Translationally controlled tumour protein is associated with podocyte hypertrophy in a mouse model of type 1 diabetes

Diabetologia

Volumn 55, Issue 4, 2012, Pages 1205-1217

  Kim, D K ^a   Nam, B Y ^b   Li, J J ^c   Park, J T ^b   Lee, S H ^b   Kim, D H ^b   Kim, J Y ^a   Kang, H Y ^b   Han, S H ^b   Yoo, T H ^b   Han, D S ^b   Kang, S W ^b  

^a Seoul National University Hospital   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Department of Internal Medicine   (China)

Author keywords

Diabetic nephropathy; Hypertrophy; Mouse; MTOR complex 1; Podocyte; TCTP

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; GLUCOSE; LENTIVIRUS VECTOR; MESSENGER RNA; STREPTOZOCIN; SYNAPTOPODIN; TRANSLATIONALLY CONTROLLED TUMOR PROTEIN; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL EXPANSION; CELL SIZE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOWN REGULATION; DRUG ACTIVITY; EFFECTOR CELL; GENE SILENCING; GLOMERULUS FILTRATION; HYPERTROPHY; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MESANGIUM CELL; MOUSE; NONHUMAN; PODOCYTE; PODOCYTE HYPERTROPHY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN URINE LEVEL; PROTEINURIA; URINE LEVEL; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; CELL ENLARGEMENT; CYCLIN-DEPENDENT KINASES; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; GENE SILENCING; KIDNEY GLOMERULUS; MALE; MICE; MICROFILAMENT PROTEINS; PODOCYTES; PROTEINS; TUMOR MARKERS, BIOLOGICAL;

EID: 84862802020     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2467-7     Document Type: Article

References (49)

1. Wolf G, Ziyadeh FN (1999) Molecular mechanisms of diabetic renal hypertrophy. Kidney Int 56:393-405
2. Mundel P, Shankland SJ (2002) Podocyte biology and response to injury. J Am Soc Nephrol 13:3005-3015
3. Dalla Vestra M, Masiero A, Roiter AM, Saller A, Crepaldi G, Fioretto P (2003) Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes. Diabetes 52:1031-1035
4. Hudkins KL, Pichaiwong W, Wietecha T et al (2010) BTBR Ob/Ob mutant mice model progressive diabetic nephropathy. J Am Soc Nephrol 21:1533-1542
5. Petermann AT, Pippin J, Durvasula R et al (2005) Mechanical stretch induces podocyte hypertrophy in vitro. Kidney Int 67:157-166
6. Wiggins JE, Goyal M, Sanden SK et al (2005) Podocyte hypertrophy, "adaptation, " and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction. J Am Soc Nephrol 16:2953-2966
7. Herbach N, Schairer I, Blutke A et al (2009) Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis. Am J Physiol Renal Physiol 296:F819-F829
8. Kip1 expression in glucose-stimulated podocytes and in diabetic glomeruli. Kidney Int 67:944-952
9. Mori H, Inoki K, Masutani K et al (2009) The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential. Biochem Biophys Res Commun 384:471-475
10. Godel M, Hartleben B, Herbach N et al (2011) Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest 121:2197-2209
11. Bommer UA, Borovjagin AV, Greagg MA et al (2002) The mRNA of the translationally controlled tumor protein P23/TCTP is a highly structured RNA, which activates the dsRNA-dependent protein kinase PKR. RNA 8:478-496
12. Kim M, Jung J, Lee K (2009) Roles of ERK, PI3 kinase, and PLC-c pathways induced by overexpression of translationally controlled tumor protein in HeLa cells. Arch Biochem Biophys 485:82-87
13. Dong X, Yang B, Li Y, Zhong C, Ding J (2009) Molecular basis of the acceleration of the GDP-GTP exchange of human Rheb by human TCTP. J Biol Chem 284:23754-23764
14. Hsu YC, Chern JJ, Cai Y, Liu M, Choi KW (2007) Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. Nature 445:785-788
15. Dittgen T, Nimmerjahn A, Komai S et al (2004) Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo. Proc Natl Acad Sci USA 101:18206-18211
16. Lois C, Refaeli Y, Qin XF, van Parijs L (2001) Retroviruses as tools to study the immune system. Curr Opin Immunol 13:496-504
17. Bursill CA, McNeill E, Wang L et al (2009) Lentiviral gene transfer to reduce atherosclerosis progression by long-term CC-chemokine inhibition. Gene Ther 16:93-102
18. Fleury S, Simeoni E, Zuppinger C et al (2003) Multiply attenuated, self-inactivating lentiviral vectors efficiently deliver and express genes for extended periods of time in adult rat cardiomyocytes in vivo. Circulation 107:2375-2382
19. El-Aouni C, Herbach N, Blattner SM et al (2006) Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis. J Am Soc Nephrol 17:1334-1344
20. Fiala JC, Harris KM (2001) Extending unbiased stereology of brain ultrastructure to three-dimensional volumes. J Am Med Inform Assoc 8:1-16
21. Ma LJ, Nakamura S, Aldigier JC et al (2005) Regression of glomerulosclerosis with high-dose angiotensin inhibition is linked to decreased plasminogen activator inhibitor-1. J Am Soc Nephrol 16:966-976
22. Rops AL, van der Vlag J, Jacobs CW et al (2004) Isolation and characterization of conditionally immortalized mouse glomerular endothelial cell lines. Kidney Int 66:2193-2201
23. Mundel P, Reiser J, Zuniga Mejia Borja A et al (1997) Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 236:248-258
24. Kim M, Chung J, Lee C et al (2011) A peptide binding to dimer-ized translationally controlled tumor protein modulates allergic reactions. J Mol Med (Berl) 89:603-610
25. Bommer UA, Thiele BJ (2004) The translationally controlled tumour protein (TCTP). Int J Biochem Cell Biol 36:379-385
26. Tessari P, Puricelli L, Iori E et al (2007) Altered chaperone and protein turnover regulators expression in cultured skin fibroblasts from type 1 diabetes mellitus with nephropathy. J Proteome Res 6:976-986
27. LaPointe MS, Batlle D (2001) Cultured skin fibroblasts as an in vitro model to assess phenotypic features in subjects with diabetic nephropathy. Am J Kidney Dis 38:646-648
28. Yoo TH, Li JJ, Kim JJ et al (2007) Activation of the renin-angiotensin system within podocytes in diabetes. Kidney Int 71:1019-1027
29. Ziyadeh FN, Wolf G (2008) Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy. Curr Diabetes Rev 4:39-45
30. Jung J, Kim HY, Kim M, Sohn K, Lee K (2011) Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src. Oncogene 30:2264-2274
31. Laplante M, Sabatini DM (2009) mTOR signaling at a glance. J Cell Sci 122:3589-3594
32. Lee MJ, Feliers D, Mariappan MM et al (2007) A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy. Am J Physiol Renal Physiol 292:F617-F627
33. Lloberas N, Cruzado JM, Franquesa M et al (2006) Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats. J Am Soc Nephrol 17:1395-1404
34. Inoki K, Mori H, Wang J et al (2011) mTORC1 activation in podo-cytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest 121:2181-2196
35. Mahimainathan L, Das F, Venkatesan B, Choudhury GG (2006) Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN. Diabetes 55:2115-2125
36. Wu D, Peng F, Zhang B et al (2009) PKC-beta1 mediates glucose-induced Akt activation and TGF-beta1 upregulation in mesangial cells. J Am Soc Nephrol 20:554-566
37. Xin X, Khan ZA, Chen S, Chakrabarti S (2005) Glucose-induced Akt1 activation mediates fibronectin synthesis in endothelial cells. Diabetologia 48:2428-2436
38. Tejada T, Catanuto P, Ijaz A et al (2008) Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death. Kidney Int 73:1385-1393
39. Coward RJ, Welsh GI, Yang J et al (2005) The human glomerular podocyte is a novel target for insulin action. Diabetes 54:3095-3102
40. Welsh GI, Hale LJ, Eremina V et al (2010) Insulin signaling to the glomerular podocyte is critical for normal kidney function. Cell Metab 12:329-340
41. Sakaguchi M, Isono M, Isshiki K, Sugimoto T, Koya D, Kashiwagi A (2006) Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice. Biochem Biophys Res Commun 340:296-301
42. Hong F, Larrea MD, Doughty C, Kwiatkowski DJ, Squillace R, Slingerland JM (2008) mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol Cell 30:701-711
43. Paternot S, Roger PP (2009) Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation. Cancer Res 69:4577-4581
44. Susini L, Besse S, Duflaut D et al (2008) TCTP protects from apoptotic cell death by antagonizing bax function. Cell Death Differ 15:1211-1220
45. Menini S, Iacobini C, Oddi G et al (2007) Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development of diabetic glomerular disease. Diabetologia 50:2591-2599
46. Advani A, Wiggins KJ, Cox AJ, Zhang Y, Gilbert RE, Kelly DJ (2011) Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy. Nephrology (Carlton) 16:573-581
47. Jung DS, Lee SH, Kwak SJ et al (2011) Apoptosis occurs differentially according to glomerular size in diabetic kidney disease. Nephrol Dial Transplant 2011. doi:10.1093/ndt/gfr301
48. Chen SH, Wu PS, Chou CH et al (2007) A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue-or cell type-specific manner. Mol Biol Cell 18:2525-2532
49. Pasmans SG, Witteman AM, Aalbers M et al (1994) Variability of IgE-dependent histamine-releasing activity in supernatants of human mononuclear cells. Int Arch Allergy Immunol 103:44-52