Identification of novel HCV RNA-dependent RNA polymerase inhibitors using pharmacophore-guided virtual screening

Chemical Biology and Drug Design

Volumn 72, Issue 6, 2008, Pages 585-591

  Kim, Jinyoung ^a   Kim, Ki Sun ^a   Kim, Dong Eun ^a   Chong, Youhoon ^a  

^a Konkuk University   (South Korea)

Author keywords

3D QSAR; CoMSIA; CScore ; FlexX Pharm; Hepatitis C virus; LeadQuest; Pharmacophore guided docking; UNITY; Virtual screening

Indexed keywords

ANTIVIRUS AGENT; OXOACID; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; RNA DIRECTED RNA POLYMERASE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG SCREENING; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER SIMULATION; DRUG DESIGN; HEPACIVIRUS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RNA REPLICASE;

HEPATITIS C VIRUS;

EID: 56649086404     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2008.00730.x     Document Type: Article

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