Inhibitory effect of zinc on the absorption of JBP485 via the gastrointestinal oligopeptide transporter (PEPT1) in rats

Drug Metabolism and Pharmacokinetics

Volumn 26, Issue 5, 2011, Pages 494-502

  Miao, Qi ^a   Liu, Qi ^a   Wang, Changyuan ^a   Meng, Qiang ^a   Guo, Xinjin ^a   Peng, Jinyong ^a   Kaku, Taiichi ^b   Liu, Kexin ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b Japan Bioproducts Industry Co Ltd   (Japan)

Author keywords

JBP485; Pharmacokinetic interaction; Small intestine; Zinc

Indexed keywords

CYCLO 4 LEVO HYDROXYPROLYL SERINE; GASTROINTESTINAL AGENT; JBP 485; MESSENGER RNA; PEPTIDE TRANSPORTER 1; UNCLASSIFIED DRUG; ZINC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BINDING; DRUG BLOOD LEVEL; DRUG INHIBITION; GENE EXPRESSION; HELA CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PH; PLASMA CONCENTRATION-TIME CURVE; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; WESTERN BLOTTING;

EID: 80055096587     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-11-RG-014     Document Type: Article

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