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Volumn 12, Issue 2, 2012, Pages 91-99

miR-15b and miR-16 induce the apoptosis of rat activated pancreatic stellate cells by targeting Bcl-2 in vitro

Author keywords

Apoptosis; Bcl 2; miR 15b; miR 16; Pancreatic stellate cells

Indexed keywords

LIPOCORTIN 5; MICRORNA 15B; MICRORNA 16; PROPIDIUM IODIDE; PROTEIN BCL 2; PROTEIN BCL XL;

EID: 84862797630     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2012.02.008     Document Type: Article
Times cited : (50)

References (40)
  • 2
    • 5444247172 scopus 로고    scopus 로고
    • Identification, culture, and characterization of pancreatic stellate cells in rats and humans
    • Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, et al. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 1998;115:421-32.
    • (1998) Gastroenterology , vol.115 , pp. 421-432
    • Bachem, M.G.1    Schneider, E.2    Gross, H.3    Weidenbach, H.4    Schmid, R.M.5    Menke, A.6
  • 4
    • 33747588068 scopus 로고    scopus 로고
    • Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis
    • DOI 10.1111/j.1440-1746.2006.04592.x
    • Bachem MG, Zhou Z, Zhou S, Siech M. Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis. J Gastroenterol Hepatol 2006;21(Suppl. 3):S92-6. (Pubitemid 44266560)
    • (2006) Journal of Gastroenterology and Hepatology , vol.21 , Issue.SUPPL. 3
    • Bachem, M.G.1    Zhou, Z.2    Zhou, S.3    Siech, M.4
  • 5
    • 33747607470 scopus 로고    scopus 로고
    • Battle-scarred pancreas: Role of alcohol and pancreatic stellate cells in pancreatic fibrosis
    • DOI 10.1111/j.1440-1746.2006.04587.x
    • Apte MV, Pirola RC, Wilson JS. Battle-scarred pancreas: role of alcohol and pancreatic stellate cells in pancreatic fibrosis. J Gastroenterol Hepatol 2006; 21(Suppl. 3):S97-101. (Pubitemid 44266561)
    • (2006) Journal of Gastroenterology and Hepatology , vol.21 , Issue.SUPPL. 3
    • Apte, M.V.1    Pirola, R.C.2    Wilson, J.S.3
  • 6
    • 78650175637 scopus 로고    scopus 로고
    • Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells
    • Kikuta K, Masamune A, Watanabe T, Ariga H, Itoh H, Hamada S, et al. Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells. Biochem Biophys Res Commun 2010;403:380-4.
    • (2010) Biochem Biophys Res Commun , vol.403 , pp. 380-384
    • Kikuta, K.1    Masamune, A.2    Watanabe, T.3    Ariga, H.4    Itoh, H.5    Hamada, S.6
  • 8
    • 44849119750 scopus 로고    scopus 로고
    • Pancreatic stellate cells promote proliferation and invasiveness of human pancreatic cancer cells via galectin-3
    • DOI 10.3748/wjg.14.2023
    • Jiang HB, Xu M, Wang XP. Pancreatic stellate cells promote proliferation and invasiveness of human pancreatic cancer cells via galectin-3. World J Gastroenterol 2008;14:2023-8. (Pubitemid 351795821)
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.13 , pp. 2023-2028
    • Jiang, H.-B.1    Xu, M.2    Wang, X.-P.3
  • 10
    • 72749103665 scopus 로고    scopus 로고
    • Stimulation of stellate cells by injured acinar cells: A model of acute pancreatitis induced by alcohol and fat (VLDL)
    • Siech M, Zhou Z, Zhou S, Bair B, Alt A, Hamm S, et al. Stimulation of stellate cells by injured acinar cells: a model of acute pancreatitis induced by alcohol and fat (VLDL). Am J Physiol Gastrointest Liver Physiol 2009;297:G1163-71.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.297
    • Siech, M.1    Zhou, Z.2    Zhou, S.3    Bair, B.4    Alt, A.5    Hamm, S.6
  • 11
    • 84872217617 scopus 로고    scopus 로고
    • Reg4 protects against acinar cell necrosis in experimental pancreatitis
    • Hu G, Shen J, Cheng L, Guo C, Xu X, Wang F, et al. Reg4 protects against acinar cell necrosis in experimental pancreatitis. Gut; 2010.
    • (2010) Gut
    • Hu, G.1    Shen, J.2    Cheng, L.3    Guo, C.4    Xu, X.5    Wang, F.6
  • 12
    • 1942435249 scopus 로고    scopus 로고
    • Micromanagers of gene expression: The potentially widespread influence of metazoan microRNAs
    • Bartel DP, Chen CZ. Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 2004;5: 396-400. (Pubitemid 38529411)
    • (2004) Nature Reviews Genetics , vol.5 , Issue.5 , pp. 396-400
    • Bartel, D.P.1    Chen, C.-Z.2
  • 13
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • DOI 10.1038/nature02871
    • Ambros V. The functions of animal microRNAs. Nature 2004;431:350-5. (Pubitemid 39265675)
    • (2004) Nature , vol.431 , Issue.7006 , pp. 350-355
    • Ambros, V.1
  • 17
    • 69449087939 scopus 로고    scopus 로고
    • Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways
    • Guo CJ, Pan Q, Cheng T, Jiang B, Chen GY, Li DG. Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways. FEBS J 2009;276:5163-76.
    • (2009) FEBS J , vol.276 , pp. 5163-5176
    • Guo, C.J.1    Pan, Q.2    Cheng, T.3    Jiang, B.4    Chen, G.Y.5    Li, D.G.6
  • 18
    • 61849096150 scopus 로고    scopus 로고
    • MiR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis
    • Guo CJ, Pan Q, Li DG, Sun H, Liu BW. miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: an essential role for apoptosis. J Hepatol 2009;50:766-78.
    • (2009) J Hepatol , vol.50 , pp. 766-778
    • Guo, C.J.1    Pan, Q.2    Li, D.G.3    Sun, H.4    Liu, B.W.5
  • 21
    • 0035710746 scopus 로고    scopus 로고
    • -δδCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using realtime quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25: 402-8. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 22
    • 35948950822 scopus 로고    scopus 로고
    • The role of inflammatory and parenchymal cells in acute pancreatitis
    • DOI 10.1002/path.2231
    • Vonlaufen A, Apte MV, Imhof BA, Frossard JL. The role of inflammatory and parenchymal cells in acute pancreatitis. J Pathol 2007;213:239-48. (Pubitemid 350074013)
    • (2007) Journal of Pathology , vol.213 , Issue.3 , pp. 239-248
    • Vonlaufen, A.1    Apte, M.V.2    Imhof, B.A.3    Frossard, J.L.4
  • 23
    • 77949308229 scopus 로고    scopus 로고
    • The microenvironment in chronic pancreatitis and pancreatic cancer induces neuronal plasticity
    • Demir IE, Ceyhan GO, Rauch U, Altintas B, Klotz M, Muller MW, et al. The microenvironment in chronic pancreatitis and pancreatic cancer induces neuronal plasticity. Neurogastroenterol Motil 2010;22:480-90. e112-3.
    • (2010) Neurogastroenterol Motil , vol.22 , Issue.480-490
    • Demir, I.E.1    Ceyhan, G.O.2    Rauch, U.3    Altintas, B.4    Klotz, M.5    Muller, M.W.6
  • 24
    • 0033828142 scopus 로고    scopus 로고
    • Collagen type I synthesized by pancreatic periacinar stellate cells (PSC) co-localizes with lipid peroxidation-derived aldehydes in chronic alcoholic pancreatitis
    • Casini A, Galli A, Pignalosa P, Frulloni L, Grappone C, Milani S, et al. Collagen type I synthesized by pancreatic periacinar stellate cells (PSC) co-localizes with lipid peroxidation-derived aldehydes in chronic alcoholic pancreatitis. J Pathol 2000;192:81-9.
    • (2000) J Pathol , vol.192 , pp. 81-89
    • Casini, A.1    Galli, A.2    Pignalosa, P.3    Frulloni, L.4    Grappone, C.5    Milani, S.6
  • 25
    • 0034733048 scopus 로고    scopus 로고
    • TGFβ1 autocrine growth control in isolated pancreatic fibroblastoid cells/stellate cells in vitro
    • DOI 10.1016/S0167-0115(00)00104-X, PII S016701150000104X
    • Kruse ML, Hildebrand PB, Timke C, Folsch UR, Schmidt WE. TGFbeta1 autocrine growth control in isolated pancreatic fibroblastoid cells/stellate cells in vitro. Regul Pept 2000;90:47-52. (Pubitemid 30331009)
    • (2000) Regulatory Peptides , vol.90 , Issue.1-3 , pp. 47-52
    • Kruse, M.-L.1    Hildebrand, P.B.2    Timke, C.3    Folsch, U.R.4    Schmidt, W.E.5
  • 26
    • 0033969266 scopus 로고    scopus 로고
    • Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: Implications in pathogenesis of pancreas fibrosis
    • Luttenberger T, Schmid-Kotsas A, Menke A, Siech M, Beger H, Adler G, et al. Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: implications in pathogenesis of pancreas fibrosis. Lab Invest 2000;80:47-55. (Pubitemid 30067379)
    • (2000) Laboratory Investigation , vol.80 , Issue.1 , pp. 47-55
    • Luttenberger, T.1    Schmid-Kotsas, A.2    Menke, A.3    Siech, M.4    Beger, H.5    Adler, G.6    Grunert, A.7    Bachem, M.G.8
  • 27
    • 0036785330 scopus 로고    scopus 로고
    • Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells
    • Jaster R, Sparmann G, Emmrich J, Liebe S. Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells. Gut 2002;51:579-84.
    • (2002) Gut , vol.51 , pp. 579-584
    • Jaster, R.1    Sparmann, G.2    Emmrich, J.3    Liebe, S.4
  • 28
    • 0035990269 scopus 로고    scopus 로고
    • Activated rat pancreatic stellate cells express intercellular adhesion molecule-1 (ICAM-1) in vitro
    • DOI 10.1097/00006676-200207000-00018
    • Masamune A, Sakai Y, Kikuta K, Satoh M, Satoh A, Shimosegawa T. Activated rat pancreatic stellate cells express intercellular adhesion molecule-1 (ICAM- 1) in vitro. Pancreas 2002;25:78-85. (Pubitemid 34760841)
    • (2002) Pancreas , vol.25 , Issue.1 , pp. 78-85
    • Masamune, A.1    Sakai, Y.2    Kikuta, K.3    Satoh, M.4    Satoh, A.5    Shimosegawa, T.6
  • 29
    • 0036282292 scopus 로고    scopus 로고
    • Pancreatic stellate cells respond to inflammatory cytokines: Potential role in chronic pancreatitis
    • DOI 10.1136/gut.50.4.535
    • Mews P, Phillips P, Fahmy R, Korsten M, Pirola R, Wilson J, et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut 2002;50:535-41. (Pubitemid 34638875)
    • (2002) Gut , vol.50 , Issue.4 , pp. 535-541
    • Mews, P.1    Phillips, P.2    Fahmy, R.3    Korsten, M.4    Pirola, R.5    Wilson, J.6    Apte, M.7
  • 31
    • 0036354166 scopus 로고    scopus 로고
    • Pancreatic stellate cell activation and MMP production in experimental pancreatic fibrosis
    • DOI 10.1006/jsre.2002.6403
    • Yokota T, Denham W, Murayama K, Pelham C, Joehl R, Bell Jr RH. Pancreatic stellate cell activation and MMP production in experimental pancreatic fibrosis. J Surg Res 2002;104:106-11. (Pubitemid 34948519)
    • (2002) Journal of Surgical Research , vol.104 , Issue.2 , pp. 106-111
    • Yokota, T.1    Denham, W.2    Murayama, K.3    Pelham, C.4    Joehl, R.5    Bell Jr., R.H.6
  • 32
    • 0037664888 scopus 로고    scopus 로고
    • In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas
    • Hasel C, Durr S, Rau B, Strater J, Schmid RM, Walczak H, et al. In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas. Lab Invest 2003;83:825-36. (Pubitemid 36723691)
    • (2003) Laboratory Investigation , vol.83 , Issue.6 , pp. 825-836
    • Hasel, C.1    Durr, S.2    Rau, B.3    Strater, J.4    Schmid, R.M.5    Walczak, H.6    Bachem, M.G.7    Moller, P.8
  • 33
    • 0037381404 scopus 로고    scopus 로고
    • Immunocytes and activated stellate cells in pancreatic fibrogenesis
    • DOI 10.1097/00006676-200304000-00006
    • Jaskiewicz K, Nalecz A, Rzepko R, Sledzinski Z. Immunocytes and activated stellate cells in pancreatic fibrogenesis. Pancreas 2003;26:239-42. (Pubitemid 36384155)
    • (2003) Pancreas , vol.26 , Issue.3 , pp. 239-242
    • Jaskiewicz, K.1    Nalecz, A.2    Rzepko, R.3    Sledzinski, Z.4
  • 34
    • 3342880954 scopus 로고    scopus 로고
    • The role of pancreatic stellate cells and cytokines in the development of chronic pancreatitis
    • Madro A, Celinski K, Slomka M. The role of pancreatic stellate cells and cytokines in the development of chronic pancreatitis. Med Sci Monit 2004;10: RA166-70. (Pubitemid 38988186)
    • (2004) Medical Science Monitor , vol.10 , Issue.7
    • Madro, A.1    Celinski, K.2    Stomka, M.3
  • 36
  • 38
    • 0141869043 scopus 로고    scopus 로고
    • Activin A is an autocrine activator of rat pancreatic stellate cells: Potential therapeutic role of follistatin for pancreatic fibrosis
    • DOI 10.1136/gut.52.10.1487
    • Ohnishi N, Miyata T, Ohnishi H, Yasuda H, Tamada K, Ueda N, et al. Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis. Gut 2003;52:1487-93. (Pubitemid 37176730)
    • (2003) Gut , vol.52 , Issue.10 , pp. 1487-1493
    • Ohnishi, N.1    Miyata, T.2    Ohnishi, H.3    Yasuda, H.4    Tamada, K.5    Ueda, N.6    Mashima, H.7    Sugano, K.8
  • 40
    • 34547623022 scopus 로고    scopus 로고
    • Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system
    • DOI 10.1101/gad.1566707
    • Wakiyama M, Takimoto K, Ohara O, Yokoyama S. Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Genes Dev 2007;21:1857-62. (Pubitemid 47204925)
    • (2007) Genes and Development , vol.21 , Issue.15 , pp. 1857-1862
    • Wakiyama, M.1    Takimoto, K.2    Ohara, O.3    Yokoyama, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.