Neuroprotective effects of icaritin against beta amyloid-induced neurotoxicity in primary cultured rat neuronal cells via estrogen-dependent pathway

Neuroscience

Volumn 145, Issue 3, 2007, Pages 911-922

  Wang, Z ^a   Zhang, X ^a   Wang, H ^a   Qi, L ^a   Lou, Y ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

amyloid protein; Alzheimer's disease; Bcl 2; estrogen receptor; icaritin; primary cultured neuronal cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; AMYLOID BETA PROTEIN; ESTROGEN; FLAVONOID; FULVESTRANT; ICARITIN; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL MEMBRANE POTENTIAL; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; ENZYME RELEASE; EPIMEDIUM; EPIMEDIUM SAGITTATUM MAXIM; FETUS; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; ESTROGENS; FETUS; FLAVONOIDS; MODELS, NEUROLOGICAL; NEURITES; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; RATS;

EID: 33947319498     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2006.12.059     Document Type: Article

References (59)

1. Alexaki V.I., Charalampopoulos I., Kampa M., Nifli A.P., Hatzoglou A., Gravanis A., and Castanas E. Activation of membrane estrogen receptors induce pro-survival kinases. J Steroid Biochem Mol Biol 98 (2006) 97-110
2. Asada H., Kaseloo P.A., Lis A., Petti D.M., and Plunkett R.J. Traumatized rat striatum produces neurite-promoting and neurotrophic activities in vitro. Exp Neurol 139 (1996) 173-187
3. Bang O.Y., Hong H.S., Kim D.H., Kim H., Boo J.H., Huh K., and Mook-Jung I. Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity. Neurobiol Dis 16 (2004) 21-28
4. Bastianetto S., Ramassamy C., Dore S., Christen Y., Poirier J., and Quirion R. The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid. Eur J Neurosci 12 (2000) 1882-1890
5. Bastianetto S., Ramassamy C., Poirier J., and Quirion R. Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage. Brain Res Mol Brain Res 66 (1999) 35-41
6. Behl C. Oestrogen as a neuroprotective hormone. Nat Rev Neurosci 3 (2002) 433-442
7. Behl C., Skutella T., Lezoualc'h F., Post A., Widmann M., Newton C.J., and Holsboer F. Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Mol Pharmacol 51 (1997) 535-541
8. Beresford S.A., Weiss N.S., Voigt L.F., and McKnight B. Risk of endometrial cancer in relation to use of oestrogen combined with cyclic progestagen therapy in postmenopausal women. Lancet 349 (1997) 458-461
9. Bost F., Caron L., Marchetti I., Dani C., Le Marchand-Brustel Y., and Binetruy B. Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage. Biochem J 361 (2002) 621-627
10. Brewer G.J., Torricelli J.R., Evege E.K., and Price P.J. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J Neurosci Res 35 (1993) 567-576
11. Brinton R.D. Impact of estrogen therapy on Alzheimer's disease: a fork in the road. CNS Drugs 18 (2004) 405-422
12. Brooks B.R., Bruccoleri R.E., Olafson B.D., States D.J., Swaminathan S., and Karplus M. CHARMM: A program for macromolecular energy, minimization, and dynamics calculations. J Comput Chem (1983) 187-217
13. Brzozowski A.M., Pike A.C., Dauter Z., Hubbard R.E., Bonn T., Engstrom O., Ohman L., Greene G.L., Gustafsson J.A., and Carlquist M. Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 389 (1997) 753-758
14. Burlacu A. Regulation of apoptosis by Bcl-2 family proteins. J Cell Mol Med 7 (2003) 249-257
15. Cardona-Gomez P., Perez M., Avila J., Garcia-Segura L.M., and Wandosell F. Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus. Mol Cell Neurosci 25 (2004) 363-373
16. Chang L., and Karin M. Mammalian MAP kinase signalling cascades. Nature 410 (2001) 37-40
17. Cho J.J., Iannucci F.A., Fraile M., Franco J., Alesius T.N., and Stefano G.B. The role of the estrogen in neuroprotection: implications for neurodegenerative diseases. Neurol Endocrinol Lett 24 (2003) 141-147
18. Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet 350 (1997) 1047-1059
19. Cordey M., Gundimeda U., Gopalakrishna R., and Pike C.J. The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection. Neurobiol Dis 19 (2005) 331-339
20. Cordey M., and Pike C.J. Neuroprotective properties of selective estrogen receptor agonists in cultured neurons. Brain Res 1045 (2005) 217-223
21. Desagher S., and Martinou J.C. Mitochondria as the central control point of apoptosis. Trends Cell Biol 10 (2000) 369-377
22. English J.M., and Cobb M.H. Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci 23 (2002) 40-45
23. Fitzpatrick J.L., Mize A.L., Wade C.B., Harris J.A., Shapiro R.A., and Dorsa D.M. Estrogen-mediated neuroprotection against beta-amyloid toxicity requires expression of estrogen receptor alpha or beta and activation of the MAPK pathway. J Neurochem 82 (2002) 674-682
24. Garcia-Segura L.M., Azcoitia I., and DonCarlos L.L. Neuroprotection by estradiol. Prog Neurobiol 63 (2001) 29-60
25. Gibbs R.B., Hashash A., and Johnson D.A. Effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult rats. Brain Res 749 (1997) 143-146
26. Ho L.W., Carmichael J., Swartz J., Wyttenbach A., Rankin J., and Rubinsztein D.C. The molecular biology of Huntington's disease. Psychol Med 31 (2001) 3-14
27. Jaffe A.B., Toran-Allerand C.D., Greengard P., and Gandy S.E. Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein. J Biol Chem 269 (1994) 13065-13068
28. Kaseloo P.A., Lis A., Asada H., Barone T.A., and Plunkett R.J. In vitro assessment of neurotrophic activity from the striatum of aging rats. Neurosci Lett 218 (1996) 157-160
29. Kornblum H.I., and Geschwind D.H. Molecular markers in CNS stem cell research: hitting a moving target. Nat Rev Neurosci 2 (2001) 843-846
30. Li L., Qin W., Qi-Xin Z., and Jing-Sha S. Protective effect of icariin against mitochondrial damage induced by oxygen free radical in rat cerebral cells. Chin J Pharmacol Toxicol 19 (2005) 333-337
31. Liu J., and Lou Y.J. Determination of icariin and metabolites in rat serum by capillary zone electrophoresis: rat pharmacokinetic studies after administration of icariin. J Pharm Biomed Anal 36 (2004) 365-370
32. Liu J., Ye H., and Lou Y. Determination of rat urinary metabolites of icariin in vivo and estrogenic activities of its metabolites on MCF-7 cells. Pharmazie 60 (2005) 120-125
33. Lustig R.H., Hua P., Smith L.S., Wang C., and Chang C. An in vitro model for the effects of androgen on neurons employing androgen receptor-transfected PC12 cells. Mol Cell Neurosci 5 (1994) 587-596
34. Mattson M.P. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev 77 (1997) 1081-1132
35. McEwen B., Akama K., Alves S., Brake W.G., Bulloch K., Lee S., Li C., Yuen G., and Milner T.A. Tracking the estrogen receptor in neurons: implications for estrogen-induced synapse formation. Proc Natl Acad Sci U S A 98 (2001) 7093-7100
36. Momany F.A., and Rone R. Validation of the general purpose QUANTA 3.2/CHARMm force field. J Comput Chem (1992) 888-900
37. Nilsen J., and Diaz Brinton R. Mechanism of estrogen-mediated neuroprotection: regulation of mitochondrial calcium and Bcl-2 expression. Proc Natl Acad Sci U S A 100 (2003) 2842-2847
38. Nilsen J., Mor G., and Naftolin F. Estrogen-regulated developmental neuronal apoptosis is determined by estrogen receptor subtype and the Fas/Fas ligand system. J Neurobiol 43 (2000) 64-78
39. 2+ channel currents in primary cultures of rat cortical neurones by amyloid beta protein (1-40) is dependent on solubility status. Brain Res 956 (2002) 254-261
40. Renvoize C., Biola A., Pallardy M., and Breard J. Apoptosis: identification of dying cells. Cell Biol Toxicol 14 (1998) 111-120
41. Ribble D., Goldstein N.B., Norris D.A., and Shellman Y.G. A simple technique for quantifying apoptosis in 96-well plates. BMC Biotechnol 5 (2005) 12
42. Shiau A.K., Barstad D., Loria P.M., Cheng L., Kushner P.J., Agard D.A., and Greene G.L. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 95 (1998) 927-937
43. Shimohama S. Apoptosis in Alzheimer's disease: an update. Apoptosis 5 (2000) 9-16
44. Shughrue P.J., Lane M.V., Scrimo P.J., and Merchenthaler I. Comparative distribution of estrogen receptor-alpha (ER-alpha) and beta (ER-beta) mRNA in the rat pituitary, gonad, and reproductive tract. Steroids 63 (1998) 498-504
45. Swerdlow R.H. Mitochondrial DNA-related mitochondrial dysfunction in neurodegenerative diseases. Arch Pathol Lab Med 126 (2002) 271-280
46. Teixeira C., Reed J.C., and Pratt M.A. Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res 55 (1995) 3902-3907
47. Venkatachalam C.M., Jiang X., Oldfield T., and Waldman M. LigandFit: a novel method for the shape-directed rapid docking of ligands to protein active sites. J Mol Graphics Model 21 (2003) 289-307
48. Wang C., Li Y., and Wang Y. [A review of pharmacological study on Epimedium grandiflorum Morr and its active constituents]. Zhongguo Zhong Yao Za Zhi 23 (1998) 183-185
49. Wang Z.Q., and Lou Y.J. Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells. Eur J Pharmacol 504 (2004) 147-153
50. Wang Z.Q., Webber N., Lou Y.J., and Proksch P. Prenylflavonoids as nonsteroidal phytoestrogens and related structure-activity relationships. Chem Med Chem 1 (2006) 482-488
51. Wickelgren I. Estrogen stakes claim to cognition. Science 276 (1997) 675-678
52. Woolley C.S., and McEwen B.S. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci 12 (1992) 2549-2554
53. Wu H., Lien E.J., and Lien L.L. Chemical and pharmacological investigations of Epimedium species: a survey. Prog Drug Res 60 (2003) 1-57
54. Xu H., Gouras G.K., Greenfield J.P., Vincent B., Naslund J., Mazzarelli L., Fried G., Jovanovic J.N., Seeger M., Relkin N.R., Liao F., Checler F., Buxbaum J.D., Chait B.T., Thinakaran G., Sisodia S.S., Wang R., Greengard P., and Gandy S. Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med 4 (1998) 447-451
55. Zhang Y.W., Morita I., Zhang L., Shao G., Yao X.S., and Murota S. Screening of anti-hypoxia/reoxygenation agents by an in vitro method. Part 2: Inhibition of tyrosine kinase activation prevented hypoxia/reoxygenation-induced injury in endothelial gap junctional intercellular communication. Planta Med 66 (2000) 119-123
56. Zhao L., Chen Q., and Brinton R.D. Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons. Exp Biol Med 227 (2002) 509-519
57. Zhao L., O'Neill K., and Diaz Brinton R. Selective estrogen receptor modulators (SERMs) for the brain: current status and remaining challenges for developing NeuroSERMs. Brain Res Brain Res Rev 49 (2005) 472-493
58. Zhou C., Wen Z.X., Shi D.M., and Xie Z.P. Muscarinic acetylcholine receptors involved in the regulation of neural stem cell proliferation and differentiation in vitro. Cell Biol Int 28 (2004) 63-67
59. Zuliani T., Duval R., Jayat C., Schnebert S., Andre P., Dumas M., and Ratinaud M.H. Sensitive and reliable JC-1 and TOTO-3 double staining to assess mitochondrial transmembrane potential and plasma membrane integrity: interest for cell death investigations. Cytometry A 54 (2003) 100-108