GSK-3β acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis

Journal of Cell Science

Volumn 120, Issue 16, 2007, Pages 2935-2943

  Lin, Chiou Feng ^a   Chen, Chia Ling ^a   Chiang, Chi Wu ^a   Jan, Ming Shiou ^b   Huang, Wei Ching ^a   Lin, Yee Shin ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Ceramide; GSK 3

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; CASPASE 2; CASPASE 8; CERAMIDE; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN BID; PROTEIN KINASE B; SERINE; SMALL INTERFERING RNA; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; PHOSPHOPROTEIN PHOSPHATASE 2; PPP2R1B PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; DOWNSTREAM PROCESSING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; METABOLISM; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASE 2; CASPASE 8; CELL LINE, TUMOR; CERAMIDES; ENZYME ACTIVATION; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; PROTEIN PHOSPHATASE 2; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 34548568958     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.03473     Document Type: Article

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