Adenovirus-mediated Aurora a shRNA driven by stathmin promoter suppressed tumor growth and enhanced paclitaxel chemotherapy sensitivity in human breast carcinoma cells

Cancer Gene Therapy

Volumn 19, Issue 4, 2012, Pages 271-281

  Long, M ^a   Yin, G ^b   Liu, L ^a   Lin, F ^a   Wang, X ^a   Ren, J ^a   Wei, J ^a   Dong, K ^a   Zhang, H ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

adenovirus; Aurora A; chemotherapy; short hairpin RNA; stathmin promoter

Indexed keywords

ADENOVIRUS VECTOR; AURORA A KINASE; MESSENGER RNA; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; SHORT HAIRPIN RNA; STATHMIN;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CARCINOMA; BREAST EPITHELIUM; CARCINOMA CELL; CELL PROLIFERATION; CHEMOSENSITIVITY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; TUMOR GROWTH;

ADENOVIRIDAE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BASE SEQUENCE; BREAST NEOPLASMS; CELL CYCLE CHECKPOINTS; CELL LINE; CELL PROLIFERATION; COMBINED MODALITY THERAPY; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE ORDER; GENETIC VECTORS; HUMANS; MICE; MICE, NUDE; PACLITAXEL; PROMOTER REGIONS, GENETIC; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STATHMIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ADENOVIRIDAE;

EID: 84862811264     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2011.89     Document Type: Article

References (35)

1. Beslija S, Bonneterre J, Burstein H, Cocquyt V, Gnant M, Goodwin P et al. Second consensus on medical treatment of metastatic breast cancer. Ann Oncol 2007; 18: 215-225. (Pubitemid 46323085)
2. Biganzoli L, Minisini A, Aapro M, Di Leo A. Chemotherapy for metastatic breast cancer. Curr Opin Obstet Gynecol 2004; 16: 37-41. (Pubitemid 38241540)
3. Glover DM, Leibowitz MH, McLean DA, Parry H. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 1995; 81: 95-105.
4. Andrews PD, Knatko E, Moore WJ, Swedlow JR. Mitotic mechanics: the auroras come into view. Curr Opin Cell Biol 2003; 15: 672-683. (Pubitemid 37487960)
5. Liu XS, Shi Y, Woods KW, Hessler P, Kroeger P, Wilsbacher J et al. Akt inhibitor A-443654 interferes with mitotic progression by regulating Aurora A kinase expression. Neoplasia 2008; 10: 828-837.
6. Marumoto T, Zhang D, Saya H. Aurora-A - a guardian of poles. Nat Rev Cancer 2005; 5: 42-50. (Pubitemid 40052324)
7. Ruchaud S, Carmena M, Earnshaw WC. Chromosomal passengers: conducting cell division. Nat Rev Mol Cell Biol 2007; 8: 798-812. (Pubitemid 47462135)
8. Guan Z, Wang XR, Zhu XF, Huang XF, Xu J, Wang LH et al. Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Cancer Res 2007; 67: 10436-10444. (Pubitemid 350070819)
9. Cammareri P, Scopelliti A, Todaro M, Eterno V, Francescangeli F, Moyer MP et al. Aurora-A is essential for the tumorigenic capacity and chemoresistance of colorectal cancer stem cells. Cancer Res 2010; 70: 4655-4665.
10. Dutta-Simmons J, Zhang Y, Gorgun G, Gatt M, Mani M, Hideshima T et al. Aurora kinase A is a target of Wnt/β-catenin involved in multiple myeloma disease progression. Blood 2009; 114: 2699-2708.
11. Dar A, Laura W, Goff L, Majid S, Berlin J, El-Rifai W. Aurora kinases' inhibitors - rising stars in cancer therapeutics? Mol Cancer Ther 2010; 9: 268.
12. Agnese V, Bazan V, Fiorentino FP, Fanale D, Badalamenti G, Colucci G et al. The role of Aurora-A inhibitors in cancer therapy. Annals Oncol 2007; 18: 47-52.
13. Lin F, Long M, Yan L, Gao P, Wang R, Zhang Y et al. Downregulation of stathmin expression is mediated directly by Egr1 and associated with p53 activity in lung cancer cell line A549. Cell Signal 2010; 22: 166-173.
14. Tong T, Zhong Y, Kong J, Dong L, Song Y, Fu M et al. Overexpression of Aurora-A contributes to malignant development of human esophageal squamous cell carcinoma. Clin Cancer Res 2004; 10: 7304-7310. (Pubitemid 39487719)
15. Kloog I, Stevens RG, Haim A, Portnov BA. Nighttime light level codistributes with breast cancer incidence worldwide. Cancer Causes Control 2010; 21: 2059-2068.
16. Pines J, Rieder CL. Re-staging mitosis: a contemporary view of mitotic progression. Nat Cell Biol 2001; 3: 3-6.
17. Schatten H. The mammalian centrosome and its functional significance. Histochem Cell Biol 2008; 129: 667-686.
18. Morris PG, Fornier MN. Microtubule active agents: beyond the taxane frontier. Clin Cancer Res 2008; 14: 7167-7172.
19. Zhou J, Giannakakou P. Targeting microtubules for cancer chemotherapy. Curr Med Chem Anticancer Agents 2005; 5: 65-71. (Pubitemid 40081295)
20. Jiang Y, Zhang Y, Lees E, Seghezzi W. AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer. Oncogene 2003; 22: 8293-8301. (Pubitemid 37485522)
21. Jantscher F, Pirker C, Mayer CE, Berger W, Sutterluety H. Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities. Mol Cancer 2011; 10: 28.
22. Shang X, Burlingame SM, Okcu MF, Ge N, Russell HV, Egler RA et al. Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma. Mol Cancer Ther 2009; 8: 2461-2469.
23. Yang H, Ou CC, Feldman RI, Nicosia SV, Kruk PA, Cheng JQ. Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells. Cancer Res 2004; 64: 463-467. (Pubitemid 38120883)
24. Keating AK, Kim GK, Jones AE, Donson AM, Ware K, Mulcahy JM et al. Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity. Mol Cancer Ther 2010; 9: 1298-1307.
25. Yao J, Yan M, Guan Z, Pan CB, Xia LP, Li CX et al. Aurora-A down-regulates I kappa B-ávia Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival. Mol Cancer 2009; 8: 95.
26. Yang H, He LL, Kruk P, Nicosia SV, Cheng JQ. Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells. Int J Cancer 2006; 10: 2304-2312. (Pubitemid 44546949)
27. Boss DS, Beijnen JH, Schellens JH. Clinical experience with Aurora kinase inhibitors: a review. Oncologist 2009; 14: 780-793.
28. Ayuk MA, Suttiprapa S, Rinaldi G, Mann VH, Lee CM, Brindley PJ. Schistosoma mansoni U6 gene promoter-driven short hairpin RNA induces RNA interference in human fibrosarcoma cells and schistosomules. Int J Parasitol 2011; 41: 783-789.
29. Nie L, Das TM, Wang Y, Su Q, Zhao Y, Feng Y. Regulation of U6 promoter activity by transcriptional interference in viral vector-based RNAi. Genomics Proteomics Bioinform 2010; 8: 170-179.
30. Dyer V, Ely A, Bloom K, Weinberg M, Arbuthnot P. tRNA Lys3 promoter cassettes that efficiently express RNAi-activating antihepatitis B virus short hairpin RNAs. Biochem Biophys Res Commun 2010; 398: 640-646.
31. Abrahamyan A, Nagy E, Golovan SP. Human H1 promoter expressed short hairpin RNAs (shRNAs) suppress avian influenza virus replication in chicken CH-SAH and canine MDCK cells. Antiviral Res 2009; 84: 159-167.
32. Dong K, Wang R, Wang X, Shen JJ, Lin F, Gao P et al. Tumor-specific RNAi targeting eIF4E suppresses tumor growth, induces apoptosis and enhances cisplatin cytotoxicity in human breast carcinoma cells. Breast Cancer Res Treat 2009; 113: 443-456.
33. Wang R, Wei SH, Lin F, Wang X, Gao P, Dong K et al. Silencing Livin gene expression to inhibit proliferation and enhance chemosensitivity in tumor cells. Cancer Gene Ther 2008; 15: 402-412. (Pubitemid 351693226)
34. Huang XF, Luo SK, Xu J, Li J, Xu DR, Wang LH et al. Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia. Blood 2008; 5: 2854-2865.
35. Ouchi M, Fujiuchi N, Sasai K, Katayama H, Minamishima YA, Ongusaha PP et al. BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem 2004; 279: 19643-19648. (Pubitemid 38623401)