메뉴 건너뛰기




Volumn 73, Issue 12, 2008, Pages 1385-1393

Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death

Author keywords

AKT; Cell death; Diabetic nephropathy; Insulin signaling; Podocytes

Indexed keywords

INSULIN; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA;

EID: 44449119048     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2008.109     Document Type: Article
Times cited : (139)

References (44)
  • 1
    • 34547467760 scopus 로고    scopus 로고
    • Podocyte biology in diabetic nephropathy
    • Li JJ, Kwak SJ, Jung DS et al. Podocyte biology in diabetic nephropathy. Kidney Int Suppl 2007; 106: S36-S42.
    • (2007) Kidney Int Suppl , vol.106
    • Li, J.J.1    Kwak, S.J.2    Jung, D.S.3
  • 2
    • 20044362239 scopus 로고    scopus 로고
    • From the periphery of the glomerular capillary wall toward the center of disease: Podocyte injury comes of age in diabetic nephropathy
    • Wolf G, Chen S, Ziyadeh FN. From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy. Diabetes 2005; 54: 1626-1634.
    • (2005) Diabetes , vol.54 , pp. 1626-1634
    • Wolf, G.1    Chen, S.2    Ziyadeh, F.N.3
  • 3
    • 0037381607 scopus 로고    scopus 로고
    • Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes
    • Dalla Vestra M, Masiero A, Roiter AM et al. Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes. Diabetes 2003; 52: 1031-1035.
    • (2003) Diabetes , vol.52 , pp. 1031-1035
    • Dalla Vestra, M.1    Masiero, A.2    Roiter, A.M.3
  • 4
    • 0031029379 scopus 로고    scopus 로고
    • Podocyte loss and progressive glomerular injury in type II diabetes
    • Pagtalunan ME, Miller PL, Jumping-Eagle S et al. Podocyte loss and progressive glomerular injury in type II diabetes. J Clin Invest 1997; 99: 342-348.
    • (1997) J Clin Invest , vol.99 , pp. 342-348
    • Pagtalunan, M.E.1    Miller, P.L.2    Jumping-Eagle, S.3
  • 5
    • 0035008793 scopus 로고    scopus 로고
    • Glomerular cell number in normal subjects and in type 1 diabetic patients
    • Steffes MW, Schmidt D, McCrery R et al. Glomerular cell number in normal subjects and in type 1 diabetic patients. Kidney Int 2001; 59: 2104-2113.
    • (2001) Kidney Int , vol.59 , pp. 2104-2113
    • Steffes, M.W.1    Schmidt, D.2    McCrery, R.3
  • 6
    • 2942720686 scopus 로고    scopus 로고
    • Structural alterations to the podocyte are related to proteinuria in type 2 diabetic patients
    • White KE, Bilous RW. Structural alterations to the podocyte are related to proteinuria in type 2 diabetic patients. Nephrol Dial Transplant 2004; 19: 1437-1440.
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 1437-1440
    • White, K.E.1    Bilous, R.W.2
  • 7
    • 0036789206 scopus 로고    scopus 로고
    • Podocyte number in normotensive type 1 diabetic patients with albuminuria
    • White KE, Bilous RW, Marshall SM et al. Podocyte number in normotensive type 1 diabetic patients with albuminuria. Diabetes 2002; 51: 3083-3089.
    • (2002) Diabetes , vol.51 , pp. 3083-3089
    • White, K.E.1    Bilous, R.W.2    Marshall, S.M.3
  • 8
    • 35848951893 scopus 로고    scopus 로고
    • Apoptosis in the kidneys of patients with type II diabetic nephropathy
    • Verzola D, Gandolfo MT, Ferrario F et al. Apoptosis in the kidneys of patients with type II diabetic nephropathy. Kidney Int 2007; 72: 1262-1272.
    • (2007) Kidney Int , vol.72 , pp. 1262-1272
    • Verzola, D.1    Gandolfo, M.T.2    Ferrario, F.3
  • 9
    • 0032710966 scopus 로고    scopus 로고
    • Podocyte number predicts long-term urinary albumin excretion in Pima Indians with type II diabetes and microalbuminuria
    • Meyer TW, Bennett PH, Nelson RG. Podocyte number predicts long-term urinary albumin excretion in Pima Indians with type II diabetes and microalbuminuria. Diabetologia 1999; 42: 1341-1344.
    • (1999) Diabetologia , vol.42 , pp. 1341-1344
    • Meyer, T.W.1    Bennett, P.H.2    Nelson, R.G.3
  • 10
    • 34547611903 scopus 로고    scopus 로고
    • Podocyte detachment and reduced glomerular capillary endothelial fenestration in human type 1 diabetic nephropathy
    • Toyoda M, Najafian B, Kim Y et al. Podocyte detachment and reduced glomerular capillary endothelial fenestration in human type 1 diabetic nephropathy. Diabetes 2007; 56: 2155-2160.
    • (2007) Diabetes , vol.56 , pp. 2155-2160
    • Toyoda, M.1    Najafian, B.2    Kim, Y.3
  • 11
    • 33644783770 scopus 로고    scopus 로고
    • Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy
    • Susztak K, Raff AC, Schiffer M et al. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 2006; 55: 225-233.
    • (2006) Diabetes , vol.55 , pp. 225-233
    • Susztak, K.1    Raff, A.C.2    Schiffer, M.3
  • 12
    • 0034053336 scopus 로고    scopus 로고
    • Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes
    • Koya D, Haneda M, Nakagawa H et al. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J 2000; 14: 439-447.
    • (2000) FASEB J , vol.14 , pp. 439-447
    • Koya, D.1    Haneda, M.2    Nakagawa, H.3
  • 13
    • 27744446645 scopus 로고    scopus 로고
    • Statins prevent oxidized LDL-induced injury of glomerular podocytes by activating the phosphatidylinositol 3-kinase/AKT-signaling pathway
    • Bussolati B, Deregibus MC, Fonsato V et al. Statins prevent oxidized LDL-induced injury of glomerular podocytes by activating the phosphatidylinositol 3-kinase/AKT-signaling pathway. J Am Soc Nephrol 2005; 16: 1936-1947.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1936-1947
    • Bussolati, B.1    Deregibus, M.C.2    Fonsato, V.3
  • 14
    • 34547746055 scopus 로고    scopus 로고
    • Darbepoetin alfa protects podocytes from apoptosis in vitro and in vivo
    • Logar CM, Brinkkoetter PT, Krofft RD et al. Darbepoetin alfa protects podocytes from apoptosis in vitro and in vivo. Kidney Int 2007; 72: 489-498.
    • (2007) Kidney Int , vol.72 , pp. 489-498
    • Logar, C.M.1    Brinkkoetter, P.T.2    Krofft, R.D.3
  • 15
    • 30044444068 scopus 로고    scopus 로고
    • Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling
    • DeAngelis T, Chen J, Wu A et al. Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling. Oncogene 2006; 25: 32-42.
    • (2006) Oncogene , vol.25 , pp. 32-42
    • DeAngelis, T.1    Chen, J.2    Wu, A.3
  • 16
    • 0037053310 scopus 로고    scopus 로고
    • Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigen
    • Lassak A, Del Valle L, Peruzzi F et al. Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigen. J Biol Chem 2002; 277: 17231-17238.
    • (2002) J Biol Chem , vol.277 , pp. 17231-17238
    • Lassak, A.1    Del Valle, L.2    Peruzzi, F.3
  • 17
    • 0030806281 scopus 로고    scopus 로고
    • Alterations in the insulin signaling pathway induced by immortalization and H-ras transformation of brown adipocytes
    • Valverde AM, Lorenzo M, Teruel T et al. Alterations in the insulin signaling pathway induced by immortalization and H-ras transformation of brown adipocytes. Endocrinology 1997; 138: 3195-3206.
    • (1997) Endocrinology , vol.138 , pp. 3195-3206
    • Valverde, A.M.1    Lorenzo, M.2    Teruel, T.3
  • 18
    • 20444487358 scopus 로고    scopus 로고
    • PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes
    • Tang X, Powelka AM, Soriano NA et al. PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes. J Biol Chem 2005; 280: 22523-22529.
    • (2005) J Biol Chem , vol.280 , pp. 22523-22529
    • Tang, X.1    Powelka, A.M.2    Soriano, N.A.3
  • 19
    • 32244446658 scopus 로고    scopus 로고
    • The human glomerular podocyte is a novel target for insulin action
    • Coward RJ, Welsh GI, Yang J et al. The human glomerular podocyte is a novel target for insulin action. Diabetes 2005; 54: 3095-3102.
    • (2005) Diabetes , vol.54 , pp. 3095-3102
    • Coward, R.J.1    Welsh, G.I.2    Yang, J.3
  • 20
    • 33745298554 scopus 로고    scopus 로고
    • Diabetes reduces basal retinal insulin receptor signaling: Reversal with systemic and local insulin
    • Reiter CE, Wu X, Sandirasegarane L et al. Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin. Diabetes 2006; 55: 1148-1156.
    • (2006) Diabetes , vol.55 , pp. 1148-1156
    • Reiter, C.E.1    Wu, X.2    Sandirasegarane, L.3
  • 21
    • 33745311841 scopus 로고    scopus 로고
    • Insulin resistance and microalbuminuria: A cross-sectional, case-control study of 158 patients with type 2 diabetes and different degrees of urinary albumin excretion
    • Parvanova AI, Trevisan R, Iliev IP et al. Insulin resistance and microalbuminuria: a cross-sectional, case-control study of 158 patients with type 2 diabetes and different degrees of urinary albumin excretion. Diabetes 2006; 55: 1456-1462.
    • (2006) Diabetes , vol.55 , pp. 1456-1462
    • Parvanova, A.I.1    Trevisan, R.2    Iliev, I.P.3
  • 24
    • 11144287218 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes
    • Foster RR, Saleem MA, Mathieson PW et al. Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes. Am J Physiol Renal Physiol 2005; 288: F48-F57.
    • (2005) Am J Physiol Renal Physiol , vol.288
    • Foster, R.R.1    Saleem, M.A.2    Mathieson, P.W.3
  • 25
    • 34247471243 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase is required for high glucose-induced hypertrophy and p21WAF1 expression in LLC-PK1 cells
    • Chuang TD, Guh JY, Chiou SJ et al. Phosphoinositide 3-kinase is required for high glucose-induced hypertrophy and p21WAF1 expression in LLC-PK1 cells. Kidney Int 2007; 71: 867-874.
    • (2007) Kidney Int , vol.71 , pp. 867-874
    • Chuang, T.D.1    Guh, J.Y.2    Chiou, S.J.3
  • 26
    • 0034924522 scopus 로고    scopus 로고
    • Activation of renal signaling pathways in db/db mice with type 2 diabetes
    • Feliers D, Duraisamy S, Faulkner JL et al. Activation of renal signaling pathways in db/db mice with type 2 diabetes. Kidney Int 2001; 60: 495-504.
    • (2001) Kidney Int , vol.60 , pp. 495-504
    • Feliers, D.1    Duraisamy, S.2    Faulkner, J.L.3
  • 27
    • 0034091792 scopus 로고    scopus 로고
    • Selective interaction between leptin and insulin signaling pathways in a hepatic cell line
    • Szanto I, Kahn CR. Selective interaction between leptin and insulin signaling pathways in a hepatic cell line. Proc Natl Acad Sci USA 2000; 97: 2355-2360.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2355-2360
    • Szanto, I.1    Kahn, C.R.2
  • 28
    • 30044447631 scopus 로고    scopus 로고
    • Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
    • Morton GJ, Gelling RW, Niswender KD et al. Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab 2005; 2: 411-420.
    • (2005) Cell Metab , vol.2 , pp. 411-420
    • Morton, G.J.1    Gelling, R.W.2    Niswender, K.D.3
  • 29
    • 33745165624 scopus 로고    scopus 로고
    • Low insulin-like growth factor binding protein-2 expression is responsible for increased insulin receptor substrate-1 phosphorylation in mesangial cells from mice susceptible to glomerulosclerosis
    • Fornoni A, Rosenzweig SA, Lenz O et al. Low insulin-like growth factor binding protein-2 expression is responsible for increased insulin receptor substrate-1 phosphorylation in mesangial cells from mice susceptible to glomerulosclerosis. Endocrinology 2006; 147: 3547-3554.
    • (2006) Endocrinology , vol.147 , pp. 3547-3554
    • Fornoni, A.1    Rosenzweig, S.A.2    Lenz, O.3
  • 30
    • 0036066931 scopus 로고    scopus 로고
    • Reversibility of glucose-induced changes in mesangial cell extracellular matrix depends on the genetic background
    • Fornoni A, Striker LJ, Zheng F et al. Reversibility of glucose-induced changes in mesangial cell extracellular matrix depends on the genetic background. Diabetes 2002; 51: 499-505.
    • (2002) Diabetes , vol.51 , pp. 499-505
    • Fornoni, A.1    Striker, L.J.2    Zheng, F.3
  • 31
    • 34047099749 scopus 로고    scopus 로고
    • Nephrin is critical for the action of insulin on human glomerular podocytes
    • Coward RJ, Welsh GI, Koziell A et al. Nephrin is critical for the action of insulin on human glomerular podocytes. Diabetes 2007; 56: 1127-1135.
    • (2007) Diabetes , vol.56 , pp. 1127-1135
    • Coward, R.J.1    Welsh, G.I.2    Koziell, A.3
  • 33
    • 0344305782 scopus 로고    scopus 로고
    • Insulin signaling in health and disease
    • White MF. Insulin signaling in health and disease. Science 2003; 302: 1710-1711.
    • (2003) Science , vol.302 , pp. 1710-1711
    • White, M.F.1
  • 34
    • 34648817335 scopus 로고    scopus 로고
    • Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects
    • Ghanim H, Aljada A, Daoud N et al. Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects. Diabetologia 2007; 50: 278-285.
    • (2007) Diabetologia , vol.50 , pp. 278-285
    • Ghanim, H.1    Aljada, A.2    Daoud, N.3
  • 35
    • 12344288180 scopus 로고    scopus 로고
    • Autocrine activation of the local insulin-like growth factor I system is upregulated by estrogen receptor (ER)-independent estrogen actions and accounts for decreased ER expression in type 2 diabetic mesangial cells
    • Karl M, Potier M, Schulman IH et al. Autocrine activation of the local insulin-like growth factor I system is upregulated by estrogen receptor (ER)-independent estrogen actions and accounts for decreased ER expression in type 2 diabetic mesangial cells. Endocrinology 2005; 146: 889-900.
    • (2005) Endocrinology , vol.146 , pp. 889-900
    • Karl, M.1    Potier, M.2    Schulman, I.H.3
  • 36
    • 0038623780 scopus 로고    scopus 로고
    • Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes
    • Foster RR, Hole R, Anderson K et al. Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes. Am J Physiol Renal Physiol 2003; 284: F1263-F1273.
    • (2003) Am J Physiol Renal Physiol , vol.284
    • Foster, R.R.1    Hole, R.2    Anderson, K.3
  • 37
    • 0038748305 scopus 로고    scopus 로고
    • Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: Relationship with diabetic nephropathy
    • Moriwaki Y, Yamamoto T, Shibutani Y et al. Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy. Metabolism 2003; 52: 605-608.
    • (2003) Metabolism , vol.52 , pp. 605-608
    • Moriwaki, Y.1    Yamamoto, T.2    Shibutani, Y.3
  • 38
    • 33751350541 scopus 로고    scopus 로고
    • The role of TNF-alpha in diabetic nephropathy: Pathogenic and therapeutic implications
    • Navarro JF, Mora-Fernandez C. The role of TNF-alpha in diabetic nephropathy: pathogenic and therapeutic implications. Cytokine Growth Factor Rev 2006; 17: 441-450.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 441-450
    • Navarro, J.F.1    Mora-Fernandez, C.2
  • 39
    • 34249017571 scopus 로고    scopus 로고
    • Renal p38 MAP kinase activity in experimental diabetes
    • Komers R, Lindsley JN, Oyama TT et al. Renal p38 MAP kinase activity in experimental diabetes. Lab Invest 2007; 87: 548-558.
    • (2007) Lab Invest , vol.87 , pp. 548-558
    • Komers, R.1    Lindsley, J.N.2    Oyama, T.T.3
  • 40
    • 33845526226 scopus 로고    scopus 로고
    • Modular activation of nuclear factor-kappaB transcriptional programs in human diabetic nephropathy
    • Schmid H, Boucherot A, Yasuda Y et al. Modular activation of nuclear factor-kappaB transcriptional programs in human diabetic nephropathy. Diabetes 2006; 55: 2993-3003.
    • (2006) Diabetes , vol.55 , pp. 2993-3003
    • Schmid, H.1    Boucherot, A.2    Yasuda, Y.3
  • 41
    • 33845252957 scopus 로고    scopus 로고
    • Puromycin aminonucleoside induces oxidant-dependent DNA damage in podocytes in vitro and in vivo
    • Marshall CB, Pippin JW, Krofft RD et al. Puromycin aminonucleoside induces oxidant-dependent DNA damage in podocytes in vitro and in vivo. Kidney Int 2006; 70: 1962-1973.
    • (2006) Kidney Int , vol.70 , pp. 1962-1973
    • Marshall, C.B.1    Pippin, J.W.2    Krofft, R.D.3
  • 42
    • 33646686362 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonist is protective in podocyte injury-associated sclerosis
    • Yang HC, Ma LJ, Ma J et al. Peroxisome proliferator-activated receptor-gamma agonist is protective in podocyte injury-associated sclerosis. Kidney Int 2006; 69: 1756-1764.
    • (2006) Kidney Int , vol.69 , pp. 1756-1764
    • Yang, H.C.1    Ma, L.J.2    Ma, J.3
  • 43
    • 33746371464 scopus 로고    scopus 로고
    • Protection of the kidney by thiazolidinediones: An assessment from bench to bedside
    • Sarafidis PA, Bakris GL. Protection of the kidney by thiazolidinediones: an assessment from bench to bedside. Kidney Int 2006; 70: 1223-1233.
    • (2006) Kidney Int , vol.70 , pp. 1223-1233
    • Sarafidis, P.A.1    Bakris, G.L.2
  • 44
    • 40749119800 scopus 로고    scopus 로고
    • Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment
    • Hojlund K, Glintborg D, Andersen NR et al. Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment. Diabetes 2007; 57: 357-366.
    • (2007) Diabetes , vol.57 , pp. 357-366
    • Hojlund, K.1    Glintborg, D.2    Andersen, N.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.