Effect of intra-articular 4-(S)-amino-5-(4-{4-[2,4-dichloro-3-(2,4- dimethyl-8-quinolyloxymethyl)phenylsulfonamido]-tetrahydro-2h-4-pyranylcarbonyl} piperazino)-5-oxopentyl(trimethyl)ammonium chloride hydrochloride (MEN16132), a kinin B2 receptor antagonist, on nociceptive response in monosodium iodoacetate-induced experimental osteoarthritis in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 331, Issue 3, 2009, Pages 1025-1032

  Cialdai, Cecilia ^a   Giuliani, Sandro ^a   Valenti, Claudio ^a   Tramontana, Manuela ^a   Maggi, Carlo Alberto ^a  

^a Menarini Ricerche SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 5[4 [4 [2,4 DICHLORO 3 (2,4 DIMETHYL 8 QUINOLYLOXYMETHYL)PHENYLSULFONAMIDO] TETRAHYDRO 2H 4 PYRANYLCARBONYL]PIPERAZINO] 5 OXOPENTYL](TRIMETHYL)AMMONIUM HYDROCHLORIDE; BRADYKININ; BRADYKININ ANTAGONIST; ICATIBANT; INDOMETACIN; INDOMETACIN MEGLUMINE; IODOACETIC ACID; MEN 16132; PROSTAGLANDIN E2; UNCLASSIFIED DRUG; (4 AMINO 5 (4 (4 (2,4 DICHLORO 3 (2,4 DIMETHYL 8 QUINOLYLOXYMETHYL)PHENYLSULFONAMIDO)TETRAHYDRO 2H 4 PYRANOYLCARBONYL)PIPERAZINO) 5 OXOPENTYL)(TRIMETHYL)AMMONIUM; (4-AMINO-5-(4-(4-(2,4-DICHLORO-3-(2,4-DIMETHYL-8-QUINOLYLOXYMETHYL)PHENYLSULFONAMIDO)TETRAHYDRO-2H-4-PYRANOYLCARBONYL)PIPERAZINO)-5-OXOPENTYL)(TRIMETHYL)AMMONIUM; BRADYKININ B2 RECEPTOR; DRUG DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; ORNITHINE; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; KNEE OSTEOARTHRITIS; NONHUMAN; PRIORITY JOURNAL; RAT; SYNOVIAL FLUID; WEIGHT BEARING; ANIMAL; ANIMAL BEHAVIOR; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG ANTAGONISM; HINDLIMB; INTRAARTICULAR DRUG ADMINISTRATION; MALE; METABOLISM; OSTEOARTHRITIS; PAIN; PATHOPHYSIOLOGY; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BEHAVIOR, ANIMAL; BRADYKININ; DINOPROSTONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HINDLIMB; INJECTIONS, INTRA-ARTICULAR; IODOACETATES; MALE; ORNITHINE; OSTEOARTHRITIS; PAIN; RATS; RATS, WISTAR; RECEPTOR, BRADYKININ B2; SULFONAMIDES; SYNOVIAL FLUID;

EID: 73349129369     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.159657     Document Type: Article

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