Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma

International Immunopharmacology

Volumn 12, Issue 4, 2012, Pages 666-674

  Jang, Ha Young ^a   Ahn, Kyung Seop ^a   Park, Mi Jeong ^a   Kwon, Ok Kyoung ^a   Lee, Hyeong Kyu ^a   Oh, Sei Ryang ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Asthma; Scutellaria baicalensis Georgi; Skullcapflavone II

Indexed keywords

BRADYKININ ANTAGONIST; DEXAMETHASONE; MONTELUKAST; OVALBUMIN; SCUTELLARIA BAICALENSIS EXTRACT; SKULLCAPFLAVONE II; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL HYPERPLASIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHILIA; FEMALE; GOBLET CELL; INFLAMMATION; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TH2 CELL;

ALANINE TRANSAMINASE; ALLERGENS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASPARTATE AMINOTRANSFERASES; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; COLLAGEN; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; FLAVONOIDS; IMMUNOGLOBULIN E; MICE; MICE, INBRED BALB C; OVALBUMIN; PNEUMONIA; SMAD PROTEINS;

EID: 84862799761     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.01.010     Document Type: Article

References (40)

1. J.A. Elias, C.G. Lee, T. Zheng, B. Ma, R.J. Homer, and Z. Zhu New insights into the pathogenesis of asthma J Clin Invest 111 2003 291 297 (Pubitemid 36182201)
2. P.J. Barnes Cytokines as mediators of chronic asthma Am J Respir Crit 150 1994 42 49
3. R. Pawankar Epithelial cells as immunoregulators in allergic airway diseases Curr Opin Allergy Clin Immunol 2 2002 1 5 (Pubitemid 34269863)
4. C.J. Corrigan, and A.B. Kay T cells and eosinophils in the pathogenesis of asthma Immunol Today 13 1992 501 507
5. H. Renz, K. Bradley, J. Saloga, J. Loader, G.L. Larsen, and E.W. Gelfand T cells expressing specific Vβ elements regulate immunoglobulin E production and airways responsiveness in vivo J Exp Med 177 1993 1175 1180 (Pubitemid 23097406)
6. I. Iwamoto, H. Nakajima, H. Endo, and S. Yoshida Interferon-γ regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4 + T cells J Exp Med 177 1993 573 576 (Pubitemid 23117112)
7. J. Punnonen, G. Aversa, B.G. Cocks, and J.E. de Vries Role of interleukin-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells Allergy 49 1994 576 586 (Pubitemid 24318459)
8. H. Saito, T. Yamagata, and S. Suzuki Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates J Biol Chem 243 1968 1536 1542
9. H.W. Chu, J.B. Trudeau, S. Balzar, and S.E. Wenzel Peripheral blood and airway tissue expression of transforming growth factor beta by neutrophils in asthmatic subjects and normal control subjects J Allergy Clin Immunol 106 2000 1115 1123 (Pubitemid 32006266)
10. E.M. Minshall, D.Y. Leung, R.J. Martin, Y.L. Song, L. Cameron, and P. Ernst Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma Am J Respir Cell Mol Biol 17 1997 326 333 (Pubitemid 127500837)
11. U. Bartram, and C.P. Speer The role of transforming growth factor beta in lung development and disease Chest 125 2004 754 765 (Pubitemid 38223659)
12. C.H. Heldin, K. Miyazono, and P. ten Dijke TGF-beta signalling from cell membrane to nucleus through SMAD proteins Nature 390 1997 465 471 (Pubitemid 28013118)
13. M. Yamaguchi, A. Niimi, H. Matsumoto, T. Ueda, M. Takemura, and H. Matsuoka Sputum levels of transforming growth factor-beta1 in asthma: relation to clinical and computed tomography findings J Investig Allergol Clin Immunol 18 2008 202 206 (Pubitemid 351872287)
14. A. Nakao, S. Miike, M. Hatano, K. Okumura, T. Tokuhisa, and C. Ra Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity J Exp Med 192 2000 151 158 (Pubitemid 30470298)
15. M. Kubo, H. Matsuda, T. Tani, S. Arichi, Y. Kimura, and H. Okuda Studies on Scutellariae radix. XII. Anti-thrombic actions of various flavonoids from Scutellariae radix Chem Pharm Bull (Tokyo) 33 1985 2411 2415 (Pubitemid 15073784)
16. Y. Lu, R. Joerger, and C. Wu Study of chemical composition and antimicrobial activities of ethanolic extracts from roots of Scutellaria baicalensis Georgi J Agric Food Chem 25 2011 Epub ahead of print
17. Y.K. Hwang, M. Jinhua, B.R. Choi, C.A. Cui, W.K. Jeon, and H. Kim Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments J Ethnopharmacol 137 2011 681 689
18. M. Kubo, H. Matsuda, M. Tanaka, Y. Kimura, H. Okuda, and M. Higashino Studies on Scutellariae radix. VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from Scutellariae radix Chem Pharm Bull (Tokyo) 32 1984 2724 2729 (Pubitemid 14051197)
19. H.S. Yun-Choi, S.H. Chung, and Y.J. Kim Evaluation of some flavonoids as potential bradykinin antagonists Arch Pharm Res 16 1993 283 288
20. M. Chen, Z. Lv, and S. Jiang The effects of triptolide on airway remodelling and transforming growth factor-βâ/Smad signalling pathway in ovalbumin-sensitized mice Immunology 132 2011 376 384
21. Y.G. Kwak, C.H. Song, H.K. Yi, P.H. Hwang, J.S. Kim, and Y.C. Lee Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma J Clin Invest 111 2003 1083 1092 (Pubitemid 36397485)
22. K.S. Lee, H.K. Lee, J.S. Hayflick, Y.C. Lee, and K.D. Puri Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model FASEB J 20 2006 455 465 (Pubitemid 44933322)
23. W.W. Busse, and L.J. Rosenwasser Mechanisms of asthma J Allergy Clin Immunol 111 2003 S799 S804
24. S.J. Galli, M. Tsai, and A.M. Piliponsky The development of allergic inflammation Nature 454 2008 445 454
25. D.S. Pearlman Pathophysiology of the inflammatory response J Allergy Clin Immunol 104 1999 S132 S137
26. N.A. Barrett, and K.F. Austen Innate cells and T helper 2 cell immunity in airway inflammation Immunity 31 2009 425 437
27. F.D. Finkelman, J. Holmes, I.M. Katona, J.F. Urban Jr., M.P. Beckmann, and L.S. Park Lymphokine control of in vivo immunoglobulin isotype selection Annu Rev Immunol 8 1990 303 333
28. M. Wills-Karp Interleukin-13 in asthma pathogenesis Immunol Rev 202 2004 175 190 (Pubitemid 39576912)
29. J.Y. Cho, M. Miller, K.J. Baek, J.W. Han, J. Nayar, and S.Y. Lee Inhibition of airway remodeling in IL-5-deficient mice J Clin Invest 113 2004 551 560 (Pubitemid 38542504)
30. M. Yang, S.P. Hogan, P.J. Henry, K.I. Matthaei, A.N. McKenzie, and I.G. Young Interleukin-13 mediates airway hyperresponsiveness through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin Am J Respir Cell Mol Biol 25 2001 522 530 (Pubitemid 33037686)
31. K. Nakagome, M. Dohi, K. Okunishi, Y. Komagata, K. Nagatani, and R. Tanaka In vivo IL-10 gene delivery suppresses airway eosinophilia and hyperreactivity by down-regulating APC functions and migration without impairing the antigen-specific systemic immune response in a mouse model of allergic airway inflammation J Immunol 174 2005 6955 6966 (Pubitemid 40705660)
32. M. Nakaya, M. Dohi, K. Okunishi, K. Nakagome, R. Tanaka, and M. Imamura Noninvasive system for evaluating allergen-induced nasal hypersensitivity in murine allergic rhinitis Lab Invest 86 2006 917 926 (Pubitemid 44268166)
33. U.C. Yadav, L. Aguilera-Aguirre, I. Boldogh, K.V. Ramana, and S.K. Srivastava Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma Respir Res 3 2011 145
34. J.H. Kim, D. Jain, O. Tliba, B. Yang, W.F. Jester Jr., and R.A. Panettieri Jr. TGF-beta potentiates airway smooth muscle responsiveness to bradykinin Am J Physiol Lung Cell Mol Physiol 289 2005 L511 L520
35. H.N. Chuang, J.Y. Wang, J.H. Chiu, T.H. Tsai, S.F. Yeh, and S.L. Fu Enhancing effects of Scutellaria baicalensis and some of its constituents on TGF-beta1 gene expression in RAW 264.7 murine macrophage cell line Planta Med 71 2005 440 445
36. S.C. Christiansen, D. Proud, and C.G. Cochrane Detection of tissue kallikrein in the bronchoalveolar lavage fluid of asthmatic subjects J Clin Invest 79 1987 188 197 (Pubitemid 17232518)
37. K. Abe, N. Watanabe, N. Kumagai, T. Mouri, T. Seki, and K. Yoshinaga Circulating plasma in patients with bronchial asthma Experientia 23 1967 626 627
38. C.E. Austin, J.C. Foreman, and G.K. Scadding Reduction by Hoe 140, the B2 kinin receptor antagonist, of antigen-induced nasal blockage Br J Pharmacol 111 1994 969 971 (Pubitemid 24148754)
39. C. Cialdai, S. Giuliani, C. Valenti, M. Tramontana, and C.A. Maggi Effect of Intra-articular 4-(S)-amino-5-(4-{4-[2,4-dichloro-3-(2,4-dimethyl-8- quinolyloxymethyl)phenylsulfonamido]-tetrahydro-2H-4-pyranylcarbonyl}piperazino) -5-oxopentyl](trimethyl)ammonium chloride hydrochloride (MEN16132), a kinin B2 receptor antagonist, on nociceptive response in monosodium iodoacetate-induced experimental osteoarthritis in rats J Pharmacol Exp Ther 331 2009 1025 1032
40. L.M. Vasquez-Pinto, F. Nantel, P. Sirois, and S. Jancar Bradykinin B(1) receptor antagonist R954 inhibits eosinophil activation/proliferation/migration and increases TGF-beta and VEGF in a murine model of asthma Neuropeptides 44 2010 107 113