Anesthetic propofol causes glycogen synthase kinase-3β-regulated lysosomal/mitochondrial apoptosis in macrophages

Anesthesiology

Volumn 116, Issue 4, 2012, Pages 868-881

  Hsing, Chung Hsi ^a,b   Chen, Yu Hong ^c   Chen, Chia Ling ^c   Huang, Wei Ching ^c   Lin, Ming Chung ^c   Tseng, Po Chun ^c   Wang, Chi Yun ^c   Tsai, Cheng Chieh ^c,d   Choi, Pui Ching ^c   Lin, Chiou Feng ^c  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE ORANGE; CASPASE; CATHEPSIN B; GLYCOGEN SYNTHASE KINASE 3BETA; LIPOCORTIN 5; PROPIDIUM IODIDE; PROPOFOL; PROTEIN BCL 2; PROTEIN MCL 1; RHODAMINE; SHORT HAIRPIN RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; DRUG OVERDOSE; IN VITRO STUDY; LYSOSOME; MACROPHAGE; MALE; MEMBRANE PERMEABILITY; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; STAPHYLOCOCCUS AUREUS;

ANESTHETICS; ANIMALS; APOPTOSIS; CELL LINE; GLYCOGEN SYNTHASE KINASE 3; HEP G2 CELLS; HUMANS; LYSOSOMES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MITOCHONDRIA; PROPOFOL;

EID: 84862808352     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e31824af68a     Document Type: Article

References (65)

1. Mackenzie N, Grant IS: Propofol for intravenous sedation. Anaesthesia 1987; 42:3-6 (Pubitemid 17218123)
2. Shao H, Li J, Zhou Y, Ge Z, Fan J, Shao Z, Zeng Y: Dose-dependent protective effect of propofol against mitochondrial dysfunction in ischaemic/reperfused rat heart: Role of cardiolipin. Br J Pharmacol 2008; 153:1641-9 (Pubitemid 351536002)
3. Li J, Han B, Ma X, Qi S: The effects of propofol on hippocam1. Mackenzie N, Grant IS: Propofol for intravenous sedation. Anaesthesia 1987; 42:3-6
4. Shao H, Li J, Zhou Y, Ge Z, Fan J, Shao Z, Zeng Y: Dose-dependent protective effect of propofol against mitochondrial dysfunction in ischaemic/reperfused rat heart: Role of cardiolipin. Br J Pharmacol 2008; 153:1641-9 (Pubitemid 351536002)
5. Li J, Han B, Ma X, Qi S: The effects of propofol on hippocampal caspase-3 and Bcl-2 expression following forebrain ischemia- reperfusion in rats. Brain Res 2010; 1356:11-23
6. Karashima Y, Oike M, Takahashi S, Ito Y: Propofol prevents endothelial dysfunction induced by glucose overload. Br J Pharmacol 2002; 137:683-91 (Pubitemid 35333094)
7. Wang B, Luo T, Chen D, Ansley DM: Propofol reduces apoptosis and up-regulates endothelial nitric oxide synthase protein expression in hydrogen peroxide-stimulated human umbilical vein endothelial cells. Anesth Analg 2007; 105: 1027-33
8. Chen J, Gu Y, Shao Z, Luo J, Tan Z: Propofol protects against hydrogen peroxide-induced oxidative stress and cell dysfunction in human umbilical vein endothelial cells. Mol Cell Biochem 2010; 339:43-54
9. Xia Z, Luo T, Liu HM, Wang F, Xia ZY, Irwin MG, Vanhoutte PM: L-arginine enhances nitrative stress and exacerbates tumor necrosis factor-alpha toxicity to human endothelial cells in culture: Prevention by propofol. J Cardiovasc Pharmacol 2010; 55:358-67
10. Marik PE: Propofol: An immunomodulating agent. Pharmacotherapy 2005; 25:28S-33S
11. Chen RM, Chen TG, Chen TL, Lin LL, Chang CC, Chang HC, Wu CH: Anti-inflammatory and antioxidative effects of propofol on lipopolysaccharide- activated macrophages. Ann N Y Acad Sci 2005; 1042:262-71 (Pubitemid 40967647)
12. Takaono M, Yogosawa T, Okawa-Takatsuji M, Aotsuka S: Effects of intravenous anesthetics on interleukin (IL)-6 and IL-10 production by lipopolysaccharide-stimulated mononuclear cells from healthy volunteers. Acta Anaesthesiol Scand 2002; 46:176-9 (Pubitemid 34250780)
13. Taniguchi T, Kanakura H, Takemoto Y, Kidani Y, Yamamoto K: Effects of ketamine and propofol on the ratio of interleukin- 6 to interleukin-10 during endotoxemia in rats. Tohoku J Exp Med 2003; 200:85-92 (Pubitemid 37258804)
14. Rodriguez-Lpez JM, Snchez-Conde P, Lozano FS, Nicols JL, Garcia-Criado FJ, Cascajo C, Muriel C: Laboratory investigation: Effects of propofol on the systemic inflammatory response during aortic surgery. Can J Anaesth 2006; 53:701-10 (Pubitemid 44262827)
15. Heller A, Heller S, Blecken S, Urbaschek R, Koch T: Effects of intravenous anesthetics on bacterial elimination in human blood in vitro. Acta Anaesthesiol Scand 1998; 42:518-26 (Pubitemid 28218472)
16. Vasile B, Rasulo F, Candiani A, Latronico N: The pathophysiology of propofol infusion syndrome: A simple name for a complex syndrome. Intensive Care Med 2003; 29:1417-25 (Pubitemid 37153585)
17. Fudickar A, Bein B: Propofol infusion syndrome: Update of clinical manifestation and pathophysiology. Minerva Anestesiol 2009; 75:339-44
18. Chen RM, Wu CH, Chang HC, Wu GJ, Lin YL, Sheu JR, Chen TL: Propofol suppresses macrophage functions and modulates mitochondrial membrane potential and cellular adenosine triphosphate synthesis. ANESTHESIOLOGY 2003; 98: 1178-85 (Pubitemid 36520205)
19. Tsuchiya M, Asada A, Arita K, Utsumi T, Yoshida T, Sato EF, Utsumi K, Inoue M: Induction and mechanism of apoptotic cell death by propofol in HL-60 cells. Acta Anaesthesiol Scand 2002; 46:1068-74
20. Straiko MM, Young C, Cattano D, Creeley CE, Wang H, Smith DJ, Johnson SA, Li ES, Olney JW: Lithium protects against anesthesia-induced developmental neuroapoptosis. ANESTHESIOLOGY 2009; 110:862-8
21. Ferri KF, Kroemer G: Organelle-specific initiation of cell death pathways. Nat Cell Biol 2001; 3:E255-63
22. Guicciardi ME, Leist M, Gores GJ: Lysosomes in cell death. Oncogene 2004; 23:2881-90 (Pubitemid 38638850)
23. Garrido C, Galluzzi L, Brunet M, Puig PE, Didelot C, Kroemer G: Mechanisms of cytochrome c release from mitochondria. Cell Death Differ 2006; 13:1423-33 (Pubitemid 44210346)
24. Kroemer G, Galluzzi L, Brenner C: Mitochondrial membrane permeabilization in cell death. Physiol Rev 2007; 87:99-163 (Pubitemid 46209992)
25. Kroemer G, Jaattela M: Lysosomes and autophagy in cell death control. Nat Rev Cancer 2005; 5:886-97 (Pubitemid 41746033)
26. Boya P, Kroemer G: Lysosomal membrane permeabilization in cell death. Oncogene 2008; 27:6434-51
27. Chwieralski CE, Welte T, Bhling F: Cathepsin-regulated apoptosis. Apoptosis 2006; 11:143-9 (Pubitemid 43291015)
28. Jttela M, Cand C, Kroemer G: Lysosomes and mitochondria in the commitment to apoptosis: A potential role for cathepsin D and AIF. Cell Death Differ 2004; 11:135-6
29. Pap M, Cooper GM: Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem 1998; 273:19929-32 (Pubitemid 28377539)
30. Jope RS, Johnson GV: The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 2004; 29:95-102 (Pubitemid 38186580)
31. Lin CF, Chen CL, Chiang CW, Jan MS, Huang WC, Lin YS: GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis. J Cell Sci 2007; 120:2935-43
32. Stambolic V, Woodgett JR: Mitogen inactivation of glycogen synthase kinase-3 β in intact cells via serine 9 phosphorylation. Biochem J 1994; 303(Pt 3):701-4 (Pubitemid 24325998)
33. Rayasam GV, Tulasi VK, Sodhi R, Davis JA, Ray A: Glycogen synthase kinase 3: More than a namesake. Br J Pharmacol 2009; 156:885-98
34. Sutherland C, Leighton IA, Cohen P: Inactivation of glycogen synthase kinase-3 beta by phosphorylation: New kinase connections in insulin and growth-factor signalling. Biochem J 1993; 296:15-9 (Pubitemid 23344723)
35. Eldar-Finkelman H, Seger R, Vandenheede JR, Krebs EG: Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/ p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells. J Biol Chem 1995; 270:987-90
36. Wang QM, Fiol CJ, DePaoli-Roach AA, Roach PJ: Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation. J Biol Chem 1994; 269:14566-74
37. Thornton TM, Pedraza-Alva G, Deng B, Wood CD, Aronshtam A, Clements JL, Sabio G, Davis RJ, Matthews DE, Doble B, Rincon M: Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science 2008; 320: 667-70 (Pubitemid 351928349)
38. Bikkavilli RK, Feigin ME, Malbon CC: p38 mitogen-activated protein kinase regulates canonical Wnt-β-catenin signaling by inactivation of GSK3β. J Cell Sci 2008; 121:3598-607
39. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci U S A 1998; 95: 11211-6 (Pubitemid 28450107)
40. Troussard AA, Mawji NM, Ong C, Mui A, St-Arnaud R, Dedhar S: Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem 2003; 278:22374-8 (Pubitemid 36830287)
41. Hartigan JA, Xiong WC, Johnson GV: Glycogen synthase kinase 3beta is tyrosine phosphorylated by PYK2. Biochem Biophys Res Commun 2001; 284:485-9 (Pubitemid 32918003)
42. Beurel E, Jope RS: The paradoxical pro-and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog Neurobiol 2006; 79:173-89 (Pubitemid 44331500)
43. Brewster JL, Linseman DA, Bouchard RJ, Loucks FA, Precht TA, Esch EA, Heidenreich KA: Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase-3 beta and a caspase-9-dependent apoptosis in cerebellar granule neurons. Mol Cell Neurosci 2006; 32:242-53 (Pubitemid 44016066)
44. Huang WC, Lin YS, Wang CY, Tsai CC, Tseng HC, Chen CL, Lu PJ, Chen PS, Qian L, Hong JS, Lin CF: Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells. Immunology 2009; 128:e275-86
45. Linseman DA, Butts BD, Precht TA, Phelps RA, Le SS, Laessig TA, Bouchard RJ, Florez-McClure ML, Heidenreich KA: Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis. J Neurosci 2004; 24:9993-10002 (Pubitemid 39463581)
46. Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR: Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell 2006; 21:749-60 (Pubitemid 43376126)
47. Werneburg NW, Guicciardi ME, Bronk SF, Kaufmann SH, Gores GJ: Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins. J Biol Chem 2007; 282:28960-70 (Pubitemid 47606073)
48. Bivik C, Ollinger K: JNK mediates UVB-induced apoptosis upstream lysosomal membrane permeabilization and Bcl-2 family proteins. Apoptosis 2008; 13:1111-20
49. Wang Y, Huang WC, Wang CY, Tsai CC, Chen CL, Chang YT, Kai JI, Lin CF: Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis. Br J Pharmacol 2009; 157: 1004-13
50. Wang CY, Lin YS, Su WC, Chen CL, Lin CF: Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis. Mol Biol Cell 2009; 20:4153-61
51. Yang-Yen HF: Mcl-1: A highly regulated cell death and survival controller. J Biomed Sci 2006; 13:201-4
52. MacAulay K, Blair AS, Hajduch E, Terashima T, Baba O, Sutherland C, Hundal HS: Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells. J Biol Chem 2005; 280:9509-18 (Pubitemid 40409646)
53. Cantley LC, Neel BG: New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 1999; 96:4240-5 (Pubitemid 29190320)
54. Azar ZM, Mehdi MZ, Srivastava AK: Activation of insulin-like growth factor type-1 receptor is required for H2O2-induced PKB phosphorylation in vascular smooth muscle cells. Can J Physiol Pharmacol 2006; 84:777-86 (Pubitemid 44897898)
55. Takemoto Y: Dose effects of propofol on hemodynamic and cytokine responses to endotoxemia in rats. J Anesth 2005; 19:40-4
56. Hsu BG, Yang FL, Lee RP, Peng TC, Chen HI: Effects of post-treatment with low-dose propofol on inflammatory responses to lipopolysaccharide-induced shock in conscious rats. Clin Exp Pharmacol Physiol 2005; 32:24-9 (Pubitemid 40314465)
57. Brasil LJ, San-Miguel B, Kretzmann NA, Amaral JL, Zettler CG, Marroni N, Gonzlez-Gallego J, Tun MJ: Halothane induces oxidative stress and NF-kappaB activation in rat liver: Protective effect of propofol. Toxicology 2006; 227:53-61 (Pubitemid 44402849)
58. Song XM, Wang YL, Li JG, Wang CY, Zhou Q, Zhang ZZ, Liang H: Effects of propofol on pro-inflammatory cytokines and nuclear factor kappaB during polymicrobial sepsis in rats. Mol Biol Rep 2009; 36:2345-51
59. Jawan B, Kao YH, Goto S, Pan MC, Lin YC, Hsu LW, Nakano T, Lai CY, Sun CK, Cheng YF, Tai MH, Eng HL, Wang CS, Huang CJ, Lin CR, Chen CL: Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-kappaB translocation. Toxicol Appl Pharmacol 2008; 229:362-73
60. Chiu WT, Lin YL, Chou CW, Chen RM: Propofol inhibits lipoteichoic acid-induced iNOS gene expression in macrophages possibly through downregulation of toll-like receptor 2-mediated activation of Raf-MEK1/2-ERK1/2-IKK-NFkappaB. Chem Biol Interact 2009; 181:430-9
61. Diehl AM, Hoek JB: Mitochondrial uncoupling: Role of uncoupling protein anion carriers and relationship to thermogenesis and weight control "the benefits of losing control". J Bioenerg Biomembr 1999; 31:493-506 (Pubitemid 30053962)
62. Ayala A, Chaudry IH: Immune dysfunction in murine polymicrobial sepsis: Mediators, macrophages, lymphocytes and apoptosis. Shock 1996; 6(Suppl 1):S27-38 (Pubitemid 126727793)
63. Turk B, Turk V: Lysosomes as "suicide bags" in cell death: Myth or reality? J Biol Chem 2009; 284:21783-7
64. Blomgran R, Zheng L, Stendahl O: Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress-induced lysosomal membrane permeabilization. J Leukoc Biol 2007; 81:1213-23 (Pubitemid 46702040)
65. Lochhead PA, Kinstrie R, Sibbet G, Rawjee T, Morrice N, Cleghon V: A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation. Mol Cell 2006; 24:627-33 (Pubitemid 350284229)