD3MXms1SmsLc%3D
29. TO Chan A Tanaka JD Bjorge DJ Fujita 1990 Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src Mol Cell Biol 10 6 3280 3283 2160600 1:CAS:528:DyaK3cXksFKntL0%3D
30. CM Pleiman WM Hertz JC Cambier 1994 Activation of phosphatidylinositol- 3′ kinase by Src-family kinase SH3 binding to the p85 subunit Science 263 5153 1609 1612 8128248 10.1126/science.8128248 1:CAS:528:DyaK2cXksFart70%3D
31. Y Lu Q Yu JH Liu J Zhang H Wang D Koul JS McMurray X Fang WK Yung KA Siminovitch GB Mills 2003 Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades J Biol Chem 278 41 40057 40066 12869565 10.1074/jbc.M303621200 1:CAS:528:DC%2BD3sXnvFamsLs%3D (Pubitemid 37248572)
32. CL Kline SS Shanmugavelandy M Kester RB Irby 2009 Delivery of PAR-4 plasmid in vivo via nanoliposomes sensitizes colon tumor cells subcutaneously implanted into nude mice to 5-FU Cancer Biol Ther 8 19 1831 1837 19729995 10.4161/cbt.8.19.9592 1:CAS:528:DC%2BC3cXnsF2isrk%3D
33. BD Wang CL Kline DM Pastor TL Olson B Frank T Luu AK Sharma G Robertson MT Weirauch SR Patierno JM Stuart RB Irby NH Lee 2010 Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network Mol Cancer 9 98 20433755 10.1186/1476-4598-9-98
34. RB Irby W Mao D Coppola J Kang JM Loubeau W Trudeau R Karl DJ Fujita R Jove TJ Yeatman 1999 Activating SRC mutation in a subset of advanced human colon cancers Nat Genet 21 2 187 190 9988270 10.1038/5971 1:CAS:528: DyaK1MXpsVCksA%3D%3D (Pubitemid 29070364)
35. H Leffers P Madsen HH Rasmussen B Honore AH Andersen E Walbum J Vandekerckhove JE Celis 1993 Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway J Mol Biol 231 4 982 998 8515476 10.1006/jmbi.1993.1346 1:CAS:528:DyaK3sXmtF2rtr8%3D (Pubitemid 23209874)
36. MJ van Hemert M Niemantsverdriet T Schmidt C Backendorf HP Spaink 2004 Isoform-specific differences in rapid nucleocytoplasmic shuttling cause distinct subcellular distributions of 14-3-3 sigma and 14-3-3 zeta J Cell Sci 117 Pt 8 1411 1420 14996909 10.1242/jcs.00990 (Pubitemid 38559817)
37. H Hermeking 2003 The 14-3-3 cancer connection Nat Rev Cancer 3 12 931 943 14737123 10.1038/nrc1230 1:CAS:528:DC%2BD3sXpvFahsbo%3D (Pubitemid 37500178)
38. JE Oh H da Jang H Kim HK Kang CP Chung WH Park BM Min 2009 alpha3beta1 integrin promotes cell survival via multiple interactions between 14-3-3 isoforms and proapoptotic proteins Exp Cell Res 315 18 3187 3200 19683525 10.1016/j.yexcr.2009.08.002 1:CAS:528:DC%2BD1MXht1Ogt7fO
39. D Bridges GB Moorhead 2005 14-3-3 proteins: a number of functions for a numbered protein Sci STKE 2005 296 re10 16091624 10.1126/stke.2962005re10
40. S Basu NF Totty MS Irwin M Sudol J Downward 2003 Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis Mol Cell 11 1 11 23 12535517 10.1016/S1097-2765(02) 00776-1 1:CAS:528:DC%2BD3sXhtFahu74%3D (Pubitemid 36126587)
41. DS Libich M Schwalbe S Kate H Venugopal JK Claridge PJ Edwards K Dutta SM Pascal 2009 Intrinsic disorder and coiled-coil formation in prostate apoptosis response factor 4 FEBS J 276 14 3710 3728 19490121 10.1111/j.1742-4658.2009. 07087.x 1:CAS:528:DC%2BD1MXovV2lsb8%3D
42. JC Obenauer LC Cantley MB Yaffe 2003 Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs Nucleic Acids Res 31 13 3635 3641 12824383 10.1093/nar/gkg584 1:CAS:528: DC%2BD3sXltVWju74%3D (Pubitemid 37442212)
43. SJ Campbell RM Jackson 2003 Diversity in the SH2 domain family phosphotyrosyl peptide binding site Protein Eng 16 3 217 227 12702802 10.1093/proeng/gzg025 1:CAS:528:DC%2BD3sXjsVKltLw%3D (Pubitemid 36565637)
44. P Puntervoll R Linding C Gemund S Chabanis-Davidson M Mattingsdal S Cameron DM Martin G Ausiello B Brannetti A Costantini F Ferre V Maselli A Via G Cesareni F Diella G Superti-Furga L Wyrwicz C Ramu C McGuigan R Gudavalli I Letunic P Bork L Rychlewski B Kuster M Helmer-Citterich WN Hunter R Aasland TJ Gibson 2003 ELM server: a new resource for investigating short functional sites in modular eukaryotic proteins Nucleic Acids Res 31 13 3625 3630 12824381 10.1093/nar/gkg545 1:CAS:528:DC%2BD3sXltVWjt78%3D (Pubitemid 37448491)
45. F Onofri S Giovedi P Vaccaro AJ Czernik F Valtorta P De Camilli P Greengard F Benfenati 1997 Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity Proc Natl Acad Sci USA 94 22 12168 12173 9342381 10.1073/pnas.94.22.12168 1:CAS:528:DyaK2sXntFSmt7c%3D (Pubitemid 27467861)
46. MD Abramoff PJ Magalhaes SJ Ram 2004 Image processing with ImageJ Biophoton Int 11 7 36 42