-
1
-
-
0033571463
-
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
-
H. Ago, T. Adashi, A. Yoshida, M. Yamamoto, N. Habuka, K. Yatsunami, M. Miyano. Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure, 7, 1417 (1999).
-
(1999)
Structure
, vol.7
, pp. 1417
-
-
Ago, H.1
Adashi, T.2
Yoshida, A.3
Yamamoto, M.4
Habuka, N.5
Yatsunami, K.6
Miyano, M.7
-
2
-
-
0036120573
-
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides
-
S. Bressanelli, L. Tomei, F.A. Rey, R. De Francesco. Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides. J. Virol., 76, 3482 (2002).
-
(2002)
J. Virol
, vol.76
, pp. 3482
-
-
Bressanelli, S.1
Tomei, L.2
Rey, F.A.3
De Francesco, R.4
-
3
-
-
0033539482
-
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
-
S. Bressanelli, L. Tomei, A. Roussel, I. Incitti, R.L. Vitale, M. Mathieu, R. De Francesco, F.A. Rey. Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc. Natl. Acad. Sci. USA, 96, 13034 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 13034
-
-
Bressanelli, S.1
Tomei, L.2
Roussel, A.3
Incitti, I.4
Vitale, R.L.5
Mathieu, M.6
De Francesco, R.7
Rey, F.A.8
-
4
-
-
0032876683
-
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
-
C.A. Lesburg, M.B. Cable, E. Ferrari, Z. Hong, A.F. Mannarino, P.C. Weber. Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat. Struct. Biol., 6, 937 (1999).
-
(1999)
Nat. Struct. Biol
, vol.6
, pp. 937
-
-
Lesburg, C.A.1
Cable, M.B.2
Ferrari, E.3
Hong, Z.4
Mannarino, A.F.5
Weber, P.C.6
-
5
-
-
9144238660
-
Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2′-deoxy-2′-fluorocytidine
-
L.J. Stuyver, T.R. McBrayer, T. Whitaker, P.M. Tharnish, M. Ramesh, S. Lostia, L. Cartee, J. Shi, A. Hobbs, R.F. Schinazi, K.A. Watanabe, M.J. Otto. Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2′-deoxy-2′-fluorocytidine. Antimicrob. Agents Chemother., 48, 651 (2004).
-
(2004)
Antimicrob. Agents Chemother
, vol.48
, pp. 651
-
-
Stuyver, L.J.1
McBrayer, T.R.2
Whitaker, T.3
Tharnish, P.M.4
Ramesh, M.5
Lostia, S.6
Cartee, L.7
Shi, J.8
Hobbs, A.9
Schinazi, R.F.10
Watanabe, K.A.11
Otto, M.J.12
-
6
-
-
0141632671
-
Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites
-
L.J. Stuyver, T.R. McBrayer, P.M. Tharnish, A.E. Hassan, C.K. Chu, K.W. Pankiewicw, K.A. Watanabe, R.F. Schinazi, M.J. Otto. Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites. J. Virol., 77, 10689 (2003).
-
(2003)
J. Virol
, vol.77
, pp. 10689
-
-
Stuyver, L.J.1
McBrayer, T.R.2
Tharnish, P.M.3
Hassan, A.E.4
Chu, C.K.5
Pankiewicw, K.W.6
Watanabe, K.A.7
Schinazi, R.F.8
Otto, M.J.9
-
7
-
-
11144355286
-
Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase
-
A.B. Eldrup, C.R. Allerson, C.F. Bennett, S. Bera, B. Bhat, N. Bhat, M.R. Bosserman, J. Brooks, C. Burlein, S.S. Carroll, P.D. Cook, K.L. Getty, M. MacCoss, D.R. McMasters, D.B. Olsen, T.P. Prakash, M. Prhavc, Q. Song, J.E. Tomassini, J. Xia. Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase. J. Med. Chem., 47, 2283 (2004).
-
(2004)
J. Med. Chem
, vol.47
, pp. 2283
-
-
Eldrup, A.B.1
Allerson, C.R.2
Bennett, C.F.3
Bera, S.4
Bhat, B.5
Bhat, N.6
Bosserman, M.R.7
Brooks, J.8
Burlein, C.9
Carroll, S.S.10
Cook, P.D.11
Getty, K.L.12
MacCoss, M.13
McMasters, D.R.14
Olsen, D.B.15
Prakash, T.P.16
Prhavc, M.17
Song, Q.18
Tomassini, J.E.19
Xia, J.20
more..
-
8
-
-
4744364179
-
-
A.B. Eldrup, M. Prhavc, J. Brooks, B. Bhat, T.P. Prakash, Q. Song, S. Bera, N. Bhat, P. Dande, P.D. Cook, C.F. Bennett, S.S. Carroll, R.G. Ball, M. Bosserman, C. Burlein, L.F. Colwell, J.F. Fay, O.A. Flores, K. Getty, R.L. Lafemina, J. Leone, M. MacCoss, D.R. McMasters, J.E. Tomassini, D. VonLangen, B. Wolanski, D.B. Olsen. Structure-activity relationship of heterobase-modified 2′-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication. J. Med. Chem., 47, 5284 (2004).
-
A.B. Eldrup, M. Prhavc, J. Brooks, B. Bhat, T.P. Prakash, Q. Song, S. Bera, N. Bhat, P. Dande, P.D. Cook, C.F. Bennett, S.S. Carroll, R.G. Ball, M. Bosserman, C. Burlein, L.F. Colwell, J.F. Fay, O.A. Flores, K. Getty, R.L. Lafemina, J. Leone, M. MacCoss, D.R. McMasters, J.E. Tomassini, D. VonLangen, B. Wolanski, D.B. Olsen. Structure-activity relationship of heterobase-modified 2′-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication. J. Med. Chem., 47, 5284 (2004).
-
-
-
-
9
-
-
23944469297
-
Design, synthesis, and antiviral activity of 2′-deoxy-2′-fluoro-2′-C-methyl-cytidine, a potent inhibitor of hepatitis C virus replication
-
J.LO. Clark, L. Hollecker, J.C. Mason, L.J. Stuyver, P.M. Tharnish, S. Lostia, T.R. McBrayer, R.F. Schinazi, K.A. Watanabe, M.J. Otto, P.A. Furman, W.J. Stec, S.E. Patterson, K.W. Pankiewicz. Design, synthesis, and antiviral activity of 2′-deoxy-2′-fluoro-2′-C-methyl-cytidine, a potent inhibitor of hepatitis C virus replication. J. Med. Chem., 48, 5504 (2005).
-
(2005)
J. Med. Chem
, vol.48
, pp. 5504
-
-
Clark, J.L.1
Hollecker, L.2
Mason, J.C.3
Stuyver, L.J.4
Tharnish, P.M.5
Lostia, S.6
McBrayer, T.R.7
Schinazi, R.F.8
Watanabe, K.A.9
Otto, M.J.10
Furman, P.A.11
Stec, W.J.12
Patterson, S.E.13
Pankiewicz, K.W.14
-
10
-
-
0347361643
-
Discovery of α, γ-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase
-
V. Summa, A. Petrocchi, P. Pace, V.G. Matassa, R. De Francesco, S. Altamura, L. Tomei, W. Koch, P. Neuner. Discovery of α, γ-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase. J. Med. Chem., 47, 14 (2004).
-
(2004)
J. Med. Chem
, vol.47
, pp. 14
-
-
Summa, V.1
Petrocchi, A.2
Pace, P.3
Matassa, V.G.4
De Francesco, R.5
Altamura, S.6
Tomei, L.7
Koch, W.8
Neuner, P.9
-
11
-
-
49149147973
-
Iterative partial equalization of orbital electronegativity - A rapid access to atomic charges
-
J. Gästeiger, M. Marsili. Iterative partial equalization of orbital electronegativity - A rapid access to atomic charges. Tetrahedron, 36, 3219 (1980).
-
(1980)
Tetrahedron
, vol.36
, pp. 3219
-
-
Gästeiger, J.1
Marsili, M.2
-
12
-
-
33751578897
-
A brief review and table of semiempirical parameters used in the Hückel molecular orbital method
-
W.P. Purcell, J.A. Singer. A brief review and table of semiempirical parameters used in the Hückel molecular orbital method. J. Chem. Eng. Data., 12, 235 (1967).
-
(1967)
J. Chem. Eng. Data
, vol.12
, pp. 235
-
-
Purcell, W.P.1
Singer, J.A.2
-
13
-
-
0020446478
-
Molecular mechanics simulation of protein-ligand interactions: Binding of thyroid hormone analogs to prealbumin
-
J.M. Blaney, P.K. Weiner, A. Dearing, P.A. Kollman, E.C. Jorgensen, S.J. Oatley, J.M. Burridge, C.C.F. Blake. Molecular mechanics simulation of protein-ligand interactions: binding of thyroid hormone analogs to prealbumin. J. Am. Chem. Soc., 104, 6424 (1982).
-
(1982)
J. Am. Chem. Soc
, vol.104
, pp. 6424
-
-
Blaney, J.M.1
Weiner, P.K.2
Dearing, A.3
Kollman, P.A.4
Jorgensen, E.C.5
Oatley, S.J.6
Burridge, J.M.7
Blake, C.C.F.8
-
14
-
-
0001154313
-
Molecular mechanics studies of enzyme-substrate interactions: The interaction of L- and D-N-acetyltryptophanamide with α-chymo-trypsin
-
G. Wipff, A. Dearing, P.K. Weiner, J.M. Blaney, P.A. Kollman. Molecular mechanics studies of enzyme-substrate interactions: the interaction of L- and D-N-acetyltryptophanamide with α-chymo-trypsin. J. Am. Chem. Soc., 105, 997 (1983).
-
(1983)
J. Am. Chem. Soc
, vol.105
, pp. 997
-
-
Wipff, G.1
Dearing, A.2
Weiner, P.K.3
Blaney, J.M.4
Kollman, P.A.5
-
15
-
-
15844407452
-
Conformational analysis of methylphenidate: Comparison of molecular orbital and molecular mechanics methods
-
K.M. Gilbert, W.J. Skawinski, M. Misra, K.A. Paris, N.H. Naik, R.A. Buono, H.M. Deutsch, C.A. Venanzi. Conformational analysis of methylphenidate: comparison of molecular orbital and molecular mechanics methods. J. Comput. Aided Mol. Des., 18, 719 (2004).
-
(2004)
J. Comput. Aided Mol. Des
, vol.18
, pp. 719
-
-
Gilbert, K.M.1
Skawinski, W.J.2
Misra, M.3
Paris, K.A.4
Naik, N.H.5
Buono, R.A.6
Deutsch, H.M.7
Venanzi, C.A.8
-
16
-
-
26444491094
-
Simple but highly effective three-dimensional chemical-feature-based pharmacophore model for diketo acid derivatives as hepatitis C virus RNA-dependent RNA polymerase inhibitors
-
R. Di Santo, M. Fermeglia, M. Ferrone, M.S. Paneni, R. Costi, M. Artico, A. Roux, M. Gabriele, K.D. Tardif, A. Siddiqui, S. Pricl. Simple but highly effective three-dimensional chemical-feature-based pharmacophore model for diketo acid derivatives as hepatitis C virus RNA-dependent RNA polymerase inhibitors. J. Med. Chem., 48, 6304 (2005).
-
(2005)
J. Med. Chem
, vol.48
, pp. 6304
-
-
Di Santo, R.1
Fermeglia, M.2
Ferrone, M.3
Paneni, M.S.4
Costi, R.5
Artico, M.6
Roux, A.7
Gabriele, M.8
Tardif, K.D.9
Siddiqui, A.10
Pricl, S.11
-
17
-
-
33645204275
-
Diketoacid-derivatives as inhibitors of polymerases.
-
PCT Int. Appl, WO 2000006529
-
S. Altamura, L. Tomei, U. Koch, P.J. Neuner, V. Summa. Diketoacid-derivatives as inhibitors of polymerases. PCT Int. Appl., WO 2000006529 (2000).
-
(2000)
-
-
Altamura, S.1
Tomei, L.2
Koch, U.3
Neuner, P.J.4
Summa, V.5
-
18
-
-
0037076324
-
Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes
-
J.A. Grobler, K. Stillmock, B. Hu, M. Witmer, P. Felock, A.S. Espeseth, A. Wolfe, M. Egbertson, M, Bourgeois, J. Melamed. Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes. Proc. Natl. Acad. Sci. USA, 99, 6661 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 6661
-
-
Grobler, J.A.1
Stillmock, K.2
Hu, B.3
Witmer, M.4
Felock, P.5
Espeseth, A.S.6
Wolfe, A.7
Egbertson, M.8
Bourgeois, M.9
Melamed, J.10
-
19
-
-
0037130159
-
Structure activity of 3-aryl-1, 3-diketo-containing compounds as HIV-1 integrase inhibitors
-
G.C. Pais, X. Zhang, C. Marchand, N. Neamati, K. Cowansage, E.S. Svarovskaia, V.K. Pathak, Y. Tang, M. Nicklaus, Y. Pommier. Structure activity of 3-aryl-1, 3-diketo-containing compounds as HIV-1 integrase inhibitors. J. Med. Chem., 45, 3184 (2002).
-
(2002)
J. Med. Chem
, vol.45
, pp. 3184
-
-
Pais, G.C.1
Zhang, X.2
Marchand, C.3
Neamati, N.4
Cowansage, K.5
Svarovskaia, E.S.6
Pathak, V.K.7
Tang, Y.8
Nicklaus, M.9
Pommier, Y.10
-
20
-
-
0036022958
-
Flexible docking under pharmacophore type constraints
-
S.A. Hindle, M. Rarey, C. Buning, T. Lengaue. Flexible docking under pharmacophore type constraints. J. Comput. Aided Mol. Des., 16, 129 (2002).
-
(2002)
J. Comput. Aided Mol. Des
, vol.16
, pp. 129
-
-
Hindle, S.A.1
Rarey, M.2
Buning, C.3
Lengaue, T.4
-
21
-
-
0032573488
-
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
-
H. Huang, R. Chopra, G. Verdine, S.C. Harrison. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science, 282, 1669 (1998).
-
(1998)
Science
, vol.282
, pp. 1669
-
-
Huang, H.1
Chopra, R.2
Verdine, G.3
Harrison, S.C.4
-
22
-
-
0037367315
-
Approaching a new era for hepatitis C virus therapy: Inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase
-
R. De Francesco, L. Tomei, S. Altamura, V. Summa, G. Migliaccio. Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase. Antiviral Res., 58, 1 (2004).
-
(2004)
Antiviral Res
, vol.58
, pp. 1
-
-
De Francesco, R.1
Tomei, L.2
Altamura, S.3
Summa, V.4
Migliaccio, G.5
|