Potent bace-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies

BMC Bioinformatics

Volumn 12, Issue SUPPL. 1, 2011, Pages

  John, Shalini ^a   Thangapandian, Sundarapandian ^a   Sakkiah, Sugunadevi ^a   Lee, Keun W ^a  

^a Gyeongsang National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEINS; COMPUTATIONAL APPROACH; CORRELATION COEFFICIENT; ESSENTIAL AMINO ACIDS; EXPERIMENTAL ACTIVITIES; LEAVE-ONE-OUT METHOD; NEURODEGENERATIVE DISORDERS; PHARMACOPHORE MODELING;

AMINO ACIDS; BIOLOGICAL MEMBRANES; CHEMICAL COMPOUNDS; DATABASE SYSTEMS; DIAGNOSIS; GLYCOPROTEINS; GOLD; MOLECULAR MODELING; NEURODEGENERATIVE DISEASES; PEPTIDES; PHARMACODYNAMICS; QUERY PROCESSING; THREE DIMENSIONAL; BIOINFORMATICS;

ENZYME INHIBITION;

AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; ENZYME INHIBITOR; SECRETASE;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; BIOLOGY; CHEMICAL MODEL; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; METABOLISM; METHODOLOGY; STRUCTURE ACTIVITY RELATION;

ALGORITHMS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; COMPUTATIONAL BIOLOGY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79951541046     PISSN: None     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/1471-2105-12-S1-S28     Document Type: Article

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