Major role of organic anion transporters in the uptake of phenolsulfonphthalein in the kidney

European Journal of Pharmacology

Volumn 475, Issue 1-3, 2003, Pages 85-92

  Itagaki, Shirou ^a   Sugawara, Mitsuru ^b   Kobayashi, Michiya ^b   Nishimura, Sachiho ^b   Fujimoto, Michio ^b   Miyazaki, Katsumi ^b   Iseki, Ken ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Basolateral membrane; Organic anion transporter 1; Organic anion transporter 3; Phenolsulfonphthalein; Renal uptake; Urinary excretion

Indexed keywords

4 AMINOHIPPURIC ACID; CIMETIDINE; ORGANIC ANION TRANSPORTER; PHENOLSULFONPHTHALEIN; PRAVASTATIN; SALICYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG EXCRETION; DRUG UPTAKE; IC 50; KIDNEY; KIDNEY SLICE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; URINARY EXCRETION;

EID: 0042381908     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(03)02111-3     Document Type: Article

References (31)

1. Abe T., Kakyo M., Tokui T., Nakagomi R., Nishio T., Nakai D., Nomura H., Unno M., Suzuki M., Naitoh T., Matsuno S., Yawo H. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J. Biol. Chem. 274:1999;17159-17163.
2. Adamson R.H., Guarino A.M. The effect of foreign compounds on elasmobranchs and the effect of elasmobranchs on foreign compounds. Comp. Biochem. Physiol. 42A:1972;171-182.
3. Bossuyt X., Muller M., Meier P.J. Multispecific amphipathic substrate transport by an organic anion transporter of human liver. J. Hepatol. 25:1996;733-738.
4. Cha S.H., Sekine T., Fukushima J.I., Kanai Y., Kobayashi Y., Goya T., Endou H. Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol. Pharmacol. 59:2001;1277-1286.
5. Eckhardt U., Schroeder A., Stieger B., Hochli M., Landmann L., Tynes R., Meier P.J., Hagenbuch B. Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. Am. J. Physiol. 276:1999;G1037-G1042.
6. Gault M.H., Koch B., Dossetor J.B. Phenolsulfonphthalein (PSP) in assessment of renal function. J. Am. Med. Assoc. 200:1967;871-873.
7. Hart L.G., Schanker L.S. The chemical forms in which phenol red is secreted into the bile of rats. Proc. Soc. Exp. Biol. Med. 123:1966;433-435.
8. Hasegawa M., Kusuhara H., Sugiyama D., Ito K., Ueda S., Endou H., Sugiyama Y. Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. J. Pharmacol. Exp. Ther. 300:2002;746-753.
9. Hsiang B., Zhu Y., Wang Z., Wu Y., Sasseville V., Yang W.P., Kirchgessner T.G. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J. Biol. Chem. 274:1999;37161-37168.
10. Inui K., Okano T., Takano M., Kitazawa S., Hori R. A simple method for the isolation of basolateral plasma membrane vesicles from rat kidney cortex. Enzyme activities and some properties of glucose transport. Biochim. Biophys. Acta. 647:1981;150-154.
11. Kobayashi M., Iseki K., Saitoh H., Miyazaki K. Uptake characteristics of polyamines into rat intestinal brush-border membrane. Biochim. Biophys. Acta. 1105:1992;177-183.
12. Kusuhara H., Sugiyama Y. Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney. J. Control. Release. 78:2002;43-54.
13. Kusuhara H., Sekine T., Utsunomiya-Tate N., Tsuda M., Kojima R., Cha S.H., Sugiyama Y., Kanai Y., Endou H. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J. Biol. Chem. 274:1999;13675-13680.
14. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
15. Meier P.J., Eckhardt U., Schroeder A., Hagenbuch B., Stieger B. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology. 26:1997;1667-1677.
16. Nagata Y., Kusuhara H., Endou H., Sugiyama Y. Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol. Pharmacol. 61:2002;982-988.
17. Pritchard J.B., Miller D.S. Proximal tubular transport of organic anions and cations. Seldin D.W., Giebisch G. The Kidney: Physiology and Pathophysiology. 1992;2921-2945 Raven Press, New York.
18. Russel F.G.M., Masereeuw R., van Aubel R.A.M.H. Molecular aspects of renal anionic drug transport. Annu. Rev. Physiol. 64:2002;563-594.
19. Sekine T., Watanabe N., Hosoyamada M., Kanai Y., Endou H. Expression cloning and characterization of a novel multispecific organic anion transporter. J. Biol. Chem. 272:1997;18526-18529.
20. Sekine T., Cha S.H., Tsuda M., Apiwattanakul N., Nakajima N., Kanai Y., Endou H. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 429:1998;179-182.
21. Sekine T., Cha S.H., Endou H. The multispecific organic anion transporter (OAT) family. Pflugers Arch. Eur. J. Physiol. 440:2000;337-350.
22. Sheikh M.I. Renal handling of phenol red: I. A comparative study on the accumulation of phenol red and p-aminohippurate in rabbit kidney tubules in vitro. J. Physiol. (Lond.). 227:1972;565-590.
23. + of p-aminohippuric acid uptake into rat renal basolateral membrane vesicles. Am. J. Physiol. 253:1987;F795-F801.
24. Simonson G.D., Vincent A.C., Roberg K.J., Huang Y., Iwanij V. Molecular cloning and characterization of a novel liver-specific transport protein. J. Cell. Sci. 107:1994;1065-1072.
25. Sperber I. Competitive inhibition and specificity of renal tubular transport mechanisms. Arch. Int. Pharmacodyn. 97:1954;221-231.
26. Sugiyama D., Kusuhara H., Shitara Y., Abe T., Meier P.J., Sekine T., Endou H., Suzuki H., Sugiyama Y. Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J. Pharmacol. Exp. Ther. 298:2001;316-322.
27. Sweet D.H., Wolef N.A., Pritchard J.B. Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J. Biol. Chem. 272:1997;30088-30095.
28. + gradient. Am. J. Physiol. 284:2003;F763-F769.
29. Tojo A., Sekine T., Nakajima N., Hosoyamada M., Kanai Y., Endou H. Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. J. Am. Soc. Nephrol. 10:1999;464-471.
30. Urakami Y., Nakamura N., Takahashi K., Okuda M., Saito H., Hashimoto Y., Inui K. Gender differences in expression of organic cation transporter OCT2 in rat kidney. FEBS Lett. 461:1999;339-342.
31. Uwai Y., Okuda M., Takami K., Hashimoto Y., Inui K. Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett. 438:1998;321-324.