Schizandrin prevents damage of murine mesangial cells via blocking NADPH oxidase-induced ROS signaling in high glucose

Food and Chemical Toxicology

Volumn 50, Issue 3-4, 2012, Pages 1045-1053

  Jeong, Seung Il ^a   Kim, Sang Jun ^a   Kwon, Tae Ho ^a   Yu, Kang Yeol ^a   Kim, Seon Young ^a  

^a Jeonju Bio Materials Institute   (South Korea)

Author keywords

Diabetic nephropathy; Murine mesangial cells; NADPH oxidase; Reactive oxygen species; Schizandrin

Indexed keywords

COLLAGEN TYPE 4; FIBRONECTIN; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE SUBUNIT P22PHOX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE SUBUNIT P47PHOX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE SUBUNIT P67PHOX; SCHIZANDRIN; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL DAMAGE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; HYPERGLYCEMIA; MESANGIUM CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; SCHISANDRA CHINENSIS; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE, TRANSFORMED; CELL PROLIFERATION; COLLAGEN TYPE IV; CYCLOOCTANES; FIBRONECTINS; GLOMERULAR MESANGIUM; GLUCOSE; LIGNANS; MAP KINASE SIGNALING SYSTEM; MICE; NADPH OXIDASE; PHOSPHORYLATION; POLYCYCLIC COMPOUNDS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

MURINAE;

EID: 84862803542     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.11.028     Document Type: Article

References (42)

1. Awazu M., Ishikura K., Hida M., Hoshiya M. Mechanisms of mitogen-activated protein kinase activation in experimental diabetes. J. Am. Soc. Nephrol. 1999, 10:738-745.
2. Ayo S.H., Radnik R.A., Garoni J.A., Glass W.F.I.I., Kreisberg J.I. High glucose causes an increase in extracellular matrix proteins in cultured mesangial cells. Am. J. Pathol. 1990, 136:1339-1348.
3. Baumer A.T., Ten F.H., Sauer H., Wartenberg M., Kappert K., Schnabel P., Konkol C., Hescheler J., Vantler M., Rosenkranz S. Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species. J. Biol. Chem. 2008, 283:7864-7876.
4. Bokemeyer D., Sorokin A., Dunn M.J. Multiple intracellular MAP kinase signaling cascades. Kidney Int. 1996, 49:1187-1198.
5. Bokoch G.M., Knaus U.G. NADPH oxidases: not just for leukocytes anymore!. Trends Biochem. Sci. 2003, 28:502-508.
6. Chen H.-C., Tsai J.-C., Tasi J.-H., Lai Y.-H. Recombinant human erythropoietin enhances supersoxide production by FMLP-stimulated polymorphonuclear leukocytes in hemodialysis patients. Kidney Int. 1997, 52:1390-1394.
7. Chiu P.Y., Leung H.Y., Ko K.M. Shisandrin B enhances renal mitochondrial antioxidant status. Functional and structural integrity and protects against gentamicin-induced nephrotoxicity in rats. Biol. Pharm. Bull. 2008, 31:602-605.
8. Danesh F.R., Sadeghi M.M., Amro, Philips N., Zeng C.L., Lin S., Sahai A., Kanwar Y.S. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: implications for diabetic nephropathy. Proc. Natl. Acad. Sci. USA 2002, 99:8301-8305.
9. Esposito F., Chirico G., Gesualdi N.M., Posadas I., Ammendola R., Russo T., Cirino G., Cimino F. Protein kinase B activation by reactive oxygen species is independent of tyrosine kinase receptor phosphorylation and requires src activity. J. Biol. Chem. 2003, 278:20828-20834.
10. Etoh T., Inoguchi T., Kakimoto N., Sonoda N., Kobayashi K., Kuroda J., Sumimoto H., Nawata H. Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibility by interventive insulin treatment. Diabetologia 2003, 46:1428-1437.
11. Fujita H., Omori S., Ishikura K., Hida M., Awazu M. ERK and p38 mediate high-glucose-induced hypertrophy and TGF-β expression in renal tubular cells. Am. J. Physiol. Renal Physiol. 2004, 286:F120-F126.
12. Geiszt M., Kopp J.B., Varnai P., Leto T.L. Identification of renox, an NAD(P)H oxidase in kidney. Proc. Natl Acad. Sci. USA 2000, 97:8010-8014.
13. Gilbert R.E., Cooper M.E. The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury?. Kidney Int. 1999, 56:1627-1637.
14. Gorin Y., Block K., Hernandez J., Bhandari B., Wagner B., Barnes J.L., Abboud H.E. NOX4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. J. Biol. Chem. 2005, 280:39616-39626.
15. Gorin Y., Ricono J.M., Kim N.H., Bhandari B., Choudhury G.G., Abboud H.E. Nox4 mediates angiotensin II-induced activation of AKT/protein kinase B in mesangial cells. Am. J. Physiol. Renal Physiol. 2003, 285:F219-F229.
16. Griendling K.K., Sorescu D., Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ. Res. 2000, 86:494-501.
17. Guo L.Y., Hung T.M., Bae K.H., Shin E.M., Zhou H.Y., Hong Y.N., Kang S.S., Kim H.P., Kim Y.S. Anti-inflammatory effect of schisandrin isolated from the fruit of Shcisandra chinensis Baill. Eur. J. Phramacol. 2008, 591:293-299.
18. Ha H., Lee H.B. Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose. Kidney Int. 2000, 58(suppl. 77):S19-S25.
19. Huang M., Sun H., Liu G.T. Reversal of P-glycoprotein-mediated multidrug resistance of cancer cells by five schizandrins isolated from the chinese herb Fructus Schizandrae. Cancer Chemother. Pharmacol. 2008, 62:1015-1026.
20. Ikeya Y., Taguchi H., Yosioka I., Kobayashi H. The constituents of Schisandra chinensis Baill I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin. Chem. Pharm. Bull. 1979, 27:1383-1394.
21. Ip S.P., Poon M.K., Wu S.S., Che C.T., Ng K.H., Kong Y.C. Effect of schisandrin B on hepatic glutathione antioxidant system in mice. Protection against carbon tetrachloride toxicity. Planta Med. 1995, 61:398-401.
22. Jia H., Qi X., Fang S., Jin Y., Han X., Wang Y., Wang A., Zhou H. Carnosine inhibits high glucose-induced mesangial cell proliferation though mediating cell cycle progression. Regul. Pept. 2009, 154:69-76.
23. Jones S.A., Hancock J.T., Jones O.T., Neubauer A., Topley N. The expression of NADPH oxidase components in human glomerular mesangial cells: detection of protein and mRNA for p47phox, p67phox, and p22phox. J. Am. Soc. Nephrol. 1995, 5:1483-1491.
24. Kang M.J., Wu X., Ly H., Thai K., Scholey J.W. Effect of glucose on stress-activated protein kinase activity in mesangial cells and diabetic glomeruli. Kidney Int. 1999, 55:2203-2214.
25. Kim S.Y., Gul R., Rah S.Y., Kim S.H., Park S.K., Im M.J., Kwon H.J., Kim U.H. Molecular mechanism of ADP-ribosyl cyclase activation in angiotensin II signaling in murine mesangial cells. Am. J. Physiol. Renal Physiol. 2008, 294:F982-F989.
26. Kim S.Y., Park K.H., Gul R., Jang K.Y., Kim U.H. Role of kidney ADP-ribosyl cyclase in diabetic nephroapathy. Am. J. Phyiol. Renal Physiol. 2009, 296:F291-F297.
27. Kitada M., Koya D., Sugimoto T., Isono M., Araki S., Kashiwagi A., Haneda M. Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy. Diabetes 2003, 52:2603-2614.
28. Koyasu S. The role of PI3K in immune cells. Nat. Immunol. 2003, 4:313-319.
29. Lambeth J.D. NOX enzymes and the biology of reactive oxygen. Nat. Rev. Immunol. 2004, 4:181-189.
30. Lee M.Y., Seo C.S., Lee N.H., Ha H., Lee J.A., Lee H., Lee K.Y., Shin H.K. Anti-asthmatic effect of shcizandrin on OVA-induced airway inflammation in a murine asthma model. Int. Immunopharmacol. 2010, 10:1374-1379.
31. Li N.-M., Shah A.M. Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells. J. Biol. Chem. 2002, 277:19952-19960.
32. Onozato M.L., Tojo A., Goto A., Fujita T., Wilcox C.S. Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB. Kidney Int. 2002, 61:186-194.
33. Paravicini T.M., Touyz R.M. NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes Care 2008, 31(suppl. 2):S170-S180.
34. Sedeek M., Callera G., Montezano A., Gutsol A., Heitz C., Szyndralewiez C., Page P., Kennedy C.R.J., Burns D., Touyz R.M., Hébert L. Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy. Am. J. Physiol. Renal Physiol. 2010, 299:F1348-F1358.
35. Seger R., Krebs E.G. The MAPK signaling cascade. FASEB J. 1996, 9:726-735.
36. Sheu M.L., Ho F.M., Chao K.F., Kuo M.L., Liu S.H. Activation of phosphoinositidie 3-kinase in response to high glucose leads to regulation of reactive oxygen species-related nuclear factor-kappaB activation and cyclooxygenanse-2 expression in mesangial cells. Mol. Pharmacol. 2004, 66:187-196.
37. Shiojima I., Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ. Res. 2002, 90:1243-1250.
38. Siow Y.L., Au-Yeung K.K.W., Woo C.W.H., O K. Homocysteine stimulates phosphorylation of NADPH oxidase p47phox and p67phox subunits in monocytes via protein kinase Cβ activation. Biochem. J. 2006, 15:73-82.
39. Sugaru E., Sakai M., Horigome K., Tokunaga T., Kitoh M., Hume W.E., Nagata R., Nakagawa T., Taiji M. SMP-534 inhibits TGF-beta-induced ECM production in fibroblast cells and reduces mesangial matrix accumulation in experimental glomerulonephritis. Am. J. Physiol. Renal Physiol. 2005, 289:F998-F1004.
40. Toker A. Protein kinases as mediators of phosphoinositide 3-kinase signaling. Mol. Pharmacol. 2000, 57:652-658.
41. Wolf G., Schroeder R., Zahner G., Stahl R.A.K., Shankland S.J. High glucose-induced hypertrophy of mesangial cells requires p27Kip1, an inhibitor of cyclin-dependent kinases. Am. J. Pathol. 2001, 158:1091-1100.
42. Yi F., Zhang A.Y., Li N., Muh R.W., Fillet M., Renert A.F., Li P.L. Inhibition of ceramide-redox signaling pathway blocks glomerular injury in hyperhomocysteinemic rats. Kidney Int. 2006, 70:88-96.